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(NYPost)   Johnson & Johnson now just Johnson   (nypost.com) divider line
    More: Spiffy, Vaccine, J&J, Vaccination, Immune system, Johnson's one-dose vaccine, coronavirus vaccine, Refrigerator, HPV vaccine  
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2861 clicks; posted to STEM » on 24 Jan 2021 at 1:50 AM (5 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



43 Comments     (+0 »)
 
View Voting Results: Smartest and Funniest
 
2021-01-23 8:32:11 PM  
That's good.  One shot is always better than two.
 
2021-01-23 8:41:35 PM  
Fark user imageView Full Size
 
2021-01-23 8:48:37 PM  
Sirrerun Johnson is right!
 
2021-01-23 8:49:13 PM  
The one shot and refrigeration differences are good, but it says it's only 90% effective and the others are 95%.  If you're in that 5% that would suck.
 
2021-01-23 8:55:21 PM  
OK. So long as it isn't in the Johnson
 
2021-01-23 9:13:02 PM  

labman: The one shot and refrigeration differences are good, but it says it's only 90% effective and the others are 95%.  If you're in that 5% that would suck.


It just stipulates the goal is greater than 90%.  This article says initial effectiveness was 97%:

https://www.verywellhealth.com/johnson​-and-johnson-covid-19-vaccine-5093160#​how-effective-is-it
 
2021-01-23 9:33:11 PM  

johnny_vegas: labman: The one shot and refrigeration differences are good, but it says it's only 90% effective and the others are 95%.  If you're in that 5% that would suck.

It just stipulates the goal is greater than 90%.  This article says initial effectiveness was 97%:

https://www.verywellhealth.com/johnson​-and-johnson-covid-19-vaccine-5093160#​how-effective-is-it


Technically it says:

Early results show that a single dose of the Johnson & Johnson vaccine could induce 97% of study participants to make antibodies that effectively neutralized the virus in the laboratory, but clinical studies to see how well the vaccine actually prevents disease are awaited. Additional information on the effectiveness of the vaccine is expected in early 2021.

So this is not a measure of the vaccine's efficacy.  In any event additional vaccines will speed reaching herd immunity and that is what is really important.
 
2021-01-23 9:56:37 PM  
We are all Johnsons on this day. And also April Fool's.
 
2021-01-23 10:44:39 PM  
I'd rather have two shots of cask strength than one shot straight from the still.
 
2021-01-23 10:48:59 PM  

dildo tontine: johnny_vegas: labman: The one shot and refrigeration differences are good, but it says it's only 90% effective and the others are 95%.  If you're in that 5% that would suck.

It just stipulates the goal is greater than 90%.  This article says initial effectiveness was 97%:

https://www.verywellhealth.com/johnson​-and-johnson-covid-19-vaccine-5093160#​how-effective-is-it

Technically it says:

Early results show that a single dose of the Johnson & Johnson vaccine could induce 97% of study participants to make antibodies that effectively neutralized the virus in the laboratory, but clinical studies to see how well the vaccine actually prevents disease are awaited. Additional information on the effectiveness of the vaccine is expected in early 2021.

So this is not a measure of the vaccine's efficacy.  In any event additional vaccines will speed reaching herd immunity and that is what is really important.


I stand corrected.  Thanks for the info.
 
2021-01-23 11:15:56 PM  
It figures. Had my first of two Pfizer shots today. No side effects whatsovadkmophgdbhwx!iflygf
 
2021-01-23 11:20:09 PM  
I'll take 2 Pfizers and one J&J thanks.
 
2021-01-24 12:03:03 AM  
Fark user imageView Full Size


/no relation
 
2021-01-24 12:25:43 AM  

BizarreMan: That's good.  One shot is always better than two.


More than one Johnson seems excessive.
 
2021-01-24 2:03:03 AM  

Dave and the Mission: [Fark user image 425x181]

/no relation


Guess we need some new Johnsons.
 
2021-01-24 2:24:23 AM  
It must be one Big Johnson, then.

/he used to be a thing...
 
2021-01-24 2:50:20 AM  

usernameguy: Dave and the Mission: [Fark user image 425x181]

/no relation

Guess we need some new Johnsons.


We're gonna need some more Johnsons, I guess.

/I really butchered that reference
 
2021-01-24 2:56:36 AM  

plecos: I'll take 2 Pfizers and one J&J thanks.


That's what I'm wondering. With new variants and mutations out there, will getting multiple vaccines that trigger different defenses to different aspects of the virus actually be beneficial?
 
2021-01-24 3:28:39 AM  

BizarreMan: That's good.  One shot is always better than two.


Not from the perspective of our immune system. Many vaccines require booster shots to generate a strong immune response. J&J are gambling that they'll get "good enough" results from a single shot. They might be able to clear the minimum threshold set by the various regulatory agencies but I'm not expecting them to be on par with the two-dose mRNA results.
 
2021-01-24 4:19:18 AM  
Okay ladies, the Johnson is ready!

/It's just a little prick.
 
2021-01-24 6:49:53 AM  
"Although they are late, some people might think, 'OK, they are using a traditional vaccine platform,'"

That's an odd way to put it when all these vaccines are being developed and released at a breakneck pace.
 
2021-01-24 7:11:11 AM  
Johnson!

Fark user imageView Full Size
 
2021-01-24 7:11:33 AM  
external-content.duckduckgo.comView Full Size
 
2021-01-24 7:18:29 AM  
From tfa:
The firm has said it plans to make the shot available on a "not-for-profit basis for emergency pandemic use,"

Nice to see a corporation having a heart. Of course the cynic in me is wondering what the catch is.
 
2021-01-24 7:27:55 AM  
Glad I grabbed some JNJ last month.
 
2021-01-24 7:31:43 AM  

Ivo Shandor: BizarreMan: That's good.  One shot is always better than two.

Not from the perspective of our immune system. Many vaccines require booster shots to generate a strong immune response. J&J are gambling that they'll get "good enough" results from a single shot. They might be able to clear the minimum threshold set by the various regulatory agencies but I'm not expecting them to be on par with the two-dose mRNA results.


It's not. I think I read that it's about 60% effective, which doesn't come close to the mRNA vaccines. However, J&J's distribution network and the relative ease of transporting their vaccine means they can likely get more people inoculated faster. Hopefully. The number of new variations are scary.
 
2021-01-24 7:47:46 AM  

Likwit: It's not. I think I read that it's about 60% effective, which doesn't come close to the mRNA vaccines. However, J&J's distribution network and the relative ease of transporting their vaccine means they can likely get more people inoculated faster. Hopefully. The number of new variations are scary.


Looks like it may be a lot better than that
 
2021-01-24 7:52:02 AM  

johnny_vegas: Likwit: It's not. I think I read that it's about 60% effective, which doesn't come close to the mRNA vaccines. However, J&J's distribution network and the relative ease of transporting their vaccine means they can likely get more people inoculated faster. Hopefully. The number of new variations are scary.

Looks like it may be a lot better than that


Woah. Great news. Hopefully that's true and it gets through. The more vaccines the merrier
 
2021-01-24 7:58:40 AM  
Fark user imageView Full Size
 
2021-01-24 8:01:52 AM  

Likwit: johnny_vegas: Likwit: It's not. I think I read that it's about 60% effective, which doesn't come close to the mRNA vaccines. However, J&J's distribution network and the relative ease of transporting their vaccine means they can likely get more people inoculated faster. Hopefully. The number of new variations are scary.

Looks like it may be a lot better than that

Woah. Great news. Hopefully that's true and it gets through. The more vaccines the merrier


You are right. Several more out there hopefully coming down the line
 
2021-01-24 8:39:10 AM  

PaulRB: BizarreMan: That's good.  One shot is always better than two.

More than one Johnson seems excessive.


Fark user imageView Full Size
 
2021-01-24 8:44:22 AM  
Fark user imageView Full Size
 
2021-01-24 12:37:47 PM  
My name is Raymond J. Johnson Jr. Now you can call me Ray, or you can call me J, or you can call me Johnny, or you can call me Sonny, or you can call me Junie, or you can call me Junior; now you can call me Ray J, or you can call me RJ, or you can call me RJJ, or you can call me RJJ Jr. . ."but you doesn't hasta call me Johnson!"
 
2021-01-24 1:27:10 PM  

johnny_vegas: Likwit: It's not. I think I read that it's about 60% effective, which doesn't come close to the mRNA vaccines. However, J&J's distribution network and the relative ease of transporting their vaccine means they can likely get more people inoculated faster. Hopefully. The number of new variations are scary.

Looks like it may be a lot better than that


Sorry I keep doing this but that is just restating what I posted above.  The Pharmacy Times should know better than to equate antibodies with efficacy.  They are not the same thing.  The phase 3 trials are what will show us that. I don't think those results have been announced yet but they are due any day now.  The reality is we will need all these vaccines to achieve herd immunity world wide.
 
2021-01-24 1:35:41 PM  
There's another key difference - J&J's shot provokes an immune response in the body by delivering a gene for the coronavirus "spike" proteins through a common-cold virus that can't make the recipient sick. That's a different method from the so-called messenger RNA found in the Moderna and Pfizer vaccines.

That's a hard pass for me. I want the new tech that alters your DNA.
 
2021-01-24 1:49:44 PM  

Resin33: There's another key difference - J&J's shot provokes an immune response in the body by delivering a gene for the coronavirus "spike" proteins through a common-cold virus that can't make the recipient sick. That's a different method from the so-called messenger RNA found in the Moderna and Pfizer vaccines.

That's a hard pass for me. I want the new tech that alters your DNA.


Help me out here because I will admit my understanding of mRNA is limited.  How exactly can mRNA change your DNA?  From what I understand only tells a cell to produce a specific protein.  That is it and it doesn't enter or change the DNA in any way.

Misinformation like this is dangerous and will prevent people from getting the vaccine possibly costing lives so seriously, help me out here or STFU.
 
2021-01-24 2:11:50 PM  

dildo tontine: Resin33: There's another key difference - J&J's shot provokes an immune response in the body by delivering a gene for the coronavirus "spike" proteins through a common-cold virus that can't make the recipient sick. That's a different method from the so-called messenger RNA found in the Moderna and Pfizer vaccines.

That's a hard pass for me. I want the new tech that alters your DNA.

Help me out here because I will admit my understanding of mRNA is limited.  How exactly can mRNA change your DNA?  From what I understand only tells a cell to produce a specific protein.  That is it and it doesn't enter or change the DNA in any way.

Misinformation like this is dangerous and will prevent people from getting the vaccine possibly costing lives so seriously, help me out here or STFU.


It's a joke on a comedy news website
 
2021-01-24 2:14:35 PM  

Likwit: dildo tontine: Resin33: There's another key difference - J&J's shot provokes an immune response in the body by delivering a gene for the coronavirus "spike" proteins through a common-cold virus that can't make the recipient sick. That's a different method from the so-called messenger RNA found in the Moderna and Pfizer vaccines.

That's a hard pass for me. I want the new tech that alters your DNA.

Help me out here because I will admit my understanding of mRNA is limited.  How exactly can mRNA change your DNA?  From what I understand only tells a cell to produce a specific protein.  That is it and it doesn't enter or change the DNA in any way.

Misinformation like this is dangerous and will prevent people from getting the vaccine possibly costing lives so seriously, help me out here or STFU.

It's a joke on a comedy news website


You mean like Fox news?
 
2021-01-24 2:17:53 PM  

dildo tontine: johnny_vegas: Likwit: It's not. I think I read that it's about 60% effective, which doesn't come close to the mRNA vaccines. However, J&J's distribution network and the relative ease of transporting their vaccine means they can likely get more people inoculated faster. Hopefully. The number of new variations are scary.

Looks like it may be a lot better than that

Sorry I keep doing this but that is just restating what I posted above.  The Pharmacy Times should know better than to equate antibodies with efficacy.  They are not the same thing.  The phase 3 trials are what will show us that. I don't think those results have been announced yet but they are due any day now.  The reality is we will need all these vaccines to achieve herd immunity world wide.


Great points all and you are right.  However I would say the 1-2a results are very encouraging and when compared to Pfizer and Moderna 1-2a results should generate optimism the efficacy will be close.

NEJM Johnson & Johnson results phases 1-2a
 
2021-01-24 2:38:03 PM  

johnny_vegas: dildo tontine: johnny_vegas: Likwit: It's not. I think I read that it's about 60% effective, which doesn't come close to the mRNA vaccines. However, J&J's distribution network and the relative ease of transporting their vaccine means they can likely get more people inoculated faster. Hopefully. The number of new variations are scary.

Looks like it may be a lot better than that

Sorry I keep doing this but that is just restating what I posted above.  The Pharmacy Times should know better than to equate antibodies with efficacy.  They are not the same thing.  The phase 3 trials are what will show us that. I don't think those results have been announced yet but they are due any day now.  The reality is we will need all these vaccines to achieve herd immunity world wide.

Great points all and you are right.  However I would say the 1-2a results are very encouraging and when compared to Pfizer and Moderna 1-2a results should generate optimism the efficacy will be close.

NEJM Johnson & Johnson results phases 1-2a


Oh, I agree!  I look forward to the results of the trials.  Even if it is only 60-70% effective at preventing Covid it may have benefit like the Moderna and Pfizer do in lessening the severity of illness.
 
2021-01-24 2:45:48 PM  

King Something: Sirrerun Johnson is right!


King Something Johnson is right about Sirrerun Johnson being right about Johnson & Johnson Johnson. Harrumph!

Also, there are some hilarious posts in this thread.
 
2021-01-24 4:08:19 PM  

Ravage: plecos: I'll take 2 Pfizers and one J&J thanks.

That's what I'm wondering. With new variants and mutations out there, will getting multiple vaccines that trigger different defenses to different aspects of the virus actually be beneficial?


Likwit: dildo tontine: Resin33: There's another key difference - J&J's shot provokes an immune response in the body by delivering a gene for the coronavirus "spike" proteins through a common-cold virus that can't make the recipient sick. That's a different method from the so-called messenger RNA found in the Moderna and Pfizer vaccines.

That's a hard pass for me. I want the new tech that alters your DNA.

Help me out here because I will admit my understanding of mRNA is limited.  How exactly can mRNA change your DNA?  From what I understand only tells a cell to produce a specific protein.  That is it and it doesn't enter or change the DNA in any way.
..
It's a joke on a comedy news website


I_told_you_so: "Although they are late, some people might think, 'OK, they are using a traditional vaccine platform,'"
That's an odd way to put it when all these vaccines are being developed and released at a breakneck pace.


The J&J vaccine isn't a traditional platform either, but it's been used at least once before.  The mRNA vaccines, which are the newest tech, got distributed first because they're the fastest to develop and manufacture at scale, and the mostly-harmless-virus-modified-to-make​-a-COVID-protein are the second fastest; the more traditional "chop up the real thing in a food processor and keep the tasty bits" vaccines are slower.

As far as whether the different kinds of vaccines might work better together, since the early ones are all focusing on the spike protein, if they've got slightly different pieces of that protein, you might get better coverage against mutations if you take both, or you might find that, having gotten the first vaccine, your body's reaction to the second one is "burn that new stuff with fire", either in a way that takes it out before it can teach your immune system anything or in a way that also makes you sick for a day or two.

Also depends on how long the first vaccine you get stays effective; if it's mostly worn out in a year, then maybe the one you get next year will be a better booster than the original.
 
2021-01-25 7:50:55 AM  
Subby, you know your mom preferred Johnson & Johnson &  Johnson.
 
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