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(Medical Xpress)   Researcher discovers delicious churros and sopapillas, finds diabetes related mutation in Mexican population   (medicalxpress.com ) divider line
    More: Followup, Mexican, Broad Institute, type 2 diabetes, indigenous populations, mutations, zygosity, upper stage, diabetes  
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892 clicks; posted to Geek » on 05 Aug 2014 at 12:56 PM (2 years ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



9 Comments     (+0 »)
 
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2014-08-05 12:12:14 PM  
I believe the proper nomenclature is "diabeetus," subby.
 
2014-08-05 01:14:18 PM  
I could really use a sopapilla right now.
 
2014-08-05 01:20:08 PM  
If this variant is truly this common, I wonder what advantages it brings.  Famine resistance?
 
2014-08-05 02:19:03 PM  

Bonzo_1116: If this variant is truly this common, I wonder what advantages it brings.  Famine resistance?


I'd guess famine too. It probably a side effect of an adaptation that allows the carriers to be able to handle times of low availability of carbohydrates or something like that. Meso-american empires rose or fell on their maize production.
 
2014-08-05 03:37:59 PM  
There are some Southwestern Native American tribes that have very serious diabetes problems.  This might explain some of those cases.
 
2014-08-05 04:00:30 PM  
famousdude.com
 
2014-08-05 04:23:34 PM  
If you aren't working in a field 16 hours a day then filling up on rice and beans and lard might make ya fat.
 
2014-08-05 05:10:44 PM  

Jiro Dreams Of McRibs: There are some Southwestern Native American tribes that have very serious diabetes problems.  This might explain some of those cases.


I saw some documentary years ago about the Pima.  The Pima on the US side of the border were like 80% diabetic by the time they turned 30 (or some other similarly outrageous rate of diabetes and obesity), and the rate of the Pima on the Mexican side was a small fraction.  The American Pimas were eating USDA crap gov't cheese and food stamp treats, and the Mexican Pimas were dirt farming for a living.
 
2014-08-05 05:33:13 PM  

cgraves67: Bonzo_1116: If this variant is truly this common, I wonder what advantages it brings.  Famine resistance?

I'd guess famine too. It probably a side effect of an adaptation that allows the carriers to be able to handle times of low availability of carbohydrates or something like that. Meso-american empires rose or fell on their maize production.


People can survive pretty well off stored fat. Native people in North America, in particular, have a diabetes epidemic because they largely haven't adapted to the abundance of carbohydrates in the modern diet.
Also, they tend to be poor, which means a lot of them live off of simple carbs because they're cheap.
A famine survival adaptation would be if a population developed a gene that increased insulin sensitivity in order to store more energy in times of plenty. With diabetes, he problem is that energy in the form of glucose circulates in the bloodstream and causes damage to cells it contacts instead of being stored, because the body isn't secreting the hormone that directs it to be stored properly.
 
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