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(Gizmodo)   Just a whiff full of nitrous makes the depression go down, in the most delightful way   (gizmodo.com) divider line
    More: Spiffy, Clinical trial, Recreational drug use, Major depressive disorder, Nitrous oxide, nitrous oxide, Pharmacology, small clinical trial, potential treatment  
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657 clicks; posted to STEM » on 10 Jun 2021 at 8:18 AM (5 days ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



17 Comments     (+0 »)
View Voting Results: Smartest and Funniest
 
5 days ago  
There's nothing to patent so it's just illegal self medicating.
 
5 days ago  
Resting your teeth on the bedsprings of the universe.

Waaamwaamwamwumwumwwummmmmm
 
5 days ago  

Tr0mBoNe: There's nothing to patent so it's just illegal self medicating.


Back in my early college days some friends stole a tank of it somehow. Looking back I don't know how one of us didn't die.
 
5 days ago  
Yeah subby, lets promote something that really farks with your brain to cure the problems your brain has


what long term problems could that possibly have?
 
5 days ago  
Whip-it. Whip it good.
 
5 days ago  
Checks out ever seen a depressed drag racer? Only if they run turbos or superchargers
 
5 days ago  
Sangamon Taylor approves

nealstephenson.comView Full Size
 
5 days ago  
Results may vary.
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5 days ago  

Sexy Jesus: Whip-it. Whip it good.


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5 days ago  

lifeslammer: Yeah subby, lets promote something that really farks with your brain to cure the problems your brain has


what long term problems could that possibly have?


Not endorsing reckless self medication, but the study actually gives information that points towards lower doses being better. Equivalent results with an impact for up to 2 weeks with less side effects for the lower dose.

Factor in the model where you mix simultaneous therapy to dosing and you might be able to make some long term impacts with a small number of sessions.

Of course, all that says is that we need more research(checking even lower doses, using with therapy and doing studies with more than just self reporting) but it is still interesting stuff.
 
5 days ago  
Using mind altering substances makes you feel better about your shiatty life. News at 11.

CSB: At a concert in the 90s, my friends and I watched some young moron (probably 18-21 ish) skateboarding through the parking lot with a giant nitrous balloon in hand. He took a big old inhale, and as one might expect, began to swerve all over the place. Maybe 10 seconds later, the guy just tipped sideways off the rolling board and his entire upper body slammed into the side of a truck bed (I think it was a Ford F 150).

It was like that Steve Young concussion video; he just laid there for 30 seconds (people were trying to help, but he was totally nonresponsive), before jumping straight up without even recognizing that anything happened. Super weird. /CSB
 
5 days ago  
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5 days ago  
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Helps the penis slide right in...
 
5 days ago  
It's easy to get out of practice feeling joy. A little performance enhancement in addition to talk therapy sounds like worth trying.
 
4 days ago  

bluenovaman: Tr0mBoNe: There's nothing to patent so it's just illegal self medicating.

Back in my early college days some friends stole a tank of it somehow. Looking back I don't know how one of us didn't die.


Back in my college days, my friends and I had easy access to a large tank of nitrous.  We'd fill 55 gal trash bags with it, then go to a different building on campus to huff.

The problem is that nitrous has an immediate, powerful, but short-lived, addictive effect.  If you're around a source, you'll huff all day long.  To solve this, we'd take the bags home, which was about a 15-minute drive from the source.  After huffing, we'd pile in the car to go get more, but the time for the trip allowed us to "sober up" and the addictive effect to disappear as quickly as it appeared.  By the time we got to the source, we were no longer on a mission to get high, so would often just drive back home without more gas.

Auditory hallucinations are pretty farking wild.
 
4 days ago  

indy_kid: bluenovaman: Tr0mBoNe: There's nothing to patent so it's just illegal self medicating.

Back in my early college days some friends stole a tank of it somehow. Looking back I don't know how one of us didn't die.

Back in my college days, my friends and I had easy access to a large tank of nitrous.  We'd fill 55 gal trash bags with it, then go to a different building on campus to huff.

The problem is that nitrous has an immediate, powerful, but short-lived, addictive effect.  If you're around a source, you'll huff all day long.  To solve this, we'd take the bags home, which was about a 15-minute drive from the source.  After huffing, we'd pile in the car to go get more, but the time for the trip allowed us to "sober up" and the addictive effect to disappear as quickly as it appeared.  By the time we got to the source, we were no longer on a mission to get high, so would often just drive back home without more gas.

Auditory hallucinations are pretty farking wild.


We were dumb and they had it in the living room at their shiatty thin walled cement city apartment.
 
4 days ago  

lifeslammer: what long term problems could that possibly have?


But consider short-term solutions.  Folks who have been intubated often struggle to remove the tubes and have to be restrained.  It may seem counter-intuitive to give nitrous to folks needing oxygen just to survive, but if the nitrous takes the edge off the sheer terror of being intubated, that patient might relax enough so that the slight reduction in O2 is more than offset when the patient is calm, thereby needing less oxygen overall.

This could be tested with healthy individuals with very good VO2/SpO2 numbers, such as professional cyclists.  Their bodies are probably the most efficient users of oxygen, so what happens if you replace regular air with nitrous?  VO2/SpO2 numbers will drop, naturally, but this simulates riding through mountains where oxygen levels are naturally lower than sea level.  Would they report less mental stress and/or anxiety, and possibly ride a faster time?

Now, obviously, racing officials won't let riders huff during a race, but it would have implications for folks suffering from high-altitude sickness, such as high-altitude pulmonary edema (HAPE), where the anxiety produced by the lack of oxygen might cause a problematic feedback effect: patient feels like he can't breathe, struggles to breathe harder/deeper, feelings of breathlessness increase, patient tries to breathe even harder/deeper.  Add in some nitrous as you're bringing the patient down the mountain, and they are calmer, are more efficient in their O2 use, and have less psychological issues with that urge to breathe harder/deeper.

As with hallucinogens, it's an area doctors have been prohibited from research properly because "Drugs are bad, mmmkay?"
 
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