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(Reuters)   Good news, everyone: We may finally have a leg up on 2020   (reuters.com) divider line
    More: Spiffy  
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5322 clicks; posted to Main » on 26 Oct 2020 at 8:22 PM (4 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



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2020-10-26 8:24:39 PM  
This may sound picky but if they want more people getting vaccines they could start by not calling it a jab.
 
2020-10-26 8:26:36 PM  
Fark user imageView Full Size

But will it mix well with the bleach?!!!
 
2020-10-26 8:28:29 PM  
But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.
 
2020-10-26 8:29:05 PM  
I'm already way ahead of the rest of you. I've been chugging bleach, shining UV lights up my ass, freebasing hydroxychloroquine, and chasing it with colloidal silver. I'm so immune to COVID-19 at this point that I could kayak all the way to China, show up in Wuhan and start licking doorknobs.
 
2020-10-26 8:36:02 PM  

wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.


Democrats when elected will fix everything. You can already see the effects of their landslide victory.
 
2020-10-26 8:38:48 PM  

wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.


True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.
 
2020-10-26 8:39:09 PM  

wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.


Get back to me when there's a vaccine that is effective enough to stop superspeading events and offers protection for long enough that it's logistically possible to keep most of the population immunized permanently with booster shots.

Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.
 
2020-10-26 8:43:25 PM  

wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.


Why I saw was mostly people rightfully pointing out that banking on an effective vaccine being ready in an historically short time would be foolish. Hope for the best and prepare for the worst of you will. Relatively few stated authoritatively that it was impossible, but only that such a feat had not been accomplished before.

That having been said, this is a great sign and an amazing demonstration of what science is capable of when funding and priority is given. However, enormous hurdles remain in the form of production and distribution at the very least.
I'll need to recheck the article to see if this vaccine candidate has adequately cleared safety trials as well.
 
2020-10-26 8:43:27 PM  

No Catchy Nickname: True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.


And the anti-maskers/qanon/covid is a hoax dotards, aka 20-30% of the population, will never take it.
 
2020-10-26 8:46:31 PM  
I am currently in a Phase II study of a potential vaccine. So that your expectations are realistic, I will be monitored through at least May of 2021

I would be more concerned about a study (thinking of Sputnik V) that fails to take a long-term view of efficacy and side effects.

\ It's a double blind study
\\ No one directly connected to me knows if I got a vaccine or a placebo
\\\ Only side effect so far: SLASHIES!!
 
2020-10-26 8:47:04 PM  

WalkingSedgwick: Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.


Uh...it would reduce that to 10 people in hours, right?

You know that making the disease 1/10 as transmissable would have a huge impact, and wouldn't be "useless"

Or maybe you're just stupid, and know absolutely jack shiat about vaccines.
 
2020-10-26 8:49:38 PM  
2020 has had its leg up on us like a dog has its leg up on a tree.
 
2020-10-26 8:59:33 PM  

wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.


Those are not experts, and yes. ...They do keep showing up. I do not know why.

Has there ever been anyone on Fark who loudly went around taking both sides of every issue and then went around trumpeting "I told you so!"?

I am not an expert, and I have no special information, but from what Fauci is saying and what international people seem to be saying, the vaccines are already here, as far as that goes. THey are being mass produced and tested at the same time. If and when they have been shown to be reasonably safe, they will be distributed and the world will move on in some fashion.

That could be weeks or a few months away. Probably not a year. Certainly not two.
 
2020-10-26 9:01:58 PM  

lolmao500: No Catchy Nickname: True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

And the anti-maskers/qanon/covid is a hoax dotards, aka 20-30% of the population, will never take it.


That probably goes up when including common, everyday pedestrian type anti-vaxxers.
 
2020-10-26 9:05:23 PM  

No Catchy Nickname: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.


Governments worldwide have been funding the manufacturing of promising candidates already, so that if one or more turn out to be viable, they will be ahead of the curve on that.  I'm not sure which ones have received that treatment, and in which countries, so there's no guarantee that this will have helped.

The distribution problem is much more important.  Even if ample doses are available on day 1, there's still a logistical limit on how many people can actually get poked per day.  Then there's the issue of the vaccines that require two doses weeks apart, effectively doubling the problem.  My own estimation is that it will be at least a year, maybe two, from the day of approval to ensure that every last person will have the opportunity to be vaccinated.
 
2020-10-26 9:09:18 PM  

Christian Bale: WalkingSedgwick: Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.

Uh...it would reduce that to 10 people in hours, right?

You know that making the disease 1/10 as transmissable would have a huge impact, and wouldn't be "useless"

Or maybe you're just stupid, and know absolutely jack shiat about vaccines.


Yours is a really good point. I see, have seen from the beginning, many parallels to efforts against climate change. I think you know the drill. "deny it exists, deny blame, deny it affects us, deny it is a problem, deny a solution, deny a cost/beneficial solution..."  It is interesting that we are at about the same stage in addressing both problems. We probably have the means to solve both, but there will be plenty of people now saying that it is useless and we should not even try.

For both problems, the evidence shows that all kinds of measures can help. Many countries have used their own strategies, to greater or lesser effect. Some societies have glaring impediments, although others are moving along etc. Battery vehicles are not going to fix the problem any more than social distancing will, but both are effective measures. Combine them with rooftop solar, wearing a mask, and vaccines and wind power, and we can move much farther down to road to limiting COVID19 spread and carbon emissions.

Or something like that. I have no idea why people are unable to understand incremental benefits or long term solutions to problems.
 
2020-10-26 9:13:42 PM  

wxboy: No Catchy Nickname: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

Governments worldwide have been funding the manufacturing of promising candidates already, so that if one or more turn out to be viable, they will be ahead of the curve on that.  I'm not sure which ones have received that treatment, and in which countries, so there's no guarantee that this will have helped.

The distribution problem is much more important.  Even if ample doses are available on day 1, there's still a logistical limit on how many people can actually get poked per day.  Then there's the issue of the vaccines that require two doses weeks apart, effectively doubling the problem.  My own estimation is that it will be at least a year, maybe two, from the day of approval to ensure that every last person will have the opportunity to be vaccinated.



True, and let's not forget this particular vaccine may not be rolled out this year (FTFA)*

British Health Secretary Matt Hancock said a vaccine was not yet ready but he was preparing logistics for a possible roll out mostly in the first half of 2021.
Asked if some people could receive a vaccine this year he told the BBC: "I don't rule that out but that is not my central expectation."
"The programme is progressing well, (but) we're not there yet," Hancock said.


Now, not being a Fark expert or any sort of expert, I have no idea what happens to the production/distribution timeline should multiple successful vaccines be rolled out, beyond that worldwide distribution ought to speed up.
 
2020-10-26 9:18:42 PM  
We can only get the Oxford vaccine if Trump loses.
 
2020-10-26 9:20:04 PM  

Christian Bale: WalkingSedgwick: Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.

Uh...it would reduce that to 10 people in hours, right?

You know that making the disease 1/10 as transmissable would have a huge impact, and wouldn't be "useless"

Or maybe you're just stupid, and know absolutely jack shiat about vaccines.


OK, I see that's covered. Thank you...


This does sound like good news, and is possibly more than we dared hope for. I look forward to hearing more about it.
 
2020-10-26 9:23:44 PM  

Russ1642: This may sound picky but if they want more people getting vaccines they could start by not calling it a jab.


Don't get yer pants shoved up yer fanny, it's just a British term!
 
2020-10-26 9:30:25 PM  

Christian Bale: WalkingSedgwick: Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.

Uh...it would reduce that to 10 people in hours, right?

You know that making the disease 1/10 as transmissable would have a huge impact, and wouldn't be "useless"


On average, a 100 infection superspeading event can, depending on demographics, kill 1 to 40 people. A 90% effective vaccine would reduce that death toll to 0.1 to 4 people. This is nowhere near good enough to make mass gatherings safe for anyone who has more of a self-preservation instinct than a Trump humper.

Even with a 90% effective vaccine, large crowd bans, social distancing, and indoor masking will need to continue permanently. For all intents and purposes, this means a even 90% effective vaccine is utterly useless for returning to what used to be normal.
 
2020-10-26 9:30:58 PM  
For those who actually want to live; a vaccine will provide a good defense against plague spreaders. It will also do a lot to slow the spread of the virus. We'll have to continue to wear masks and social distance to to an extent, but it will open up options for those of us at risk that don't want to die.
 
2020-10-26 9:35:38 PM  
I'm smoking way more than I used to. I saw on the internet that nicotine prevents COVID19, so I'm bolstering my immune system. What could go wrong?
/cancer
 
2020-10-26 9:36:42 PM  

lolmao500: No Catchy Nickname: True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

And the anti-maskers/qanon/covid is a hoax dotards, aka 20-30% of the population, will never take it.


I will only take it if Dr. Fauci says it's safe
 
2020-10-26 9:39:49 PM  

No Catchy Nickname: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

developed by the University of Oxford


I'm cautiously optimistic, and rather relieved that it was developed outside of the US.
2020. When you trusted other countries more than your own government in the US.
 
2020-10-26 9:41:50 PM  

i.voted.for.Drew: I am currently in a Phase II study of a potential vaccine. So that your expectations are realistic, I will be monitored through at least May of 2021

I would be more concerned about a study (thinking of Sputnik V) that fails to take a long-term view of efficacy and side effects.

\ It's a double blind study
\\ No one directly connected to me knows if I got a vaccine or a placebo
\\\ Only side effect so far: SLASHIES!!


Thanks for stepping up, many of us really appreciate it.
 
2020-10-26 9:52:59 PM  

WalkingSedgwick: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

Get back to me when there's a vaccine that is effective enough to stop superspeading events and offers protection for long enough that it's logistically possible to keep most of the population immunized permanently with booster shots.

Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.


That's called soap.
Not alcohol sanitizer, not masks.  Soap.
Superspreader events are caused by someone infected not washing their hands and then smearing their crap-covered mitts all over the glassware in a bar, or the fridge handle in the breakroom, or similar.
 
2020-10-26 9:57:31 PM  

Elkad: WalkingSedgwick: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

Get back to me when there's a vaccine that is effective enough to stop superspeading events and offers protection for long enough that it's logistically possible to keep most of the population immunized permanently with booster shots.

Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.

That's called soap.
Not alcohol sanitizer, not masks.  Soap.
Superspreader events are caused by someone infected not washing their hands and then smearing their crap-covered mitts all over the glassware in a bar, or the fridge handle in the breakroom, or similar.


Is that what happened in the Rose Garden?
 
2020-10-26 10:03:09 PM  

wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.


FTFA: British Health Secretary Matt Hancock said a vaccine was not yet ready but he was preparing logistics for a possible roll out mostly in the first half of 2021.

So we get "mostly" rolled out by June 2021.

This isn't something happening tomorrow, or even before the end of the year, even if their trials perform spectacularly. That's not how this works, even when fast tracked.

This isn't a Hollywood movie, where the military and Dr. Demonsemen take samples of Trump's blood and roll out a cure to the masses as they line up for the ballot boxes.

I don't recall anybody saying it was impossible, only that the hype behind some of the vaccines being used in China and Russia were exactly that - Ad5-based vaccines that have never delivered on their promises, and that even if we get a vaccine within the year, it will likely require boosters. That outlook still hasn't changed.

Also at this point, the logistics are still a nightmare. We have no legitimate national effort to secure the supply chain and manufacturing that will be needed to deliver 300 million doses in a reasonable time frame (not even considering the potential need for a booster and whatever time frame that requires)... instead we have an administration willing to fight over IP rights and exclusivity - trying to secure the highest prices and sweetest deals for the pharmaceutical companies, rather than operating in the nation's (hell, the entire world's) best interest.

I see others have also brought up the specter or anti-vaxxers, a whole other can of worms. Let's also mention testing is still critical, and probably just as fraught with issues, logistically, as the vaccine itself. We need better tests, and some are on the horizon, but the effort for that should have been in full gear back in February.

It's not all doom and gloom, just being realistic. Hope for the best, but plan for the worst.

....but hey, you got to show yer brain power over those Debbie Downers, amiright?
 
2020-10-26 10:04:32 PM  

Elkad: WalkingSedgwick: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

Get back to me when there's a vaccine that is effective enough to stop superspeading events and offers protection for long enough that it's logistically possible to keep most of the population immunized permanently with booster shots.

Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.

That's called soap.
Not alcohol sanitizer, not masks.  Soap.
Superspreader events are caused by someone infected not washing their hands and then smearing their crap-covered mitts all over the glassware in a bar, or the fridge handle in the breakroom, or similar.


You seem confused. We're talking about SARS-CoV-2 here, not norovirus.  SARS-CoV-2 spreads overwhelmingly through respiratory droplets rather than by surface contact.
 
2020-10-26 10:05:03 PM  

i.voted.for.Drew: I am currently in a Phase II study of a potential vaccine. So that your expectations are realistic, I will be monitored through at least May of 2021

I would be more concerned about a study (thinking of Sputnik V) that fails to take a long-term view of efficacy and side effects.

\ It's a double blind study
\\ No one directly connected to me knows if I got a vaccine or a placebo
\\\ Only side effect so far: SLASHIES!!


Thank you.
 
2020-10-26 10:13:35 PM  
The first trial vaccine for HIV was in 1987. That was 33 years ago.

According to HIV.gov:
There is currently no vaccine available that will prevent HIV infection or treat those who have it. However, scientists are working to develop one.

I'm not saying Covid-19 is the same as HIV; but I am saying let's not get ahead of ourselves...
 
2020-10-26 10:21:59 PM  

whisper in the wind: lolmao500: No Catchy Nickname: True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

And the anti-maskers/qanon/covid is a hoax dotards, aka 20-30% of the population, will never take it.

I will only take it if Dr. Fauci says it's safe


I'm not sure if your are trolling or not; but he repeatedly told everyone that there was no reason to wear masks and warned that doing so could even be worse.
 
2020-10-26 10:29:36 PM  

Fark_Guy_Rob: whisper in the wind: lolmao500: No Catchy Nickname: True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

And the anti-maskers/qanon/covid is a hoax dotards, aka 20-30% of the population, will never take it.

I will only take it if Dr. Fauci says it's safe

I'm not sure if your are trolling or not; but he repeatedly told everyone that there was no reason to wear masks and warned that doing so could even be worse.


Get back under your bridge.

https://www.cnn.com/2020/10/23/health​/​fauci-covid-mask-mandate-bn/index.html​
 
2020-10-26 10:32:45 PM  
Yes, but this is a product of Socialist Medicine, so no TRUE American will submit to it.
 
2020-10-26 10:40:20 PM  
Admittedly my alma mater has produced a few duds such as Boris Johnson and myself, but I was hoping we would hear about some success soon from our medicos.  Now to start working some old connections...
 
2020-10-26 10:40:24 PM  

Fark_Guy_Rob: whisper in the wind: lolmao500: No Catchy Nickname: True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

And the anti-maskers/qanon/covid is a hoax dotards, aka 20-30% of the population, will never take it.

I will only take it if Dr. Fauci says it's safe

I'm not sure if your are trolling or not; but he repeatedly told everyone that there was no reason to wear masks and warned that doing so could even be worse.


First of all, the only thing he said its that people dont go buy masks like they bought toilet paper at the start of the pandemic so health care workers would have masks to work with.

Second of all he never said that wearing masks would be worse.

Third of all : fark off, Fauci is pro science unlike you and your ilk.
 
2020-10-26 10:52:29 PM  
Everyone needs to understand it's not only masks.....It's a combination of masks, distance, and time. I just had someone I know catch covid at a funeral and she told me multiple times everyone was wearing masks. I asked if she kept her distance from everyone and she said no. I told her it's like a math problem. She told me she was assured there would be no maths......
 
2020-10-26 11:00:28 PM  

Russ1642: This may sound picky but if they want more people getting vaccines they could start by not calling it a jab.


As long as the Oxford jab doesn't lead to an Oxford coma...
 
2020-10-26 11:07:09 PM  

WalkingSedgwick: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

Get back to me when there's a vaccine that is effective enough to stop superspeading events and offers protection for long enough that it's logistically possible to keep most of the population immunized permanently with booster shots.

Even a 90% effective vaccine is useless against a virus so transmissible that one superpreader can infect 100 people in hours.


Just wait. Someone on Fox News will start the rumor that the vaccine actually gives you Covid, and 30% of the population will actively avoid it.
 
2020-10-26 11:55:29 PM  

Fark_Guy_Rob: whisper in the wind: lolmao500: No Catchy Nickname: True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

And the anti-maskers/qanon/covid is a hoax dotards, aka 20-30% of the population, will never take it.

I will only take it if Dr. Fauci says it's safe

I'm not sure if your are trolling or not; but he repeatedly told everyone that there was no reason to wear masks and warned that doing so could even be worse.


Don't be silly.

https://www.boredpanda.com/cough-snee​z​e-covid-19-mask-anthony-fauci-slow-mot​ion/?cexp_id=33694&cexp_var=9&_f=featu​red&utm_source=fark&utm_medium=website​&utm_content=link&ICID=ref_fark
 
2020-10-27 12:39:05 AM  
Save this for when things go to shiat again:

Good news, everyone: We may finally have a leg up on 2020

You just had to friggin say it.
 
2020-10-27 12:42:50 AM  

No Catchy Nickname: wxboy: No Catchy Nickname: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

True, but even if this vaccine is successful, the evidence seems to suggest it will take a couple of years at the very least to manufacture and distribute to everyone.

Governments worldwide have been funding the manufacturing of promising candidates already, so that if one or more turn out to be viable, they will be ahead of the curve on that.  I'm not sure which ones have received that treatment, and in which countries, so there's no guarantee that this will have helped.

The distribution problem is much more important.  Even if ample doses are available on day 1, there's still a logistical limit on how many people can actually get poked per day.  Then there's the issue of the vaccines that require two doses weeks apart, effectively doubling the problem.  My own estimation is that it will be at least a year, maybe two, from the day of approval to ensure that every last person will have the opportunity to be vaccinated.


True, and let's not forget this particular vaccine may not be rolled out this year (FTFA)*

British Health Secretary Matt Hancock said a vaccine was not yet ready but he was preparing logistics for a possible roll out mostly in the first half of 2021.
Asked if some people could receive a vaccine this year he told the BBC: "I don't rule that out but that is not my central expectation."
"The programme is progressing well, (but) we're not there yet," Hancock said.

Now, not being a Fark expert or any sort of expert, I have no idea what happens to the production/distribution timeline should multiple successful vaccines be rolled out, beyond that worldwide distribution ought to speed up.


Matt Handjob has been next to useless throughout the pandemic so I would take anything he says with a large dose of skepticism.
 
2020-10-27 12:46:26 AM  

The Third Man: Admittedly my alma mater has produced a few duds such as Boris Johnson and myself, but I was hoping we would hear about some success soon from our medicos.  Now to start working some old connections...


Also alumnus, and fark Boris. But well done to the vaccine boffins.
 
2020-10-27 1:29:32 AM  

Russ1642: This may sound picky but if they want more people getting vaccines they could start by not calling it a jab.


Yeah. It should be a poke.
 
2020-10-27 1:31:55 AM  

Amelia Earhart's Black Box: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

Democrats when elected will fix everything. You can already see the effects of their landslide victory.


Every single positive thing this year is the direct result of a Democrat trying their best to do good.

Every negative thing this year is the direct result of the inability for a Republican to lead.

Not that I have opinions or anything
 
2020-10-27 1:34:03 AM  
This is what having a leg up on 2020 looks like...
Fark user imageView Full Size
 
2020-10-27 2:06:08 AM  

wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.


the wait isnt for a vaccine.  the wait is for a vaccine that wont give you something worse.

you should really read ALL the fine print on the TV screen before talking to your doctor about Wrecksital.  You would want to risk anal leakage or bleeding from your prostate.
 
2020-10-27 2:14:45 AM  

Amelia Earhart's Black Box: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

Democrats when elected will fix everything. You can already see the effects of their landslide victory.


if the US were a medical patient, right now it would be in the ICU suffering from multiple organ failure from a combination of Coronavirus, injecting bleach, and overdosing on hydroxychloroquine.

If the Democats sweep the election then the patient has a chance to stabilize.  That's still only a chance, and that's not healed.  It's going to take a lot of "surgery" and "rehabilitation" before the country will be mobile again.  And even then, it'll never be able to perform as it once did.

Think Steven Strange after the car accident but without the magical healing...and that's the best case scenario.
 
2020-10-27 2:16:17 AM  

FunkJunkie: wxboy: But I have been repeatedly assured by the experts here on Fark that a vaccine is impossible, or at least many years away.

Why I saw was mostly people rightfully pointing out that banking on an effective vaccine being ready in an historically short time would be foolish. Hope for the best and prepare for the worst of you will. Relatively few stated authoritatively that it was impossible, but only that such a feat had not been accomplished before.

That having been said, this is a great sign and an amazing demonstration of what science is capable of when funding and priority is given. However, enormous hurdles remain in the form of production and distribution at the very least.
I'll need to recheck the article to see if this vaccine candidate has adequately cleared safety trials as well.


and long term side effects.

watch out for the anal leakage
 
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