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(Telegraph)   Infecting patients with worms could cure asthma, cause skid marks on the rug   (telegraph.co.uk) divider line
    More: Scary  
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2133 clicks; posted to Fandom » on 29 Jan 2009 at 8:52 PM (14 years ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



26 Comments     (+0 »)
 
2009-01-29 7:51:01 PM  
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2009-01-29 8:27:38 PM  
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2009-01-29 9:11:52 PM  
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2009-01-29 9:26:59 PM  
Hmmmm... Asthma, or allowing parasitic worms to burrow beneath my skin...

Also, I hear tapeworms cure obesity.
 
2009-01-29 9:28:02 PM  
HOW ABOUT YES

Where do you think autoimmune disorders come from?

TFA: Known as the "hygiene hypothesis" the theory that certain diseases are on the rise in rich countries because their inhabitants are exposed to fewer infections first hit the headlines in the late 1980s.

Genetically, we haven't changed much since the middle ages. Our immune systems haven't changed. We just... smell better. And like bored cats, our immune systems are becoming dangerously mischievous.
 
2009-01-29 10:03:45 PM  
If they find out this actually works, I'm in. I've had chronic asthma since I was five and inhalers just went up to $68. That's one per month for me and I still can't be very active without an attack.

Sucks to my asthmar!
 
2009-01-29 10:04:27 PM  
old news is good news

/yawn
//wheeze
 
2009-01-29 10:09:09 PM  
So they've finally given approval to that pill to give worms to ex-girlfriends?
 
2009-01-29 10:13:33 PM  
Skin.Crawl.Now.Thanks.
 
2009-01-29 10:17:56 PM  
adrants.comView Full Size

Hot!
 
2009-01-29 10:30:55 PM  
Why, oh why, does the Telegraph insist on having exactly one sentence per paragraph?

It breaks the flow, and makes it feel like you're in remedial reading class.

I really don't like that, but it's taking over at other places as well.

As for the content of the article, seems like common sense to me that our immune systems are going haywire these days, with our addiction to disinfectants and antibacterial wipes and such as.
 
2009-01-29 11:01:54 PM  
HELLO?!

Flying Spaghetti Monster believers here? The Decreasing amount of Pirates in the World and the Increase in Global Warming are not related to each other.

And neither is Worms helping Cure Asthma. Asthma is not a germ that the body can fight with its immune system.

I have very little biology experience, but having asthma myself, I say to you, Good Day Sir! I SAID Good day!
 
2009-01-29 11:20:22 PM  

No Such Agency: HOW ABOUT YES

Where do you think autoimmune disorders come from?

TFA: Known as the "hygiene hypothesis" the theory that certain diseases are on the rise in rich countries because their inhabitants are exposed to fewer infections first hit the headlines in the late 1980s.

Genetically, we haven't changed much since the middle ages. Our immune systems haven't changed. We just... smell better. And like bored cats, our immune systems are becoming dangerously mischievous.


This.
 
2009-01-29 11:23:56 PM  

Rhames: HELLO?!

Flying Spaghetti Monster believers here? The Decreasing amount of Pirates in the World and the Increase in Global Warming are not related to each other.

And neither is Worms helping Cure Asthma. Asthma is not a germ that the body can fight with its immune system.

I have very little biology experience, but having asthma myself, I say to you, Good Day Sir! I SAID Good day!


No, but it is not too far fetched to see a potentially causal link between a lack of valid threats to train the naive immune system and in increase in autoimmune diseases. In fact, it's believed that the immunoglobulin E that is responsible for some allergic conditions originally existed to deal with (now nearly non-existent) parasitic threats.

/The more you know
//Asthmatic and biologist
 
2009-01-29 11:36:42 PM  
Having some bad allergies myself, I would gladly stick a few pinworms in my arm to have that shiat go away!
 
2009-01-29 11:45:00 PM  
/Biologist
//known about this for four years now
///yawn
 
2009-01-30 12:06:36 AM  
weirdwildrealm.comView Full Size


/obscure?
 
2009-01-30 12:28:35 AM  
If successful researchers hope that pharmaceutical companies could develop drugs which have the same positive effect on the immune system as worms.

Thats some bullshiat right there. It works, but they cant figure out a way to patent it. Prepare for these worms to be outlawed. Just like Marinol.
 
2009-01-30 12:51:27 AM  

solenoid: Rhames: HELLO?!

Flying Spaghetti Monster believers here? The Decreasing amount of Pirates in the World and the Increase in Global Warming are not related to each other.

And neither is Worms helping Cure Asthma. Asthma is not a germ that the body can fight with its immune system.

I have very little biology experience, but having asthma myself, I say to you, Good Day Sir! I SAID Good day!

No, but it is not too far fetched to see a potentially causal link between a lack of valid threats to train the naive immune system and in increase in autoimmune diseases. In fact, it's believed that the immunoglobulin E that is responsible for some allergic conditions originally existed to deal with (now nearly non-existent) parasitic threats.

/The more you know
//Asthmatic and biologist


Its actually pretty well known that IgE (along with eosinophils and mast cells) is one of your bodies main defenses against helminth parasites. Also, as mentioned earlier its also central to allergic reactions, especially Type 1 hypersensitivity (which includes asthma). So I'm assuming the theory here is that its a way to regulate IgE. There was also some significant success in a small scale human trial with using nematode intestinal worms (pinworms, I think) to alleviate the symptoms of Crohn's disease and severe IBD. But since the pinworms are technically contagious the FDA put a stop to the study and now the research has moved into the veterinary field, working on dogs with IBD. And I completely agree with the "hygiene hypothesis." The best things you can do for your kid's health is get rid of the "antibiotic" soap and encourage them to go play in the dirt.

/biologist and vet student - so we have to learn about this stuff since our patients still get worms
//thankfully, not asthmatic
 
2009-01-30 12:55:59 AM  
NNNNNNNNNNNNNgah.

Might beat having a lifelong dependency on medication just to be able to breathe reasonably normally, but... *shudder*

At least it's about hookworms, not ascaris or tapeworms.

/Doesn't recommend GISing 'ascaris'.
 
2009-01-30 12:59:33 AM  

Darwin's Prophet: solenoid: Rhames: HELLO?!

Flying Spaghetti Monster believers here? The Decreasing amount of Pirates in the World and the Increase in Global Warming are not related to each other.

And neither is Worms helping Cure Asthma. Asthma is not a germ that the body can fight with its immune system.

I have very little biology experience, but having asthma myself, I say to you, Good Day Sir! I SAID Good day!

No, but it is not too far fetched to see a potentially causal link between a lack of valid threats to train the naive immune system and in increase in autoimmune diseases. In fact, it's believed that the immunoglobulin E that is responsible for some allergic conditions originally existed to deal with (now nearly non-existent) parasitic threats.

/The more you know
//Asthmatic and biologist

Its actually pretty well known that IgE (along with eosinophils and mast cells) is one of your bodies main defenses against helminth parasites. Also, as mentioned earlier its also central to allergic reactions, especially Type 1 hypersensitivity (which includes asthma). So I'm assuming the theory here is that its a way to regulate IgE. There was also some significant success in a small scale human trial with using nematode intestinal worms (pinworms, I think) to alleviate the symptoms of Crohn's disease and severe IBD. But since the pinworms are technically contagious the FDA put a stop to the study and now the research has moved into the veterinary field, working on dogs with IBD. And I completely agree with the "hygiene hypothesis." The best things you can do for your kid's health is get rid of the "antibiotic" soap and encourage them to go play in the dirt.

/biologist and vet student - so we have to learn about this stuff since our patients still get worms
//thankfully, not asthmatic



eosinophils doesnt protect against worm parasites. IgE and mast cells do.

/and one other thing
//been a couple years since i've had immunology
//oh yeah, IgD!! (joke to other immunonerds here)
 
2009-01-30 1:12:25 AM  
I read an article last year written by a man who was fighting Crohn's or some similar disease. He'd intentionally infect himself with a worm that seems to live only in Africa by walking barefoot where they throw out their shiat buckets. Has to go back every few years, but claimed that it pretty much killed his symptoms.
 
2009-01-30 1:25:04 AM  

fortean chicken: If they find out this actually works, I'm in. I've had chronic asthma since I was five and inhalers just went up to $68. That's one per month for me and I still can't be very active without an attack.

Sucks to my asthmar!


Yes, it looks very interesting. I've been aware of the hygiene hypothesis for some time now (although I believe there is a genetic component to my problems) but this report surprises me--I wouldn't have thought it could be fixed after the fact.

There is an asthma drug out for severe cases that's based along related lines that's based on going after the errant reaction sequence. Fiendishly expensive and you take the first injection under supervision because it may cause an anaphylactic reaction.
 
2009-01-30 1:41:08 AM  

Megasmilax: It's like a party in my mouth, and everyone's throwing up!


I was going to snark on 'post hoc, ergo propter hoc', but I'll bow to your truck stop egg-salad sandwich.
 
2009-01-30 3:06:12 AM  

genzoman:
eosinophils doesnt protect against worm parasites. IgE and mast cells do.

/and one other thing
//been a couple years since i've had immunology
//oh yeah, IgD!! (joke to other immunonerds here)


Afraid you're incorrect here. Eos are actually very important in anti-helminth defenses. Mast cells are the first cells to respond to an IgE bound to a parasite but they themselves don't due a lot of damage because the cuticle of helminths is rather tough. However part of a mast cell degranulation is eosinophil chemotactic factor which attracts eosinophils to the site. Once there they bind with the FC portion of IgE and degranulate releasing their main products (major basic protein, eosinophil cationic protein, eosinophil neurotoxin, and eosinophil peroxidase) that work to both dissolve the cuticle of the helminth and cause neurotoxicity. If the worms are in the GI tract than the paralyzation caused by this toxicity generally causes them to "lose their grip" and they get flushed out. In fact the two differentials for marked eosinophilia are either parasitic infection or allergies/hypersensitivities.

/Class dismissed.
//I kind of always like immunology (otherwise known as: How your body tries its best to kill you)
 
2009-01-30 10:35:03 AM  
Ancient Chinese wiseman once say:

If your assshole itches, scratch it.

and.........

He who goes to bed with itchy butt, wake up with smelly finger.
 
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