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(Johns Hopkins Medicine)   Johns Hopkins University receives first federal grant in 50 years for a double-blinded randomized clinical trial of psilocybin for purple monkey dishwasher addiction, and if that doesn't work, maybe it'll help you quit smoking tobacco   (hopkinsmedicine.org) divider line
    More: Spiffy, Psychology, Johns Hopkins University, Mental disorder, Tobacco smoking, Major depressive disorder, Cognitive behavioral therapy, Psychotherapy, Psilocybin mushrooms  
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410 clicks; posted to STEM » on 19 Oct 2021 at 6:06 AM (6 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



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2021-10-19 6:12:37 AM  
If psilocybin can free junkies from the grip of one of the most deadly and addictive drugs in the world we need to know.
 
2021-10-19 6:55:24 AM  

anuran: If psilocybin can free junkies from the grip of one of the most deadly and addictive drugs in the world we need to know.


Eight months in county works too.  Took me six months before I woke up in the morning and it wasn't my first thought.

Got a scopolamine/atropine shot in the 80s to quit smoking.  Went home and realized I was entering a very weird trip. Used to do acid so I knew what was up but I can't imagine a normie getting that shot and being sent home, can only imagine the calls fielded by answering services over that shot.

It worked, didn't touch a cigarette for almost two years and then, while shiat faced drunk on New Years Eve I smoked and that was it. I was smoking half of New Years Day before I even realized it.  Tried patches, gum, chewing patches and everything short of getting that shot again, it was such a dark trip to face again.

I kept seeing/living this dream sequence where I went down to a small pond that was the Caribbean in miniature, there were two fish in there, which I knew to be the progenitors of the entire human race long ago. I'd stick my hands in the water and download "history" from them and walk back through this house that became a temple complex to a Saturn V rocket.  I would enter the rocket and upload what I had and it would lift off, playing the whole history of mankind on a tv until it started skipping and the rocket would crash. I was dead or something but I'd end up back in the temple complex, being rolled over by a giant stone cylinder until I was whole again. Back to the pond.  As vivid and real as any true memory I have, sitting here thinking about it is still like it actually happened. The terror every time that rocket fell is a very real part of me.

God bless alkaloids.
 
2021-10-19 7:08:05 AM  

Sexy Jesus: anuran: If psilocybin can free junkies from the grip of one of the most deadly and addictive drugs in the world we need to know.

Eight months in county works too.  Took me six months before I woke up in the morning and it wasn't my first thought.

Got a scopolamine/atropine shot in the 80s to quit smoking.  Went home and realized I was entering a very weird trip. Used to do acid so I knew what was up but I can't imagine a normie getting that shot and being sent home, can only imagine the calls fielded by answering services over that shot.

It worked, didn't touch a cigarette for almost two years and then, while shiat faced drunk on New Years Eve I smoked and that was it. I was smoking half of New Years Day before I even realized it.  Tried patches, gum, chewing patches and everything short of getting that shot again, it was such a dark trip to face again.

I kept seeing/living this dream sequence where I went down to a small pond that was the Caribbean in miniature, there were two fish in there, which I knew to be the progenitors of the entire human race long ago. I'd stick my hands in the water and download "history" from them and walk back through this house that became a temple complex to a Saturn V rocket.  I would enter the rocket and upload what I had and it would lift off, playing the whole history of mankind on a tv until it started skipping and the rocket would crash. I was dead or something but I'd end up back in the temple complex, being rolled over by a giant stone cylinder until I was whole again. Back to the pond.  As vivid and real as any true memory I have, sitting here thinking about it is still like it actually happened. The terror every time that rocket fell is a very real part of me.

God bless alkaloids.


you sound like Hunter S Thompson here big time.
 
2021-10-19 7:12:29 AM  

anuran: If psilocybin can free junkies from the grip of one of the most deadly and addictive drugs in the world we need to know.


Oxygen?
 
2021-10-19 7:14:53 AM  
Every time i've shroomed i've wanted to smoke like crazy so i must be doing it wrong.

I quit smoking after a 10 year process. Three steps forward 2 steps back over and over...until finally you realize you've taken a lot of steps.

I have this theory:

when you become addicted to smoking cigarettes, its as much the habituation as the physical addiction. The physical part you come off of in 3 days, its the habits that need to be carefully curated and rewired, one at a time, each time they come up, for years, until you've re-wired them. I havent smoked in years now but i would expect there are still some ancient sleeping balrogs in there where if i ever awaken them i'll be dying for a cig.

So what would happen, I'd rewire the easy use cases and be fine.... and then hit a trigger, and fall off the wagon until i could rewire that trigger. The first ones to rewire...the morning cuppa coffee, the beer and a cig, the party cig, the driving in traffic cig...these i got over pretty quick. But the 'chewing out of the boss omg i get fired' cig? The 'fighting with the ex about my kid and she wants to do something stupid again that will waste my money' cig? These took much longer to learn to rewire. And the "coming out of a movie theater' cig... man that one was just stupid tough. Like, why was that one harder than 'fear of job loss'? yet it was.

So then I'd get all set up in an environment where i'd never hit a trigger, then change environments, and uncover new mines like cleaning a beach in denmark in 1945. Oh look i can not smoke in California, lets go to Germany where i've not been since i was a smoker and HEY NOW all these triggers that have to be redone.

Now i think i'm finaly there. But who knows, maybe not.

But as such, from my perspective, trying to treat cigarette cessation as a catalytic event is folly. You cant just "heal" or "be cured" from cigarettes, it takes a long time. And that's ok, dont beat yourself up, just keep trying again. it does get easier and easier until eventually, you're done.
 
2021-10-19 7:25:46 AM  
Unlike a lot of medical trials, I'm pretty sure the patients will know who gets the placebo and who gets the drug fairly quickly.
 
2021-10-19 7:26:22 AM  

Father_Jack: Every time i've shroomed i've wanted to smoke like crazy so i must be doing it wrong.



I knew I had successfully quit smoking and that it would keep the first time I did an illegal drug (which I won't mention here as it's generally not as socially acceptable as other drugs that people talk about freely) and had absolutely no urge to smoke.

/Smoke free since June 2010
//mostly free of that other stuff since 2017.
///I still dabble I just don't spend money on it.
 
2021-10-19 7:52:13 AM  

Father_Jack: Every time i've shroomed i've wanted to smoke like crazy so i must be doing it wrong.

I quit smoking after a 10 year process. Three steps forward 2 steps back over and over...until finally you realize you've taken a lot of steps.

I have this theory:

when you become addicted to smoking cigarettes, its as much the habituation as the physical addiction. The physical part you come off of in 3 days, its the habits that need to be carefully curated and rewired, one at a time, each time they come up, for years, until you've re-wired them. I havent smoked in years now but i would expect there are still some ancient sleeping balrogs in there where if i ever awaken them i'll be dying for a cig.

So what would happen, I'd rewire the easy use cases and be fine.... and then hit a trigger, and fall off the wagon until i could rewire that trigger. The first ones to rewire...the morning cuppa coffee, the beer and a cig, the party cig, the driving in traffic cig...these i got over pretty quick. But the 'chewing out of the boss omg i get fired' cig? The 'fighting with the ex about my kid and she wants to do something stupid again that will waste my money' cig? These took much longer to learn to rewire. And the "coming out of a movie theater' cig... man that one was just stupid tough. Like, why was that one harder than 'fear of job loss'? yet it was.

So then I'd get all set up in an environment where i'd never hit a trigger, then change environments, and uncover new mines like cleaning a beach in denmark in 1945. Oh look i can not smoke in California, lets go to Germany where i've not been since i was a smoker and HEY NOW all these triggers that have to be redone.

Now i think i'm finaly there. But who knows, maybe not.

But as such, from my perspective, trying to treat cigarette cessation as a catalytic event is folly. You cant just "heal" or "be cured" from cigarettes, it takes a long time. And that's ok, dont beat yourself up, just keep trying again. it does get easier and easier until eventually, you're done.


I found that smoking on a strict schedule worked for me. Something about aligning all the effects of smoking in a recognizable pattern disgusted me so much I couldn't touch another one. I certainly think about them, but the thought of actually smoking another one myself gives me the heebie-jeebies.
 
2021-10-19 7:55:00 AM  
Lemme know when a trial for depression and/or anxiety pops up.
Asking for an SO.
 
2021-10-19 7:55:21 AM  
After 40 years of smoking at least a pack a day my cure was vaping. The first time I put a vape pen to my mouth was the last day I smoked a cigarette. I've been at least 10 years off cigarettes and 8 or 9 off vape.

The vape was easy to quit due to being able to reduce down to zero nicotine.
 
2021-10-19 8:16:35 AM  
Can i get some money? Id like to do some research too.
 
2021-10-19 8:16:49 AM  
A little over a year ago I had an intense mushroom trip, and as I lay shuddering on my bed attempting to shut out any outward sensation, I realized I had problems with addiction. I needed to make a change. So after I came down, I pulled out a blank book and made a fitness journal, outlined goals, and started recovery. I tracked my mood twice a day, what I ate, how much I weighed, and more. I managed to quit cigarettes cold turkey, using some Xanax to manage the sensation of my skin crawling during the first week of detox. I did smoke one or two from friends in the months following, but I managed to avoid buying a pack, and I haven't picked it back up. I stopped other drugs slowly over a six month period, and I am now drug free almost a year. I still deal with the cravings when I'm very stressed, but overall my life and my health have improved substantially.
 
2021-10-19 8:25:58 AM  

Snapper Carr: Father_Jack: Every time i've shroomed i've wanted to smoke like crazy so i must be doing it wrong.


I knew I had successfully quit smoking and that it would keep the first time I did an illegal drug (which I won't mention here as it's generally not as socially acceptable as other drugs that people talk about freely) and had absolutely no urge to smoke.

/Smoke free since June 2010
//mostly free of that other stuff since 2017.
///I still dabble I just don't spend money on it.


Guessing meth since coke is pretty acceptable online and heroin isn't really a story telling drug.
 
2021-10-19 8:31:44 AM  
i wish micro dosing were legal.
 
2021-10-19 8:49:53 AM  
external-content.duckduckgo.comView Full Size
 
2021-10-19 9:22:36 AM  

Bathtub Cynic: Snapper Carr: Father_Jack: Every time i've shroomed i've wanted to smoke like crazy so i must be doing it wrong.


I knew I had successfully quit smoking and that it would keep the first time I did an illegal drug (which I won't mention here as it's generally not as socially acceptable as other drugs that people talk about freely) and had absolutely no urge to smoke.

/Smoke free since June 2010
//mostly free of that other stuff since 2017.
///I still dabble I just don't spend money on it.

Guessing meth since coke is pretty acceptable online and heroin isn't really a story telling drug.


shiat, all my best stories are from my years on heroin. I dealt with more dead girls than Ted Bundy, committed thousands of bizarre land pirate crimes (always against corporations and money lenders, never individuals) and experienced so many bizarre things - like the Atlanta cop handing me back my bag of dope, "That's farking sad man, get out of here." I'm writing a book, but the statue of imitations and all that.
 
2021-10-19 9:40:52 AM  

SeaMan Stainz: Can i get some money? Id like to do some research too.


Sure, just write an nimh grant. That one on tobacco was probably aboutn120 pages long into total. The research proposal itself is only 10 pages, thats the hardest part . But stuff like the protection for human subjects is all very nitpick and takes time.

The next application round is probably April? You got some time, but start soon. Success rates are only around 20%, and you need a well polished grant to have a chance at funding.

The psilocybin stuff is taking off like a rocket, the hype train is at full speed. There's been like 4 half decent (but not great) trials, and so far we have about 30 companies fighting over market share abd sending shiatty patents.

I figure our Canadian trials will get funded in the next year, two at the outset . I think we did a really good job on the applications and assembled the right team, but its always a crap shoot. Abd CIHR only gives a fraction of the funds NIMH usually gives. So we have to run much tighter budgets.
 
2021-10-19 9:57:37 AM  
As long as we are talking tripping, I've done all sorts of alkaloids, back in the day. Most bizarre: San Pedro cactus somebody stole out of a hotel lobby. We tortured it with fire, ice and fists to make it amp up it's alkaloids, ostensibly. We all managed to get down one big pickle slice shaped piece without puking more than a couple of times and then... nothing.

We were sitting around a big fire being disappointed when the subject of how we were shifting backwards and forwards in time came up.  None of us have ever been able to explain it but I'd be talking to someone and I'd have to excuse myself because I knew I was about to have another conversation or event with someone. We audio recorded part of this and it made even less sense listening sober but at one point somebody stated that dudes wife was about to come out of the house and ask us if we needed ice and when she did we all went apewire. Grown men cried. Atheists beseeched Jesus for help. Most mind bending thing ever, you could go back to a fun part of the trip and relive it as real as the current moment.

The tail end was all of us sitting around the fire while astrally projecting around the mountain valley. No visuals, no body high just absolutely bent perception of time and space.  That temporal chaos still makes me question certain things, and I am no mystic.  It was real damnit.

Worst trip started when some kid accidentally sprayed OFF in my face while I'm on a rapidly ascending elevator with the 6 Hit button pressed.  I ended up wandering the forest alone in the rain, convinced I was dead and was somehow charged with helping regulate the rain with the speed of my walking. If I stopped moving, the ground around me would rise up around me and leave me standing in a grave.  Nine hours of being an undead weather control zombie left me wrung out and a complete mess.

Best visuals ever: quitting a Xanax habit cold turkey and going 12 days without sleep.  Everything, especially plant life was surrounded by a very real (not fleeting or implied) wireframe geometry spinning around it in an impossible way, where it's parts would disappear into nowhere and reappear from nowhere in a completely confounding way. I accidentally left a four minute voice mail on the ex wife's phone where I'm trying to describe what I saw to my junkie neighbor.  That went well. I ended up taking a hatchet to my own car for reasons I cannot properly explain but seemed perfectly cromulent at the time.  My neighbor said I kept calling the female cop who responded a potato body lesbian until she launched on me, chased me into a bedroom where I ran around the bed like a little kid until she caught me and smashed my face on the wall until unconscious.  I don't remember day 12. 13,14 and 15 are a blank too but I spent them in the county jail infirmary shot full of librium, I came to just a few hours before I was to be shipped off to a state nuthouse.  Those visuals, never saw anything like it, even on the weird mushrooms we bought from a hippie in a parking lot downtown before a Grateful Dead show.

I havent tripped in years, or even smoked weed.  I kind of ruined all chemicals by taking heroin as a biatch mistress.  I lost my trust in myself when it comes to chemicals.  When you spend a week in the winter wandering around homeless on the streets in a trenchcoat while naked underneath with blue shop rags tied to your calves so shopkeeps would not freak out, you learn that maybe you cannot trust yourself at managing your affairs when chemicals get involved.  But man, I could sure do with a face melting, gripping the grass to not fall off the planet trip like we used to have on that Owsley precursor stuff.
 
2021-10-19 10:26:43 AM  
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Didn't work for me, YMMV
 
2021-10-19 11:29:34 AM  
Bookmarking this thread for more stories later.
 
2021-10-19 4:23:32 PM  
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