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(Science Alert)   Red blood cells deserve more credit than we've been giving tehm. Please forgive the type-O   (sciencealert.com) divider line
    More: Interesting, Red blood cell, red blood cell, Blood, Immune system, COVID-19 patients, Hematology, Cell nucleus, red blood cells  
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559 clicks; posted to STEM » on 25 Oct 2021 at 3:50 PM (5 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



16 Comments     (+0 »)
View Voting Results: Smartest and Funniest
 
2021-10-25 2:29:55 PM  
i.pinimg.comView Full Size


Guess Frank was right...
 
2021-10-25 2:44:30 PM  
I'm slightly miffed. Slightly Miffed. The remake of "FANTASTIC VOYAGE" is now in development hell due to funding etc.

The original was a great story and educational tool.
I especially liked the part where Rachael Welch was attacked by antibodies, on a 'away mission"

FANTASTIC VOYAGE
Youtube 7MOJmnQH4Q0
 
2021-10-25 3:54:08 PM  
Subby stepped up to the plate lets forgive the typo.
 
2021-10-25 4:20:11 PM  
"Now that we know more about the mechanism of anemia, it allows us to look at new therapies for treating acute inflammatory anemia without transfusions, such as blocking TLR9 on the red blood cells."

good
 
2021-10-25 5:55:18 PM  
This headline deserves more credit than it's gonna get buried in the STEM section. Good one, subby.
 
2021-10-25 6:08:17 PM  
Erythrocytes (RBCs) are really cool for a whole lot of reasons. If nothing else, they're easily accessible and the analysis of many of their characteristics is cheap. One big reason they are cool is that they have a relatively predictable lifespan (3-4 months, generally), and get bigger as they age, so as the lifespan gets altered, you get changes in MCV (the average volume of the individual RBCs) and also RDW (the range of widths of the cells in circulation).

There's also a tie into insulin sensitivity/resistance. Since insulin mediates potassium uptake, you can use the potassium levels in RBCs as a proxy for the level of insulin sensitivity on a cellular level. Populations that are more prone to insulin resistance (primarily people of color) show lower levels of RBC K+, and also have longer erythrocyte lifespans, which can skew the results of the tests most commonly used to diagnose and monitor treatment of diabetes.

It would not surprise me if further research along the lines discussed in TFA revealed that part of the TLR9 inflammatory cascade involves sensitizing the RBCs to insulin, significantly shortening their lifespans and resulting in the anemia.

/Currently conducting research in this area
//Love me some red blood cells
//Slashies
 
2021-10-25 6:29:23 PM  
Forgive the Type-O? Negative.
 
2021-10-25 6:41:11 PM  
cellsatwork-anime.comView Full Size
 
2021-10-25 7:32:56 PM  

Noah_Tall: Forgive the Type-O? Negative.


I am type O negative and I can give blood to ANYBODY!
I don't need to be forgiven!
/I should be honored.
//Feted!
///At least given more than a stale cookie and watery orange juice!
 
2021-10-25 8:13:20 PM  

skybird659: Noah_Tall: Forgive the Type-O? Negative.

I am type O negative and I can give blood to ANYBODY!
I don't need to be forgiven!
/I should be honored.
//Feted!
///At least given more than a stale cookie and watery orange juice!


Actually, you're a Farker, so you are probably also a virgin.  That makes your blood even more useful amongst my coven.  Please come to the altar at my next Fark party.
 
2021-10-25 8:14:11 PM  

skybird659: Noah_Tall: Forgive the Type-O? Negative.

I am type O negative and I can give blood to ANYBODY!
I don't need to be forgiven!
/I should be honored.
//Feted!
///At least given more than a stale cookie and watery orange juice!


Fark user imageView Full Size
 
2021-10-25 8:40:42 PM  

Dr.Fey: skybird659: Noah_Tall: Forgive the Type-O? Negative.

I am type O negative and I can give blood to ANYBODY!
I don't need to be forgiven!
/I should be honored.
//Feted!
///At least given more than a stale cookie and watery orange juice!

Actually, you're a Farker, so you are probably also a virgin.  That makes your blood even more useful amongst my coven.  Please come to the altar at my next Fark party.


Lol! I am a 63 year old Farker who lost 1st virginity (to a guy) in '74 and second (to the first of soooo many glorious girls!) in '77.  Gay farkin' Pride, baby! I could LEAD your paltry coven!
 
2021-10-25 9:20:03 PM  

GWSuperfan: It would not surprise me if further research along the lines discussed in TFA revealed that part of the TLR9 inflammatory cascade involves sensitizing the RBCs to insulin, significantly shortening their lifespans and resulting in the anemia.


If the lifespan is shorter, shouldn't the average size of the red cells be smaller?  I thought larger red cells associated with anemia? I guess abnormally small cells would also have that problem.

I recently had my annual blood test and this time it was 5 tubes.  The phlebotomists mentioned there were lots of odd results so they were doing far more tests when standard tests are ordered.  The results I got were 8 pages vs the normal 4.  This time there were far more line items for many standard tests.  There were new immunity response tests and a few that are generally used for arthritis related testing.
 
2021-10-25 9:39:17 PM  

skybird659: Dr.Fey: skybird659: Noah_Tall: Forgive the Type-O? Negative.

I am type O negative and I can give blood to ANYBODY!
I don't need to be forgiven!
/I should be honored.
//Feted!
///At least given more than a stale cookie and watery orange juice!

Actually, you're a Farker, so you are probably also a virgin.  That makes your blood even more useful amongst my coven.  Please come to the altar at my next Fark party.

Lol! I am a 63 year old Farker who lost 1st virginity (to a guy) in '74 and second (to the first of soooo many glorious girls!) in '77.  Gay farkin' Pride, baby! I could LEAD your paltry coven!


Haha! A warning against assuming!
/ Not sure why I'm A negative person.
 
2021-10-25 10:00:05 PM  

dammit just give me a login: skybird659: Dr.Fey: skybird659: Noah_Tall: Forgive the Type-O? Negative.

I am type O negative and I can give blood to ANYBODY!
I don't need to be forgiven!
/I should be honored.
//Feted!
///At least given more than a stale cookie and watery orange juice!

Actually, you're a Farker, so you are probably also a virgin.  That makes your blood even more useful amongst my coven.  Please come to the altar at my next Fark party.

Lol! I am a 63 year old Farker who lost 1st virginity (to a guy) in '74 and second (to the first of soooo many glorious girls!) in '77.  Gay farkin' Pride, baby! I could LEAD your paltry coven!

Haha! A warning against assuming!
/ Not sure why I'm A negative person.


Probably in your blood.
 
2021-10-26 12:23:05 AM  

DON.MAC: GWSuperfan: It would not surprise me if further research along the lines discussed in TFA revealed that part of the TLR9 inflammatory cascade involves sensitizing the RBCs to insulin, significantly shortening their lifespans and resulting in the anemia.

If the lifespan is shorter, shouldn't the average size of the red cells be smaller?  I thought larger red cells associated with anemia? I guess abnormally small cells would also have that problem.

I recently had my annual blood test and this time it was 5 tubes.  The phlebotomists mentioned there were lots of odd results so they were doing far more tests when standard tests are ordered.  The results I got were 8 pages vs the normal 4.  This time there were far more line items for many standard tests.  There were new immunity response tests and a few that are generally used for arthritis related testing.


In iron deficiency anemia, the cells live longer, so they tend to be bigger. Other types of anemia can go either way.
 
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