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(Stat News)   SARS-CoV-2 is compromising cellular mechanics in ways heretofore never observed by virologists   (statnews.com) divider line
    More: Unlikely, Immune system, Virus, Influenza, first group of genes produces interferons, SARS-CoV-2, human cells, hostile takeover of their genes, Recent studies  
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5451 clicks; posted to Main » and Geek » on 22 May 2020 at 4:23 PM (8 days ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



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2020-05-23 12:25:29 AM  

lolmao500: You know who get lots of sun and vitamin d?


Your mom?
 
2020-05-23 12:34:05 AM  

TheOtherGuy: Also anyone drinking pasteurized milk in the U.S.


No religious milk for me thankyouverymuch.
 
2020-05-23 12:39:33 AM  

dbaggins: Interferon as a preventative will never work.  You can only tolerate interferon for a week or so, which means you would have to time your exposure quite accurately.     It be that we can use interferon as an adjuvant for a potential vaccine, or as a therapy to an early stage infection to "wake up" the immune system.


i.gifer.comView Full Size
 
2020-05-23 12:40:14 AM  

lolmao500: You know who get lots of sun and vitamin d? Iranians and brazilians


Oh hi, person who doesn't know the science. Thanks for shooting down my point. I'm sure you're saving lives.

Oh by the way, you're farking stupid. Maybe give Google a farking try next time before you add your sagely advice. Oh, you might also google the farking mutation a lot of them have that--you know what, fark this. Don't take my advice. Stay the fark indoors.

/farking done with trying to help people as of late. There's always some asshole like this.
 
2020-05-23 1:19:01 AM  

WalkingSedgwick: freakay: so why has it not totally taken off in Africa?

Timing, mostly. The pandemic has taken long enough to arrive in Africa that most of the continent is in about the same place the west was a few months ago. They'll have an explosion of cases sooner or later.

Also, keep in mind that while African countries have very little money, they have a lot of hands-on experience dealing with pandemics. The educational, contact-tracing, and quarantine infrastructure they have developed for responding to Ebola has been repurposed for responding to SARS2. Africa is not entirely defenseless.


Africa has come up with a whole bunch of solutions that we are not discussing in north American news.

https://www.thenation.com/article/wor​l​d/coronavirus-colonialism-africa/

https://www.theguardian.com/commentis​f​ree/2020/may/21/africa-coronavirus-suc​cesses-innovation-europe-us
 
2020-05-23 1:22:37 AM  

JungleBoogie: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

From The Economist magazine, May 2nd, 2020, in an article titled "Only Connect":
------
"Western experts say categorically the sequence of the new virus' genome - which Chinese scientists published early on, openly and accurately - reveals none of the telltales genetic engineering would leave in its wake. But it remains a fact that in Wuhan, where the outbreak was first spotted, there is a laboratory where scientists have in the past deliberately made coronaviruses more pathogenic.

Such research is carried out in laboratories around the world. Its proponents see it as a vital way of studying the question that COVID-19 has brought so cruelly into the spotlight: how does a virus become the sort of thing that starts a pandemic? That some of this research has been done at the Wuhan Institute of Virology (WIV) seems all but certainly a coincidence. Without a compelling alternative account of the disease's origin, however, there is room for doubt to remain."
------

The Economist is a respected, pro-business publication with a liberal bent. Not the sort to espouse conspiracy theories without evidence. But the prior two paragraphs suggest that while it is 99 percent certain that COVID-19 resulted from natural processes, it's not 100 percent certain.


more like a D20
 
2020-05-23 1:23:06 AM  
80/20

damn voice
 
2020-05-23 1:30:15 AM  

koder: lolmao500: You know who get lots of sun and vitamin d? Iranians and brazilians

Oh hi, person who doesn't know the science. Thanks for shooting down my point. I'm sure you're saving lives.

Oh by the way, you're farking stupid. Maybe give Google a farking try next time before you add your sagely advice. Oh, you might also google the farking mutation a lot of them have that--you know what, fark this. Don't take my advice. Stay the fark indoors.

/farking done with trying to help people as of late. There's always some asshole like this.


LOL

seems a little strong
 
2020-05-23 3:29:11 AM  

fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.

Modification is distinct from Weaponization.


Feel free to look into Gain-of-Function viral research on your own time. Now before you call this a loss of function, consider how a researcher might isolate a viral function for study.

Here's something relevant though

If you have to resort to scare headlines...

Risky Coronavirus Research

...then you've already failed.  Guess what, concern troll?  Just about all infectious-disease research is "risky."  Which is why it's done in dedicated facilities.

Good God you're a fool.

The point is that Gain-of-function research is dedicated to genetic modification, without weaponization.

Dedicated facilities are only as good as their oversight.


A few novel genes do not constitute proof of gain-of-function research, or anything else other than that novel genes exist.  But keep pushing your little conspiracy theory, of which you have yet to present any actual evidence.
 
2020-05-23 7:37:49 AM  

Enigmamf: koder: But when cells growing in lab dishes received the interferon IFN-1 before exposure to the coronavirus, "the virus has a difficult time replicating."

Consider going outside at least once per week, ideally more, and getting 20-30 minutes of direct sunlight (more if you're not white) on exposed limbs. Do not wear sunscreen, and do not have glass in between you and the sun. Vitamin D, which is produced by your body in abundance from UV exposure, enhances IFN-B (an IFN-1) activity while reducing cytokine storm.  With regard to COVID-19, specifically, several preliminary studies have been pointing to D deficiencies as being positively correlated with poor outcomes.  See also:

* https://www.thelancet.com/journals/l​andia/article/PIIS2213-8587(20)30183-2​/fulltext
* https://dailynorthwestern.com/2020/0​5/20/campus/nu-researchers-discover-st​rong-correlation-between-vitamin-d-def​iciency-and-covid-19-mortality-rates/
* https://www.webmd.com/lung/news/2020​0518/more-vitamin-d-lower-risk-of-seve​re-covid-19

So give it a shot. It's not patented. It's not something you have to buy.  It's not anything anyone can hoard. It's not something you can make money with on the stock market. Just go outside when it's sunny, and stay the fark away from other people when you're doing it.

I'm reflexively wary of Vitamin D claims. Like Vitamin C claims, many preliminary studies promised miraculous therapeutic benefits on a wide variety of ailments, only to fall flat (and sometimes prove detrimental) in broader studies.

I take a short walk every day, though.


Cochrane meta analysis says vitamin D supplementation decreases all cause mortality. What more do you want? https://www.cochrane.org/CD0074​70/ENDO​C_vitamin-d-supplementation-for-preven​tion-of-mortality-in-adults
 
2020-05-23 7:45:38 AM  

Rosyna: There was a study on socioeconomic factors leading to more outbreaks and worse systems. Since "socioeconomic factors" always equates to "those that face systematic and everyday racism vs those that don't", some idjit claimed Vitamin D was a factor (because black people). It's not.


No, an effect driven by socioeconomic status is not necessarily caused by racism. Maybe the effect persists when we only look at data from one race.

Determining whether that is true for the study you have in mind requires you to cite it.
 
2020-05-23 8:54:59 AM  

WalkingSedgwick: Bennie Crabtree: orneryredguy: Yeah, the vitamin D link is very intriguing.  Even if you have to go the supplement route, it's very low risk, unlike certain other (*cough* malaria *cough*) pills.  Just use some sense and stick to recommended doses.  There are reports now of people ODing on vitamin D supplements in the U.K.  The good news is, that's probably not fatal.  The bad news is, you might wish it was, especially when the kidney stones hit.

I was under the impression that Vitamin D overdose is also known as sunstroke, and the symptoms would be just basically feeling lightheaded, sweating, wanting a good lie-down. Also that it's one of the fat soluble vitamins, so take the supplements with a peanuts or something. Am I wrong?

Chronic excessive vitamin D intake causes serious health issues and might lead to heart disease. It's not something to mess with.


Quoting: Overdose has been observed at 1,925 µg/d (77,000 IU per day).

I'm a family doc. In cases of deficiency, we will use D2 50,000 IU weekly or 10,000 IU daily (five days a week) quite commonly. https://www.merckmanuals.com/professi​o​nal/nutritional-disorders/vitamin-defi​ciency,-dependency,-and-toxicity/vitam​in-d-deficiency-and-dependency I've seen one vitamin D overdose in my career- where the patient took 100,000 IU daily for a month.
 
2020-05-23 9:40:59 AM  
This is a really good article. Damn good find, subby
 
2020-05-23 9:54:51 AM  

Geotpf: Slightly unrelated to the article (but koder's mention of Vitamin D reminded me of it), but here's a thought that has been bouncing around my head:

Various news stories have said the following things separately.

1. Vitamin D seems to kill the virus or make it harder to get sick in the first place.
2. People with darker skin get less Vitamin D from the sun.
3. African Americans seem to die or get seriously ill from the virus more than white people.

But nobody seems to have added 1 + 2 + 3 together and made the seemingly obvious conclusion that a likely reason for higher death counts for African Americans isn't somehow racism (as most news stories pointing out #3 imply), but the fact that they have darker skin and therefore less Vitamin D and therefore are genetically more likely to be more susceptible to bad outcomes from the virus.  And it's not somehow "racist" to point out one ethnic group gets a particular disease more than other; for African Americans, they get sickle cell disorder more often, for instance.


I watch Dr. John Campbell's daily updates from the UK on YouTube and he mentions it all the time.

https://www.youtube.com/channel/UCF9I​O​B2TExg3QIBupFtBDxg

Racism claims are likely the reason why US sources are less likely to mention it, but there's definitely reasons for that.
 
2020-05-23 1:30:21 PM  

Sword and Shield: I'm a family doc. In cases of deficiency, we will use D2 50,000 IU weekly or 10,000 IU daily (five days a week) quite commonly.


One of the first things my oncologist did was check my vitamin d levels and put me on 50,000 IU a week for six weeks to bring it up.  Five years along and I still take 4000 IU a day and she checks my level every six months. Skeptical, but if there is anything to the vitamin d/covid theory I hope I'm covered.
 
2020-05-23 2:15:19 PM  

common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.

Modification is distinct from Weaponization.


Feel free to look into Gain-of-Function viral research on your own time. Now before you call this a loss of function, consider how a researcher might isolate a viral function for study.

Here's something relevant though

If you have to resort to scare headlines...

Risky Coronavirus Research

...then you've already failed.  Guess what, concern troll?  Just about all infectious-disease research is "risky."  Which is why it's done in dedicated facilities.

Good God you're a fool.

The point is that Gain-of-function research is dedicated to genetic modification, without weaponization.

Dedicated facilities are only as good as their oversight.

A few novel genes do not constitute proof of gain-of-function research, or anything else other than that novel genes exist.  But keep pushing your little conspiracy theory, of which you have yet to present any actual evidence.


That was in response to your statement about weaponizing a virus.

"Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system."


Modification is distinct from Weaponization.

I'm not pushing anything but possibilities.
 
2020-05-23 4:11:23 PM  

fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.

Modification is distinct from Weaponization.


Feel free to look into Gain-of-Function viral research on your own time. Now before you call this a loss of function, consider how a researcher might isolate a viral function for study.

Here's something relevant though

If you have to resort to scare headlines...

Risky Coronavirus Research

...then you've already failed.  Guess what, concern troll?  Just about all infectious-disease research is "risky."  Which is why it's done in dedicated facilities.

Good God you're a fool.

The point is that Gain-of-function research is dedicated to genetic modification, without weaponization.

Dedicated facilities are only as good as their oversight.

A few novel genes do not constitute proof of gain-of-function research, or anything else other than that novel genes exist.  But keep pushing your little conspiracy theory, of which you have yet to present any actual evidence.

That was in response to your statement about weaponizing a virus.

"Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system."


Modification is distinct from Weaponization.

I'm not pushing anything but possibilities.


Conspiratorial, xenophobic possibilities.
 
2020-05-23 5:26:39 PM  

bsmz: Cochrane meta analysis says vitamin D supplementation decreases all cause mortality. What more do you want? https://www.cochrane.org/CD00747​0/ENDOC_vitamin-d-supplementation-for-​prevention-of-mortality-in-adults


"May"... "seems to"... "concers".... Hardly an unqualified endorsement.

"Because of risks of attrition bias originating from substantial dropout of participants and of outcome reporting bias due to a number of trials not reporting on mortality, as well as a number of other weaknesses in our evidence, further placebo-controlled randomised trials seem warranted."
 
2020-05-23 8:18:04 PM  

bobbyjoebobby: TheOtherGuy: Also anyone drinking pasteurized milk in the U.S.

No religious milk for me thankyouverymuch.


Pastorized milk sounds like a chiorboy's nightmare.
 
2020-05-23 11:25:18 PM  

common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.

Modification is distinct from Weaponization.


Feel free to look into Gain-of-Function viral research on your own time. Now before you call this a loss of function, consider how a researcher might isolate a viral function for study.

Here's something relevant though

If you have to resort to scare headlines...

Risky Coronavirus Research

...then you've already failed.  Guess what, concern troll?  Just about all infectious-disease research is "risky."  Which is why it's done in dedicated facilities.

Good God you're a fool.

The point is that Gain-of-function research is dedicated to genetic modification, without weaponization.

Dedicated facilities are only as good as their oversight.

A few novel genes do not constitute proof of gain-of-function research, or anything else other than that novel genes exist.  But keep pushing your little conspiracy theory, of which you have yet to present any actual evidence.

That was in response to your statement about weaponizing a virus.

"Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system."


Modification is distinct from Weaponization.

I'm not pushing anything but possibilities.

Conspiratorial, xenophobic possibilities.


Oh, there are all sorts of possibilities.

These are all from mid 2019. 1 in the United States the other in Canada. I'll leave wuhan out since that was your assumption anyway.

Deadly Germ Research Is Shut Down at Army Lab Over Safety Concerns. 8/2019

The Army's premier biological laboratory on Fort Detrick reported two breaches of containment earlier this year. Same closure, military times reporting.


Canadian researchers are reacting with puzzlement to the news that a "policy breach" has caused the nation's only high-containment disease laboratory to bar a prominent Chinese Canadian virologist, her biologist husband, and a number of students from the facility.
 
6 days ago  

fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.

Modification is distinct from Weaponization.


Feel free to look into Gain-of-Function viral research on your own time. Now before you call this a loss of function, consider how a researcher might isolate a viral function for study.

Here's something relevant though

If you have to resort to scare headlines...

Risky Coronavirus Research

...then you've already failed.  Guess what, concern troll?  Just about all infectious-disease research is "risky."  Which is why it's done in dedicated facilities.

Good God you're a fool.

The point is that Gain-of-function research is dedicated to genetic modification, without weaponization.

Dedicated facilities are only as good as their oversight.

A few novel genes do not constitute proof of gain-of-function research, or anything else other than that novel genes exist.  But keep pushing your little conspiracy theory, of which you have yet to present any actual evidence.

That was in response to your statement about weaponizing a virus.

"Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system."


Modification is distinct from Weaponization.

I'm not pushing anything but possibilities.

Conspiratorial, xenophobic possibilities.

Oh, there are all sorts of possibilities.

These are all from mid 2019. 1 in the United States the other in Canada. I'll leave wuhan out since that was your assumption anyway.

Deadly Germ Research Is Shut Dow ...


Thanks for confirming your agenda.  There have been violations of lab protocols in the past; therefore, COVID-19 must be the result of something similar.

Ooga-booga.
 
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