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(Vice)   Two new patients have been cleared of HIV. Still no cure for cancer, but damn if this isn't a great achievement   (motherboard.vice.com ) divider line
    More: Spiffy, HIV, antiretroviral drugs, International AIDS Conference, National Institutes of Health  
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1839 clicks; posted to Geek » on 21 Jul 2014 at 3:04 PM (2 years ago)   |   Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



40 Comments     (+0 »)
 
View Voting Results: Smartest and Funniest
 
ZAZ [TotalFark]
2014-07-21 09:14:46 AM  
The takeaway for me is, it's now OK to chop up AIDS-free gay men to extract their bone marrow.  I've got a cooler, ice, and a full tank of gas. It's 106 miles to Provincetown. Hit it.
 
2014-07-21 09:40:09 AM  
Except for that first kid who was cleared and then the virus came back two years later.

Except for that.
 
2014-07-21 09:46:31 AM  

bdub77: Except for that first kid who was cleared and then the virus came back two years later.

Except for that.


these are two others

and that kid hadn't been continuing to get treatment after she and her mother had left the hospital.
 
2014-07-21 10:12:34 AM  

somedude210: and that kid hadn't been continuing to get treatment after she and her mother had left the hospital.


That's the goal.

Anything short of that isn't "free" but just remission.
 
2014-07-21 10:15:23 AM  

doglover: somedude210: and that kid hadn't been continuing to get treatment after she and her mother had left the hospital.

That's the goal.

Anything short of that isn't "free" but just remission.


right, but it may be that they need to continue the treatment a bit more beyond the kid getting the "all clear" just to be sure it stays dead

/"HIV Double Tap"
 
2014-07-21 10:25:17 AM  

somedude210: doglover: somedude210: and that kid hadn't been continuing to get treatment after she and her mother had left the hospital.

That's the goal.

Anything short of that isn't "free" but just remission.

right, but it may be that they need to continue the treatment a bit more beyond the kid getting the "all clear" just to be sure it stays dead

/"HIV Double Tap"


Screw that.

I want them to develop robotic immune system controlled by a field generator which can be implanted in the robotic liver that 130% more effective than a normal human liver but can be potted down when you want to get drunk for a few hours.

Also, unicons with fart rainbows directly into your mouth when you're hungry.
 
2014-07-21 12:46:11 PM  
I have AIDES, which are my dietician and my financial advisor.
 
2014-07-21 03:08:16 PM  

kdawg7736: I have AIDES, which are my dietician and my financial advisor.


Jared?
 
2014-07-21 03:13:19 PM  
 
2014-07-21 03:19:27 PM  
Congratulations, subby... You managed to turn one of the MOST annoying Fark Headline trends into a nice little joke. Good job. The "Still no cure for cancer' people usually make me stabby, you made me smile...
 
2014-07-21 03:21:20 PM  
Until tomorrow?
 
2014-07-21 03:24:38 PM  

doglover: That's the goal.

Anything short of that isn't "free" but just remission.


People like you are why we have anti-biotic resistant bacteria.
 
2014-07-21 03:38:34 PM  
I can't wait for the AIDS prevention lobby to start telling us how this is a terrible thing and curing AIDS is bad.

Anyone hear about Truvada? A daily pill that essentially acts as an AIDS inoculation with a 99.9% effectiveness rate. The AIDS community has basically trashed it and said it's evil and people shouldn't take it and only cowards are "Truvada Whores."
 
2014-07-21 03:41:17 PM  
I think I'll wait until they pass the 5 year survivability and virus free test.
 
2014-07-21 03:42:53 PM  

dr-shotgun: Anyone hear about Truvada? A daily pill that essentially acts as an AIDS inoculation with a 99.9% effectiveness rate. The AIDS community has basically trashed it and said it's evil and people shouldn't take it and only cowards are "Truvada Whores."


imgs.xkcd.com \

Calling bullshiat on this one. The only time I've heard someone speak negatively about this was a person who is well established in the leather community lamenting at how the methods of advertising and targeting of media on drugs like Truvada have lead to a change in people taking reasonable precautions with partners, and run the risk of glamorizing and minimizing the risk of HIV, especially among the MSM population.
 
2014-07-21 03:49:18 PM  
So given the model where the guys immune system was eliminated by radition thearpy and reseeded with a bone marrow transplant.   Have they any evidence that the guy who remained free remained that way because:

a) the new immune system is immune to HIV
b) HIV hides in the bone marrow somehow and elimination of it eliminates the reservoir from which symptomatic infections can re-appear.

/Yeah, the answer is always C)
 
2014-07-21 03:49:25 PM  

dr-shotgun: I can't wait for the AIDS prevention lobby to start telling us how this is a terrible thing and curing AIDS is bad.

Anyone hear about Truvada? A daily pill that essentially acts as an AIDS inoculation with a 99.9% effectiveness rate. The AIDS community has basically trashed it and said it's evil and people shouldn't take it and only cowards are "Truvada Whores."


But only when taken with Forsythia?

/I enjoyed that movie
 
2014-07-21 03:50:44 PM  

hardinparamedic: ullshiat on this one. The only time I've heard someone speak negatively about this was a person who is well established in the leather community lamenting at how the methods of advertising and targeting of media on drugs like Truvada have lead to a change in people taking reasonable precautions with partners, and run the risk of glamorizing and minimizing the risk of HIV, especially among the MSM population.


http://www.onthemedia.org/story/truvadamedia/

http://www.slate.com/blogs/outward/2014/01/06/truvada_prep_hiv_gay_m en _should_take_pre_exposure_prophylaxis.html

http://www.nytimes.com/2013/12/31/health/a-resisted-pill-to-prevent- hi v.html?src=recg&_r=0
 
2014-07-21 04:01:56 PM  

dr-shotgun: http://www.slate.com/blogs/outward/2014/01/06/truvada_prep_hiv_gay_m en _should_take_pre_exposure_prophylaxis.html


Again, I'm calling bullshiat. The HIV activists quoted in your linked article were saying that the use of an unproven at the time pill would result in the MSM population taking riskier sexual practices under the impression of being immune to HIV.

In addition, Truvada is cost prohibitive to many people. The out of pocket cost for those who don't have insurance is USD 1360/30 day supply - 45 bucks a pill. In addition, Truvada has some very significant side effects that make it unattractive to some people as well.

But in the end, you're cherry-picking here in a form that blames the victim. Your NYT article even points out there is a low adherence to the regiment required to continue to obtain the pill, and a low rate of use among those who do obtain it.

Maybe the issue lies more in the attitude we have towards the MSM population, and the way society encourages an environment which promotes risky sexual behavior as a reason why Truvada alone isn't a final measure in stopping HIV.

And the use of a universal health system that could provide Truvada free of cost to at-risk members of the population would make it far more accessible.
 
2014-07-21 04:05:38 PM  

somedude210: doglover: somedude210: and that kid hadn't been continuing to get treatment after she and her mother had left the hospital.

That's the goal.

Anything short of that isn't "free" but just remission.

right, but it may be that they need to continue the treatment a bit more beyond the kid getting the "all clear" just to be sure it stays dead

/"HIV Double Tap"


It's not that simple.  HIV is a retrovirus.  Most viruses simply hijack cellular machinery to self-replicate very quickly, but HIV writes itself into your DNA and reproduces itself very slowly.  As a result, there's no way to identify and eradicate infected cells and even 1 infected cell is enough to allow continued reproduction of the virus.  The people who have been "cured" may not have active HIV viruses in their bloodstream, but that doesn't mean that they aren't still infected.  Stop their treatment for a short period of time, and the virus will reassert itself.

That being said, if the treatment can suppress viral replication and allow people to live a normal life, that's a far sight better than where we stand currently.
 
2014-07-21 04:09:56 PM  

hardinparamedic: Again, I'm calling bullshiat. The HIV activists quoted in your linked article were saying that the use of an unproven at the time pill would result in the MSM population taking riskier sexual practices under the impression of being immune to HIV.


Look, the simple fact is that Truvada is basically the miracle pill. Sure, that claim comes with a couple of, in my view, relatively minor foot-notes, but the damn thing works (by all accounts) as advertised. It's the HIV/AIDS inoculation solution.

Over time, it will get less expensive. One can also assume it will be formulated in a variant that requires less frequent dosing (say, weekly).

The fact is, this should be universally praised as the breakthrough solution it is. Between Truvada and treatments that get HIV/AIDS down to undetectable levels, this epidemic is - for all intents and purposes - cured. Growing up in the first generation to get HIV/AIDS pounded into our heads as a death sentence, it simply boggles my mind that the AIDS community isn't whole-heartedly embracing Truvada as the astonishing breakthrough it is.
 
2014-07-21 04:16:34 PM  

somedude210: these are two others


nerdywithchildren.com
 
2014-07-21 04:20:28 PM  

dr-shotgun: hardinparamedic: Again, I'm calling bullshiat. The HIV activists quoted in your linked article were saying that the use of an unproven at the time pill would result in the MSM population taking riskier sexual practices under the impression of being immune to HIV.

Look, the simple fact is that Truvada is basically the miracle pill. Sure, that claim comes with a couple of, in my view, relatively minor foot-notes, but the damn thing works (by all accounts) as advertised. It's the HIV/AIDS inoculation solution.

Over time, it will get less expensive. One can also assume it will be formulated in a variant that requires less frequent dosing (say, weekly).

The fact is, this should be universally praised as the breakthrough solution it is. Between Truvada and treatments that get HIV/AIDS down to undetectable levels, this epidemic is - for all intents and purposes - cured. Growing up in the first generation to get HIV/AIDS pounded into our heads as a death sentence, it simply boggles my mind that the AIDS community isn't whole-heartedly embracing Truvada as the astonishing breakthrough it is.


Reporting for duty!

img.fark.net
 
2014-07-21 04:20:43 PM  

dr-shotgun: I can't wait for the AIDS prevention lobby to start telling us how this is a terrible thing and curing AIDS is bad.

Anyone hear about Truvada? A daily pill that essentially acts as an AIDS inoculation with a 99.9% effectiveness rate. The AIDS community has basically trashed it and said it's evil and people shouldn't take it and only cowards are "Truvada Whores."


The issue with Truvada isn't the drug itself but that people are stupid in general. People are using it as an excuse to stop using condoms which leads to the transmission of all the other bugs out there. With the number of cases of antibiotic resistant STDs on the rise, that's not a good thing. So it is great for reducing HIV transmission (btw, that 99.9% statistic is when it's used with condoms. When it's used alone, the effectiveness is closer to 60%) but the unintended consequences are a biatch.
 
2014-07-21 04:24:25 PM  

dr-shotgun: The fact is, this should be universally praised as the breakthrough solution it is. Between Truvada and treatments that get HIV/AIDS down to undetectable levels, this epidemic is - for all intents and purposes - cured. Growing up in the first generation to get HIV/AIDS pounded into our heads as a death sentence, it simply boggles my mind that the AIDS community isn't whole-heartedly embracing Truvada as the astonishing breakthrough it is.


Because Truvada isn't a cure, like you claim. It's an effective prophylactic preventive treatment that has less side effects than previous PrEP or PEP therapies. It still costs an arm and a leg that much of the MSM population cannot afford, and thanks to the political climate in the United States will be relegated to those with high discretionary incomes for the foreseeable future. And there are still major social issues with the MSM population in the United States which impede widespread acceptance of it. That was my point. The fact that OpEd commenters and blogosphere reporters are glossing over that to point out all the positives should give you pause in wondering why if this pill is so amazing is it not being used by everyone, and maybe that it just isn't the evil HIV activists.

The fact you don't see the actual and real problems with the availability and social stigma of the MSM population at risk, while lambasting the HIV activism community is pretty telling here.
 
2014-07-21 04:24:56 PM  

doglover: somedude210: and that kid hadn't been continuing to get treatment after she and her mother had left the hospital.

That's the goal.

Anything short of that isn't "free" but just remission.


Its not 'remission'.... Medication prevents the virus from replicating, and the immune system gets rid of most everything else already floating along in the blood.

Thats why this article isn't really noteworthy.... ANYbody taking the meds should feasbily reach 'undetectable' viral status.    Its quite common..... So for them to say that these patients are 'cured' based on being undetectable, (yet they are still taking meds), doesn't mean anything.....   They are no different than millions of other people, also taking the meds.
 
2014-07-21 05:13:31 PM  

bdub77: Except for that first kid who was cleared and then the virus came back two years later.

Except for that.


Which isn't this kid. Try to keep up.
 
2014-07-21 05:38:04 PM  
In my town, there was a building with AIDS across the top.  About 15-20 years ago, they changed it to their address.  AIDS deniers.
 
2014-07-21 06:14:55 PM  

highendmighty: In my town, there was a building with AIDS across the top.  About 15-20 years ago, they changed it to their address.  AIDS deniers.


upload.wikimedia.org  Ayds deniers too
 
2014-07-21 06:35:58 PM  

dr-shotgun: I can't wait for the AIDS prevention lobby to start telling us how this is a terrible thing and curing AIDS is bad.

Anyone hear about Truvada? A daily pill that essentially acts as an AIDS inoculation with a 99.9% effectiveness rate. The AIDS community has basically trashed it and said it's evil and people shouldn't take it and only cowards are "Truvada Whores."


It isn't 99.9% effective or anywhere near that. The claim stems from an analysis of the main study on the drug that found that effectiveness could be as high as 99% under the assumption of perfect compliance in combination with the use of condoms and counseling on safe sex practices. In real life, evidence shows that it reduces the rate of HIV infection by less than half (44% in the registration study). I'm not saying it isn't a good drug or that it shouldn't be available to high risk people, but claiming that just taking Truvada solves the AIDS problem is wildly irresponsible.
 
2014-07-21 07:04:10 PM  
This is the problem with science reporting. We're reading a story from the beginnings of some interesting research, and as usual the reporting guys ignore the fact that this is in the beginning stages. They're rushing ahead.

It's either panic or triumph boys and girls! !! The war is over WE'RE JUST NOT SURE WHO WON YET! Tune in next week to find out if we're all alive or all dead.

hardinparamedic: [phdcomics.com image 600x667]


In other words this.
 
2014-07-21 10:22:38 PM  

doglover: I want them to develop robotic immune system controlled by a field generator which can be implanted in the robotic liver that 130% more effective than a normal human liver but can be potted down when you want to get drunk for a few hours.Also, unicons with fart rainbows directly into your mouth when you're hungry.


Um if my liver is 130% more effective I'd never get drunk.  Fark that!
 
2014-07-21 10:23:46 PM  

doglover: somedude210: doglover: somedude210: and that kid hadn't been continuing to get treatment after she and her mother had left the hospital.

That's the goal.

Anything short of that isn't "free" but just remission.

right, but it may be that they need to continue the treatment a bit more beyond the kid getting the "all clear" just to be sure it stays dead

/"HIV Double Tap"

Screw that.

I want them to develop robotic immune system controlled by a field generator which can be implanted in the robotic liver that 130% more effective than a normal human liver but can be potted down when you want to get drunk for a few hours.

Also, unicons with fart rainbows directly into your mouth when you're hungry.


A Few hours isn't drunk.  That's Monday morning breakfast!
 
2014-07-21 10:49:29 PM  
www.quickmeme.com
 
2014-07-21 10:59:30 PM  

doomjesse: doglover: I want them to develop robotic immune system controlled by a field generator which can be implanted in the robotic liver that 130% more effective than a normal human liver but can be potted down when you want to get drunk for a few hours.Also, unicons with fart rainbows directly into your mouth when you're hungry.

Um if my liver is 130% more effective I'd never get drunk.  Fark that!


You say that now, but think of the new DUI laws.


Legal Limit for Auto-Livs: 0.3%

Even if whiskey was water, I don't think I'd want to try for 0.3%
 
2014-07-22 02:51:52 AM  

Gaddiel: btw, that 99.9% statistic is when it's used with condoms. When it's used alone, the effectiveness is closer to 60%


Citation needed.

I've read a different story - even when Truvada is not used in perfect accordance with guidelines (less regular), it's effectiveness is still around 90%.

Also, Tyrecten  or Tirecten  (don't remember which one is correct) is, apparently, a generic Truvada and probably a lot less expensive.
 
2014-07-22 09:12:41 AM  

neon_god: dr-shotgun: I can't wait for the AIDS prevention lobby to start telling us how this is a terrible thing and curing AIDS is bad.

Anyone hear about Truvada? A daily pill that essentially acts as an AIDS inoculation with a 99.9% effectiveness rate. The AIDS community has basically trashed it and said it's evil and people shouldn't take it and only cowards are "Truvada Whores."

It isn't 99.9% effective or anywhere near that. The claim stems from an analysis of the main study on the drug that found that effectiveness could be as high as 99% under the assumption of perfect compliance in combination with the use of condoms and counseling on safe sex practices. In real life, evidence shows that it reduces the rate of HIV infection by less than half (44% in the registration study). I'm not saying it isn't a good drug or that it shouldn't be available to high risk people, but claiming that just taking Truvada solves the AIDS problem is wildly irresponsible.


I'm guessing that the mathematical modeling that was used to get 99% effectiveness was an epidemiology study. It probably assumed vaccine-level use, increasing the herd immunity, which in turn results in a lot of people never getting exposed.

The obvious problems with this include the fairly high cost of inoculating the entire population with Truvada, and the potential deaths resulting from the side effects (which are >>>> more common than with most vaccines) if distributed that widely.

I think that the 99% figure is completely unrealistic.

/Yes, dizziness and nausea can kill, especially if we're talking about giving this drug out nationwide to anyone remotely at risk, including healthcare workers.
 
2014-07-22 07:34:30 PM  

Grahor: Citation needed.

I've read a different story - even when Truvada is not used in perfect accordance with guidelines (less regular), it's effectiveness is still around 90%.


Citation given. Use of the pill alone is only 44% effective, while a Cochrane Review found it 51% effective alone.

Truvada is not a generic medication in the United States. Washington State is the only one I'm aware of that will subsidize the 1600/month cost of the medication for those without insurance.
 
2014-07-22 07:36:31 PM  

draypresct: The obvious problems with this include the fairly high cost of inoculating the entire population with Truvada, and the potential deaths resulting from the side effects (which are >>>> more common than with most vaccines) if distributed that widely.


Truvada is not a vaccine. It's a combination anti-retroviral medication which prevents replication of the HIV virus. It has to be taken by mouth once every 24 hours as long as the person is participating in high risk behavior, continually, to be effective.

draypresct: I think that the 99% figure is completely unrealistic.


It is. Truvada is 99% effective ONLY when taken by an HIV - person who is also using condoms and is following the exact instructions of the drug.
 
2014-07-22 08:31:04 PM  

hardinparamedic: draypresct: The obvious problems with this include the fairly high cost of inoculating the entire population with Truvada, and the potential deaths resulting from the side effects (which are >>>> more common than with most vaccines) if distributed that widely.

Truvada is not a vaccine. It's a combination anti-retroviral medication which prevents replication of the HIV virus. It has to be taken by mouth once every 24 hours as long as the person is participating in high risk behavior, continually, to be effective.

draypresct: I think that the 99% figure is completely unrealistic.

It is. Truvada is 99% effective ONLY when taken by an HIV - person who is also using condoms and is following the exact instructions of the drug.


Sorry I wasn't clear. I wasn't trying to imply that Truvada was a vaccine. I was speculating that the 99% figure came from vaccine-esque herd immunity. Thanks for the clarification on how it's used, though.

I didn't see 99% in the reference you provided. Did I miss it? Or were you making the point that it's much less than 99% without condoms?

Since the condoms are >90% effective by themselves, it looks like Truvada probably helps, but it certainly does not replace condoms.
 
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