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(NBC News)   Well if it is that expensive, it must work, right?   (nbcnews.com) divider line
102
    More: Unlikely, Obesity, Medicine, Eli Lilly drug, Pharmacology, Weight loss, best-selling drug of all time, Body mass index, weight loss  
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6447 clicks; posted to Main » and Business » on 01 Jan 2023 at 3:26 PM (12 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



102 Comments     (+0 »)
View Voting Results: Smartest and Funniest


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kdawg7736 [TotalFark] [OhFark]
2023-01-01 12:40:48 PM  
If it is too good to be true, it probably is.
 
edmo [TotalFark] [OhFark]
2023-01-01 1:06:59 PM  
Cheaper to eat.
 
Hoopy Frood
2023-01-01 1:08:40 PM  
Being unable to afford food is a highly effective weight-loss strategy.
 
Badmoodman [TotalFark]
2023-01-01 1:12:50 PM  
Kelly Smith, a spokesperson for Eli Lilly, declined to comment on what tirzepatide will cost.

Ok, I'm done with this story.
 
Some Junkie Cosmonaut
2023-01-01 3:30:07 PM  

kdawg7736: If it is too good to be true, it probably is.


Sounds a little too good to be true to me
 
gottagopee
2023-01-01 3:31:39 PM  
And no mention how this has already impacted diabetics (not good), and no mention of possible future impacts on diabetics. Yay journalisms.
 
Feel_the_velvet
2023-01-01 3:33:51 PM  
At $1300/month, I'm going to have to stop buying food in order to afford it.
 
Pinnacle Point [TotalFark] [OhFark]
2023-01-01 3:34:55 PM  
Is it meth?
 
Ketchuponsteak
2023-01-01 3:35:28 PM  
Wasn't approved in Denmark (the Novo Nordisk one). I suspect the state feels the best, healthiest, and cheapest way, is to excercise and eat less if you want to lose weight.
 
UberNeuman
2023-01-01 3:35:45 PM  
Fark user imageView Full Size
 
HempHead
2023-01-01 3:38:09 PM  

Feel_the_velvet: At $1300/month, I'm going to have to stop buying food in order to afford it.


Chances are the food your eating will give you diabetes, so just buy the diabetes version of the drug and take two.
 
thornhill
2023-01-01 3:38:17 PM  
At $1300/month you could hire a personal trainer and dietitian for less.
 
Walker [TotalFark]
2023-01-01 3:39:26 PM  
Cheaper to sew your mouth shut.
 
Shaggy_C
2023-01-01 3:40:21 PM  
$1300 is chump price. The negotiated price with insurance will be closer to half that, and then insurance will cover a huge chunk. I imagine the Medicaid set with their 40+ BMI and on "the disbilty" won't have to pay anything out of pocket. The taxpayer will pick up the tab, naturally.
 
nakmuay
2023-01-01 3:44:45 PM  
Requiring anti-obesity drugs to be covered by insurance may require legislative action, Stanford said.

So insurance companies vs Big Pharma, with Congress in the middle? The bribes lobbying will be legendary.
 
sleze
2023-01-01 3:45:45 PM  
What's old is new again...

www-tc.pbs.orgView Full Size
 
nealb2 [TotalFark]
2023-01-01 3:46:01 PM  
brain is fat
 
functionisalwaystaken
2023-01-01 3:46:02 PM  

thornhill: At $1300/month you could hire a personal trainer and dietitian for less.


Unfortunately some people are too foolish or stubborn to utilize either.

If effective, this might be good for my FIL who refused to start exercising 15 years ago, is pushing 375, has knees in too rough shape to exercise now, can't have bariatric surgery because of the congestive heart failure, and can only help to resolve the congestive heart failure by not being so obese.
 
big pig peaches
2023-01-01 3:48:10 PM  
Wasn't there a zombie apocalypse movie that started likw this?
 
cefm
2023-01-01 3:49:46 PM  
Or just put the fork down. That's free. Saves you money actually.
 
genner
2023-01-01 3:50:52 PM  
Fark user imageView Full Size
 
Excelsior
2023-01-01 3:51:23 PM  

kdawg7736: If it is too good to be true, it probably is.


What/s the worst that could happen?

/potential side effects:anal leakage, tumors, and starvation once the body stops absorbing and processing any further nutrients
 
Loucifer
2023-01-01 3:53:31 PM  
This drug could exceed Stummies profits.

Fark user imageView Full Size
 
basicstock
2023-01-01 3:53:50 PM  
I was prescribed Ozempic (semaglutide) by my Endocrinologist back in July.  It's a once-a-week simple injection.
It has done wonders for my blood sugar levels, the best they have ever been.
But it gives me horrible heartburn and bloating.  On cue, around 1:00 am, my stomach empties into my throat and I have to get up and take some antacid powder to try to get back to sleep.  It also gives me constipation.  My Endo told me to stop taking it for a few weeks over the holidays and the heartburn, bloating and constipation have gone away.  Apparently these symptoms don't happen to everyone who takes it.  I hope I can continue on it as, like I said, it's been great for my blood sugar levels.
 
mistahtom
2023-01-01 3:54:01 PM  
Don't consume ultraprocessed fiberless carb-heavy foods, seed oils, and added sugar.
 
Russ1642
2023-01-01 3:54:24 PM  
The US is so fat they're going to add it to the water supply. Strike that. Add it to McDonalds french fries.
 
End_Of_Line
2023-01-01 3:55:43 PM  

Shaggy_C: $1300 is chump price. The negotiated price with insurance will be closer to half that, and then insurance will cover a huge chunk. I imagine the Medicaid set with their 40+ BMI and on "the disbilty" won't have to pay anything out of pocket. The taxpayer will pick up the tab, naturally.


Yep. That money would be better spent on bailouts and tax breaks for the rich.
 
Excelsior
2023-01-01 3:56:38 PM  
the best weight loss drug would be something that either knocks out your taste buds or change them so everything tastes gross, to take away the incentive to snack/graze unnecessarily all day long.

In the end, it's all still physics: Your body can't magically create fat out of thin air, so every ounce of weight gain is caused by calories you ate. If you consume fewer calories than it takes to operate your body all day, it is literally physically impossible to gain weight over time.

/Sure, you may initially gather some bonus weight through water retention, but that will only go so far
 
cepson
2023-01-01 3:58:09 PM  

Loucifer: This drug could exceed Stummies profits.

[Fark user image 303x166]


But can it beat penicillin?
 
Lsherm [TotalFark]
2023-01-01 4:03:49 PM  

Some Junkie Cosmonaut: kdawg7736: If it is too good to be true, it probably is.

Sounds a little too good to be true to me


Nah, it works. My little brother is on the highest dose of Ozempic for diabetes, which is the same as Wegovy, and he lost 56 pounds in 3 months. They all suppress your appetite by mimicking a hormone that makes you feel full. He's managed to get off his blood pressure medication and his cholesterol medication. They really are wonder drugs.

Excelsior: the best weight loss drug would be something that either knocks out your taste buds or change them so everything tastes gross, to take away the incentive to snack/graze unnecessarily all day long.


These drugs make you feel full all the time so you eat less. It does the same thing.
 
maxandgrinch [TotalFark] [OhFark]
2023-01-01 4:03:58 PM  
Expensive drugs that also make you buy all new clothes?  It's a scam
 
Fark_Guy_Rob
2023-01-01 4:04:44 PM  

Excelsior: the best weight loss drug would be something that either knocks out your taste buds or change them so everything tastes gross, to take away the incentive to snack/graze unnecessarily all day long.

In the end, it's all still physics: Your body can't magically create fat out of thin air, so every ounce of weight gain is caused by calories you ate. If you consume fewer calories than it takes to operate your body all day, it is literally physically impossible to gain weight over time.

/Sure, you may initially gather some bonus weight through water retention, but that will only go so far


That's kinda sorta basically what this does. It might still taste the same but you'll lose that sense of satisfaction, drive to eat that most people have.

My first bite of pizza tastes the same as my 5th. I don't stop eating when it stops tasting good, I just care less about it as I feel full. But, it seems like, that feeling I get is because of a hormone and we can cheat the system.
 
SpectroBoy [TotalFark] [OhFark]
2023-01-01 4:06:31 PM  

kdawg7736: If it is too good to be true, it probably is.


"FDA testing for efficacy does not exist"
 
goodncold
2023-01-01 4:09:20 PM  

Excelsior: the best weight loss drug would be something that either knocks out your taste buds or change them so everything tastes gross, to take away the incentive to snack/graze unnecessarily all day long.

In the end, it's all still physics: Your body can't magically create fat out of thin air, so every ounce of weight gain is caused by calories you ate. If you consume fewer calories than it takes to operate your body all day, it is literally physically impossible to gain weight over time.

/Sure, you may initially gather some bonus weight through water retention, but that will only go so far


Yes and no.

It is also important to know when you
Are those calories.

Your liver is the organ that burns fat but also makes fat.  It can only do one thing at a time. Once the body burns through its blood sugar the liver then burns through its glycogen then it resorts to fat (this process can take
Between 24-36 hours).

You can speed that process by exercising like crazy and/or eating a low/no sugar diet (no carb).  Or you can do intermittent fasting.

Or you can do all three.

But if all you do is reduce your calories but still eat three meals plus snacks your Liver will Never get to the fat burning stage.
 
Some Junkie Cosmonaut
2023-01-01 4:13:57 PM  

Lsherm: Nah, it works. My little brother is on the highest dose of Ozempic for diabetes, which is the same as Wegovy, and he lost 56 pounds in 3 months. They all suppress your appetite by mimicking a hormone that makes you feel full. He's managed to get off his blood pressure medication and his cholesterol medication. They really are wonder drugs.


Oh not indicting it - don't even know enough to if I wanted to - I was just hassling kdawg.  Glad it's been of help to your family
 
alex10294
2023-01-01 4:21:32 PM  

Hoopy Frood: Being unable to afford food is a highly effective weight-loss strategy.


Why are so many poor people fat then?

/Jk. Know why
 
ansius
2023-01-01 4:22:10 PM  

kdawg7736: If it is too good to be true, it probably is.


It does work, here's a link to the NEJM report on its efficacy and safety.

https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

Bottom line:

"At baseline, the mean body weight was 104.8 kg, the mean BMI was 38.0, and 94.5% of participants had a BMI of 30 or higher. The mean percentage change in weight at week 72 was −15.0% (95% confidence interval [CI], −15.9 to −14.2) with 5-mg weekly doses of tirzepatide, −19.5% (95% CI, −20.4 to −18.5) with 10-mg doses, and −20.9% (95% CI, −21.8 to −19.9) with 15-mg doses and −3.1% (95% CI, −4.3 to −1.9) with placebo (P<0.001 for all comparisons with placebo)."

"Improvements in all prespecified cardiometabolic measures were observed with tirzepatide."

"The most common adverse events with tirzepatide were gastrointestinal, and most were mild to moderate in severity, occurring primarily during dose escalation. Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-mg, 10-mg, and 15-mg tirzepatide doses and placebo, respectively."

To put this in context, most traditional weight loss plans are considered to be a success if they bring at least a sustained (over 12-months) average 5% reduction in body weight across all people who engage in it.
 
Bonzo_1116
2023-01-01 4:24:22 PM  

goodncold: Excelsior: the best weight loss drug would be something that either knocks out your taste buds or change them so everything tastes gross, to take away the incentive to snack/graze unnecessarily all day long.

In the end, it's all still physics: Your body can't magically create fat out of thin air, so every ounce of weight gain is caused by calories you ate. If you consume fewer calories than it takes to operate your body all day, it is literally physically impossible to gain weight over time.

/Sure, you may initially gather some bonus weight through water retention, but that will only go so far

Yes and no.

It is also important to know when you
Are those calories.

Your liver is the organ that burns fat but also makes fat.  It can only do one thing at a time. Once the body burns through its blood sugar the liver then burns through its glycogen then it resorts to fat (this process can take
Between 24-36 hours).

You can speed that process by exercising like crazy and/or eating a low/no sugar diet (no carb).  Or you can do intermittent fasting.

Or you can do all three.

But if all you do is reduce your calories but still eat three meals plus snacks your Liver will Never get to the fat burning stage.


The stupid dieting advice from the 80s and 90s to keep eating tiny meals/snacks throughout the day so you "never feel hungry" probably doomed tens of millions of Americans to a fate of type2 diabetes.

It's actually OK to feel hungry.  You aren't going to die if you didn't have breakfast today.
 
JRoo
2023-01-01 4:26:31 PM  
Why don't we treat food addiction like we do with any other drug addiction? Dehumanize them, throw them in jail or let them die on the streets.

Or;

Why don't we treat drug addiction like we do with food addiction? Find ways to take their money in cynical attempts to help them. Make other drugs to treat them along with weird diets?
 
mistahtom
2023-01-01 4:27:08 PM  

Excelsior: the best weight loss drug would be something that either knocks out your taste buds or change them so everything tastes gross, to take away the incentive to snack/graze unnecessarily all day long.

In the end, it's all still physics: Your body can't magically create fat out of thin air, so every ounce of weight gain is caused by calories you ate. If you consume fewer calories than it takes to operate your body all day, it is literally physically impossible to gain weight over time.

/Sure, you may initially gather some bonus weight through water retention, but that will only go so far


Believe it or not, processed food and added sugar alters the brain's chemistry to become more inclined to crave the bad food.

If a person refrains from those things for a long enough, it basically changes food preference akin to tastebud alteration.
 
mchaboud
2023-01-01 4:28:01 PM  

goodncold: Excelsior: the best weight loss drug would be something that either knocks out your taste buds or change them so everything tastes gross, to take away the incentive to snack/graze unnecessarily all day long.

In the end, it's all still physics: Your body can't magically create fat out of thin air, so every ounce of weight gain is caused by calories you ate. If you consume fewer calories than it takes to operate your body all day, it is literally physically impossible to gain weight over time.

/Sure, you may initially gather some bonus weight through water retention, but that will only go so far

Yes and no.

It is also important to know when you
Are those calories.

Your liver is the organ that burns fat but also makes fat.  It can only do one thing at a time. Once the body burns through its blood sugar the liver then burns through its glycogen then it resorts to fat (this process can take
Between 24-36 hours).

You can speed that process by exercising like crazy and/or eating a low/no sugar diet (no carb).  Or you can do intermittent fasting.

Or you can do all three.

But if all you do is reduce your calories but still eat three meals plus snacks your Liver will Never get to the fat burning stage.


I think "never" is a strong (wrong) statement. If you graze all day but consume only 500 calories, you're going to lose weight (unless you're a very small child who consumes less than 500 calories per day).

Now, crack human photosynthesis (wasn't that a Darkwing Duck plot line?) and you can erase the above.
 
alex10294
2023-01-01 4:28:31 PM  

Excelsior: the best weight loss drug would be something that either knocks out your taste buds or change them so everything tastes gross, to take away the incentive to snack/graze unnecessarily all day long.

In the end, it's all still physics: Your body can't magically create fat out of thin air, so every ounce of weight gain is caused by calories you ate. If you consume fewer calories than it takes to operate your body all day, it is literally physically impossible to gain weight over time.

/Sure, you may initially gather some bonus weight through water retention, but that will only go so far


But what about breathairians.  They can obtain sustenance from sunshine and breathing.

Calorie cutting works until you don't do it.  People who think it doesn't don't realize how many calories they are eating.
 
Some Junkie Cosmonaut
2023-01-01 4:28:57 PM  

Bonzo_1116: It's actually OK to feel hungry. You aren't going to die if you didn't have breakfast today.


True, just don't push it past about 2.5 days.  You start getting a little wobbly at that point

/don't push it that far either if you have a choice
//but if you don't
///that's about how long it is before you're gonna start seeing immediate issues
 
HighlanderRPI
2023-01-01 4:30:28 PM  
Bundle it with another injectable to tighten skin to remove wrinkles and double your money.

Call it Bozempic
 
foo monkey
2023-01-01 4:30:34 PM  
If we spent half of McDonalds' advertising budget on extolling the value of eating vegetables every day, our culture wouldn't need miracle weight-loss drugs.  Obesity will never stop being a problem until we stop advertising a 2000 calorie entrée with 40 grams of fat and 2500 mg of sodium as a normal thing for a human to eat.  Want it as a treat?  Go for it.  Want it as a staple?  Welcome to phase 2:  $1300/month diabetes/weight-loss drugs.
 
sirrerun
2023-01-01 4:33:48 PM  

kdawg7736: If it is too good to be true, it probably is.


Never believe it's not so
 
LamOtter [TotalFark]
2023-01-01 4:34:48 PM  

thornhill: At $1300/month you could hire a personal trainer and dietitian for less.


Dieticians/nutritionists are still stuck in the 80's with their whole low fat/high carbs thing. Also, have you ever talked to one for more than a few minutes? Not the brightest bulbs.
 
TheSubjunctive
2023-01-01 4:46:05 PM  
Yes, if you can manage to restrict yourself to 1500-1700 calories, you will lose weight.  Absolutely true.

That's also really hard because that's near-starvation "thinking about food constantly, more than sex" randomly-shivering level and most skinny people are also eating a lot more than that in modern society.  And wouldn't have the willpower to do that for a month (let alone years) either, they just haven't needed to.

We've known this since the Vermont Prisoner Overfeeding Study in the late 1960s.  They took prisoners, so they could know exactly what they consumed, and that they weren't getting any exercise (controlled for that too).  Some of the subjects ate more calories and bulked up predictably.  Some gained a modest amount of weight.  And some were force-feeding themselves 5000+ calories a day for weeks on end and not gaining weight.
 
Fireproof [OhFark]
2023-01-01 4:46:09 PM  
So if it really works, we need to just manage to not die of diabetes until a generic version comes out?
 
Fireproof [OhFark]
2023-01-01 4:47:48 PM  

TheSubjunctive: Yes, if you can manage to restrict yourself to 1500-1700 calories, you will lose weight.  Absolutely true.

That's also really hard because that's near-starvation "thinking about food constantly, more than sex" randomly-shivering level and most skinny people are also eating a lot more than that in modern society.  And wouldn't have the willpower to do that for a month (let alone years) either, they just haven't needed to.

We've known this since the Vermont Prisoner Overfeeding Study in the late 1960s.  They took prisoners, so they could know exactly what they consumed, and that they weren't getting any exercise (controlled for that too).  Some of the subjects ate more calories and bulked up predictably.  Some gained a modest amount of weight.  And some were force-feeding themselves 5000+ calories a day for weeks on end and not gaining weight.


I understood everything until the last sentence.
 
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