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(BBC)   UK scientists discover most seriously ill Covid-19 patients have extremely low T-cell count, raising hopes for possible treatment   (bbc.co.uk) divider line
    More: News, Immune system, Lymphocyte, White blood cell, Natural killer cell, Antibody, clinical trial, Thymus, low numbers of an immune cell  
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4089 clicks; posted to Main » on 22 May 2020 at 2:37 PM (11 days ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook



60 Comments     (+0 »)
 
View Voting Results: Smartest and Funniest
 
2020-05-22 2:13:01 PM  
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He'll fix ya right up.
 
2020-05-22 2:38:45 PM  
Its Resident Evil all over again!
 
2020-05-22 2:39:26 PM  
...isn't that just how illness works? Are they reinventing the wheel here?
 
2020-05-22 2:40:35 PM  
vignette.wikia.nocookie.netView Full Size
 
2020-05-22 2:41:39 PM  
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fool
 
2020-05-22 2:41:40 PM  
Thank God.  We were almost a Jill sandwich!
 
2020-05-22 2:42:16 PM  
Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?
 
2020-05-22 2:43:40 PM  
Low T
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High tea
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Iced T
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2020-05-22 2:43:48 PM  
Oh, good - I was afraid there wouldn't be a treatment option that costs hundreds of thousands of dollars.

Extracting T cells, culturing them in vitro (and even tailoring them for specific receptors) then reintroducing them via injection is a relatively new & viable cancer treatment, but it's expensive as hell. I guess someone figured out an off-label use and hopes to sell this for COVID-19.
 
2020-05-22 2:44:19 PM  
More desperate lies from Commie, Fascist, Socialist, Liberals!!

It's a well known FACT that FARTBAMA and KILLERY have BILLIONS of stock in T-Cells!!! This is nothing more than another COUPE attempt to unseat a duly elected President who is carrying out everything needed in America and making this country great again!
 
2020-05-22 2:45:45 PM  
Doesn't it target t cells?
 
2020-05-22 2:46:00 PM  
Just wait till the T-Virus goes crazy.
 
2020-05-22 2:46:11 PM  
T-cells? What about N-cells? A-cells? TNA treatment!
 
2020-05-22 2:46:33 PM  
Fark user imageView Full Size


/ shakes tiny fist at 2farknfunny
 
2020-05-22 2:46:59 PM  

2farknfunny: [Fark user image 644x500]
fool


Fark user imageView Full Size
 
2020-05-22 2:48:45 PM  

Gunner's Mate First Class Phillip Asshole: Just wait till the T-Virus goes crazy.


Or when it can move.

Fark user imageView Full Size
 
2020-05-22 2:52:01 PM  

fragMasterFlash: 2farknfunny: [Fark user image 644x500]
fool

[Fark user image 549x413]


I'm gonna steal this one, if ok with fMF.
 
2020-05-22 2:54:15 PM  
dsogaming.comView Full Size

Intrigued
 
2020-05-22 2:58:46 PM  
Good.L Un-Fark this planet.
 
2020-05-22 2:59:03 PM  
Ow!! My corpuscles!!
Fark user imageView Full Size
 
2020-05-22 3:00:04 PM  

Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?


It has been known for a while that in some cases, lymphocytes take a beating and losing your immune system never helps. Several T cell types have ACE2 receptors. The current consensus (but there's not much data here) is that while the virus CAN infect these cells, it can't replicate in them. But if it kills the cell...that doesn't help.

However, unlike HIV, it doesn't always win and wipe out the immune system, but it does damage it in severe cases. (This may also be related to the syndrome children see with this disease, which I forget the name of.)

Emcrit has these labs as signs the patient is going south.

D-dimer > 1000 ng/ml (sign of clotting in the blood)
Ferritin >300 ug/L (sign of a hyperinflammatory response/cytokine storm)
LDH >245 IU/L (sign of tissue breakdown, esp. cardiac tissue)
Absolute lymphocyte count < 0.8 (sign of a weakened immune system.)
C-reactive protein >100 mg/L (sign of inflammation and cardiac damage.)

Basically, you don't want any of these, and apparently, the worse those numbers are, the worse the prognosis.
 
2020-05-22 3:01:08 PM  
Sooo, is the answer gonna be Milla Jovovich clones? For everyone? Because, I'd be okay with that.
What? You don't want yours? Okay, *fine* I guess I can take that one, too, but I'm not happy about it.
 
2020-05-22 3:01:37 PM  
This is the part where he tells everyone to start taking AZT, isn't it?
 
2020-05-22 3:06:34 PM  
With that high Scrabble score name, I assume the price will be in the low teens (and reserved for the richest folk).
 
2020-05-22 3:07:39 PM  

Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?


No, it's light on details.  From what I gather, cases with the worst outcomes had low levels of T cells.  It's not saying whether the virus caused that low T cell count or whether the cases typically had low T cell counts beforehand.

Many infections are impacted by the balance of the immune response, with different forms of T cells vs. B cells responding - cause and effect still have not been completely sorted out.  The authors of this study hope that a cell signaling molecule - interleukin 7, which helps stimulate the development of T cells, might help improve outcomes.
 
2020-05-22 3:07:44 PM  

Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?


More proof that Covid19 was made in the same lab that created AIDS. The Democrats duplicity knows no bounds.
 
2020-05-22 3:07:45 PM  
NUGENIX TOTAL-T LIKE A MOTHERF*CKER, GET IN HERE
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2020-05-22 3:11:36 PM  

walkerhound: Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?

No, it's light on details.  From what I gather, cases with the worst outcomes had low levels of T cells.  It's not saying whether the virus caused that low T cell count or whether the cases typically had low T cell counts beforehand.

Many infections are impacted by the balance of the immune response, with different forms of T cells vs. B cells responding - cause and effect still have not been completely sorted out.  The authors of this study hope that a cell signaling molecule - interleukin 7, which helps stimulate the development of T cells, might help improve outcomes.


Nevermind, I need to read further into the article before responding.  The patients had low T cells and it was likely due to the virus.
 
2020-05-22 3:19:47 PM  
Some studies have found low t-cells in COVID patients. Here is one from China.

Also, nCoV19 invades and destroys certain t-cells. An article about it was posted to the Geek tab a few weeks ago.  I think this is the one. (I was the submitter but it's been a long time). That study concluded it destroys the t-cells but does not replicate in them. (So, it does not function like HIV but maybe the last few days of life are somewhat, sort of, like dying of AIDS...?)

I would do a lot to explain the major infections. It might also explain why COVID seems to be the virus that does everything.
 
2020-05-22 3:20:49 PM  

Bennie Crabtree: (So, it does not function like HIV but maybe the last few days of life are somewhat, sort of, like dying of AIDS...?)


Most AIDS patients succumb to influenza or pneumonia, so yes, the end stage is similar.
 
2020-05-22 3:21:59 PM  

thedingoatemybaby: fragMasterFlash: 2farknfunny: [Fark user image 644x500]
fool

[Fark user image 549x413]

I'm gonna steal this one, if ok with fMF.


I stole it from GIS so by all means plz enjoy posting it here, there and everywhere.

/can't stop the signal
 
2020-05-22 3:26:28 PM  
I'm a fully accredited Internet medicalist scientician, and I can tell you what this article is hiding from you:

AIDS reduces T-cell counts.
COVID reduces T-cell counts.
Therefore:
COVID IS AIRBORNE AIDS.
 
2020-05-22 3:35:27 PM  

Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?


TFA is light on facts.
Not a Dr, & I definitely ANAL.
Did low T-cell count already exist?  Or did it happen as a result Rona?
Latter would be alarming, but not likely...  HIV takes months to turn into AIDS...  seems suspicious Rona could do it overnight.
Low T count as pre-existing condition... means patient has depressed immune system...  holy Fark!  People with depressed immune function get sick????
 
2020-05-22 3:39:39 PM  

kdawg7736: T-cells? What about N-cells? A-cells? TNA treatment!


TNA treatment?

Why do you think people are in such a hurry to reopen the strip clubs?
 
2020-05-22 3:44:30 PM  

Nicholas D. Wolfwood: kdawg7736: T-cells? What about N-cells? A-cells? TNA treatment!

TNA treatment?

Why do you think people are in such a hurry to reopen the strip clubs?


Trumpers cannot wait to snort a big rail of hydroxychloroquine off of a strippers big fake tits.
 
2020-05-22 3:51:44 PM  

I hereby demand that I be given a Fark account: However, unlike HIV, it doesn't always win and wipe out the immune system, but it does damage it in severe cases. (This may also be related to the syndrome children see with this disease, which I forget the name of.)


MISC with a hyphen somewhere?
 
2020-05-22 3:53:50 PM  
An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.
 
2020-05-22 3:57:58 PM  

J_Kushner: Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?

TFA is light on facts.
Not a Dr, & I definitely ANAL.
Did low T-cell count already exist?  Or did it happen as a result Rona?
Latter would be alarming, but not likely...  HIV takes months to turn into AIDS...  seems suspicious Rona could do it overnight.
Low T count as pre-existing condition... means patient has depressed immune system...  holy Fark!  People with depressed immune function get sick????


The COVID virus attacks and kills t-cells, which means it also is protected while it sits inside them.
 
2020-05-22 3:58:10 PM  

J_Kushner: Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?

TFA is light on facts.
Not a Dr, & I definitely ANAL.
Did low T-cell count already exist?  Or did it happen as a result Rona?
Latter would be alarming, but not likely...  HIV takes months to turn into AIDS...  seems suspicious Rona could do it overnight.
Low T count as pre-existing condition... means patient has depressed immune system...  holy Fark!  People with depressed immune function get sick????


[phrasing.jpg]

/alternatively, [thatsmyfetish.jpg]
 
2020-05-22 3:58:44 PM  

I hereby demand that I be given a Fark account: Opacity: Someone with an armchair MD please help out here- is it just a really light on facts article or is covid19 now looking like airborne HIV?

It has been known for a while that in some cases, lymphocytes take a beating and losing your immune system never helps. Several T cell types have ACE2 receptors. The current consensus (but there's not much data here) is that while the virus CAN infect these cells, it can't replicate in them. But if it kills the cell...that doesn't help.

However, unlike HIV, it doesn't always win and wipe out the immune system, but it does damage it in severe cases. (This may also be related to the syndrome children see with this disease, which I forget the name of.)

Emcrit has these labs as signs the patient is going south.

D-dimer > 1000 ng/ml (sign of clotting in the blood)
Ferritin >300 ug/L (sign of a hyperinflammatory response/cytokine storm)
LDH >245 IU/L (sign of tissue breakdown, esp. cardiac tissue)
Absolute lymphocyte count < 0.8 (sign of a weakened immune system.)
C-reactive protein >100 mg/L (sign of inflammation and cardiac damage.)

Basically, you don't want any of these, and apparently, the worse those numbers are, the worse the prognosis.


Kawasaki Disease.
 
2020-05-22 3:59:49 PM  

Satampra Zeiros: Sooo, is the answer gonna be Milla Jovovich clones? For everyone? Because, I'd be okay with that.
What? You don't want yours? Okay, *fine* I guess I can take that one, too, but I'm not happy about it.


Not sure how I'd explain that to my wife.
 
2020-05-22 4:01:50 PM  
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They need Tall Teeth?
 
2020-05-22 4:04:41 PM  

orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.


I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.
 
2020-05-22 4:05:59 PM  

2farknfunny: [Fark user image 644x500]
fool


I do you one better.

Fark user imageView Full Size
 
2020-05-22 4:08:48 PM  

Nicholas D. Wolfwood: orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.

I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.


Hepatitis C, if you can afford it.
 
2020-05-22 4:15:19 PM  

LessO2: Gunner's Mate First Class Phillip Asshole: Just wait till the T-Virus goes crazy.

Or when it can move.

[Fark user image 850x304]


i.pinimg.comView Full Size
 
2020-05-22 4:50:46 PM  
I've read that although it can infect T-cells, it probably can't replicate in them. If it can, then all bets are off, as an EFFECTIVE vaccine might prove, well, very difficult to produce.
 
2020-05-22 5:07:57 PM  
If you're anything less than T-800, you're screwed.
 
2020-05-22 5:18:54 PM  

Warthog: I'm a fully accredited Internet medicalist scientician, and I can tell you what this article is hiding from you:

AIDS reduces T-cell counts.
COVID reduces T-cell counts.
Therefore:
COVID IS AIRBORNE AIDS.


So you die but you don't at least get to have sex? Harsh.
 
2020-05-22 6:27:24 PM  

orbister: I hereby demand that I be given a Fark account: However, unlike HIV, it doesn't always win and wipe out the immune system, but it does damage it in severe cases. (This may also be related to the syndrome children see with this disease, which I forget the name of.)

MISC with a hyphen somewhere?


Right, that's it.
 
2020-05-22 6:46:25 PM  

Nicholas D. Wolfwood: orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.

I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.


I'll settle for "finding an effective treatment", then.
 
2020-05-22 7:23:06 PM  
vignette.wikia.nocookie.netView Full Size
 
2020-05-22 7:31:23 PM  

Ivo Shandor: Nicholas D. Wolfwood: orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.

I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.

Hepatitis C, if you can afford it.


Thank you.
 
2020-05-22 7:31:43 PM  

orbister: Nicholas D. Wolfwood: orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.

I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.

I'll settle for "finding an effective treatment", then.


Agreed.
 
2020-05-22 8:04:32 PM  
There are four left in the box.

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2020-05-22 8:11:34 PM  

I hereby demand that I be given a Fark account: orbister: I hereby demand that I be given a Fark account: However, unlike HIV, it doesn't always win and wipe out the immune system, but it does damage it in severe cases. (This may also be related to the syndrome children see with this disease, which I forget the name of.)

MISC with a hyphen somewhere?

Right, that's it.


MIS-C
 
2020-05-22 8:52:56 PM  

Nicholas D. Wolfwood: orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.

I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.


It is incorrect.
 
2020-05-23 5:58:24 AM  

Nicholas D. Wolfwood: orbister: Nicholas D. Wolfwood: orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.

I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.

I'll settle for "finding an effective treatment", then.

Agreed.


Thank you for correcting me. One lives and learns.
 
2020-05-23 11:10:11 PM  

orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.


It's not that fewer people need ventilation... it's that in some instances ventilation seems to do more harm then good.
 
2020-05-23 11:44:44 PM  

This text is now purple: Nicholas D. Wolfwood: orbister: An interesting piece of good news. While there is a lot of talk about possible vaccines, treatment for COVID-19 has been getting better and better (for example many fewer patients need ventilation compared to a couple of months ago) and "finding a cure" may be the dark horse coming up from behind.

I was under the impression that we have never managed to actually *cure* a viral disease.

I will be very happy if I find out that this is incorrect.

It is incorrect.


Phew, rest easy science! Somebody has asserted the viruses can be cured! Somebody get the lights and fire the treatments.
 
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