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(BBC)   UK scientists discover most seriously ill Covid-19 patients have extremely low T-cell count, raising hopes for possible treatment   (bbc.co.uk) divider line
    More: News, Immune system, Lymphocyte, White blood cell, Natural killer cell, Antibody, clinical trial, Thymus, low numbers of an immune cell  
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4163 clicks; posted to Main » on 22 May 2020 at 2:37 PM (6 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



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View Voting Results: Smartest and Funniest

 
2020-05-22 3:00:04 PM  
12 votes:

Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?


It has been known for a while that in some cases, lymphocytes take a beating and losing your immune system never helps. Several T cell types have ACE2 receptors. The current consensus (but there's not much data here) is that while the virus CAN infect these cells, it can't replicate in them. But if it kills the cell...that doesn't help.

However, unlike HIV, it doesn't always win and wipe out the immune system, but it does damage it in severe cases. (This may also be related to the syndrome children see with this disease, which I forget the name of.)

Emcrit has these labs as signs the patient is going south.

D-dimer > 1000 ng/ml (sign of clotting in the blood)
Ferritin >300 ug/L (sign of a hyperinflammatory response/cytokine storm)
LDH >245 IU/L (sign of tissue breakdown, esp. cardiac tissue)
Absolute lymphocyte count < 0.8 (sign of a weakened immune system.)
C-reactive protein >100 mg/L (sign of inflammation and cardiac damage.)

Basically, you don't want any of these, and apparently, the worse those numbers are, the worse the prognosis.
 
2020-05-22 2:43:48 PM  
9 votes:
Oh, good - I was afraid there wouldn't be a treatment option that costs hundreds of thousands of dollars.

Extracting T cells, culturing them in vitro (and even tailoring them for specific receptors) then reintroducing them via injection is a relatively new & viable cancer treatment, but it's expensive as hell. I guess someone figured out an off-label use and hopes to sell this for COVID-19.
 
2020-05-22 2:38:45 PM  
7 votes:
Its Resident Evil all over again!
 
2020-05-22 2:40:35 PM  
3 votes:
vignette.wikia.nocookie.netView Full Size
 
2020-05-22 4:08:48 PM  
2 votes:

Nicholas D. Wolfwood: orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.

I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.


Hepatitis C, if you can afford it.
 
2020-05-22 2:44:19 PM  
2 votes:
More desperate lies from Commie, Fascist, Socialist, Liberals!!

It's a well known FACT that FARTBAMA and KILLERY have BILLIONS of stock in T-Cells!!! This is nothing more than another COUPE attempt to unseat a duly elected President who is carrying out everything needed in America and making this country great again!
 
2020-05-22 2:41:39 PM  
2 votes:
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fool
 
2020-05-22 2:13:01 PM  
2 votes:
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He'll fix ya right up.
 
2020-05-22 4:05:59 PM  
1 vote:

2farknfunny: [Fark user image 644x500]
fool


I do you one better.

Fark user imageView Full Size
 
2020-05-22 4:01:50 PM  
1 vote:
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They need Tall Teeth?
 
2020-05-22 3:51:44 PM  
1 vote:

I hereby demand that I be given a Fark account: However, unlike HIV, it doesn't always win and wipe out the immune system, but it does damage it in severe cases. (This may also be related to the syndrome children see with this disease, which I forget the name of.)


MISC with a hyphen somewhere?
 
2020-05-22 3:26:28 PM  
1 vote:
I'm a fully accredited Internet medicalist scientician, and I can tell you what this article is hiding from you:

AIDS reduces T-cell counts.
COVID reduces T-cell counts.
Therefore:
COVID IS AIRBORNE AIDS.
 
2020-05-22 3:19:47 PM  
1 vote:
Some studies have found low t-cells in COVID patients. Here is one from China.

Also, nCoV19 invades and destroys certain t-cells. An article about it was posted to the Geek tab a few weeks ago.  I think this is the one. (I was the submitter but it's been a long time). That study concluded it destroys the t-cells but does not replicate in them. (So, it does not function like HIV but maybe the last few days of life are somewhat, sort of, like dying of AIDS...?)

I would do a lot to explain the major infections. It might also explain why COVID seems to be the virus that does everything.
 
2020-05-22 3:07:39 PM  
1 vote:

Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?


No, it's light on details.  From what I gather, cases with the worst outcomes had low levels of T cells.  It's not saying whether the virus caused that low T cell count or whether the cases typically had low T cell counts beforehand.

Many infections are impacted by the balance of the immune response, with different forms of T cells vs. B cells responding - cause and effect still have not been completely sorted out.  The authors of this study hope that a cell signaling molecule - interleukin 7, which helps stimulate the development of T cells, might help improve outcomes.
 
2020-05-22 3:06:34 PM  
1 vote:
With that high Scrabble score name, I assume the price will be in the low teens (and reserved for the richest folk).
 
2020-05-22 3:01:08 PM  
1 vote:
Sooo, is the answer gonna be Milla Jovovich clones? For everyone? Because, I'd be okay with that.
What? You don't want yours? Okay, *fine* I guess I can take that one, too, but I'm not happy about it.
 
2020-05-22 2:43:40 PM  
1 vote:
Low T
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High tea
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Iced T
Fark user imageView Full Size
 
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