The fabrication issues with a titanium alloy are more than worth it, but I'd go with a screen effect rather than truss-work.  And I'd make the screen hole diameter sufficiently large that you could clean it with a pipe cleaner.

And it should work over an induction mat so you don't have to worry about batteries *ever*.  And that mat can also be the receiving antenna so you have no issues there, either.

Some people say you can make a symmetrical mouse, but I'd make left and right-handed versions.

Other than that, I'd want a nice matte finish on it.  Black with red trim or an olive / brown combo.  Two buttons and a roller, plus a side button for your thumb.  And maybe another roller under that thumb button for audio control or something.