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(Stat News)   SARS-CoV-2 is compromising cellular mechanics in ways heretofore never observed by virologists   (statnews.com) divider line
    More: Unlikely, Immune system, Virus, Influenza, first group of genes produces interferons, SARS-CoV-2, human cells, hostile takeover of their genes, Recent studies  
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5451 clicks; posted to Main » and Geek » on 22 May 2020 at 4:23 PM (8 days ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



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2020-05-22 6:00:01 PM  
Clearly no one read the article because I didn't see one comment about tenOever. I had to google his name because I didn't believe it was real, turned out it was.
 
2020-05-22 6:00:12 PM  
Oh, goody! COVID-19's putting the "novel" in "novel coronavirus!"
 
2020-05-22 6:01:00 PM  

Reverend J: Clearly no one read the article because I didn't see one comment about tenOever. I had to google his name because I didn't believe it was real, turned out it was.


Read the article, didn't goggle because someone had an odd name. I get stranger things every morning in my breakfast cereal.
 
2020-05-22 6:01:23 PM  
Wheretofore?
 
2020-05-22 6:01:41 PM  
And, no, that's not a typo. "Goggle," as in "go bug-eyed."
 
2020-05-22 6:05:08 PM  

WalkingSedgwick: Bennie Crabtree: orneryredguy: Yeah, the vitamin D link is very intriguing.  Even if you have to go the supplement route, it's very low risk, unlike certain other (*cough* malaria *cough*) pills.  Just use some sense and stick to recommended doses.  There are reports now of people ODing on vitamin D supplements in the U.K.  The good news is, that's probably not fatal.  The bad news is, you might wish it was, especially when the kidney stones hit.

I was under the impression that Vitamin D overdose is also known as sunstroke, and the symptoms would be just basically feeling lightheaded, sweating, wanting a good lie-down. Also that it's one of the fat soluble vitamins, so take the supplements with a peanuts or something. Am I wrong?

Chronic excessive vitamin D intake causes serious health issues and might lead to heart disease. It's not something to mess with.


Looks like you would have to take a metric farkton (a specific medical term) to OD on it, though.
 
2020-05-22 6:09:09 PM  
Insomuchas
 
2020-05-22 6:11:16 PM  
just read the article
this is, in fact,  f*cked up
just like in 1918 this is an outlier virus with "aberrant and unique" characteristics
most of all it just loves to reproduce (read the article) which allows more mutations
and will make any vaccine less likely
good luck everyone
 
2020-05-22 6:11:34 PM  

Bennie Crabtree: orneryredguy: Yeah, the vitamin D link is very intriguing.  Even if you have to go the supplement route, it's very low risk, unlike certain other (*cough* malaria *cough*) pills.  Just use some sense and stick to recommended doses.  There are reports now of people ODing on vitamin D supplements in the U.K.  The good news is, that's probably not fatal.  The bad news is, you might wish it was, especially when the kidney stones hit.

I was under the impression that Vitamin D overdose is also known as sunstroke, and the symptoms would be just basically feeling lightheaded, sweating, wanting a good lie-down. Also that it's one of the fat soluble vitamins, so take the supplements with a peanuts or something. Am I wrong?


I'm not a doctor, my research took me as far as "probably won't kill me", and I kinda stopped there.  I've been on a supplement since forever after a Dr's recommendation many years ago, my levels have always tested normal since. I have never seen anything claiming high levels do any good at all, for covid or anything else, but admit people probably aren't testing for that right now.

I don't know if an acute OD *is* sunstroke, but what you're describing would be consistent with both.  Longer term, apparently it can mess with calcium levels, hurt your kidneys and cause a buildup of calcium stones.  So claimeth Dr. Google when I looked.  But all indications are that you have to really, really try to mess yourself up that way.
 
2020-05-22 6:14:07 PM  
Okay, other people are doing the sciencey talk better than me, so listen to them, but I think the message is all the same.
 
2020-05-22 6:15:41 PM  

Somacandra: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

If it wasn't natural, we'd see the precise gene splicing cuts in the publicly available genome. We don't. The genome is just as messy as natural selection would make it.


10 years ago, sure.  Now they just program cells to produce single-stranded RNA viruses.  You can see the edits in the DNA of the parent cell, but the virions produced are smooth as a baby's bottom.
 
2020-05-22 6:37:41 PM  
so why has it not totally taken off in Africa?  because people are outside more?  seriously?

I think the vitamin D thing and being outside thing are worth looking into...but something seems off about it all.  I have a feeling it will be like War of the Worlds, and we will all say "THATS what keeps it from being bad?  seriously?"
 
2020-05-22 6:48:34 PM  

Bennie Crabtree: orneryredguy: Yeah, the vitamin D link is very intriguing.  Even if you have to go the supplement route, it's very low risk, unlike certain other (*cough* malaria *cough*) pills.  Just use some sense and stick to recommended doses.  There are reports now of people ODing on vitamin D supplements in the U.K.  The good news is, that's probably not fatal.  The bad news is, you might wish it was, especially when the kidney stones hit.

I was under the impression that Vitamin D overdose is also known as sunstroke, and the symptoms would be just basically feeling lightheaded, sweating, wanting a good lie-down. Also that it's one of the fat soluble vitamins, so take the supplements with a peanuts or something. Am I wrong?


Eh... no.

Sunstroke is a result of overwhelming your bodies ability to maintain a consistent internal temperature, usually as a result of dehydration and the resulting electrolite imbalance.  This can occur in any number of ways, not all of which involve sun exposure.  Either way, the amount of vitD recieved on even an extreme exposure event is miniscule.
 
2020-05-22 6:52:56 PM  

AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.


So by that reasoning, you think HIV was also manufactured.  It is also unique amoung human virii in that it targets T-cells, effectvely hamstringing the immune system.

Shiat evolves, and this bug found an interesting twist.
 
2020-05-22 6:57:41 PM  

lolmao500: koder: But when cells growing in lab dishes received the interferon IFN-1 before exposure to the coronavirus, "the virus has a difficult time replicating."

Consider going outside at least once per week, ideally more, and getting 20-30 minutes of direct sunlight (more if you're not white) on exposed limbs. Do not wear sunscreen, and do not have glass in between you and the sun. Vitamin D, which is produced by your body in abundance from UV exposure, enhances IFN-B (an IFN-1) activity while reducing cytokine storm.  With regard to COVID-19, specifically, several preliminary studies have been pointing to D deficiencies as being positively correlated with poor outcomes.  See also:

* https://www.thelancet.com/journals/l​andia/article/PIIS2213-8587(20)30183-2​/fulltext
* https://dailynorthwestern.com/2020/0​5/20/campus/nu-researchers-discover-st​rong-correlation-between-vitamin-d-def​iciency-and-covid-19-mortality-rates/
* https://www.webmd.com/lung/news/2020​0518/more-vitamin-d-lower-risk-of-seve​re-covid-19

So give it a shot. It's not patented. It's not something you have to buy.  It's not anything anyone can hoard. It's not something you can make money with on the stock market. Just go outside when it's sunny, and stay the fark away from other people when you're doing it.

You know who get lots of sun and vitamin d? Iranians and brazilians


Also anyone drinking pasteurized milk in the U.S.
 
2020-05-22 7:00:15 PM  
Yeah, sunstroke is not the same thing as Vitamin D overdose. Sunstroke is an umtraviolet radiation burn plus hyperthermia and probable dehydration. The two can go together, sure, but they're not the same.
 
2020-05-22 7:04:41 PM  
Thanks for the Vitamin D information! I have doled out the coveted "smart" clicks.
S M R T that spells Smartie
 
2020-05-22 7:06:47 PM  

koder: Do not wear sunscreen


Does not approve

pbs.twimg.comView Full Size
 
2020-05-22 7:17:28 PM  

FormlessOne: Reverend J: Clearly no one read the article because I didn't see one comment about tenOever. I had to google his name because I didn't believe it was real, turned out it was.

Read the article, didn't goggle because someone had an odd name. I get stranger things every morning in my breakfast cereal.


i.imgflip.comView Full Size
 
2020-05-22 7:19:29 PM  

freakay: so why has it not totally taken off in Africa?


Timing, mostly. The pandemic has taken long enough to arrive in Africa that most of the continent is in about the same place the west was a few months ago. They'll have an explosion of cases sooner or later.

Also, keep in mind that while African countries have very little money, they have a lot of hands-on experience dealing with pandemics. The educational, contact-tracing, and quarantine infrastructure they have developed for responding to Ebola has been repurposed for responding to SARS2. Africa is not entirely defenseless.
 
2020-05-22 7:23:39 PM  
We at the Jersey Shore have a leg up as homes are required to have a tanning bed to get a certificate of occupancy.
 
2020-05-22 7:30:41 PM  

orneryredguy: Okay, other people are doing the sciencey talk better than me, so listen to them, but I think the message is all the same.


I'm not going to take medical advice from random accounts on a news aggregator site, thanks anyhow.
 
2020-05-22 7:33:40 PM  

AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.


Only about 1200 viruses have been studied. There are millions of strains/species thought to exist. Most can't even infect mammals. There's one type of virus that can only infect and replicate when another type of virus hijacks the host cell first.

Just about every virus studied in depth displays new tricks.
 
2020-05-22 7:34:02 PM  

comrade: EyeHaveRisen: Look folks,   Trumpy started a trade and tax war with China.

They are showing him and the world that they Haz Germ Warfare.

Welcome to the new World War folks.

Good luck

A post like this would be deleted on twitter as misleading.


So would this entire thread. Full of disinformation. Twitter, Facebook, and Instagram have higher standards than this site.
 
2020-05-22 7:41:17 PM  

pup.socket: What "cellular mechanics", when tfa is entirely about chemical reactions and immune system responses?

For an outsider in the field it is kind of hard to say if the claims are correct, but if they are it would be an easy virus to beat - just stimulate the missing response by medication and it's goodbye corona, no?

Let's see a followup with some tests.


Cellular mechanisms are chemical reactions. That's what life is. Organic chemistry is basically locksmithing and lockpicking using chains of carbon-based molecules with various ionic bonding sites on each carefully constructed chain so it folds into just the right shape and connects to just the right sites on its intended mate. This causes a change: something unfolds or revolts in response, triggering other reactions. That is the description of a cellular mechanism.
 
2020-05-22 7:41:43 PM  
Begoggle:
So would this entire thread. Full of disinformation. Twitter, Facebook, and Instagram have higher standards than this site.

Welcome to the internet ?
 
2020-05-22 7:52:04 PM  
Revolts should be refolds.
 
2020-05-22 7:52:14 PM  

orneryredguy: Yeah, the vitamin D link is very intriguing.  Even if you have to go the supplement route, it's very low risk, unlike certain other (*cough* malaria *cough*) pills.  Just use some sense and stick to recommended doses.  There are reports now of people ODing on vitamin D supplements in the U.K.  The good news is, that's probably not fatal.  The bad news is, you might wish it was, especially when the kidney stones hit.


Everyone living above 45° north latitude should be adding 1K unit of D3 to theire daily vitamin regimen.
 
2020-05-22 8:02:50 PM  

AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.


Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.
 
2020-05-22 8:05:21 PM  

freakay: so why has it not totally taken off in Africa?  because people are outside more?  seriously?

I think the vitamin D thing and being outside thing are worth looking into...but something seems off about it all.  I have a feeling it will be like War of the Worlds, and we will all say "THATS what keeps it from being bad?  seriously?"


Because there are not very many international travelers in Africa.
 
2020-05-22 8:06:13 PM  
From the article.

"The "something" he and his colleagues saw is how SARS-CoV-2 blocks one virus-fighting set of genes but allows another set to launch, a pattern never seen with other viruses. Influenza and the original SARS virus (in the early 2000s), for instance, interfere with both arms of the body's immune response - what tenOever dubs "call to arms" genes and "call for reinforcement" genes."

From 2009

"The sudden emergence of severe acute respiratory syndrome (SARS) has boosted research on innate immune responses to coronaviruses. It is now well established that the causative agent, a newly identified coronavirus termed SARS-CoV, employs multiple passive and active mechanisms to avoid induction of the antiviral type I interferons in tissue cells. By contrast, chemokines such as IP-10 or IL-8 are strongly upregulated."
 
2020-05-22 8:08:06 PM  

fark'emfeed'emfish: From the article.

"The "something" he and his colleagues saw is how SARS-CoV-2 blocks one virus-fighting set of genes but allows another set to launch, a pattern never seen with other viruses. Influenza and the original SARS virus (in the early 2000s), for instance, interfere with both arms of the body's immune response - what tenOever dubs "call to arms" genes and "call for reinforcement" genes."

From 2009

"The sudden emergence of severe acute respiratory syndrome (SARS) has boosted research on innate immune responses to coronaviruses. It is now well established that the causative agent, a newly identified coronavirus termed SARS-CoV, employs multiple passive and active mechanisms to avoid induction of the antiviral type I interferons in tissue cells. By contrast, chemokines such as IP-10 or IL-8 are strongly upregulated."


Now with reference

https://www.sciencedirect.com/science​/​article/pii/S1359610108000026
 
2020-05-22 8:10:52 PM  

AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.


From The Economist magazine, May 2nd, 2020, in an article titled "Only Connect":
------
"Western experts say categorically the sequence of the new virus' genome - which Chinese scientists published early on, openly and accurately - reveals none of the telltales genetic engineering would leave in its wake. But it remains a fact that in Wuhan, where the outbreak was first spotted, there is a laboratory where scientists have in the past deliberately made coronaviruses more pathogenic.

Such research is carried out in laboratories around the world. Its proponents see it as a vital way of studying the question that COVID-19 has brought so cruelly into the spotlight: how does a virus become the sort of thing that starts a pandemic? That some of this research has been done at the Wuhan Institute of Virology (WIV) seems all but certainly a coincidence. Without a compelling alternative account of the disease's origin, however, there is room for doubt to remain."
------

The Economist is a respected, pro-business publication with a liberal bent. Not the sort to espouse conspiracy theories without evidence. But the prior two paragraphs suggest that while it is 99 percent certain that COVID-19 resulted from natural processes, it's not 100 percent certain.
 
2020-05-22 8:12:26 PM  

koder: But when cells growing in lab dishes received the interferon IFN-1 before exposure to the coronavirus, "the virus has a difficult time replicating."

Consider going outside at least once per week, ideally more, and getting 20-30 minutes of direct sunlight (more if you're not white) on exposed limbs. Do not wear sunscreen, and do not have glass in between you and the sun. Vitamin D, which is produced by your body in abundance from UV exposure, enhances IFN-B (an IFN-1) activity while reducing cytokine storm.  With regard to COVID-19, specifically, several preliminary studies have been pointing to D deficiencies as being positively correlated with poor outcomes.  See also:

* https://www.thelancet.com/journals/l​andia/article/PIIS2213-8587(20)30183-2​/fulltext
* https://dailynorthwestern.com/2020/0​5/20/campus/nu-researchers-discover-st​rong-correlation-between-vitamin-d-def​iciency-and-covid-19-mortality-rates/
* https://www.webmd.com/lung/news/2020​0518/more-vitamin-d-lower-risk-of-seve​re-covid-19

So give it a shot. It's not patented. It's not something you have to buy.  It's not anything anyone can hoard. It's not something you can make money with on the stock market. Just go outside when it's sunny, and stay the fark away from other people when you're doing it.


As someone who has a Vit D deficiency, 'just go out into the sun with no sunscreen' is not quite the answer.
 
2020-05-22 8:18:19 PM  

common sense is an oxymoron: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.


Modification is distinct from Weaponization.


Feel free to look into Gain-of-Function viral research on your own time. Now before you call this a loss of function, consider how a researcher might isolate a viral function for study.

Here's something relevant though
 
2020-05-22 8:26:47 PM  

foo monkey: foo monkey: Nadie_AZ: EyeHaveRisen: Look folks,   Trumpy started a trade and tax war with China.

They are showing him and the world that they Haz Germ Warfare.

Welcome to the new World War folks.

Good luck

Uhhhh really?

China aside, the US did this with the native peoples here. I'd say the Spanish did but they took longer to figure it out.

http://www.history.com/news/colonists-​native-americans-smallpox-blankets

The only documented case of this was done by the Brits and there's no evidence it worked.

Which is not to say what the US did to natives was anything short of systematic genocide.


It was actually well short of systematic genocide, actually. Something can be horrible without being the most horrible thing ever!111!11oneone!

Almost in the same way that someone who disagrees with you isn't automatically Hitler
 
2020-05-22 8:56:46 PM  

Mikeyworld: Everyone living above 45° north latitude should be adding 1K unit of D3 to theire daily vitamin regimen.


I take 5k iu/day.  Healthline recommends a max of 4k iu/day, so I am in the right ballpark. Minimum is 600-800 iu/day depending on age, based on IOM article cited from that Healthline article.  So 1k iu/day is reasonable.

IIRC the amount you would get from being in the sun a lot every day would be around 25k iu/day. I don't want to dig up a citation for that, though.
 
2020-05-22 8:57:07 PM  

dbaggins: Interferon as a preventative will never work.  You can only tolerate interferon for a week or so, which means you would have to time your exposure quite accurately.     It be that we can use interferon as an adjuvant for a potential vaccine, or as a therapy to an early stage infection to "wake up" the immune system.


Fark user imageView Full Size

AND YOU'RE "INTERFERON" WITH OUR GOOD TIME.
 
2020-05-22 9:09:04 PM  

Carousel Beast: foo monkey: foo monkey: Nadie_AZ: EyeHaveRisen: Look folks,   Trumpy started a trade and tax war with China.

They are showing him and the world that they Haz Germ Warfare.

Welcome to the new World War folks.

Good luck

Uhhhh really?

China aside, the US did this with the native peoples here. I'd say the Spanish did but they took longer to figure it out.

http://www.history.com/news/colonists-​native-americans-smallpox-blankets

The only documented case of this was done by the Brits and there's no evidence it worked.

Which is not to say what the US did to natives was anything short of systematic genocide.

It was actually well short of systematic genocide, actually. Something can be horrible without being the most horrible thing ever!111!11oneone!

Almost in the same way that someone who disagrees with you isn't automatically Hitler


Genocide was the stated goal of federal reservation policy.

When that didn't work, the US funded anthropology to study how to at least destroy their culture. There's a reason that Indiana University's anthropology program was the seat of American eugenics and frequently referenced by Hitler.

Problem was, too many who were sent out to study various tribes "went native." Also, many anthropologists are cautious about "applied anthropology" (which is what my undergrad is in) because of the legacy of the discipline, but really it's just a method of investigating situations, using comparative approaches to understand how one situation differs from another and how to take off-the-shelf solutions and customize them to a specific situation.

But it was originally part of an official policy.

What did you think that the Trail of Tears was? It was an act of genocide. What do you think that the removal of tribes east of the Mississippi was? The reason for the Army stopping bands trying to leave the US? Corralling tribes onto wasteland that could not support them, then settling the most active racists they could pay around the borders of the reservations? The Battle of Little Bighorn and other attempted and successful massacres was specifically to stop them from going to Canada where they might actually not die, rather than keep them penned up where they were intended to die out.

This is actual, literal history. If you think that Red Earth, White Lies by Vine Deloria Jr is too biased, go read Skull Wars by David Hurst Thomas, it gives a very good accounting of Indian policy over the years as it explains the history of the fight between the Smithsonian and native tribes over Kennewick Man (which was not resolved until long after the book was published).
 
2020-05-22 9:34:43 PM  

koder: But when cells growing in lab dishes received the interferon IFN-1 before exposure to the coronavirus, "the virus has a difficult time replicating."

Consider going outside at least once per week, ideally more, and getting 20-30 minutes of direct sunlight (more if you're not white) on exposed limbs. Do not wear sunscreen, and do not have glass in between you and the sun. Vitamin D, which is produced by your body in abundance from UV exposure, enhances IFN-B (an IFN-1) activity while reducing cytokine storm.  With regard to COVID-19, specifically, several preliminary studies have been pointing to D deficiencies as being positively correlated with poor outcomes.  See also:

* https://www.thelancet.com/journals/l​andia/article/PIIS2213-8587(20)30183-2​/fulltext
* https://dailynorthwestern.com/2020/0​5/20/campus/nu-researchers-discover-st​rong-correlation-between-vitamin-d-def​iciency-and-covid-19-mortality-rates/
* https://www.webmd.com/lung/news/2020​0518/more-vitamin-d-lower-risk-of-seve​re-covid-19

So give it a shot. It's not patented. It's not something you have to buy.  It's not anything anyone can hoard. It's not something you can make money with on the stock market. Just go outside when it's sunny, and stay the fark away from other people when you're doing it.


I'm reflexively wary of Vitamin D claims. Like Vitamin C claims, many preliminary studies promised miraculous therapeutic benefits on a wide variety of ailments, only to fall flat (and sometimes prove detrimental) in broader studies.

I take a short walk every day, though.
 
2020-05-22 9:40:57 PM  

fark'emfeed'emfish: common sense is an oxymoron: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.

Modification is distinct from Weaponization.


Feel free to look into Gain-of-Function viral research on your own time. Now before you call this a loss of function, consider how a researcher might isolate a viral function for study.

Here's something relevant though


If you have to resort to scare headlines...

Risky Coronavirus Research

...then you've already failed.  Guess what, concern troll?  Just about all infectious-disease research is "risky."  Which is why it's done in dedicated facilities.
 
2020-05-22 9:41:48 PM  

JungleBoogie: The Economist is a respected, pro-business publication with a liberal bent.


Liberal in the sense of 'classical liberalism', Adam Smith and free trade and the like...
 
2020-05-22 9:52:00 PM  

El Trolo: koder: But when cells growing in lab dishes received the interferon IFN-1 before exposure to the coronavirus, "the virus has a difficult time replicating."

Consider going outside at least once per week, ideally more, and getting 20-30 minutes of direct sunlight (more if you're not white) on exposed limbs. Do not wear sunscreen, and do not have glass in between you and the sun. Vitamin D, (...)

So give it a shot. It's not patented. It's not something you have to buy.  It's not anything anyone can hoard.

[metro.co.uk image 696x422]


Hello lamppost, what ya knowin'?  I've come to watch your power flowin'...
 
2020-05-22 10:18:38 PM  

robodog: lolmao500: koder: But when cells growing in lab dishes received the interferon IFN-1 before exposure to the coronavirus, "the virus has a difficult time replicating."

Consider going outside at least once per week, ideally more, and getting 20-30 minutes of direct sunlight (more if you're not white) on exposed limbs. Do not wear sunscreen, and do not have glass in between you and the sun. Vitamin D, which is produced by your body in abundance from UV exposure, enhances IFN-B (an IFN-1) activity while reducing cytokine storm.  With regard to COVID-19, specifically, several preliminary studies have been pointing to D deficiencies as being positively correlated with poor outcomes.  See also:

* https://www.thelancet.com/journals/l​andia/article/PIIS2213-8587(20)30183-2​/fulltext
* https://dailynorthwestern.com/2020/0​5/20/campus/nu-researchers-discover-st​rong-correlation-between-vitamin-d-def​iciency-and-covid-19-mortality-rates/
* https://www.webmd.com/lung/news/2020​0518/more-vitamin-d-lower-risk-of-seve​re-covid-19

So give it a shot. It's not patented. It's not something you have to buy.  It's not anything anyone can hoard. It's not something you can make money with on the stock market. Just go outside when it's sunny, and stay the fark away from other people when you're doing it.

You know who get lots of sun and vitamin d? Iranians and brazilians

Do they? I know southern Europeans have lower amounts of Vitamin D than northern Europeans, same in the US. When it's brutally hot and the sun is harsh you tend to avoid exposure, vs those of us in higher climes that tend to bake in it when available.


No, not really. There was a study on socioeconomic factors leading to more outbreaks and worse systems. Since "socioeconomic factors" always equates to "those that face systematic and everyday racism vs those that don't", some idjit claimed Vitamin D was a factor (because black people). It's not.
 
2020-05-22 10:20:09 PM  

BolloxReader: Cellular mechanisms are chemical reactions.


https://en.wikipedia.org/wiki/Cell_me​c​hanics
 
2020-05-22 10:28:00 PM  
-It has long been known that vitamin D is important for the immune system.
-It may play a role in the seasonality of some diseases.
-In Germany 40 years ago, the only supplement pediatricians recommended for babies was Vitamin D.
-Old women don't make vitamin D from sunshine as efficiently as young women, a doctor once told me.
-Old people, in general, are more likely to be deficient in vitamin D.
 
2020-05-22 10:41:44 PM  

twocent: -It has long been known that vitamin D is important for the immune system.
-It may play a role in the seasonality of some diseases.
-In Germany 40 years ago, the only supplement pediatricians recommended for babies was Vitamin D.
-Old women don't make vitamin D from sunshine as efficiently as young women, a doctor once told me.
-Old people, in general, are more likely to be deficient in vitamin D.


On the upside - most people who are taking a calcium supplement (which a lot of olds do) are getting a D3 supplement with it.
 
2020-05-22 11:12:44 PM  

pup.socket: BolloxReader: Cellular mechanisms are chemical reactions.

https://en.wikipedia.org/wiki/Cell_mec​hanics


Oh, so you are nitpicking subby over using a slightly different word that most people (including most likely subby) wouldn't know refers to a specialized branch of biological research?

That's useful.
 
2020-05-22 11:41:01 PM  

lolmao500: koder: But when cells growing in lab dishes received the interferon IFN-1 before exposure to the coronavirus, "the virus has a difficult time replicating."

Consider going outside at least once per week, ideally more, and getting 20-30 minutes of direct sunlight (more if you're not white) on exposed limbs. Do not wear sunscreen, and do not have glass in between you and the sun. Vitamin D, which is produced by your body in abundance from UV exposure, enhances IFN-B (an IFN-1) activity while reducing cytokine storm.  With regard to COVID-19, specifically, several preliminary studies have been pointing to D deficiencies as being positively correlated with poor outcomes.  See also:

* https://www.thelancet.com/journals/l​andia/article/PIIS2213-8587(20)30183-2​/fulltext
* https://dailynorthwestern.com/2020/0​5/20/campus/nu-researchers-discover-st​rong-correlation-between-vitamin-d-def​iciency-and-covid-19-mortality-rates/
* https://www.webmd.com/lung/news/2020​0518/more-vitamin-d-lower-risk-of-seve​re-covid-19

So give it a shot. It's not patented. It's not something you have to buy.  It's not anything anyone can hoard. It's not something you can make money with on the stock market. Just go outside when it's sunny, and stay the fark away from other people when you're doing it.

You know who get lots of sun and vitamin d? Iranians and brazilians


Not Iranian women.  Nor any women living in Muslim-led countries where they're required to cover themselves from head to toe.
 
2020-05-22 11:59:28 PM  

common sense is an oxymoron: fark'emfeed'emfish: common sense is an oxymoron: AngryDragon: Yes, this totally natural coronavirus that has exhibited a number of unique attributes never before seen in a coronavirus simultaneously is totally natural.

Totally.

Because the first thing someone would do if they were trying to weaponize a virus is to disable a key part of its camouflage against the immune system.

Modification is distinct from Weaponization.


Feel free to look into Gain-of-Function viral research on your own time. Now before you call this a loss of function, consider how a researcher might isolate a viral function for study.

Here's something relevant though

If you have to resort to scare headlines...

Risky Coronavirus Research

...then you've already failed.  Guess what, concern troll?  Just about all infectious-disease research is "risky."  Which is why it's done in dedicated facilities.


Good God you're a fool.

The point is that Gain-of-function research is dedicated to genetic modification, without weaponization.

Dedicated facilities are only as good as their oversight.
 
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