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(BBC-US)   Researchers are refusing to sugarcoat it - the diabeetus may be five different diseases   ( bbc.com) divider line
    More: Interesting, blood sugar levels, Diabetes mellitus, Insulin, Immune system, Lund University Diabetes, Diabetes mellitus type 1, Diabetes mellitus type 2, diabetes care  
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1741 clicks; posted to Geek » on 02 Mar 2018 at 4:50 PM (29 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2018-03-02 02:36:01 PM  
It's not entirely new but it's good progress. It's the same situation for many things that are labeled by symptoms. There are likely different types of Alzheimer's for example.

The many diseases in one problem makes it really difficult to work out treatments because when you do clinical trials a drug that is good for one root cause of a complex syndrome can be ineffective or even bad for those with a different root cause. And that makes a drug that's actually a great drug for the right people look like a poor drug. So research has to find an independent diagnostics to differentiate these different flavors of a disease first --- or --- you need to collect lots and lots of extra data to search out those differentiating factors after the fact. But that means giving many people substandard treatments just as a fishing expedition plus subjecting them to many more blood draws and other invasive testing.
 
2018-03-02 04:36:27 PM  

wademh: But that means giving many people substandard treatments just as a fishing expedition plus subjecting them to many more blood draws and other invasive testing.


Why aren't we allowed to give our body to science? Yeah, yeah, I know...organ donation, those places where they pay you to try out experimental drugs.

I mean, honest to goodness, "I'll let you bring me to within an inch of my life to better study how various things affect the human body."

Waiting longer for treatment to get a better idea of what happens in more advanced stages of diseases and being able to monitor it along the way.

Cutting off a limb to learn more about neurological impacts.

These seem far-fetched, but there are people out there that want to be heroes and would make sacrifices for the betterment of society as a whole.
 
2018-03-02 04:59:50 PM  
Well, it'll certainly simplify the double-billing.
 
2018-03-02 05:05:34 PM  
Is this dildoes?
 
2018-03-02 05:20:30 PM  
Diabeetus may not be what it seems. Get your blood checked!

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2018-03-02 06:07:29 PM  

wademh: It's not entirely new but it's good progress. It's the same situation for many things that are labeled by symptoms. There are likely different types of Alzheimer's for example.


In fact a true diagnosis of Alzheimer's can only be made post mortem. Many cases of AD are likely other forms of dimentia, which may not have obviuobvi different symptom profiles but distinct causal neuropathology.
 
2018-03-02 06:23:49 PM  

chawco: wademh: It's not entirely new but it's good progress. It's the same situation for many things that are labeled by symptoms. There are likely different types of Alzheimer's for example.

In fact a true diagnosis of Alzheimer's can only be made post mortem. Many cases of AD are likely other forms of dimentia, which may not have obviuobvi different symptom profiles but distinct causal neuropathology.


I see I'm not the only one whose autocorrect predictions have been putting in some really jacked up words.
 
2018-03-02 06:34:18 PM  

Smackledorfer: chawco: wademh: It's not entirely new but it's good progress. It's the same situation for many things that are labeled by symptoms. There are likely different types of Alzheimer's for example.

In fact a true diagnosis of Alzheimer's can only be made post mortem. Many cases of AD are likely other forms of dimentia, which may not have obviuobvi different symptom profiles but distinct causal neuropathology.

I see I'm not the only one whose autocorrect predictions have been putting in some really jacked up words.


I think my autocorrect and autocomplete have dimentia. Sometimes they just make gibberish.
 
2018-03-02 09:10:23 PM  

chawco: wademh: It's not entirely new but it's good progress. It's the same situation for many things that are labeled by symptoms. There are likely different types of Alzheimer's for example.

In fact a true diagnosis of Alzheimer's can only be made post mortem. Many cases of AD are likely other forms of dimentia, which may not have obviuobvi different symptom profiles but distinct causal neuropathology.


It's more than that. One hypothesis is that Alzheimer's is the result of various types of failures of proteostasis --- the recycling process of proteins including but not limited to defectively folded proteins. There's an intersection with prion diseases. Why cells fail to clean up after misfolded proteins can have myriad reasons. The rate of misfolding can increase so that it overwhelms the mechanisms of scavenging and cleanup, and/or the rate the clean-up can be reduced. And cells that die from catastrophic levels of  misfolded proteins can "infect" other cells if cellular scavenging falls short for any number of reasons. So ultimately, many different pathways can fail and result in very similar phenotypes.

A therapeutic that  can enhance protein scavenging might be effective across many different sources of failure of proteostatis. Or perhaps more specific therapies could be effective against specific types of failure. Bottom line is that it's complicated.
 
2018-03-02 09:22:55 PM  
I just got diagnosed 2 weeks ago. Almost under control now, thanks to one of the most advanced diabetes clinics in the world. And hooray for Canadian socialized medicine! It's free!

Banting's and Best's graves are 3 miles from me. You can bet the farm that I will be visiting them this summer.

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2018-03-02 10:36:46 PM  
Pentabeetus, then. Fine.
 
2018-03-02 11:28:44 PM  
Type 1 and similar problems are a lack of insulin. The rest are all about how the body reacts to glucose. If they could test all these sub types by adopting a ketogenic diet or fasting, we might actually have a breakthrough.
 
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