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(CNBC)   Two COVIDs, One Death   (cnbc.com) divider line
    More: Sick, Influenza, Rio Grande do Sul, Infectious disease, Microbiology, beta variants of Covid-19, Shotgun sequencing, Biotechnology, Common cold  
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3876 clicks; posted to Main » on 12 Jul 2021 at 2:50 PM (12 days ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



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2021-07-12 2:53:38 PM  
That stinks.
 
2021-07-12 2:53:43 PM  
How am I supposed to stock up on all the COVIDs when I have already tried all the vaccines?
 
2021-07-12 2:57:19 PM  
Well that's just fantastic. Now the variants can have a chance to mix up their mutations and see if they work better together.
 
2021-07-12 3:00:21 PM  
Well I'm sure that new variants will have plenty of time to mutate, like the offspring of a Trump supporter who humped his sister, given that the anti-vax twats in this country are unfortunately so numerous.
 
2021-07-12 3:00:52 PM  

40 degree day: Well that's just fantastic. Now the variants can have a chance to mix up their mutations and see if they work better together.


I came in to mention that's exactly what happens IRL - when someone is infected with two different strains that's when they can mix genetic material inside our cells, and strains with the strengths of both parent viruses can be created.
 
2021-07-12 3:01:01 PM  
So that brings to mind the question if there exists porn where a woman is with two partners and infected with two venereal diseases at the same time.
 
2021-07-12 3:06:40 PM  
My wife is currently suffering through a COVID infection. She was vaccinated with the Moderna vaccine. She was confirmed positive on 7/5. Been monitoring her O2 saturation rates every hour on the hour. Here, they will not hospitalize you unless you have a fever of 103 and higher and your O2 sat rate is less than 93.

This is not fun, y'all. Please do get vaccinated, wear a mask, and take all the best precautions you can.
 
2021-07-12 3:09:37 PM  
They can only hang me once, right?

Fark user imageView Full Size
 
2021-07-12 3:14:05 PM  
res.cloudinary.comView Full Size


/window seat please
 
2021-07-12 3:14:36 PM  
Maybe she was infected with the Alpha variant and experienced the mutation as a host rather as a victim of dual infection? Predicting which hosts have the greatest likelihood of generating mutations would be rather helpful, yes?
 
2021-07-12 3:15:07 PM  
Fark user imageView Full Size
 
2021-07-12 3:15:39 PM  
For the first time in medical history, a virus has tag-teamed to pounce on fans of professional wrestling.
 
2021-07-12 3:18:52 PM  
Forget it, Jake, it's Belgium.
 
2021-07-12 3:21:10 PM  

Porous Horace: So that brings to mind the question if there exists porn where a woman is with two partners and infected with two venereal diseases at the same time.


I think that you might be alone in that question.
 
2021-07-12 3:21:46 PM  
Lemon COVID Party?
 
2021-07-12 3:23:34 PM  

40 degree day: Well that's just fantastic. Now the variants can have a chance to mix up their mutations and see if they work better together.


It's a non-segmented genome virus, so no need to worry about two infections mixing genes.

The flu is the bastard that's infamous for that.
 
2021-07-12 3:23:41 PM  
90 year olds aren't known for their robust immune system.  There's no reason you couldn't be coinfected if exposed to both and have both thrive as long as they're not outcompeting each other for the same resources.
 
2021-07-12 3:25:37 PM  

strathmeyer: How am I supposed to stock up on all the COVIDs when I have already tried all the vaccines?


Why can't I hold all this COVID?

Fark user imageView Full Size
 
2021-07-12 3:29:26 PM  

bhcompy: 90 year olds aren't known for their robust immune system.  There's no reason you couldn't be coinfected if exposed to both and have both thrive as long as they're not outcompeting each other for the same resources.


Apparently they used up their resources.

I wonder if the coronavirus variants were arguing about infrastructure and global warming when their host died?

The Alphas were all, "we need to have a sustainable plan to share the host, her temperatures are reaching a point where life will no longer be possible."

The Deltas were all, "PWN THE ALFAS!!!! FILIBUSTER!!!1" and tried to stage a coup.

Then everything died.
 
2021-07-12 3:41:35 PM  
The woman, whose medical history was unremarkable

Well at least she was up to date on her colonoscopy.
 
2021-07-12 3:42:35 PM  
TheCruxOfTheBiscuitIsTheApostrophe:​ [Fark user image 498x372] [View Full Size image _x_]

Ignore at your own peril shiatstick
 
2021-07-12 3:46:00 PM  
I've heard of people getting sick "again", but realizing it's probably different variants rather than getting the same variant twice.
 
2021-07-12 3:50:53 PM  

40 degree day: Well that's just fantastic. Now the variants can have a chance to mix up their mutations and see if they work better together.


Always have. How do you suppose it took weeks for delta to do what gamma couldn't in months?
 
2021-07-12 3:54:05 PM  

40 degree day: Well that's just fantastic. Now the variants can have a chance to mix up their mutations and see if they work better together.


She died, so they don't work better together.
 
2021-07-12 3:55:25 PM  

fragMasterFlash: Maybe she was infected with the Alpha variant and experienced the mutation as a host rather as a victim of dual infection? Predicting which hosts have the greatest likelihood of generating mutations would be rather helpful, yes?


It's possible, but that implies that beta is a naturally-occuring evolution of alpha and we just happened to detect it. That's actually worse because it implies all alpha infections have the same propensity.
 
2021-07-12 3:56:53 PM  
What multiple variants might look like:

Fark user imageView Full Size
 
2021-07-12 3:57:11 PM  

40 degree day: Well that's just fantastic. Now the variants can have a chance to mix up their mutations and see if they work better together.


They will.
 
2021-07-12 3:58:55 PM  

Caelistis: My wife is currently suffering through a COVID infection. She was vaccinated with the Moderna vaccine. She was confirmed positive on 7/5. Been monitoring her O2 saturation rates every hour on the hour. Here, they will not hospitalize you unless you have a fever of 103 and higher and your O2 sat rate is less than 93.

This is not fun, y'all. Please do get vaccinated, wear a mask, and take all the best precautions you can.


Yet Fauci wants to deny early adopters boosters.  What a bastard.
 
2021-07-12 4:04:23 PM  

Caelistis: My wife is currently suffering through a COVID infection. She was vaccinated with the Moderna vaccine. She was confirmed positive on 7/5. Been monitoring her O2 saturation rates every hour on the hour. Here, they will not hospitalize you unless you have a fever of 103 and higher and your O2 sat rate is less than 93.

This is not fun, y'all. Please do get vaccinated, wear a mask, and take all the best precautions you can.


Make sure she's taking aspirin.  It's antiplatelet activity reduced mortality between 20 to 40 percent vs previous strains.
 
2021-07-12 4:10:21 PM  
They had a party, but killed their venue.
 
2021-07-12 4:21:52 PM  

TeddyRooseveltsMustache: Well I'm sure that new variants will have plenty of time to mutate, like the offspring of a Trump supporter who humped his sister, given that the anti-vax twats in this country are unfortunately so numerous.


The best part is, since there also a lot of vaccinated people, this gives the virus more chances to hit upon a mutation that reduces the efficacy of the vaccines.

Awesome.
 
2021-07-12 4:22:27 PM  

Porous Horace: So that brings to mind the question if there exists porn where a woman is with two partners and infected with two venereal diseases at the same time.


Almost 100% certainty
 
2021-07-12 4:31:09 PM  
Flash forward two weeks: Dual Strain Infection Common.
 
2021-07-12 4:31:29 PM  

deanis: TheCruxOfTheBiscuitIsTheApostrophe: [Fark user image 498x372] [View Full Size image _x_]

Ignore at your own peril shiatstick


Double barreled CoVid is coming for you my panicky friend.
 
2021-07-12 4:32:01 PM  

fragMasterFlash: Maybe she was infected with the Alpha variant and experienced the mutation as a host rather as a victim of dual infection? Predicting which hosts have the greatest likelihood of generating mutations would be rather helpful, yes?


I'm not sure you can predict that. Mutation is random, and it's from an error in the gene coding polymerase contained in the actual virus. Most mutations are either of no value to the original organism, or detrimental. The chance of it mutating with each successive generation is higher, but still random.

The problem is, the most hosts and transmission vectors you have, the more mutations, but, unless the spike protein mutates (which, my understanding is that is unlikely because it would fundamentally change the mechanism of infection) vaccines should retain much of their effectiveness.

But, people much more knowledgeable than me are worried a large vaccinated population with a sizeable unvaccinated group give the virus the best chance to find that mutation, so, who knows?
 
2021-07-12 4:47:14 PM  

Natalie Portmanteau: The problem is, the most hosts and transmission vectors you have, the more mutations, but, unless the spike protein mutates (which, my understanding is that is unlikely because it would fundamentally change the mechanism of infection) vaccines should retain much of their effectiveness.


Coronavirus: "Challenge accepted."

https://www.sciencedaily.com/releases​/​2021/07/210706093857.htm
 
2021-07-12 4:52:40 PM  
TheCruxOfTheBiscuitIsTheApostrophe:​ deanis: TheCruxOfTheBiscuitIsTheApostrophe: [Fark user image 498x372] [View Full Size image _x_]

Ignore at your own peril shiatstick

Double barreled CoVid is coming for you my panicky friend.

Double Barrel Covid
.  Not bad.  I'll be borrowing that without permission.
 
2021-07-12 4:59:03 PM  

Natalie Portmanteau: The problem is, the most hosts and transmission vectors you have, the more mutations, but, unless the spike protein mutates (which, my understanding is that is unlikely because it would fundamentally change the mechanism of infection) vaccines should retain much of their effectiveness.


The spike protein can and does mutate. In fact the variants of concern all have some spike protein mutations compared to the original COVID sequence found in the 1st Wuhan outbreak. There's every reason to believe that over time new spike mutations will continue to arise.

The alpha variant has 23 mutations compared with the original Wuhan strain, with eight of those in the virus's spike protein

Gamma
is closely related to beta (B.1.351), and the two variants share some of the same mutations in their spike proteins, the Times reported. These spike protein mutations include N501Y, which helps the virus bind tightly to cells and is also found in the alpha (B.1.1.7) lineage. The spike mutation K417T may also help gamma latch onto cells, while the E484K mutation likely helps the variant dodge certain antibodies. And according to the CDC, in addition to these three mutations, the variant carries eight additional sequence changes in its spike: L18F, T20N, P26S, D138Y, R190S, D614G, H655Y and T1027I.

The delta variant has several important mutations in the spike protein, including T19R, del157/158, L452R, T478K, D614G, P681R, D950N mutations, according to outbreak.info. Two of these mutations - L452R and D614G - allow the variant to attach more firmly to ACE2 receptors, Live Science previously reported. Others, such as P681R, may allow delta to evade host immunity.
 
2021-07-12 5:08:30 PM  

Stibium: fragMasterFlash: Maybe she was infected with the Alpha variant and experienced the mutation as a host rather as a victim of dual infection? Predicting which hosts have the greatest likelihood of generating mutations would be rather helpful, yes?

It's possible, but that implies that beta is a naturally-occuring evolution of alpha and we just happened to detect it. That's actually worse because it implies all alpha infections have the same propensity.


Yes, they can all occur spontaneously.  And they do, regularly.  Selection pressures and hygiene make all the difference.

Antibody evading mutations like the epsilon mutations happen all the time, but so long as the host isn't actually on monoclonals, those mutations carry no benefit, making it very unlikely that those mutations get amplified in the host.  Any particular set of selection pressures--the presence of monoclonals in this example--can amplify some mutations, and suppress others.

As long as proper isolation protocols are obeyed, the emerging variant is not transmitted. I made a big deal of this when Trumpy pulled his mask off upon release from the hospital.  It was literally the least responsible thing to do in that moment.
 
2021-07-12 6:05:35 PM  
A second COVID you say?

Fark user imageView Full Size
 
2021-07-12 6:07:40 PM  
Yo mama got two infections.
 
2021-07-12 6:10:26 PM  
Two strains fight it out and the winner is the one which leaves you alive. That's how genetic resistence works. Eventually, what doesn't kill you outright makes you stronger. If it can be inherited genetically, it has a change of running its rival to extinct. Simply by higher rates of reproduction.

Voilà! A key driver of natural selection and thus evolution of species.

In this case, the winning species is likely to be liberal Democrats. Not Tories, Republicans or Russian dupes and religious con artist victims.

My condoleances. Sorry to hear that your family was wiped out by stupidity and credulity. But it all adds to the viability of critical thinking and altruism.
 
2021-07-12 6:15:50 PM  

backhand.slap.of.reason: Yes, they can all occur spontaneously. And they do, regularly. Selection pressures and hygiene make all the difference.


Yes, I do know that, but I just thought I was taking crazy pills. The sheep get antsy when you say this stuff out loud.

The whole virus thing is farking insane. And stupid. And unnecessary. But because the stonk market doesn't want to take the correction hit we can't just stop it right now. That and because a bunch of people are whiney babies and don't want to do inconvenient things. But it's likely going to happen this year anyway just like last year when covid was suddenly a big deal. A general strike is primed and home prices are whacked off. The stock market will be fine if you stop farking with it and let it happen but a bunch of boomer stocks are going to get nuked and sold off to buy Gamestop and a bunch of other things for retail investors.

In this case the casino is rigged in some way or another, but if you have enough money you can run your own table. As long as the marks don't know that and don't understand how the game works then they lose over time. Sometimes it's their own fault for picking crap and doing stupid things, but not always. Some casino makers loan out tables where the dealer always wins. Unless he loses his ass and then straight up refuses to pay. Because the casino is rigged anyway owing to how it's structured, they write it off and the dealer pays a fee for the paperwork headache. The casino makers mark it off in the books and the dealer gets a slap on the wrist and a fine for the paperwork. The casino doesn't tell you, or anyone else that. Especially the company who's shares you wrote off!

So much ill-gotten shareholder wealth will be destroyed. Lawsuits will be filed. Lots amazing. Much wow!

/Also, about the "as long as you're not taking monoclonals" thing...
//that's supposedly how alpha started in Britain
///monoclonals used in a person with suppressed immunity
 
2021-07-12 6:34:11 PM  

Resident Muslim: I've heard of people getting sick "again", but realizing it's probably different variants rather than getting the same variant twice.


At this point it's probably both. Natural COVID immunity wanes pretty quickly. One of my coworkers was infected back in March 2020, then infected again in July of 2020 - that was before the variants had time to emerge, when the main initial strain was first making its way around the globe.

Luckily for her, since she's already had a bad bout with it in March (she wasn't hospitalized, but was very sick, and it took weeks for the cough to go away and smell/taste to come back) the second round was soon enough that it was much, much more mild the second time around. But really both scenarios of catching it twice or just catching a different strain later are just as possible.
 
2021-07-12 6:54:26 PM  
Approves?

Fark user imageView Full Size
 
2021-07-12 7:27:24 PM  

Madman drummers bummers: What multiple variants might look like:

[Fark user image image 527x276]


Needs more crocodiles.
 
2021-07-12 9:49:43 PM  

fragMasterFlash: Maybe she was infected with the Alpha variant and experienced the mutation as a host rather as a victim of dual infection? Predicting which hosts have the greatest likelihood of generating mutations would be rather helpful, yes?


Immunocompromised people. People who have had various cancer treatments, transplants, are on immunosuppressants, etc.

Radiolab reported a story of one person in the UK who was immunocompromised, was diagnosed with COVID-19, didn't clear the original infection, was hospitalized on day 34-35 of his infection, then started developing mutations in his body. He had sub-populations of COVID-19 in his body with mutations that wouldn't be seen in the wild for months after his death.

"...these patients end up being, like, a blueprint. Like, with them, you could see what the virus might do in the future. And to break that down, what they saw happen inside those bodies were the formation and creation of mutations that then appeared out in the wild six months later in, like, the U.K. variant, the South African variant and the Brazil variant" Radiolab "COVID Dispatch 14"
 
2021-07-12 10:25:33 PM  

cyberspacedout: Natalie Portmanteau: The problem is, the most hosts and transmission vectors you have, the more mutations, but, unless the spike protein mutates (which, my understanding is that is unlikely because it would fundamentally change the mechanism of infection) vaccines should retain much of their effectiveness.

Coronavirus: "Challenge accepted."

https://www.sciencedaily.com/releases/​2021/07/210706093857.htm


Eh, that overcomes the immunity people get from monoclonal antibody plasma infusions, not vaccination.

At least as far as I read in the link.
 
2021-07-12 10:30:14 PM  

40 degree day: Natalie Portmanteau: The problem is, the most hosts and transmission vectors you have, the more mutations, but, unless the spike protein mutates (which, my understanding is that is unlikely because it would fundamentally change the mechanism of infection) vaccines should retain much of their effectiveness.

The spike protein can and does mutate. In fact the variants of concern all have some spike protein mutations compared to the original COVID sequence found in the 1st Wuhan outbreak. There's every reason to believe that over time new spike mutations will continue to arise.

The alpha variant has 23 mutations compared with the original Wuhan strain, with eight of those in the virus's spike protein

Gamma is closely related to beta (B.1.351), and the two variants share some of the same mutations in their spike proteins, the Times reported. These spike protein mutations include N501Y, which helps the virus bind tightly to cells and is also found in the alpha (B.1.1.7) lineage. The spike mutation K417T may also help gamma latch onto cells, while the E484K mutation likely helps the variant dodge certain antibodies. And according to the CDC, in addition to these three mutations, the variant carries eight additional sequence changes in its spike: L18F, T20N, P26S, D138Y, R190S, D614G, H655Y and T1027I.

The delta variant has several important mutations in the spike protein, including T19R, del157/158, L452R, T478K, D614G, P681R, D950N mutations, according to outbreak.info. Two of these mutations - L452R and D614G - allow the variant to attach more firmly to ACE2 receptors, Live Science previously reported. Others, such as P681R, may allow delta to evade host immunity.


Sorry, was unclear on what I meant by that, it's not that the protein can't mutate, it's that the vaccine works in part by impairing the virus' ability to attach to the cell, so it would need to change its entire attachment mechanism
 
2021-07-12 10:40:26 PM  

Natalie Portmanteau: 40 degree day: Natalie Portmanteau: The problem is, the most hosts and transmission vectors you have, the more mutations, but, unless the spike protein mutates (which, my understanding is that is unlikely because it would fundamentally change the mechanism of infection) vaccines should retain much of their effectiveness.

The spike protein can and does mutate. In fact the variants of concern all have some spike protein mutations compared to the original COVID sequence found in the 1st Wuhan outbreak. There's every reason to believe that over time new spike mutations will continue to arise.

The alpha variant has 23 mutations compared with the original Wuhan strain, with eight of those in the virus's spike protein

Gamma is closely related to beta (B.1.351), and the two variants share some of the same mutations in their spike proteins, the Times reported. These spike protein mutations include N501Y, which helps the virus bind tightly to cells and is also found in the alpha (B.1.1.7) lineage. The spike mutation K417T may also help gamma latch onto cells, while the E484K mutation likely helps the variant dodge certain antibodies. And according to the CDC, in addition to these three mutations, the variant carries eight additional sequence changes in its spike: L18F, T20N, P26S, D138Y, R190S, D614G, H655Y and T1027I.

The delta variant has several important mutations in the spike protein, including T19R, del157/158, L452R, T478K, D614G, P681R, D950N mutations, according to outbreak.info. Two of these mutations - L452R and D614G - allow the variant to attach more firmly to ACE2 receptors, Live Science previously reported. Others, such as P681R, may allow delta to evade host immunity.

Sorry, was unclear on what I meant by that, it's not that the protein can't mutate, it's that the vaccine works in part by impairing the virus' ability to attach to the cell, so it would need to change its entire attachment mechanism


The mutations are already chipping away at the vaccine effectiveness and there's no reason to think things can't continue to get incrementally worse and we work our way through the Greek alphabet. Think of the virus working less like a precise key opening a lock, and more like a lock pick. Evolution can give you different ways to pick that lock, and we'll have to update the vaccine to match (hopefully they will work well--we have been lucky on that front so far).
 
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