Skip to content
 
If you can read this, either the style sheet didn't load or you have an older browser that doesn't support style sheets. Try clearing your browser cache and refreshing the page.

(BBC-US)   Could Alzheimer's be an infection and therefore possibly curable? There's a germ of hope   (bbc.com) divider line
    More: Spiffy, Alzheimer's disease, Virus, Herpes simplex virus, Genetic studies, Ruth Itzhaki, understanding of Alzheimer, amyloid beta, large study  
•       •       •

1232 clicks; posted to STEM » on 07 Oct 2021 at 2:33 PM (7 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



22 Comments     (+0 »)
View Voting Results: Smartest and Funniest
 
2021-10-07 2:48:52 PM  
TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.
 
2021-10-07 2:52:32 PM  
Didn't science identify a clear hereditary component in Alzheimer's decades ago?
 
2021-10-07 2:52:44 PM  

Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.


This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.
 
2021-10-07 3:01:17 PM  

Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.


They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.
 
2021-10-07 3:08:56 PM  

Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.


Better theory: your brain just says fark it im out after a random amount of time
 
2021-10-07 3:22:28 PM  

Wine Sipping Elitist: Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.

They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.


Like pretty much everyone my age (growing up pre-vaccine), I have the chicken pox variant, but I am lucky to have escaped the others.  Since my wife is in the same situation we're likely to stay that way for the remainder of our years - but not certain, because there is more than one way to catch it.

Regardless, I am going to enjoy the idea that Parkinson's may be a less likely end-of-life scenario for us.
 
2021-10-07 3:22:59 PM  

Unsung_Hero: Wine Sipping Elitist: Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.

They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.

Like pretty much everyone my age (growing up pre-vaccine), I have the chicken pox variant, but I am lucky to have escaped the others.  Since my wife is in the same situation we're likely to stay that way for the remainder of our years - but not certain, because there is more than one way to catch it.

Regardless, I am going to enjoy the idea that Parkinson's may be a less likely end-of-life scenario for us.


...or Alzheimer's.  Yeah, that one.
 
2021-10-07 4:04:53 PM  

Unsung_Hero: Wine Sipping Elitist: Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.

They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.

Like pretty much everyone my age (growing up pre-vaccine), I have the chicken pox variant, but I am lucky to have escaped the others.  Since my wife is in the same situation we're likely to stay that way for the remainder of our years - but not certain, because there is more than one way to catch it.

Regardless, I am going to enjoy the idea that Parkinson's may be a less likely end-of-life scenario for us.


Parkinson's is a biatch. My Dad is towards the end of his journey with it.
 
2021-10-07 4:10:24 PM  

majestic: Unsung_Hero: Wine Sipping Elitist: Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.

They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.

Like pretty much everyone my age (growing up pre-vaccine), I have the chicken pox variant, but I am lucky to have escaped the others.  Since my wife is in the same situation we're likely to stay that way for the remainder of our years - but not certain, because there is more than one way to catch it.

Regardless, I am going to enjoy the idea that Parkinson's may be a less likely end-of-life scenario for us.

Parkinson's is a biatch. My Dad is towards the end of his journey with it.


We are currently dealing with an end stage case of dementia in our family.  My sympathies.
 
2021-10-07 4:41:59 PM  

Unsung_Hero: majestic: Unsung_Hero: Wine Sipping Elitist: Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.

They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.

Like pretty much everyone my age (growing up pre-vaccine), I have the chicken pox variant, but I am lucky to have escaped the others.  Since my wife is in the same situation we're likely to stay that way for the remainder of our years - but not certain, because there is more than one way to catch it.

Regardless, I am going to enjoy the idea that Parkinson's may be a less likely end-of-life scenario for us.

Parkinson's is a biatch. My Dad is towards the end of his journey with it.

We are currently dealing with an end stage case of dementia in our family.  My sympathies.


Same to you. Sucks all around for everyone.
 
2021-10-07 4:59:06 PM  
Sure, I've been feeling a little more optimistic lately.

/actually no
 
2021-10-07 5:34:38 PM  

Wine Sipping Elitist: Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.

They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.


HSV1 or HSV2 can cause symptoms on mouths/throats OR junk. There's not that much difference between the two. Varicella-zoster (also a herpes virus) is not limited to mucosa.
/can't wait for my first case of shingles
 
2021-10-07 5:46:54 PM  
I'm solidly in the disbelief category. Quality of sleep determining how much your brain gets washed seems to be the most likely answer.
 
2021-10-07 5:49:20 PM  
Dementia absolutely terrifies me.  I've watched one of my grandmothers and one of my wife's grandmothers slip away into a fog that they never returned from.  It was absolutely heartbreaking to watch the progression, because they knew what was happening.

I wouldn't wish it on anyone and if there is hope, I welcome it.
 
2021-10-07 5:58:07 PM  

recondite cetacean: I'm solidly in the disbelief category. Quality of sleep determining how much your brain gets washed seems to be the most likely answer.


Good news, the military is developing a brainwashing helmet.  As in proper cleaning, not manipulating your thoughts.  The day may come when you put on a metal sleep cap at night to ensure your brain gets the optimal garbage collection cycle while you slumber.
 
2021-10-07 6:33:40 PM  

majestic: Unsung_Hero: Wine Sipping Elitist: Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.

They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.

Like pretty much everyone my age (growing up pre-vaccine), I have the chicken pox variant, but I am lucky to have escaped the others.  Since my wife is in the same situation we're likely to stay that way for the remainder of our years - but not certain, because there is more than one way to catch it.

Regardless, I am going to enjoy the idea that Parkinson's may be a less likely end-of-life scenario for us.

Parkinson's is a biatch. My Dad is towards the end of his journey with it.


All of the dementias suck. I lost 1 grandparent to Parkinson's and 2 to Alzheimer's. The last that died without dementia (cardiac issues i think) was by far the least brutal on both the individual and family.
 
2021-10-07 6:35:41 PM  
There's been a lot of backlash to the amyloid hypothesis due to the failure in clinical trials of scores of amyloid targeted drugs.

But it's worth remembering that the amyloid hypothesis has been the dominant hypothesis for a very good scientific reason: humans with mutations in APP (which encodes the amyloid precursor protein) or PSEN (which processes amyloid protein, almost invariably develop early-onset Alzheimer's disease.  These are heritable cases, and extremely strong genetic evidence dysfunction of proteins encoded by these genes leads to Alzheimer's.  It's as close as you can get to cause-and-effect in human genetics.  And since those cases are clearly heritable, and since variants in other genes (such as APOE) cause a clear increase in susceptibility, this is very strong evidence that these genes are involved in the disease process, regardless of any environmental factors like viruses.

Yet, the failure of amyloid-targeting drugs, and the observation that some elderly people have loads of amyloid plaques in the brains but don't have neurodegeneration or dementia, indicates that there is more to the story.

In the end, it's probably going to be like a cancer.  A horrifically complex disease caused by an interplay of genetic and environmental factors, the relative impact of each varying by the individual patient.
 
2021-10-07 7:58:03 PM  

Unsung_Hero: recondite cetacean: I'm solidly in the disbelief category. Quality of sleep determining how much your brain gets washed seems to be the most likely answer.

Good news, the military is developing a brainwashing helmet.  As in proper cleaning, not manipulating your thoughts.  The day may come when you put on a metal sleep cap at night to ensure your brain gets the optimal garbage collection cycle while you slumber.


I heard that.  It was on this website you might have heard of, fork dot corn. You should try reading it some time.
 
2021-10-07 9:25:30 PM  

Unsung_Hero: Unsung_Hero: Wine Sipping Elitist: Unsung_Hero: Wine Sipping Elitist: TL;DR   Frequent herpes cold sore outbreaks in people with a specific gene is suspected to be responsible for developing dementia. Interesting theory.

This is where I express relief because I don't have herpes, then someone comes in to tell me I do because other common infections are in the same family and I probably have it anyway and I'm just asymptomatic.

But you know what?  It's OK.  Now I know it's not that you want to normalize your infection so you don't have to be considerate of the health of others, but that you're in the early stages of dementia and not entirely rational.

They were talking about Herpes Simplex 1, which is cold sores on and around your mouth and not the kind that likes your junk (as far as I know) Chicken Pox is also a herpes virus, and it stays dormant for your life and might develop into shingles.  I think I read somewhere that maybe 70% of people around the world carry a herpes variant.

You probably have it and just forgot because, you know, dementia and all.

Like pretty much everyone my age (growing up pre-vaccine), I have the chicken pox variant, but I am lucky to have escaped the others.  Since my wife is in the same situation we're likely to stay that way for the remainder of our years - but not certain, because there is more than one way to catch it.

Regardless, I am going to enjoy the idea that Parkinson's may be a less likely end-of-life scenario for us.

...or Alzheimer's.  Yeah, that one.



...The doctor says, "I have some bad news; you have cancer and Alzheimer's." The man replies, "well, at least it's not cancer."
 
2021-10-08 12:18:15 AM  
Well that was interesting. Yes I read the whole damn thing, thanks subs.
 
2021-10-08 7:25:12 AM  
No mention of prions.
 
2021-10-08 8:57:40 AM  
Yeah this is both awesome and terrible at the same time.  Your brain is who you are, so the thought of these diseases being communicable is extra terrifying.  But if that's the way it works, figuring that part out is step 1 in figuring the rest out.
 
Displayed 22 of 22 comments

View Voting Results: Smartest and Funniest

This thread is closed to new comments.

Continue Farking




On Twitter


  1. Links are submitted by members of the Fark community.

  2. When community members submit a link, they also write a custom headline for the story.

  3. Other Farkers comment on the links. This is the number of comments. Click here to read them.

  4. Click here to submit a link.