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(Medical Xpress)   Severe acute respiratory syndrome coronavirus #2   (medicalxpress.com) divider line
    More: Followup, Virus, Infection, Immune system, Infectious disease, Gastroenterology, long-term infection of the gut, Disease, COVID patients  
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1385 clicks; posted to STEM » on 18 Apr 2022 at 5:25 PM (9 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



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2022-04-18 5:41:30 PM  
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2022-04-18 5:55:19 PM  
Lockdown Boogaloo?
 
2022-04-18 5:58:47 PM  
From the earliest days of the pandemic, remember a short article on COVID where they interviewed a virologist from Cambridge. I could swear she said -- or maybe my memory is mangled -- that nobody sheds virus for more than a week or so. Maybe the presence in feces, while not benign, is not a danger.
 
2022-04-18 6:07:42 PM  
So spray lysol up me keister?
 
2022-04-18 6:13:09 PM  
Oh yay, Coronavirus that lives in our gut and outlasts the 6 month vaccine efficacy.

Is this the thread where all the Farkers who tell us not to panic, and denied there was evidence [whatever] come in, and tell us that they always said there waf evidence of [whatever] and they always said that [whatever] was what they were warning us about all the time?

Fark is full of unscientific idiots who think they're goddam Linus Pauling. It's my perosnal erotica site to see children disabled by Covid, and then watch those Farkers come there and pretend they are not personally responsible by refusing social isolation for all their stupid reasons. Usually reasons based on what the think should happen instead of evidence.

Anyhoo, I'm not coming back to this thread. But I will rant more because nobody reads this far anyhow. I think every Fark account that begins with the letter Q, though, will show up to this thread. Each Q account is someone who talks about how smart and calm they are, while they spread obviously unscientific lies about Covid and illiterate nonsense about how the GOP will never attack the Capitol and anyways the Jan 6th committee is going great. The way all the Q-begun Fark handles do the same thing, and are equally wrong about it, is my personal conspiracy theory though. It's just too perfect, they have to be coordinated trolls.

Stay home, people. Covid is evolving and our vaccines aren't.
 
2022-04-18 6:32:33 PM  

yakmans_dad: From the earliest days of the pandemic, remember a short article on COVID where they interviewed a virologist from Cambridge. I could swear she said -- or maybe my memory is mangled -- that nobody sheds virus for more than a week or so. Maybe the presence in feces, while not benign, is not a danger.


It's not a danger as long as the virus is destroyed, but there isn't a whole lot between your mouth and your ass that accomplishes that. Recall that all this coronavirus research business in China started from miners in Yunan breathing in guano dust back in 2012.

Bennie Crabtree: Stay home, people. Covid is evolving and our vaccines aren't.


Mods 'round these here parts don't take kindly to besmirching our silver bullets and panacea cures.
 
2022-04-18 6:49:31 PM  
I'm curious. For things like TB, you get necrotic tissue that takes time to clear away. It can be a source for virus as the body gets around to eventually clearing out the necrotic tissue. Could something similar be happening with covid?

The SARS-CoV-2 virus has two ways of releasing virus particles from infected cells. It can shed new virions by exocytosis, meaning the cell stays alive while making more and exporting more new virus particles. That's the normal way. But at some point the cell can lyse, meaning bust wide open, and release whatever remaining virus particles are left (though matured virus particles have generally already been exported out.

But what about cells that get exhausted and essentially die, running out of energy. There are a couple different ways for cells to die. One is called apoptosis which is pre-programmed cell death. It's a cleaner way for a cell to die and have it's contents recycled by cells that are good at recycling cell debris. (grossly simplifying here)  Another is to go necrotic which is to, lets call it shrivel up and die. This isn't as clear.

When you immune system is cleaning up virus infected cells, it generally induces apoptosis. But multiple pathways are at work and things don't always go perfect.

Anyway, I'm stretching here but if there is a reservoir of necrotic tissue around, that could be a source of dead virus (fragmented viral RNA). Once you system gets around to cleaning these up.

I confess, after writing that I've struggled a bit because while the route of phagocytic white cells to the liver to bile is well characterized as far as cleaning up old blood cells (and in particular heme to bilirubin) my instincts suggest that RNA fragments would be rapidly digested down to monomers. And I've spent years around science involving liver function. But searching and reviewing some recent reports, I see that therapeutic RNA does get eliminated through the liver into bile and thus the intestines. So cleanup of various bits of old necrotic tissue that died with viral remnants is feasible. And thus the referenced work does not indicate the necessity of an gastrointestinal reservoir of virus.

I'll also note that there have been studies about this prolonged fecal shedding of viral fragments going back to May of 2000 so it isn't brand new results, though those studies weren't as well controlled nor did they have nearly as many observations.
 
2022-04-18 6:57:59 PM  
The CDC is up against it.   New case reports are suppressed in many counties in nearly every state.   Deaths are similarly suppressed.   The only reasonable data they have is hospitalizations and some sites going over excess-deaths numbers.   The map shows mostly green counties save for a few areas of the Northeast.   Reality is a lot harsher.
 
2022-04-18 7:08:25 PM  
You heard it guys. Time to stop eating shiat and quit grinning.
 
2022-04-18 7:13:19 PM  
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2022-04-18 7:25:03 PM  
Fecal?

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2022-04-18 7:39:00 PM  

wademh: I confess, after writing that I've struggled a bit because while the route of phagocytic white cells to the liver to bile is well characterized as far as cleaning up old blood cells (and in particular heme to bilirubin) my instincts suggest that RNA fragments would be rapidly digested down to monomers. And I've spent years around science involving liver function. But searching and reviewing some recent reports, I see that therapeutic RNA does get eliminated through the liver into bile and thus the intestines. So cleanup of various bits of old necrotic tissue that died with viral remnants is feasible. And thus the referenced work does not indicate the necessity of an gastrointestinal reservoir of virus.


Metabolizing this out isn't what's doing this, if that's what you are getting at. These symptoms are from eating things with coronavirus on them. Having bits and pieces exit out the back door isn't a big deal. What is a big deal is getting viable coronavirus on the inside of your intestinal lining. It's on the wrong side of your body to fight against, so the only thing you can do is quickly shiat it out lest you wind up wiping corona across the entire intestinal tract over the course of several days. Going forward this needs more attention, as it's found that coronavirus decreases bowel motility.
 
2022-04-18 8:06:18 PM  

Bennie Crabtree: Oh yay, Coronavirus that lives in our gut and outlasts the 6 month vaccine efficacy.

Is this the thread where all the Farkers who tell us not to panic, and denied there was evidence [whatever] come in, and tell us that they always said there waf evidence of [whatever] and they always said that [whatever] was what they were warning us about all the time?

Fark is full of unscientific idiots who think they're goddam Linus Pauling. It's my perosnal erotica site to see children disabled by Covid, and then watch those Farkers come there and pretend they are not personally responsible by refusing social isolation for all their stupid reasons. Usually reasons based on what the think should happen instead of evidence.

Anyhoo, I'm not coming back to this thread. But I will rant more because nobody reads this far anyhow. I think every Fark account that begins with the letter Q, though, will show up to this thread. Each Q account is someone who talks about how smart and calm they are, while they spread obviously unscientific lies about Covid and illiterate nonsense about how the GOP will never attack the Capitol and anyways the Jan 6th committee is going great. The way all the Q-begun Fark handles do the same thing, and are equally wrong about it, is my personal conspiracy theory though. It's just too perfect, they have to be coordinated trolls.

Stay home, people. Covid is evolving and our vaccines aren't.


You are going to be so owned when scientists discover that shiatting your brains out after eating horse dewormer sloughs off the insides of your GI tract is the only way to flush the virus out.
 
2022-04-18 8:16:41 PM  
What a load of crap.
 
2022-04-18 8:16:56 PM  

Stud Gerbil: The CDC is up against it.   New case reports are suppressed in many counties in nearly every state.   Deaths are similarly suppressed.   The only reasonable data they have is hospitalizations and some sites going over excess-deaths numbers.   The map shows mostly green counties save for a few areas of the Northeast.   Reality is a lot harsher.


shait don't lie
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Wastewater monitoring is an excellent way to get a broad level surveillance of increasing or decreasing infection levels. The Easter week had lots of people travelling and mixing. The observed rise could be the beginning of another big surge, or not. The prior peak is off the chart to the left over 10,000 units.

This reporting doesn't take off for long holiday weekends.
 
2022-04-18 8:43:32 PM  

Stibium: wademh: I confess, after writing that I've struggled a bit because while the route of phagocytic white cells to the liver to bile is well characterized as far as cleaning up old blood cells (and in particular heme to bilirubin) my instincts suggest that RNA fragments would be rapidly digested down to monomers. And I've spent years around science involving liver function. But searching and reviewing some recent reports, I see that therapeutic RNA does get eliminated through the liver into bile and thus the intestines. So cleanup of various bits of old necrotic tissue that died with viral remnants is feasible. And thus the referenced work does not indicate the necessity of an gastrointestinal reservoir of virus.

Metabolizing this out isn't what's doing this, if that's what you are getting at. These symptoms are from eating things with coronavirus on them. Having bits and pieces exit out the back door isn't a big deal. What is a big deal is getting viable coronavirus on the inside of your intestinal lining. It's on the wrong side of your body to fight against, so the only thing you can do is quickly shiat it out lest you wind up wiping corona across the entire intestinal tract over the course of several days. Going forward this needs more attention, as it's found that coronavirus decreases bowel motility.


Continually shedding virus (by PCR assay) in feces for multiple weeks after becoming PCR negative for nasopharyngeal swabs is from ingesting things with the virus on them? And multiple people (1/7) responding similarly? That's some mighty strange dietary habits. They further specified the fecally detected "virus" was viral fragments. The publication itself suggest an endogenous reservoir.

The questions are if it's a live virus reservoir, say liver cells that shed into the bile? Bile duct endothelium? Or could it be clean up of necrotic tissue.

In early studies of people who had severe covid and showed long lasting viral shedding in nasopharyngeal swabs there were papers that suggested it was necrotic lung tissue that was slowly clearing. This has parallels to tuberculomas in my mind (I could be nuts). Maybe consider necrotic alveoli that take time to clear. So my question is, what other tissue sources? I tend to think the intestinal lining turns over too quickly to be a candidate.

By now, I'd think there would be some post-mortem data searching for any obvious sources but I don't have any familiarity with that sort of pathology literature.
 
2022-04-18 8:45:23 PM  
Suppose I'll get a booster shot before the next time I jam my tongue up a hooker's asshole. Thanks Fark.
 
2022-04-18 9:09:22 PM  

Stud Gerbil: The CDC is up against it.   New case reports are suppressed in many counties in nearly every state.   Deaths are similarly suppressed.   The only reasonable data they have is hospitalizations and some sites going over excess-deaths numbers.   The map shows mostly green counties save for a few areas of the Northeast.   Reality is a lot harsher.


The last number I heard is that the estimated reporting bias has gone from 4:1 to 7:1 (i.e. 7x more cases than recorded), largely due to at-home testing that doesn't get reported.

Plus, the CDC has officially flat-out surrendered and no longer considers "cases" bad. The reason everything magically went from red to green on their maps is because those are no longer even considering cases, it's just hospitalizations / deaths.

Reminder: Originally, having the monstrosity "under control" (green) was considered as 5 cases / 100K / day, not 25 or whereever they've lowered the bar for success to now.
 
2022-04-18 9:18:20 PM  
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Detailed for testing
 
2022-04-18 11:35:49 PM  

yakmans_dad: From the earliest days of the pandemic, remember a short article on COVID where they interviewed a virologist from Cambridge. I could swear she said -- or maybe my memory is mangled -- that nobody sheds virus for more than a week or so. Maybe the presence in feces, while not benign, is not a danger.


https://www.news-medical.net/news/20220418/New-longest-documented-case-of-persistent-acute-SARS-CoV-2-infection.aspx
 
2022-04-19 2:22:22 AM  
"Bhatt was quick to note that the RNA constituted genetic remnants of the coronavirus, and not actual live virus"
 
2022-04-19 11:28:03 AM  
I didn't think viruses were alive.

Sort of live and learn.
 
2022-04-19 1:40:33 PM  

yakmans_dad: I didn't think viruses were alive.

Sort of live and learn.


Opinions differ, but it's reasonable to consider them alive while they're replicating inside a host cell. The particles floating around in the environment are like seeds, not doing much in that state but able to activate once they land in a suitable environment.
 
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