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(Science Daily)   Leukemia drug works, but still no cure for ... oh wait   (sciencedaily.com) divider line 36
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7243 clicks; posted to Main » on 12 Jun 2014 at 7:33 PM (11 weeks ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



36 Comments   (+0 »)
   
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2014-06-12 06:30:30 PM
I'll drink to that!

How awesome does your drug need to be that they stop the study and give it to all the patients?!

/Yes, I know that additional studies will be needed to test safety and and and and and.
/wow
 
2014-06-12 07:34:02 PM
And it will probably only cost $10,000 per dose!
 
2014-06-12 07:39:32 PM
FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.
 
2014-06-12 07:42:46 PM
A drug not invented in the US. Witchcraft!!!
 
2014-06-12 07:43:00 PM

namatad: I'll drink to that!

How awesome does your drug need to be that they stop the study and give it to all the patients?!

/Yes, I know that additional studies will be needed to test safety and and and and and.
/wow


Well, it depends.
If the patients are mice...
 
2014-06-12 07:43:22 PM

fusillade762: And it will probably only cost $10,000 per dose!


You can't take it with you.
 
2014-06-12 07:47:24 PM

jfarkinB: fusillade762: And it will probably only cost $10,000 per dose!

You can't take it with you.


Whole Lotta ^^^^^
 
2014-06-12 07:50:09 PM

rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.



i.telegraph.co.uk
eil.com
 
2014-06-12 07:53:49 PM

namatad: I'll drink to that!

How awesome does your drug need to be that they stop the study and give it to all the patients?!

/Yes, I know that additional studies will be needed to test safety and and and and and.
/wow


Seeing the hell that my buddy's niece has gone through with her leukemia treatments, this seems very promising. She is getting better, but watching the progress on her Facebook page has been heartbreaking. It's hard to watch a 10 year old go through that stuff.
 
2014-06-12 07:57:52 PM

Aaaaaaand ...


i1.ytimg.com


 The FDA bans it in the US.

 
2014-06-12 08:07:39 PM
I think this article is just an advertisement for another drug.      There have been many drugs used for over a decade that are known for specific T-cell activation on various cancer types.     Tested drugs.
 
2014-06-12 08:13:53 PM

rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.


Delta.
 
2014-06-12 08:18:48 PM
Read it carefully. It's not a cure, it's a treatment that makes cancer a chronic disease that requires lifelong treatment.
 
2014-06-12 08:23:35 PM

wildcardjack: Read it carefully. It's not a cure, it's a treatment that makes cancer a chronic disease that requires lifelong treatment.


Most cancer treatments are lifelong. The point is to make "lifelong" as long as possible. If you'd rather die in months than enrich eeeevil pharmaceutical companies for years, you're free to make that choice.
 
2014-06-12 08:28:08 PM

toadist: I think this article is just an advertisement for another drug.      There have been many drugs used for over a decade that are known for specific T-cell activation on various cancer types.     Tested drugs.


What the fark do you think clinical trials are?

And this drug treats multiple cancers, from leukemia to non-hematological cancers. Any research into cancer treatment/cures is a good thing.
 
2014-06-12 08:29:01 PM

wildcardjack: Read it carefully. It's not a cure, it's a treatment that makes cancer a chronic disease that requires lifelong treatment.


Read more carefully

The team's data further show that following p110δ inhibition, the immune system could develop an effective memory response to completely fight off the cancer.
 
2014-06-12 08:35:11 PM

fusillade762: And it will probably only cost $10,000 per dose!


Hey everybody, just inject yourselves with all your cash!
 
2014-06-12 08:43:00 PM

sporkme: rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.

Delta.


Well I'm not taking a drug made by that airline....
 
2014-06-12 08:49:26 PM

sporkme: rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.

Delta.


Yes?
 
2014-06-12 08:57:42 PM
Or.. you can down a shiaton of myo-inositol and quercetin...  but what do I know...I am not even a doctor.
 
2014-06-12 08:58:29 PM

aseras: Read more carefully


Read more carefully

There is no cure for cancer.  They can put it to rest.  But It USUALLY raises its ugly mother farking head again.

FTFY.
 
2014-06-12 09:00:49 PM
As someone who had AML in 1989 and spent more than a year in the hospital getting an autologous bone marrow transplant I must say that is really good news.
 
2014-06-12 09:04:07 PM
disclaimer: don't take this random guy's post on fark as medical advice.  seek the help of a physician.  learn to use pubmed. search for pi3k and you can figure out there are a number of natural inhibitors.  they probably mostly suck.. but maybe not.
 
2014-06-12 09:16:34 PM

ladodger34: namatad: I'll drink to that!

How awesome does your drug need to be that they stop the study and give it to all the patients?!

/Yes, I know that additional studies will be needed to test safety and and and and and.
/wow

Seeing the hell that my buddy's niece has gone through with her leukemia treatments, this seems very promising. She is getting better, but watching the progress on her Facebook page has been heartbreaking. It's hard to watch a 10 year old go through that stuff.


There's a reason I'm on the marrow donor list.

Currently a potential match for a 13 year old girl, waiting to hear back-
 
2014-06-12 09:20:10 PM

SpdrJay: sporkme: rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.

Delta.

Well I'm not taking a drug made by that airline....


Maybe they could lose your cancer like they lose your luggage.
 
2014-06-12 09:27:20 PM

fusillade762: And it will probably only cost $10,000 per dose!


So what?

A day in the ICU is more than $1000.

A year of dialysis is $50,000.
 
2014-06-12 10:04:43 PM

lake_huron: fusillade762: And it will probably only cost $10,000 per dose!

So what?

A day in the ICU is more than $1000.

A year of dialysis is $50,000.


One dose of stelara is $7000 and that's only for psoriasis. I get 4 per year. thankfully insurance covers it.
 
2014-06-12 10:07:47 PM

sporkme: rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.

Delta.


I thought Delta was a triangle.   Like the Greek letter.
 
2014-06-12 10:18:32 PM

Billy Liar: sporkme: rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.

Delta.

I thought Delta was a triangle.   Like the Greek letter.


δ is lowercase. Δ is uppercase. Both are used in calculus. The lowercase is used in sigma-delta notation. I don't know its significance in genomics or medicine.
 
2014-06-12 11:43:13 PM

rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.


It's the lower-case symbol for delta. The compounds are p110delta inhibitors.
 
2014-06-12 11:56:19 PM

rkiller1: FTA: "The drugs, called p110δ inhibitors"

I dunno what the funky symbol is, but I sure the hell ain't taking it orally.


Your choice, bend over and try to keep loose.
 
2014-06-13 12:48:01 AM
My mom's doctors might be interested (or maybe even involved, I have no idea).  Dacogen is preventing her MPN from converting into leukemia after the Pegasys Interferon stopped working (that was a bit of a shocker to the docs when that happened).

Clicking around elsewhere there lead me to another interesting article about Swedish researchers finding conclusive evidence for the existence of cancer stem cells when studying a group of patients with myelodysplastic syndromes:

http://www.sciencedaily.com/releases/2014/05/140515123303.htm
 
2014-06-13 02:25:42 AM
FTFA: A class of drug currently being used to treat leukemia has the unexpected side-effect of boosting immune responses against many different cancers, reports a new study

That's one hell of a side effect.

Sam:  Hey Jim, you're looking better.  No limp today.  How's the arthritis?
Jim:  It's great!  My doctor proscribed me a new painkiller and it's working like a charm.
Sam:  I'm glad to hear that.
Jim:  Yeah, it's good to finally be able to walk without pain.  Also, it gave me the power of flight.
Sam: Well, I have to be getting back to...wait, what?
 
2014-06-13 09:23:04 AM

aseras: wildcardjack: Read it carefully. It's not a cure, it's a treatment that makes cancer a chronic disease that requires lifelong treatment.

Read more carefully

The team's data further show that following p110δ inhibition, the immune system could develop an effective memory response to completely fight off the cancer.


That  was the part that stuck out to me when reading the article: that there could be such persistent effect resulting from the initial treatment/use.
 
2014-06-13 09:35:13 AM

fusillade762: And it will probably only cost $10,000 per dose!


I have no idea if this is the same type of medicine they're talking about or not, but my dog has been taking a medicine called Hydroxyurea for leukemia. 60 pills, which lasts 40 days under her current dosage, costs me $56 when I buy it online.
 
2014-06-13 10:06:22 AM
Good news. I lost a really great friend to cancer last year, I hope this can save people.
 
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