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(Minnesota Public Radio)   What do autism, ADHD, Schizophrenia, bi-polar disorder and major depressive disorder have in common? No, not the makings of a memorable party. They share genetic links   ( minnesota.publicradio.org) divider line
    More: Interesting, ADHD, autism, schizophrenias  
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1681 clicks; posted to Geek » on 28 Feb 2013 at 10:11 AM (5 years ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»

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2013-02-28 10:25:05 AM  
2 votes:
They are all overdiagnosed so drug companies can make money?
2013-02-28 01:08:11 PM  
1 vote:

torusXL: Subby, what does all these things have to do with each other? Well, for one, you did not decline the verb correctly

Came here to say this.  This.

Bad subby.  No cookie for you.
2013-02-28 12:54:10 PM  
1 vote:

Vercengetorix: what she's on now works well, so why fark with it?

Because every doctor has to prove they are as good as Dr House and knows more than everyone else in the world ESPECIALLY YOU.
2013-02-28 11:00:35 AM  
1 vote:
Interesting, indeed, submitter. Good headline, too.
2013-02-28 11:00:31 AM  
1 vote:

Zel: The last time I saw a study about genetic links between autism and schizophrenia... it was that they both had an increased rate of sporadic random segmental mutation (CNV). Nothing actually in common, other than some poorly-understood duplications or deletions of some hundred distinct genes. Turns out throwing off the biochemistry of the most complex system ever 'designed' is easy to do in many ways. So the brain's blueprint is fragile, but we're not a whole lot closer to understanding how it works.
I'm not actually convinced autism and schizophrenia are all that tightly defined in a biochemical sense. There are no drugs to treat a miswiring. They're not broken, they just think differently.

Thanks, Mr. Expert! You surely have helped those suffering from the effects of disorders by simply stating that you're vaguely not convinced. Wow why didn't anyone ever think of that??? Here we are spending millions on research.

But seriously...it is possible that autism itself isn't a disease and just represents some new form of neurodiversity. However, in the context of our society, it can be debilitating. We can't know what we don't know about autism until we scrutinize it and...learn what we don't know.

Schizophrenia is very most likely a disease. It's just very complex, and I think part of that complexity is being uncovered with the "glutamate hypothesis". Basically, recent evidence suggests that a root cause of schizophrenia might involve some malfunction or collapse of the NMDA system which then causes other systems to malfunction, such as executive control and dopamine regulation. The reason the disease is confusing is because the NMDA system is a critical link to these feedback systems which underly fundamental features of the human mind, such as consciousness, memory recall, and just about everything. For example, the NMDA antagonist PCP is known to induce schizophrenic like symptoms in mice (a drug antagonists basically means "turns off / turns down").

Considering how this article suggests common links between schizophrenia and the others is very interesting with the fact that NMDA antagonists like ketamine are known to relieve depression immediately, even on cases that were resistant to every other antidepressant tried (as an aside, this is one reason why the War On Drugs is inhumane and absolutely idiotic). Of course, this wouldn't necessarily mean that schizophrenia and major depression are both exactly caused by glutamate abnormalities, but rather that there may be some complex, cyclical feedback effects that contribute to causing the symptoms of seemingly unrelated mental disorders.

That may sound like a clusterfark of a confusing explanation, but that's because language just doesn't do the human brain justice. And neither do your arbitrary opinions based on nothing do the human brain and sufferers of broken human brains justice.
2013-02-28 10:29:23 AM  
1 vote:
Subby, what does all these things have to do with each other? Well, for one, you did not decline the verb correctly ^^

Vercengetorix: My wife's manic phase is extreme, sudden anger.  Beats the shiat out of a pillow every time.

That's interesting, I didn't know bipolar could express that way. So instead of sad/happy manias, she has anger manias? How is that different from, say, borderline rage outbursts or ADHD impulsive outbursts?

Btw I'm not at all saying "Pssh she doesn't have bipolar!". I'm genuinely curious to just learn more about it in contrast to the more "standard" disorders that tend to involve some anger.
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