Skip to content
 
If you can read this, either the style sheet didn't load or you have an older browser that doesn't support style sheets. Try clearing your browser cache and refreshing the page.

(Yahoo)   Moderna throws down with U.S. scientists over COVID-19 vaccine trials, asks where are the contenders in such an 'advanced' country   (news.yahoo.com) divider line
    More: Interesting, Clinical trial, Moderna Inc, Moderna's vaccine project, coronavirus vaccine, Federal government of the United States, large-scale human trials, trial of the Moderna, government scientists  
•       •       •

3736 clicks; posted to Main » on 07 Jul 2020 at 6:35 PM (4 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



33 Comments     (+0 »)
 
View Voting Results: Smartest and Funniest
 
2020-07-07 6:00:59 PM  
Fark user imageView Full Size
 
2020-07-07 6:17:26 PM  
The federal government is supporting Moderna's vaccine project with nearly half a billion dollars and has chosen it as one of the first to enter large-scale human trials.

But the company - which has never produced an approved vaccine or run a large trial...


You know, I was just thinking earlier today that this pandemic needs more giant cash infusions to companies who have no experience or track records of doing what they're being paid to do.
 
2020-07-07 6:42:31 PM  

Ambivalence: The federal government is supporting Moderna's vaccine project with nearly half a billion dollars and has chosen it as one of the first to enter large-scale human trials.

But the company - which has never produced an approved vaccine or run a large trial...

You know, I was just thinking earlier today that this pandemic needs more giant cash infusions to companies who have no experience or track records of doing what they're being paid to do.


I (actually, truly) misread as "Madonna throws down..." on my first pass. She also has no experience developing a vaccine, but she did put out that Sex book a while back. So that's something.

/Holy shiat, it was in 1992? Geez I'm old
 
2020-07-07 6:45:35 PM  
Having participated in multiple clinical trial launches, I can definitely say that execution of the trial itself is the hardest part. And this is coming from a scientist. The R&D is challenging, but at least most of the work is within the company. There's an element of control. When you launch the trial, there are suddenly dozens or hundreds of people outside the company to manage. Every weak link threatens progress. An inexperienced company will be learning on the fly and that rarely goes well the first time.
 
2020-07-07 6:47:21 PM  
Moderna is the Trump of medicine manufacturing.
 
2020-07-07 6:47:51 PM  

UninformedButEnthusiastic: Having participated in multiple clinical trial launches, I can definitely say that execution of the trial itself is the hardest part. And this is coming from a scientist. The R&D is challenging, but at least most of the work is within the company. There's an element of control. When you launch the trial, there are suddenly dozens or hundreds of people outside the company to manage. Every weak link threatens progress. An inexperienced company will be learning on the fly and that rarely goes well the first time.


Very much this.

"Four players hit a grand slam in their first Major League at-bat: Bill Duggleby (1898), Jeremy Hermida (2005), Kevin Kouzmanoff (2006), and Daniel Nava (2010)."
 
2020-07-07 6:49:29 PM  
But she just posted a topless pic while leaning on a crutch.  Can she be THAT bad?
 
2020-07-07 6:51:38 PM  

UninformedButEnthusiastic: Having participated in multiple clinical trial launches, I can definitely say that execution of the trial itself is the hardest part. And this is coming from a scientist. The R&D is challenging, but at least most of the work is within the company. There's an element of control. When you launch the trial, there are suddenly dozens or hundreds of people outside the company to manage. Every weak link threatens progress. An inexperienced company will be learning on the fly and that rarely goes well the first time.


Your handle is basically how Moderna is approaching this
 
2020-07-07 6:53:23 PM  

LeoffDaGrate: But she just posted a topless pic while leaning on a crutch.  Can she be THAT bad?


I literally had to go back to the article in case I'd missed topless Elizabeth Holmes.

//hell yes I would
//would not let her near my precious bodily fluids though
//third slashy has signed an NDA
 
2020-07-07 6:54:48 PM  

Albert911emt: Moderna is the Trump of medicine manufacturing.


Behind every Pharma R&D project is a Trump  clone telling you to launch months to years too soon.  Every project champion at the executive level needs to be tactfully dressed down behind closed doors at the risk of your career in favor of risking patient lives.  Every last f*cking one of them.
 
2020-07-07 6:56:00 PM  

Lochsteppe: /Holy shiat, it was in 1992? Geez I'm old


Fark user imageView Full Size
 
2020-07-07 6:56:06 PM  

Lochsteppe: Ambivalence: The federal government is supporting Moderna's vaccine project with nearly half a billion dollars and has chosen it as one of the first to enter large-scale human trials.

But the company - which has never produced an approved vaccine or run a large trial...

You know, I was just thinking earlier today that this pandemic needs more giant cash infusions to companies who have no experience or track records of doing what they're being paid to do.

I (actually, truly) misread as "Madonna throws down..." on my first pass. She also has no experience developing a vaccine, but she did put out that Sex book a while back. So that's something.

/Holy shiat, it was in 1992? Geez I'm old


Madonna herself was born closer to the Spanish-American War than to the present day. She also just put a topless pic of herself on the 'gram, if you're interested.

/we're all getting old
 
2020-07-07 6:57:14 PM  

Albert911emt: Moderna is the Trump of medicine manufacturing.


A Moderna board member resigned to be the chief scientist in Trump's "Operation Warp Speed".

Moderna's medicine development is based on exclusively introducing synthetic messenger RNA into people's cells.

The fact that we're farking with peoples' genes here and the fact that the development program seems to be less-than-ethically tilted towards Moderna is a very good reason why scientists should take a long hard look at any vaccine they're developing.
 
2020-07-07 7:01:26 PM  
Wasn't there a thread earlier about Moderna showing her tits or something? I'm too lazy to look.
 
2020-07-07 7:01:58 PM  
Every thing this administration touches turns to shiat ..
 
2020-07-07 7:06:13 PM  

Ambivalence: The federal government is supporting Moderna's vaccine project with nearly half a billion dollars and has chosen it as one of the first to enter large-scale human trials.

But the company - which has never produced an approved vaccine or run a large trial...

You know, I was just thinking earlier today that this pandemic needs more giant cash infusions to companies who have no experience or track records of doing what they're being paid to do.


It's the Trump Method(tm)!
How much would you pay now?
Wait! There's more! (Bullshiat)

Now with extra relief aid to mega churches and televangelists!
 
2020-07-07 7:11:52 PM  
Sounds like they're having study design issues. It's not unusual for regulators to ask for things the sponsor doesn't want to do. They ask because someone realized there's a gap in the data, who is going to generate the data to fill that gap? You are, applicant.

"Oh, you want marketing authorization for your green pill, but this time it's yellow? We really need a QT study."

In this case though, I have a hard time believing anyone is asking for the moon. Everyone wants to get this done quickly.
 
2020-07-07 7:12:21 PM  
The new luxury suvs are for moving sensitive equipment and the Lamborghini Veneno is for emergencies!
 
2020-07-07 7:16:57 PM  
the company - which has never produced an approved vaccine or run a large trial


So how much stock does the Trump family own?
 
2020-07-07 7:18:53 PM  

Ambivalence: The federal government is supporting Moderna's vaccine project with nearly half a billion dollars and has chosen it as one of the first to enter large-scale human trials.

But the company - which has never produced an approved vaccine or run a large trial...

You know, I was just thinking earlier today that this pandemic needs more giant cash infusions to companies who have no experience or track records of doing what they're being paid to do.


Do they live in Whitefish?  Because all the best companies come from Whitefish, Montana.
 
2020-07-07 7:29:42 PM  

1derful: Albert911emt: Moderna is the Trump of medicine manufacturing.

A Moderna board member resigned to be the chief scientist in Trump's "Operation Warp Speed".

Moderna's medicine development is based on exclusively introducing synthetic messenger RNA into people's cells.

The fact that we're farking with peoples' genes here and the fact that the development program seems to be less-than-ethically tilted towards Moderna is a very good reason why scientists should take a long hard look at any vaccine they're developing.


Messenger RNA tells the cell to produce a particular protein. It doesn't mess with any host genes unless you also throw in a reverse-transcriptase enzyme (which does not apply to these vaccines).
 
2020-07-07 7:35:42 PM  
OMG. Biotech graveyards are filled with companies where inexperienced "experts" insisted on fighting against the FDA.

Only this time it could me more than "corporate" persons in graveyards because people with zero real experience refused to listen.
 
2020-07-07 7:38:15 PM  

1derful: Albert911emt: Moderna is the Trump of medicine manufacturing.

A Moderna board member resigned to be the chief scientist in Trump's "Operation Warp Speed".

Moderna's medicine development is based on exclusively introducing synthetic messenger RNA into people's cells.

The fact that we're farking with peoples' genes here and the fact that the development program seems to be less-than-ethically tilted towards Moderna is a very good reason why scientists should take a long hard look at any vaccine they're developing.


You don't understand what you're talking about and should stop regarding the vaccine design.
 
2020-07-07 7:45:25 PM  

UninformedButEnthusiastic: Having participated in multiple clinical trial launches, I can definitely say that execution of the trial itself is the hardest part. And this is coming from a scientist. The R&D is challenging, but at least most of the work is within the company. There's an element of control. When you launch the trial, there are suddenly dozens or hundreds of people outside the company to manage. Every weak link threatens progress. An inexperienced company will be learning on the fly and that rarely goes well the first time.


Figure out how much effort it should take to run the trial and how much it should cost. If you've got experienced people, multiple those numbers by 5. If you're new to it, multiple by 10.

Then, when you think you're just about ready, hire some outside experts to come in and tell you about all the mistakes you're making --- and listen to them. Not accept everything you tell them, listen to them. Don't be stubborn.

Realize that the FDA is your partner. They would love you to succeed but they are going to make your product actually succeed, not pass you because it would feel nice. And they'll fail things to give you a chance to fix it if it's fixable.

The FDA will ultimately be the people who review  the data and decide if it's good enough. Listen to them because they'll be telling you about what they will be looking at. If you ignore them and don't generate the data they are asking for, when you're done, they ask you to go back and get that data. Trying to tell them there's another way, or that they don't need it won't work. So listen. If you really have better ideas, they might listen but don't be stubborn --- or you will lose.
 
2020-07-07 7:54:59 PM  
I knew Moderna vaccine development program was a swindle.  I didn't know they were being paid half a million dollars to swindle the American public into believing help was on the horizon.  Remember when that guy shot himself up with that experimental AIDS Vaccine and the guy that convinced him to do it was dead a few weeks later in a sensory deprivation tank?  That's the type of vaccine we're talking about here.  It's kinda beyond the pale that the government just handed these guys $500,000,000 because some woman on Twitter told Trump they could have a vaccine ready by November.
 
2020-07-07 8:18:14 PM  

edmo: [Fark user image image 292x213]


Came for this...leaving happy.
 
2020-07-07 8:29:17 PM  

wademh: UninformedButEnthusiastic: Having participated in multiple clinical trial launches, I can definitely say that execution of the trial itself is the hardest part. And this is coming from a scientist. The R&D is challenging, but at least most of the work is within the company. There's an element of control. When you launch the trial, there are suddenly dozens or hundreds of people outside the company to manage. Every weak link threatens progress. An inexperienced company will be learning on the fly and that rarely goes well the first time.

Figure out how much effort it should take to run the trial and how much it should cost. If you've got experienced people, multiple those numbers by 5. If you're new to it, multiple by 10.

Then, when you think you're just about ready, hire some outside experts to come in and tell you about all the mistakes you're making --- and listen to them. Not accept everything you tell them, listen to them. Don't be stubborn.

Realize that the FDA is your partner. They would love you to succeed but they are going to make your product actually succeed, not pass you because it would feel nice. And they'll fail things to give you a chance to fix it if it's fixable.

The FDA will ultimately be the people who review  the data and decide if it's good enough. Listen to them because they'll be telling you about what they will be looking at. If you ignore them and don't generate the data they are asking for, when you're done, they ask you to go back and get that data. Trying to tell them there's another way, or that they don't need it won't work. So listen. If you really have better ideas, they might listen but don't be stubborn --- or you will lose.


You nailed it. The agency gets a bad rap, but they are generally fair and reasonable. The patients are human beings on the other end of a clinical trial. They need an advocate. The FDA looks out for patients, and, in my experience, they are willing to take acceptable risks in dire situations such as terminal cancer (or a raging pandemic).

Do good work and your INDs will clear. Do shoddy work and cut corners, and you'll be wishing that you did things the right way.
 
2020-07-07 8:30:49 PM  
So they are arguing with government scientists over monitoring patient health for a vaccine being rushed to market in 1/10th the time of normal vaccines? Yeah, I'll wait for the Astra Zeneca vaccine.
 
2020-07-07 8:37:39 PM  
See also: thalidomide.
 
2020-07-07 8:40:11 PM  

sleze: So they are arguing with government scientists over monitoring patient health for a vaccine being rushed to market in 1/10th the time of normal vaccines? Yeah, I'll wait for the Astra Zeneca vaccine.


The more conventional adenovirus and inactivated vaccines that are already in trials are likely to complete testing before Moderna's and the other RNA vaccines anyway, so it's a bit of a false dilemma at this point.
 
2020-07-07 8:41:51 PM  
People are dying, but whatever.
 
2020-07-07 11:43:57 PM  

1derful: Albert911emt: Moderna is the Trump of medicine manufacturing.

A Moderna board member resigned to be the chief scientist in Trump's "Operation Warp Speed".

Moderna's medicine development is based on exclusively introducing synthetic messenger RNA into people's cells.

The fact that we're farking with peoples' genes here and the fact that the development program seems to be less-than-ethically tilted towards Moderna is a very good reason why scientists should take a long hard look at any vaccine they're developing.


what's the worst that can happen?

(I am Legend - the Will Smith version)
 
2020-07-07 11:54:08 PM  
Just waiting for the FDA is a deep state conspiracy story to ooze out of the bowels of foX neWs.
 
Displayed 33 of 33 comments

View Voting Results: Smartest and Funniest

This thread is closed to new comments.

Continue Farking




On Twitter



  1. Links are submitted by members of the Fark community.

  2. When community members submit a link, they also write a custom headline for the story.

  3. Other Farkers comment on the links. This is the number of comments. Click here to read them.

  4. Click here to submit a link.