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(Yahoo)   NyanyanyanyanyanyanyaDEAD   ( news.yahoo.com) divider line
    More: Sad, cats, marty, incurable, little buddy, Rick Astley  
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11178 clicks; posted to Geek » on 02 Nov 2012 at 6:53 AM (5 years ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»

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2012-11-02 08:31:34 AM  
3 votes:
teecraze.comView Full Size

Goodnight, kitty
2012-11-02 06:59:38 AM  
3 votes:
Don't scare me like that. By the headline, I thought Adam West had died.
2012-11-02 06:14:35 PM  
2 votes:
I'd like to thank Great Porn Dragon for saying "Shut up you retarded, unknowing, stupid-arse fartbag of a human being" in a much nicer, kinder way than I could ever have. His genuine effort to educate a horrible human being, despite their ignorance of a very serious and deadly animal disease is truly a scourge on this planet, is admirable. I commend him for his efforts. Personally, the only words I could have wasted upon dababler and Contents Under Pressure were curses to their mothers and families.

GPD - You are a much better person than I. For that, I salute you.

appygamesblog.comView Full Size
2012-11-02 09:59:38 AM  
2 votes:
FIP is a horrible kitty cat disease. It is incurable, always fatal and sometimes can't even be diagnosed until after a necropsy is done.

I've lost two cats to this - I hate it when I hear about others having to go through it.
2012-11-02 03:07:50 PM  
1 vote:

dababler: Should have gotten his cat vaccinated.

Unfortunately, FIP is one of the few fatal infectious diseases of cats for which really effective vaccination doesn't exist (yes, there is an FIP vaccine, but it doesn't really work all that well and is still controversial among vets); we still aren't 100% sure if it's even possible to really vaccinate cats against it.

FIP has been tentatively linked to a feline coronavirus related to Feline Enteric Coronavirus but one of the complicating factors is that it's now thought FIPV develops from a mutation in FECV when a cat has been previously infected with FECV and resulting from a mutation in the FECV the cat carries (which does not normally make kitties sick)--there really ISN'T a good analogue with human diseases, because we don't really have any kind of infectious disease that arises from a harmless virus (that everyone carries) mutating into Captain Trips in a few unlucky people (who are ALL Patient Zero).

(The REAL human analogue would be if you had a mild 24-hour cold that spontaneously mutated into SARS while you still had the cold (bascally, FECV virus mutates to where it can invade white blood cells and infect them, and it causes a massive cytokine storm in kitteh). Primates don't really HAVE anything like FIP (in that the virus causing the disease is a mutated version of an innocuous virus in such a way that EVERY patient with it is Patient Zero) so it's been particularly difficult to find the cause; also, since FIP is likely caused by a benign virus spontaneously mutating into something akin to Kitty Cholera-SARS virus, that's going to be a lot harder to develop an effective vaccine for, especially as coronaviruses are known to mutate pretty rapidly and it's entirely likely that every kitty with FIP may have a different virus strain.)

Even some human bacterial diseases that are out there (and we know how they work) tend to be hard to actually effectively vaccinate against--we have cholera vaccines, but hardly any infectious disease or tropical medicine specialist really RECOMMENDS them because they don't work worth a damn (only about 60-70 percent effectiveness). Same for typhoid vaccine--for whatever reason, those vaccines just aren't terribly immunogenic (in the case of cholera, it's complicated by the fact that cholera bacteria that can give you actual cholera are THEMSELVES infected with a virus that makes them pathogenic, so cholera in particular is tricky to make a working vaccine against).

In the case of FIP, this is even further complicated by both a) the virus becoming infectious (and deadly) inside the kitty (all FIPV infections are from their own bad luck of having FECV that had the mutation that turns it into FIP--the FIP virus proper only lives in macrophages) AND its primary target being a certain type of white blood cell--imagine an infectious disease that in its own way was (immunologically) some farked-up mix of cholera and HIV and you get the idea. :P (And yes, cats who are immunocompromised have a higher chance of getting FIP from a pre-existing FECV infection--young kitties, unfortunately, tend to be among the vulnerable as well. Also--much like with HIV infection in humans--there are genetic factors in cats involved; there are known genes that increase likelihood of a cat contracting FIP if a "bad mutation" occurs.)

And FIP vaccination is even LESS effective than cholera vaccination, which should give you an idea of why even a lot of vets don't offer it routinely. Pretty much to effectively vaccinate against FIP you really have to vaccinate against FECV, and you run into the exact problem that you run into with cholera vaccination--it's one of those rare diseases where the "neutered" version isn't all that immunogenic against the disease that actually makes people sick, and it's difficult (without possibly some genetic engineering which people WILL WHARGARBL about) to make a vaccine that works without giving the patient the disease. (The fact that there does seem to be a fairly strong tie to genetic susceptibility doesn't help, either--even in feral cat colonies where FIP exists, almost all kitties have FECV infection but only 8-20% get the "bad mutation" and go into FIP.)

Even worse still for the prospect of an effective FIP vaccine, it turns out that most immunity that is actually effective against FIPV is with cellular immunity--not humoral/antibody-based immunity...and it's the latter how vaccination works. Basically, kitties with good cellular immunity can fight off FECV when it mutates to FIPV, whilst kitties who don't have good cellular immunity can go into FIP. (Yes, this is basically a similar issue to not only problems with cholera vaccination but issues we've run into developing an effective HIV vaccine.) In fact, for kitties with poor cellular immunity who've been vaccinated against FECV, it can throw them into the full-blown cytokine storm (and thus fatal FIP--FIP is actually a misnomer, and should really be called "feline cytokine-storm peritonitis").

It's actually a surprisingly difficult disease to protect kitties against--more on the relationship here.

About the only thing that's been found effective is an immunostimulant which is still very much in clinical trials in cats (and probably unavailable outside of one or two specialised veterinary research hospitals)--I guess you could feed them elderberries en masse, as there's been some experimentation with elderberry extract with humans in cytokine storms, but there's not much to help with that otherwise, sadly.
2012-11-02 02:34:29 PM  
1 vote:

Felgraf: Contents Under Pressure: dababler: Should have gotten his cat vaccinated.

So much THIS. Add to it that his other cat died. Some people should not have pets.

With a vaccine that doesn't exist?


It's the same principle about how you're a bad parent for not getting your child an AIDS and Cancer vaccine.
2012-11-02 02:24:44 PM  
1 vote:
Ah, my bad. One exists, but is ineffective. Meaning he may *HAVE* vaccinated the cat.
2012-11-02 02:23:23 PM  
1 vote:

Contents Under Pressure: dababler: Should have gotten his cat vaccinated.

So much THIS. Add to it that his other cat died. Some people should not have pets.

With a vaccine that doesn't exist?
2012-11-02 09:57:05 AM  
1 vote:
It's very sad to lose a cat when they're so very young (Marty was 3).

6.mshcdn.comView Full Size
2012-11-02 07:38:13 AM  
1 vote:
hastac.orgView Full Size
2012-11-02 07:29:59 AM  
1 vote:

Tommy Moo: adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.

I thought so too, but then I realized that Adam West would warrant a NEWSFLASH tag.

He would indeed.
2012-11-02 07:22:31 AM  
1 vote:

adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.

I thought so too, but then I realized that Adam West would warrant a NEWSFLASH tag.
2012-11-02 07:06:56 AM  
1 vote:

adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.

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