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(Medical Daily)   Newly discovered drug is effective against both SARS-COV-2 and cancer, still no cure for the "still no cure for cancer" cliche   (medicaldaily.com) divider line
    More: Cool, Protein, Lung cancer, Lung, findings of the study, vital protein GRP, newly discovered drug, entry of the SARS-COV-2 virus, infected lung cells  
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1165 clicks; posted to STEM » on 27 Nov 2022 at 7:20 AM (9 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



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2022-11-27 5:37:02 AM  
Just a few easy monthly payments.
 
2022-11-27 7:55:55 AM  
Sounds like it's specific types of cancer, ones that happen to share the thing they're targeting to fight covid, but that's still a very nice bonus.

A lot of the research that's been done on covid will also help fight cancer more broadly - remember, mRNA vaccine tech was originally aimed at targeting tumors, and it got a huge boost forward when dozens of major labs used it to make the covid vaccines.

So yeah, there is a silver lining on this plague, and it's this.

johnryan51: Just a few easy monthly payments.


In Murica? Yeah, but unfortunately that applies to basically every medical breakthrough. That said, I'll take a bankruptcy over dying of cancer any day.
 
2022-11-27 8:05:36 AM  
Inhibiting KRAS is a game changer in oncology.  KRAS is an oncogene that is recurrently mutated, with most mutations involving 3 amino acids.  KRAS has been of medical interest for decades because it is mutated in lung, pancreatic, colorectal, and other solid and heme malignancies.  There are FDA approved drugs for KRAS G12C in lung cancer, but a pan-KRAS drug would be great, especially one that is well tolerated.
 
2022-11-27 8:12:43 AM  

trerro: Sounds like it's specific types of cancer, ones that happen to share the thing they're targeting to fight covid, but that's still a very nice bonus.

A lot of the research that's been done on covid will also help fight cancer more broadly - remember, mRNA vaccine tech was originally aimed at targeting tumors, and it got a huge boost forward when dozens of major labs used it to make the covid vaccines.

So yeah, there is a silver lining on this plague, and it's this.

johnryan51: Just a few easy monthly payments.

In Murica? Yeah, but unfortunately that applies to basically every medical breakthrough. That said, I'll take a bankruptcy over dying of cancer any day.


Covid hit just as seriously-funded nano-biological R&D was getting off the ground, with new tools such as CRISPR, and the whole mRNA field. The resulting focus of energy has been, IMHO, a turbo-charging of the entire discipline of the biological sciences. This goes beyond, in potential scope, anything accomplished in computer electronics. At this rate we literally could have immortality, or at least rejuvenation and greatly extended lifespans, in a couple of decades.

And if you combine the coming advances in Materials Science, Artificial Intelligence, and the biological sciences, the near future starts to look scary-different. Everything changes.
 
2022-11-27 9:25:41 AM  
If they found a working cure for cancer today, ten years from now, the majority of Americans would still be getting radiation and chemo. Only a small percentage of people have access to cutting edge medicine. The rest of us just get to die.
 
2022-11-27 10:07:13 AM  

transporter_ii: If they found a working cure for cancer today, ten years from now, the majority of Americans would still be getting radiation and chemo. Only a small percentage of people have access to cutting edge medicine. The rest of us just get to die.


Not if the cutting-edge treatment were less expensive than radiation and chemo.  Health insurance companies (conspiracy theorists to the contrary) are entirely on board with vaccines, because they'd rather cover a $25 shot than a week in the hospital.
 
2022-11-27 10:16:02 AM  

transporter_ii: If they found a working cure for cancer today, ten years from now, the majority of Americans would still be getting radiation and chemo. Only a small percentage of people have access to cutting edge medicine. The rest of us just get to die.


Everytime a cell divides its not quite as perfect as the cell before it.

Which means if you live long enough you will get cancer.  Period.

The cure for cancer folks dont mention that
 
2022-11-27 10:19:08 AM  

transporter_ii: If they found a working cure for cancer today, ten years from now, the majority of Americans would still be getting radiation and chemo. Only a small percentage of people have access to cutting edge medicine. The rest of us just get to die.


The money is in the "cure" not the prevention.

All that can be done is to minimize damage to cells.  Eat right, sleep, minimize drug use, etc.

Cancer will come eventually given enough time.
 
2022-11-27 10:20:59 AM  

Harlee: At this rate we literally could have immortality, or at least rejuvenation and greatly extended lifespans, in a couple of decades.


JFC, I sure as fark hope not.

Can you imagine if people like Mitch McConnell, Donald Trump, and Ron DeSantis can be made immortal? The only thing saving us from these individuals is the fact that eventually, even if it usually seems to take way too farking long, they all farking die. Immortality would give them FOREVER to take over everything permanently.

No, thanks.
 
2022-11-27 10:39:11 AM  

Harlee: trerro: Sounds like it's specific types of cancer, ones that happen to share the thing they're targeting to fight covid, but that's still a very nice bonus.

A lot of the research that's been done on covid will also help fight cancer more broadly - remember, mRNA vaccine tech was originally aimed at targeting tumors, and it got a huge boost forward when dozens of major labs used it to make the covid vaccines.

So yeah, there is a silver lining on this plague, and it's this.

johnryan51: Just a few easy monthly payments.

In Murica? Yeah, but unfortunately that applies to basically every medical breakthrough. That said, I'll take a bankruptcy over dying of cancer any day.

Covid hit just as seriously-funded nano-biological R&D was getting off the ground, with new tools such as CRISPR, and the whole mRNA field. The resulting focus of energy has been, IMHO, a turbo-charging of the entire discipline of the biological sciences. This goes beyond, in potential scope, anything accomplished in computer electronics. At this rate we literally could have immortality, or at least rejuvenation and greatly extended lifespans, in a couple of decades.

And if you combine the coming advances in Materials Science, Artificial Intelligence, and the biological sciences, the near future starts to look scary-different. Everything changes.


I was talking with my primary care doctor about mRNA and CRISPR and the like...and he painted a much more dystopian hellscape than what you just described, heh. For all the great advances...a few assholes could create a super-virus that could be hyper-spreadable and hyper-lethal that'd make COVID look like child's play, like the anthrax scare but huge.

I remember when the internet first started being adopted and it was all sunshine and rainbows about how it will bring us all together...and look at the cesspool we have. Humans are our own worst enemies. We're the problem...it's us.
 
2022-11-27 12:23:45 PM  
99% of what works in lab mice does not in humans. It is too soon for sensational headlines.
 
2022-11-27 12:58:18 PM  
Fasting helps attenuate Covid infectivity
Source 1
Source 2
Source 3

Processed foods makes Covid infection worse.
source 1
Expert discussion
Source 2

Processed foods increase colorectal cancer risks
Source 1
Source 2
 
2022-11-27 1:14:27 PM  

I know a guy: Harlee: At this rate we literally could have immortality, or at least rejuvenation and greatly extended lifespans, in a couple of decades.

JFC, I sure as fark hope not.

Can you imagine if people like Mitch McConnell, Donald Trump, and Ron DeSantis can be made immortal? The only thing saving us from these individuals is the fact that eventually, even if it usually seems to take way too farking long, they all farking die. Immortality would give them FOREVER to take over everything permanently.

No, thanks.


Yeah, that is going to be a problem. A big one.
 
2022-11-27 1:17:07 PM  

JTtheCajun: Harlee: trerro: Sounds like it's specific types of cancer, ones that happen to share the thing they're targeting to fight covid, but that's still a very nice bonus.

A lot of the research that's been done on covid will also help fight cancer more broadly - remember, mRNA vaccine tech was originally aimed at targeting tumors, and it got a huge boost forward when dozens of major labs used it to make the covid vaccines.

So yeah, there is a silver lining on this plague, and it's this.

johnryan51: Just a few easy monthly payments.

In Murica? Yeah, but unfortunately that applies to basically every medical breakthrough. That said, I'll take a bankruptcy over dying of cancer any day.

Covid hit just as seriously-funded nano-biological R&D was getting off the ground, with new tools such as CRISPR, and the whole mRNA field. The resulting focus of energy has been, IMHO, a turbo-charging of the entire discipline of the biological sciences. This goes beyond, in potential scope, anything accomplished in computer electronics. At this rate we literally could have immortality, or at least rejuvenation and greatly extended lifespans, in a couple of decades.

And if you combine the coming advances in Materials Science, Artificial Intelligence, and the biological sciences, the near future starts to look scary-different. Everything changes.

I was talking with my primary care doctor about mRNA and CRISPR and the like...and he painted a much more dystopian hellscape than what you just described, heh. For all the great advances...a few assholes could create a super-virus that could be hyper-spreadable and hyper-lethal that'd make COVID look like child's play, like the anthrax scare but huge.

I remember when the internet first started being adopted and it was all sunshine and rainbows about how it will bring us all together...and look at the cesspool we have. Humans are our own worst enemies. We're the problem...it's us.


I'll come right out and say it: I'm an sapient AI booster. We need a keeper, and we would make great pets. I'll take my chances on a benevolent controlling AI.
 
2022-11-27 1:37:46 PM  

Harlee: At this rate we literally could have immortality, or at least rejuvenation and greatly extended lifespans, in a couple of decades.


Absolutely not true.

We have not meaningfully extended life in any way, pretty much ever.

We've gotten much better at preventing people from dying young and getting people TO old age, yes.  But the maximum lifespan is stuck where it's at.

Even if we could cure all cancer and stop heart disease, there's still plenty of other things that kill us.  We still have no idea how dementias work, for example (there's age-related senility, there's lewy-body, there's alzheimer's, there's hydroplasia, etc).  We still don't really know how the immune system works.  That greatly diminishes as you get older and opens you up to be killed by all sorts of things.  Especially now that anti-vax nutters are becoming a bigger and bigger thing.  Organs that aren't the heart/brain tend to start failing over time.

And if we could do it... We still have no idea how to regenerate cartilage in joints.  Eyesight and hearing greatly diminish as you get older.  Our skin ages like crazy.  Those things make it very undesirable to BE old.

/And I'm sure if somehow do extend life in a meaningful way, I'm sure many other things will pop up we never even knew about because so few people ever got there before.
 
2022-11-27 1:45:37 PM  
It's a hormone your body makes on it's own when there's no glucose available (fasted state):

"When K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased."
 
2022-11-27 2:17:54 PM  
and people will still refuse it. Great for the medical debt collection industry. Cancer is a great money maker.

Get Keytruda(tm), a chance to live longer, only 6999.99/Mo.
 
2022-11-27 2:28:28 PM  

AlphaG33k: and people will still refuse it. Great for the medical debt collection industry. Cancer is a great money maker.

Get Keytruda(tm), a chance to live longer, only 6999.99/Mo.


At that price, I think you could probably just take out a long term loan citing your potential for future earnings.
 
2022-11-27 5:29:51 PM  

Harlee: JTtheCajun: Harlee: trerro: Sounds like it's specific types of cancer, ones that happen to share the thing they're targeting to fight covid, but that's still a very nice bonus.

A lot of the research that's been done on covid will also help fight cancer more broadly - remember, mRNA vaccine tech was originally aimed at targeting tumors, and it got a huge boost forward when dozens of major labs used it to make the covid vaccines.

So yeah, there is a silver lining on this plague, and it's this.

johnryan51: Just a few easy monthly payments.

In Murica? Yeah, but unfortunately that applies to basically every medical breakthrough. That said, I'll take a bankruptcy over dying of cancer any day.

Covid hit just as seriously-funded nano-biological R&D was getting off the ground, with new tools such as CRISPR, and the whole mRNA field. The resulting focus of energy has been, IMHO, a turbo-charging of the entire discipline of the biological sciences. This goes beyond, in potential scope, anything accomplished in computer electronics. At this rate we literally could have immortality, or at least rejuvenation and greatly extended lifespans, in a couple of decades.

And if you combine the coming advances in Materials Science, Artificial Intelligence, and the biological sciences, the near future starts to look scary-different. Everything changes.

I was talking with my primary care doctor about mRNA and CRISPR and the like...and he painted a much more dystopian hellscape than what you just described, heh. For all the great advances...a few assholes could create a super-virus that could be hyper-spreadable and hyper-lethal that'd make COVID look like child's play, like the anthrax scare but huge.

I remember when the internet first started being adopted and it was all sunshine and rainbows about how it will bring us all together...and look at the cesspool we have. Humans are our own worst enemies. We're the problem...it's us.

I'll come right out and say it: I'm an sapient AI booster. We need a keeper, and we would make great pets. I'll take my chances on a benevolent controlling AI.


The problem is, if we're talking about becoming pets, that implies a fully sentient self-motivating AI, as opposed to merely a human-class "expert system at generating new expert systems" like our brains are that just does what we ask it to.

What happens when the self motivating intelligence decides it doesn't feel like taking care of the pets any more?
 
2022-11-27 6:33:08 PM  
Looks like a ten year old drug.  This is what happens when you grant treatment monopolies to pharmaceutical companies before you even know if their products will work.  Hope it pans out because every single person infected with SARS-CoV-2 is going to be doing pretty rough by 2030.  Pathogenic Coronaviruses are didn't get their name by being obscure colds, they got it by provoking serious illness in just about all that caught them.

Don't worry if you feel left out.  It took a while for most.
 
2022-11-27 11:22:17 PM  

erik-k: The problem is, if we're talking about becoming pets, that implies a fully sentient self-motivating AI, as opposed to merely a human-class "expert system at generating new expert systems" like our brains are that just does what we ask it to.

What happens when the self motivating intelligence decides it doesn't feel like taking care of the pets any more?



That's that whole "taking our chances" part.

More seriously, that's what the core programming is for, building in the software "restraining bolts" that determine the sapient AI's emotions and concerns for it's charges.

I thought a lot about this for my in-progress novel, The Voyage of the New Beginning. In the book, the alien society is run by such a Controller AI. Known as "The Presence" due to his plethora of surveillance devices and his ability to incorporate all electronic systems into his framework, this AI is "part ruler, part mentor, part savant, and part servant" to the society.

The key is that the nidus of The Presence is that he was designed as an economic czar, with specific yet universally-applicable criteria for "Action Completed" status. His core optimization criterion was defined as "maximum economic utility" with the universal capabilities of robustness and flexibility.  By definition, an economy is robust and flexible in relation to the number of economic players. The key factor for this is "maximum number of able entities." The success yardstick was coded as "greatest feasible minimum equal sustenance for all members of the society."

This pragmatically translated to a dualistic economic system where the criterion for inelastic (i.e.: existential) goods and services was "minimal equal provision to all" and the criterion for elastic (i.e.: non-essential to life) goods and services was "maximal profit to the owners of the production assets." In other words, a two-tier mixed socialist/capitalist economic system. The socialist part worked because non-sapient robots and automation at all levels of the economic production ladder soaked up the vast majority of labor cost, thus making the socialized inelastic stuff very cheap or free. A universal BGI (the vast majority of the aliens were unemployable, because the automation was just that good) paid for the cheap essentials and a big chunk of the free market production.
 
2022-11-27 11:25:26 PM  
*Aussies that ride ostriches to work*
shutterstock.comView Full Size
 
2022-11-28 3:28:46 AM  
Medical Daily may be into pseudo-science.

Medical Daily - Media Bias/Fact Check (mediabiasfactcheck.com)
 
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