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(NPR)   A new Alzheimer's drug didn't cause bleeding brains in 4/5 patients   (npr.org) divider line
10
    More: Interesting, Alzheimer's disease, Clinical trial, experimental drug, Dr. Madhav Thambisetty of the National Institute, infusions of lecanemab, Dr. Christopher van Dyck, Cognition, rate of cognitive decline  
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410 clicks; posted to STEM » on 30 Nov 2022 at 3:30 PM (17 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



10 Comments     (+0 »)
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natazha [BareFark]
2022-11-30 3:49:16 PM  
Sounds like you have to administer the drug before there's any signs of Alzheimer's. Is this the new statin?
 
Arkanaut
2022-11-30 4:08:20 PM  
People who got infusions of lecanemab scored about half a point better on a zero-to-18-point scale of mental functioning, a slight but statistically significant difference.

Question is, how far behind normal people are Alzheimer patients (or at least, Alzheimer patients at this stage of the disease) on this scale? If it's 1 or 2 points, then maybe that's a pretty big deal; if it's 10 points, it seems like it's not worth the risk.
 
LockeOak
2022-11-30 4:24:26 PM  

Arkanaut: People who got infusions of lecanemab scored about half a point better on a zero-to-18-point scale of mental functioning, a slight but statistically significant difference.

Question is, how far behind normal people are Alzheimer patients (or at least, Alzheimer patients at this stage of the disease) on this scale? If it's 1 or 2 points, then maybe that's a pretty big deal; if it's 10 points, it seems like it's not worth the risk.


I think the NYTimes article said it slowed the progression by 27%.
 
LurkerSupreme [TotalFark] [OhFark]
2022-11-30 4:47:36 PM  
Don't worry about that 5th patient, he was an asshole anyway.
 
Arkanaut
2022-11-30 4:51:57 PM  

LurkerSupreme: Don't worry about that 5th patient, he was an asshole anyway.


Was he the dentist who didn't recommend Trident?
 
LurkerSupreme [TotalFark] [OhFark]
2022-11-30 5:35:01 PM  

Arkanaut: LurkerSupreme: Don't worry about that 5th patient, he was an asshole anyway.

Was he the dentist who didn't recommend Trident?


Yes, and also the one person who refused to save money on their car insurance by switching to Geico.

/I read all that somewhere else, so it may not be true
 
IgG4 [TotalFark]
2022-11-30 9:08:13 PM  
"I'm a person living with a progressive and fatal disease," says Michael Zuendel, 68, who has been taking Aduhelm since he was diagnosed with mild cognitive impairment, an early stage of Alzheimer's. "I do not have time to wait for the perfect research study."

Sucks to be you who can afford the 50K+ per year for for Aduhelm. Unfortunately science is not based on your wallet or your feelings. If a drug causes adverse events in 20% of the people who receive it it is not good enough. I am sorry you do not understand how clinical trials work.
 
Ghastly [TotalFark]
2022-11-30 9:33:06 PM  
Dave Brubeck - Take Five
Youtube tT9Eh8wNMkw
 
backhand.slap.of.reason
2022-11-30 10:41:36 PM  

LockeOak: Arkanaut: People who got infusions of lecanemab scored about half a point better on a zero-to-18-point scale of mental functioning, a slight but statistically significant difference.

Question is, how far behind normal people are Alzheimer patients (or at least, Alzheimer patients at this stage of the disease) on this scale? If it's 1 or 2 points, then maybe that's a pretty big deal; if it's 10 points, it seems like it's not worth the risk.

I think the NYTimes article said it slowed the progression by 27%.


37%, which given what I've seen about lecanemab prior to today's claim that 37% seems incredibly misleading.
 
IgG4 [TotalFark]
2022-12-01 7:19:24 PM  
https://www.science.org/content/blog-post/lecanemab-and-alzheimer-s-more-data
 
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