Skip to content
Do you have adblock enabled?
 
If you can read this, either the style sheet didn't load or you have an older browser that doesn't support style sheets. Try clearing your browser cache and refreshing the page.

(Singularity Hub)   One CRISPR treatment lowered cholesterol in monkeys by 60 Percent while retaining that classic great taste   (singularityhub.com) divider line
    More: Spiffy, Atherosclerosis, Cholesterol, Low-density lipoprotein, Myocardial infarction, Familial hypercholesterolemia, much PCSK9 protein, high cholesterol, High-density lipoprotein  
•       •       •

290 clicks; posted to STEM » on 07 Jun 2021 at 8:18 AM (9 days ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



16 Comments     (+0 »)
View Voting Results: Smartest and Funniest
 
2021-06-07 3:12:37 AM  
The statin drug pusher, billionaires can't be happy with that. Those stupid drugs don't work well, and have horrible side effects.
 
2021-06-07 4:18:37 AM  
"It tastes like a monkey... A monkey that's past his prime!"
 
2021-06-07 6:16:57 AM  
So putting a monkey in the bottom drawer of a fridge lowered its cholesterol? Well, if you insist. *squeezes into refrigerator..
 
2021-06-07 8:52:22 AM  

Lambskincoat: The statin drug pusher, billionaires can't be happy with that. Those stupid drugs don't work well, and have horrible side effects.


I'm on two of the heaviest statins, have been for two years. They're working really well, and so far I've had no side effects.
I know, ymmv. Funny thing, though, I've never had anything close to high cholesterol, yet my arteries into my heart, and my carotids, are pretty blocked.  It's most likely genetic, because my mom, and all 15 of my aunts and uncles had their chests cracked at some point in their 70s.

/ Fun fact: written while waiting to go in to see my cardiologist
 
2021-06-07 8:54:29 AM  
Fark user imageView Full Size


And we all know that brains are very high in cholesterol.
 
2021-06-07 8:57:49 AM  
I feel the headline is channeling this guy:
Fark user imageView Full Size
 
2021-06-07 9:40:52 AM  
Seems like they should have just tried it on a cow first, something I actually eat.
 
2021-06-07 9:56:23 AM  
I prefer Diet Monkey.
 
2021-06-07 10:03:32 AM  
Hmmm...
What's in the CRISPR?

Fark user imageView Full Size
 
2021-06-07 10:40:28 AM  
Made from Monkey Cum
Youtube f9Xdx2E1CY8
 
2021-06-07 10:49:39 AM  
Am I the only one waiting for the "Oh shiat!" CRISPR event?

Maybe Ian Malcolm too.
 
2021-06-07 11:04:22 AM  
Reminds me of an ancient Onion article... "New, Delicious Species Discovered"

Although the creature resembles a large kitten, as a member of the Ateles genus, it is more closely related to wooly and spider monkeys. Ateles saporis, informally known as the delicacy ape, is a tree-dwelling herbivore that can measure up to a meter from head to tail. The adult delicacy ape weighs between 35 and 40 pounds and tastes wonderful with a currant glaze.
 
2021-06-07 11:05:03 AM  

Mollari: Am I the only one waiting for the "Oh shiat!" CRISPR event?

Maybe Ian Malcolm too.


*cough* We may have already had it... *cough*

Seriously, nutty conspiracy theories aside, yeah, I can't wait for our first genetic accident either.
 
2021-06-07 12:07:53 PM  
"Too much PCSK9 protein means more breakdown of receptors, which means fewer receptors standing ready on cells to do their job of removing cholesterol from the blood.

Conversely, if there's less PCSK9 floating around in the blood, more LDL receptors will bind to cells, and more cholesterol will get cleaned out of the system."



Damn that's clumsily written.  Here's my translation (words: often less is more):

"Excess PCSK9 means fewer LDL receptors, leaving more free LDL in the bloodstream to cause trouble."
 
2021-06-07 12:53:33 PM  

FormlessOne: Mollari: Am I the only one waiting for the "Oh shiat!" CRISPR event?

Maybe Ian Malcolm too.

*cough* We may have already had it... *cough*

Seriously, nutty conspiracy theories aside, yeah, I can't wait for our first genetic accident either.


I think that is and should be an on-going concern for research and treatment, but the "base editors" the article references (news to me!) sound like an awesome mitigation for a known path for unintended consequences of treatments.

The original CRISPR editing process, amazing and powerful itself, cuts DNA strands and *hopes* that the intended patch will take before something else (bad?) happens to the dangling ends.  The new base editor method will only swap a single base pair from A-T to G-C or C-G to T-A (from the link in the article) without breaking the strand.

That single-base edit may not sound like much, but many of our ugliest human genetic diseases are down to a single base pair mutation (single nucleotide polymorphism or SNP) and A instead of a G (or T instead of C).  The difference between the E3 (neutral) and E4 (Alzheimer-y) versions of of the APOE gene/protein is one base: a C at position 112 and you're like ~78% of the population.  But if you have an A at that position, you have an increased risk of atherosclerosis, Alzheimer's, impaired cognitive function, reduced hippocampal volume, HIV, [longer list of bad shiat].

TL;DR

Safely flip one bit with a base pair editor and no Alzheimers for you.
 
2021-06-07 7:32:21 PM  

Lambskincoat: The statin drug pusher, billionaires can't be happy with that. Those stupid drugs don't work well, and have horrible side effects.



God DAMN the pusher man.

Hoyt Axton - The Pusher.
Youtube 6-7WpPk00jA
 
Displayed 16 of 16 comments

View Voting Results: Smartest and Funniest

This thread is closed to new comments.

Continue Farking




On Twitter


  1. Links are submitted by members of the Fark community.

  2. When community members submit a link, they also write a custom headline for the story.

  3. Other Farkers comment on the links. This is the number of comments. Click here to read them.

  4. Click here to submit a link.