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(Medical Xpress)   New patch uses micro-needles to turn energy-storing (white) fats into energy-burning (brown) ones. There's a bad joke in there somewhere, but subby's not going to waste the energy on it   ( medicalxpress.com) divider line
    More: Interesting, Adipose tissue, beta-3 adrenergic receptor, Obesity, Adrenergic receptor, Asst Prof Xu, Thyroid, brown fats, weight gain  
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1873 clicks; posted to Geek » on 28 Dec 2017 at 10:50 AM (8 weeks ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



29 Comments     (+0 »)
 
View Voting Results: Smartest and Funniest
 
2017-12-28 10:36:22 AM  
Scruffy approves.
i.imgur.comView Full Size
 
2017-12-28 10:54:39 AM  
"...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?
 
2017-12-28 11:07:06 AM  

Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?

Both have been shown in other research studies to be able to turn white fats brown, but their use in reducing weight gain is hampered by potentially serious side-effects and drug accumulation in non-targeted tissues if conventional drug delivery routes were used, such as through oral intake.


I guess you didn't notice why?

Also, you wouldn't feel needless that small. But it would be a bit disconcerting rubbing the patch into your butt or stomach knowing that you need those needles to get in you.

I wonder just how targeted the needless would be... Would you need a huge patch for your fat ass, or your Thunder thighs... If you used a little one, would you just lose like an mandarin orange sized chunk of your leg fat and have a large indentation?
 
2017-12-28 11:19:44 AM  
pre14.deviantart.netView Full Size
 
2017-12-28 11:25:21 AM  
A drug that will alter the body from what it normally does so people don't have to change their diet or have to exercise?
I cannot see how this would cause further medical problems side effects.
/sarcasm
 
2017-12-28 11:32:09 AM  
Trans fats will have to get their own needle room.
 
2017-12-28 11:35:17 AM  

AlanMooresBeard: A drug that will alter the body from what it normally does so people don't have to change their diet or have to exercise?
I cannot see how this would cause further medical problems side effects.
/sarcasm


Yes some people are black holes of food, but I've seen first hand what a malfunctioning thyroid gland can do in a short amount of time.
 
2017-12-28 11:37:27 AM  

Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?


Generally oral medications fall into two camps: Those that don't work and things that kill your heart.
The easiest solution, of course is for the fat people to just stop eating so goddamn much, but I guess micro-needle patches are easier than that.
 
2017-12-28 11:37:59 AM  
Roasting and basting will also turn white fat into brown fat.
 
2017-12-28 11:47:51 AM  
"With the embedded microneedles in the skin of the mice, the surrounding fats started browning in five days, which helped to increase the energy expenditure of the mice, leading to a reduction in body fat gain"

That's going to help solve the energy problem.  You could heat your house by eating Big Macs.
 
2017-12-28 11:50:07 AM  

Uriel: Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?


They're not going to tell you that.  They'll call it the "Two Day Fluffy Pillow Patch" or something like that.
 
2017-12-28 11:52:17 AM  
FTFA:
The team estimates that their prototype patch had a material cost of about S$5 (US$3.50) to make

So expect to see it in your local pharmacy for $600 a ten pack.
 
2017-12-28 12:10:58 PM  

Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?


No pain, no gain.

/or loss, in this case.
 
2017-12-28 12:30:30 PM  

Ravage: FTFA:
The team estimates that their prototype patch had a material cost of about S$5 (US$3.50) to make

So expect to see it in your local pharmacy for $600 a ten pack.


Sadly this.
 
2017-12-28 12:51:12 PM  
is it bad that I mis-read the headline as farts....not fats?
 
2017-12-28 01:17:21 PM  

cchinni: is it bad that I mis-read the headline as farts....not fats?


You definitely don't want brown farts.
 
2017-12-28 01:24:44 PM  
cpubus:
Yes some people are black holes of food, but I've seen first hand what a malfunctioning thyroid gland can do in a short amount of time.

You don't even need to be a black hole... let's say you are magically really close to eating your exact maintenance budget every single day, but you mindlessly top it up with a single can of coke over maintenance every day (regular coke, 138 kcal per 12oz). I mean, it's just one can per day... not the end of the world, right?

A pound of fat is worth 3500 kcal. Over the course of the year, you've ingested 14.39 lbs worth of fat in excess calories ((138 * 365) / 3500). Of course, I have simplified the calculation by keeping your TDEE constant or considering that you'd still stick to your evolving TDEE. Your TDEE could slowly creep up as you gained weight if you kept the same activity level... but you'd probably start eating more as well. Your TDEE could also go down because your activity level would drop as your weight goes up and now you're gaining fat even faster.

You can replace that one can of coke by one ounce of nuts you munched on and forgot to account in your daily calories budget... bam, that's 20 lbs worth of fat in excess calories for that year (I used grilled salted pistachio, 197 kcal per ounce... 187 for walnuts, 204 for macadamia, 164 for almonds). Or some pretzels (108 per ounce) or crisps (152 kcal per ounce)

Or even funnier, not requiring you to actually eat extra... the calorie count of your diet crept above your TDEE because carbs are added to more and more food nowadays (both ready meals and eating out).

I personally fell in a similar trap after getting married... I switched from a fat/protein heavy diet (typical central European country side food) to a carb heavy diet (Japanese food) without recalculating the portion sizes. Fast forward 12 years... I'm carrying 20 lbs more fat than the day I got married. That translates to an average of 16 kcal above my daily TDEE (roughly 0.0066% of my daily calorie budget)... which is basically the equivalent of between half a walnut and a walnut a day.
 
2017-12-28 01:27:47 PM  
misdirected leisure activity:

After reading your post I am happy to report that your handle checks out :)
 
2017-12-28 01:35:13 PM  

Jormungandr: Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?

Generally oral medications fall into two camps: Those that don't work and things that kill your heart.
The easiest solution, of course is for the fat people to just stop eating so goddamn much, but I guess micro-needle patches are easier than that.


Sigh. There are many reasons for being fat. Eating too much is only one of them. Please get educated and stop being a fat-bigot.
 
2017-12-28 01:41:25 PM  

Marcus Aurelius: misdirected leisure activity:

After reading your post I am happy to report that your handle checks out :)


Unfortunately not :)
 
2017-12-28 02:37:03 PM  

Quantumbunny: Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?

Both have been shown in other research studies to be able to turn white fats brown, but their use in reducing weight gain is hampered by potentially serious side-effects and drug accumulation in non-targeted tissues if conventional drug delivery routes were used, such as through oral intake.

I guess you didn't notice why?

Also, you wouldn't feel needless that small. But it would be a bit disconcerting rubbing the patch into your butt or stomach knowing that you need those needles to get in you.

I wonder just how targeted the needless would be... Would you need a huge patch for your fat ass, or your Thunder thighs... If you used a little one, would you just lose like an mandarin orange sized chunk of your leg fat and have a large indentation?


That's what I was picturing. Looking at the petri dish in those scientists hands, I imagine your skin would look like that depending on where the drug was delivered. How do they keep the distribution even?
 
2017-12-28 02:37:56 PM  
Proof of concept in humans will be to take 1000 men and test it on one moob, but not the other and then compare.
 
2017-12-28 02:46:58 PM  

Harlee: Jormungandr: Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?

Generally oral medications fall into two camps: Those that don't work and things that kill your heart.
The easiest solution, of course is for the fat people to just stop eating so goddamn much, but I guess micro-needle patches are easier than that.

Sigh. There are many reasons for being fat. Eating too much is only one of them. Please get educated and stop being a fat-bigot.


Smarting yourself is considered in poor taste.
All fat comes back to eating more than you need, whether that is because you double fist cheese burgers down your gullet or because your thyroid is bad and you're eating like it isn't, it comes back to too many calories. Or are you suggesting there is some sort of disorder that causes people to create calories from nothing?
 
2017-12-28 04:28:53 PM  

Harlee: Jormungandr: Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?

Generally oral medications fall into two camps: Those that don't work and things that kill your heart.
The easiest solution, of course is for the fat people to just stop eating so goddamn much, but I guess micro-needle patches are easier than that.

Sigh. There are many reasons for being fat. Eating too much is only one of them. Please get educated and stop being a fat-bigot.


What are some of the other reasons?
 
2017-12-28 04:36:12 PM  
shutupandtakemymoney.jpg
 
2017-12-28 06:44:51 PM  
Or you could just turn off the heat. Humans are actually capable of entering a state of near hibernation, sleep through the darkest months, live off the stored fat. Well, at least those of us that are part neanderthal.
 
2017-12-28 08:05:50 PM  

Marcus Aurelius: "With the embedded microneedles in the skin of the mice, the surrounding fats started browning in five days, which helped to increase the energy expenditure of the mice, leading to a reduction in body fat gain"

That's going to help solve the energy problem.  You could heat your house by eating Big Macs.


Even better: use a gas heater and order Taco Bell.
 
2017-12-28 11:46:59 PM  

Jormungandr: Harlee: Jormungandr: Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?

Generally oral medications fall into two camps: Those that don't work and things that kill your heart.
The easiest solution, of course is for the fat people to just stop eating so goddamn much, but I guess micro-needle patches are easier than that.

Sigh. There are many reasons for being fat. Eating too much is only one of them. Please get educated and stop being a fat-bigot.

Smarting yourself is considered in poor taste.
All fat comes back to eating more than you need, whether that is because you double fist cheese burgers down your gullet or because your thyroid is bad and you're eating like it isn't, it comes back to too many calories. Or are you suggesting there is some sort of disorder that causes people to create calories from nothing?


>>>>"Smarting yourself is considered in poor taste."

Yeah, and I did it five times.
img.fark.netView Full Size

>>>>All fat comes back to eating more than you need, whether that is because you double fist cheese burgers down your gullet or because your thyroid is bad and you're eating like it isn't, it comes back to too many calories. Or are you suggesting there is some sort of disorder that causes people to create calories from nothing?
img.fark.netView Full Size
 
2017-12-29 02:11:14 PM  

Harlee: Jormungandr: Harlee: Jormungandr: Uriel: "...this approach could address the worldwide obesity problem without resorting to surgical operations or oral medication."

Because why would you want to resort to oral medication when you could EMBED MICRO NEEDLES, right?

Generally oral medications fall into two camps: Those that don't work and things that kill your heart.
The easiest solution, of course is for the fat people to just stop eating so goddamn much, but I guess micro-needle patches are easier than that.

Sigh. There are many reasons for being fat. Eating too much is only one of them. Please get educated and stop being a fat-bigot.

Smarting yourself is considered in poor taste.
All fat comes back to eating more than you need, whether that is because you double fist cheese burgers down your gullet or because your thyroid is bad and you're eating like it isn't, it comes back to too many calories. Or are you suggesting there is some sort of disorder that causes people to create calories from nothing?

>>>>"Smarting yourself is considered in poor taste."

Yeah, and I did it five times.
[img.fark.net image 259x194][View Full Size image _x_]
>>>>All fat comes back to eating more than you need, whether that is because you double fist cheese burgers down your gullet or because your thyroid is bad and you're eating like it isn't, it comes back to too many calories. Or are you suggesting there is some sort of disorder that causes people to create calories from nothing?
[img.fark.net image 259x194][View Full Size image _x_]


So... you have nothing. Good to know.
 
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