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(NPR)   Article on "special sauce" that makes some vaccines work. No, it's not THAT kind of shot   (npr.org) divider line
    More: Interesting, Immune system, immune system, adjuvant research, lot of adjuvants, strange thing, immune response, first immune cell, new adjuvants  
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666 clicks; posted to Fandom » on 11 Aug 2020 at 8:55 AM (10 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



13 Comments     (+0 »)
 
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2020-08-11 7:38:53 AM  
Just remember folks: working on a vaccine, articles about people working on a vaccine, and articles about people working on a vaccine using different approaches does not equal a vaccine.
 
2020-08-11 8:36:03 AM  
Thousand Island dressing?
 
2020-08-11 8:39:34 AM  
G. Love & Special Sauce - Cold Beverage
Youtube pk9-28HgxfE
 
2020-08-11 8:59:46 AM  
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2020-08-11 9:04:36 AM  
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2020-08-11 9:06:54 AM  
i.pinimg.comView Full Size
 
2020-08-11 9:22:09 AM  
Special sauce?
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2020-08-11 9:48:56 AM  

The_Sponge: Thousand Island dressing?


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2020-08-11 9:56:58 AM  

The_Sponge: Thousand Island dressing?


Ketchup and mayonnaise
 
2020-08-11 10:18:34 AM  
Hot          Bleach         Injection
 
2020-08-11 10:19:41 AM  
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2020-08-11 12:06:07 PM  
Fun Fact: Adjuvants were discovered by accident.

When vaccines were first being developed there was varying immune responses between batches. Scientists traced it back to contamination during manufacturing and thought that dirty equipment made the vaccines less effective, so they thoroughly sterilized and cleaned the equipment. They were wrong: it was contamination in some batches that was stimulating the immune systems to get a better result from some batches.
 
2020-08-11 10:35:30 PM  

mrmopar5287: Fun Fact: Adjuvants were discovered by accident.

When vaccines were first being developed there was varying immune responses between batches. Scientists traced it back to contamination during manufacturing and thought that dirty equipment made the vaccines less effective, so they thoroughly sterilized and cleaned the equipment. They were wrong: it was contamination in some batches that was stimulating the immune systems to get a better result from some batches.


This is also a problem in vaccine manufacturing today.

Usually, when making a drug you want the process to give you as pure a drug as possible.
But paradoxically for vaccines, the impurities can have an adjuvant effect (or in other cases the impurities were more antigenic than the intended vaccine), enhancing the immune response.

So there have been a few vaccines that worked really well in early clinical studies but failed in later ones because as the manufacturing got better, the vaccine got worse...

Which all goes back to why the clinical studies are so important.
 
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