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(Science Daily)   Hepatitis C treatment cures over 90 percent of patients with cirrhosis. Still no cure for Pamela Anderson   (sciencedaily.com) divider line 54
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5102 clicks; posted to Main » on 12 Apr 2014 at 11:07 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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NFA [TotalFark]
2014-04-12 07:42:25 PM  
I worked with someone who committed suicide because they had Hep C.
 
2014-04-12 07:59:08 PM  
Isn't that the same treatment that costs $20-30k?  Seems obvious the company that makes it would find a more marketable condition to use it on.
 
2014-04-12 08:59:39 PM  
I know 2 people that got this treatment. 1 died of liver cancer after treatment, the other got cirrhosis and died. The good news is they had good insurance and didn't leave spouses too far in debt.
 
2014-04-12 11:11:29 PM  
So they finally came out with a cure for something after decades, well good, I guess they couldn't make it a "permanent treatment" like they usually do.
 
2014-04-12 11:12:41 PM  
It doesn't cure cirrhosis, it reduces the HepC count to zero.  You'll still need to deal with the liver damage.
 
2014-04-12 11:13:14 PM  

pippi longstocking: So they finally came out with a cure for something after decades, well good, I guess they couldn't make it a "permanent treatment" like they usually do.


The millions of people who have survived because of antibiotics would like to have a word with you.

And the hundreds of thousands of people alive today because of thrombolytics.
 
2014-04-12 11:16:52 PM  
img2.wikia.nocookie.net

/I think they're just good guys."
 
2014-04-12 11:18:41 PM  

hardinparamedic: pippi longstocking: So they finally came out with a cure for something after decades, well good, I guess they couldn't make it a "permanent treatment" like they usually do.

The millions of people who have survived because of antibiotics would like to have a word with you.

And the hundreds of thousands of people alive today because of thrombolytics.


And when were these marvels invented? I have no idea if you lack reading comprehension or don't know what a decade is.
 
2014-04-12 11:19:11 PM  
There is a flavonoid in Milk Thistle called silymarin, that may help repair the cirrhosis somewhat.  It shows a lot of potential for both protecting the liver and encouraging repair faster than normal.

University of Maryland Medical Center
 
2014-04-12 11:22:49 PM  
2.bp.blogspot.com
Still no cure for diseased ridden c*cks!
 
2014-04-12 11:23:12 PM  

pippi longstocking: And when were these marvels invented? I have no idea if you lack reading comprehension or don't know what a decade is.


Well, if you mean "Decade', you really shouldn't write "decades"

Which antibiotic would you like to pick? They've been out in some form since the early 1900s. New ones are developed every year.

Streptokinase was first used in 1960.

Cure versus treatment to manage is a pretty complex thing you're talking about. Some diseases are incapable of being cured. For some, the best cure that can be managed is to mitigate or treat the symptoms of a disease.
 
2014-04-12 11:28:35 PM  

Lsherm: It doesn't cure cirrhosis, it reduces the HepC count to zero.  You'll still need to deal with the liver damage.


So, can I keep drinking?

Been working on a scientific study of just how much my liver can take.
 
2014-04-12 11:33:28 PM  
 
2014-04-12 11:34:10 PM  
I'm glad there is this option.  My understanding is that Hep C is something that might not show up until well after someone gets it.  This is especially true as the boomers get older.

But the complaint: the treatment is about $1k per dose, averaging about $84k for the cure.  The company that makes the drug certainly has every right to price the drug, but at that rate it's cheaper to move to Egypt for treatment since the drug costs are based in part on the wealth of the country.  IIRC this particular drug is ten cents on the dollar in Egypt.
 
2014-04-12 11:35:15 PM  

gfid: Lsherm: It doesn't cure cirrhosis, it reduces the HepC count to zero.  You'll still need to deal with the liver damage.

So, can I keep drinking?

Been working on a scientific study of just how much my liver can take.


Diagnosed with cirrhosis 4 years ago at 34 years old. Some livers can take more some can take less.
Cirrhosis sucks donkey balls.
 
2014-04-12 11:37:07 PM  

Badafuco: gfid: Lsherm: It doesn't cure cirrhosis, it reduces the HepC count to zero.  You'll still need to deal with the liver damage.

So, can I keep drinking?

Been working on a scientific study of just how much my liver can take.

Diagnosed with cirrhosis 4 years ago at 34 years old. Some livers can take more some can take less.
Cirrhosis sucks donkey balls.


That's brutal. Good wishes to you.
 
2014-04-12 11:39:31 PM  
This is an amazing leap forward in treating Hepatitis C.  Not sure why the knee-jerk reaction of the first dozen posts is to pile scorn on a therapy that has over 90% success rate, especially as current treatment works less than half of the time and is poorly tolerated with many side effects.
 
2014-04-12 11:41:42 PM  

NFA: I worked with someone who committed suicide because they had Hep C.


Me too.
 
2014-04-12 11:45:41 PM  
stigofthedump.files.wordpress.com

I would have given her some time with my tool.

Now, not so much. Even without hepatitis.
 
2014-04-12 11:45:47 PM  

AcademGreen: I'm glad there is this option.  My understanding is that Hep C is something that might not show up until well after someone gets it.  This is especially true as the boomers get older.

But the complaint: the treatment is about $1k per dose, averaging about $84k for the cure.  The company that makes the drug certainly has every right to price the drug, but at that rate it's cheaper to move to Egypt for treatment since the drug costs are based in part on the wealth of the country.  IIRC this particular drug is ten cents on the dollar in Egypt.


Nobody but medicare pays $1k. Its a stupid msrp that sane insurances negotiate down
 
2014-04-12 11:47:20 PM  

Badafuco: gfid: Lsherm: It doesn't cure cirrhosis, it reduces the HepC count to zero.  You'll still need to deal with the liver damage.

So, can I keep drinking?

Been working on a scientific study of just how much my liver can take.

Diagnosed with cirrhosis 4 years ago at 34 years old. Some livers can take more some can take less.
Cirrhosis sucks donkey balls.


Damn.  Can't they give part of someone else's liver to you?  That's my backup plan because I have a twin brother.
 
2014-04-12 11:48:21 PM  
My sister went through Interferon, and it did drop her Hep-C counts to zero, and they're still zero.  But she got Hep-C
  when her liver was already in rough shape from a 30-year booze and valium addiction.  But since she
  "cleaned up", her liver, despite being cirrhotic (is that a word?) is functioning remarkably well--the doctors
  are quite astonished.  She has only-yearly liver and kidney tests these days to make sure things haven't
  turned into cancer.

She says the Interferon was horrible, and wishes they'd had this stuff back when she was going through
  Interferon treatment.
 
2014-04-12 11:49:26 PM  

Badafuco: gfid: Lsherm: It doesn't cure cirrhosis, it reduces the HepC count to zero.  You'll still need to deal with the liver damage.

So, can I keep drinking?

Been working on a scientific study of just how much my liver can take.

Diagnosed with cirrhosis 4 years ago at 34 years old. Some livers can take more some can take less.
Cirrhosis sucks donkey balls.


Sorry to hear that.  I've quit drinking a few times.  Nothing good has ever come of it, but I keep doing it anyway.
 
2014-04-12 11:58:13 PM  
Maybe something to do with elevated enzymes over time, or chicken v. egg, but most people I know with hep C aren't totally with it upstairs. Not judging. It's a helluva disease.
 
2014-04-12 11:59:16 PM  
90+% farking cure rate on a previously nearly-untreatable condition, and we still get the numbfarks spewing "durr drug companies don't want cures, they just want to keep taking your money".

Hey, guys, milk thistle is still free! Don't let us stop you from making your informed choice.
 
2014-04-13 12:00:57 AM  
gross. don't stick it in dirty pussy.
 
2014-04-13 12:12:21 AM  
Hep C treatment kills people with cirrhosis, so I guess it does cure them... technically.
 
2014-04-13 12:12:49 AM  

jfarkinB: Hey, guys, milk thistle is still free! Don't let us stop you from making your informed choice


Silmarin has actually shown some incredible efficacy in reducing or preventing damage after ingestion of hepatotoxic medications and plants. The problem is that this is anecdotal, and that it has to be compounded by a pharmacy that carries it.
 
2014-04-13 12:18:41 AM  

hardinparamedic: jfarkinB: Hey, guys, milk thistle is still free! Don't let us stop you from making your informed choice

Silmarin has actually shown some incredible efficacy in reducing or preventing damage after ingestion of hepatotoxic medications and plants. The problem is that this is anecdotal, and that it has to be compounded by a pharmacy that carries it.


Dude, I've had 2 blood tests in the lasts 12 weeks. Both showed massively elevated liver enzymes and I'm terrified. I think it may be due to the high fat / moderate protein / super low carb diet I was on (and lost 60 lbs in 4 months.) I'm on edge. My doctor is being cool about it, but I don't think he's being straight. What do you think?
 
2014-04-13 12:19:53 AM  
Starting the other recent "new" treatment in a few weeks, it's a few years old.  I'm 42 and survived having type B in 1994. My treatment consists of Interferon, the "new" part of my treatment is the addition of a protein that is supposed to help stop the liver from being damaged further from the Interferon on top of whatever damage there already is.  Some people can live with it for years or even their entire life and not even know they have it.

Hep B sucked, back then they just put me on bed rest and let it run it's course.

I've also been Lymphoma free for two years now.  A few rounds of radiation and Interferon and I got lucky and knocked it out.

My hips degenerated from the booze and the radiation and I've had both replaced and now I am arthritis's biatch.

Interferon treatment farking sucks a LOT and having this Hep C sucks so bad that I am looking forward to it.  Today for instance, I had a PB&J and a Ensure protein shake and ended up vomiting for two hours until I literately passed out.  Now I am up and feeling a lot better.  The best way I can explain it is that on a good day, I feel like I have the worst flu ever times two with a hangover on top and on a bad day multiply by ten.

This is a new wonder pill for Hep C but $900 a pill is bullshiat. Even at $90 a pill, there will be a Hep C pandemic; even if they could get this pill out for free it's spread too far some third world countries.
 
2014-04-13 12:21:00 AM  
According to Jerry Stahl, the side effects are similar to taking LSD.
 
2014-04-13 12:24:35 AM  

ginkor: There is a flavonoid in Milk Thistle called silymarin, that may help repair the cirrhosis somewhat.  It shows a lot of potential for both protecting the liver and encouraging repair faster than normal.

University of Maryland Medical Center


I always take one capsule of that before and after I drink, and then set days during the week.
 
2014-04-13 12:30:17 AM  

WhoopAssWayne: hardinparamedic: jfarkinB: Hey, guys, milk thistle is still free! Don't let us stop you from making your informed choice

Silmarin has actually shown some incredible efficacy in reducing or preventing damage after ingestion of hepatotoxic medications and plants. The problem is that this is anecdotal, and that it has to be compounded by a pharmacy that carries it.

Dude, I've had 2 blood tests in the lasts 12 weeks. Both showed massively elevated liver enzymes and I'm terrified. I think it may be due to the high fat / moderate protein / super low carb diet I was on (and lost 60 lbs in 4 months.) I'm on edge. My doctor is being cool about it, but I don't think he's being straight. What do you think?


Possibly non-alcoholic fatty liver?

http://www.liverfoundation.org/abouttheliver/info/nafld/
"NAFLD tends to develop in people who are overweight or obese or have diabetes, high cholesterol or high triglycerides. Rapid weight loss and poor eating habits also may lead to NAFLD. "

If it is diagnosed early enough, it is reversible.
 
2014-04-13 12:33:08 AM  

WhoopAssWayne: Dude, I've had 2 blood tests in the lasts 12 weeks. Both showed massively elevated liver enzymes and I'm terrified. I think it may be due to the high fat / moderate protein / super low carb diet I was on (and lost 60 lbs in 4 months.) I'm on edge. My doctor is being cool about it, but I don't think he's being straight. What do you think


Do you have a way to get in to see a gastroenterology doctor? It all depends on the pattern of elevation, as well as your total physical, and diet can affect it. Also, certain kinds of medications metabolized by the liver, and even alcohol use can elevate it. ALT can indicate liver damage, but is looked at with other labs, such as Creatine Phosphokinase and Alkaline Phosphate, and AST can actually be caused by multiple things.

If you're concerned, I'd encourage you to get a referral to a GI Specialist or an actual Hepatologist at a GI practice for a second opinion.
 
2014-04-13 12:38:23 AM  

Alicious: If it is diagnosed early enough, it is reversible.


Yes, I'm hoping it was just some transitory thing with the diet I was on. But look, I have 2-3 stiff drinks a night - have for years. After reading up on this - these two enzymes they check - it could be 1) short term and mean nothing, 2) medium term, change your diet, or 3) Indicating permanent, irreversible liver damage. Those stiff drinks.... I've had my share.
 
2014-04-13 12:41:51 AM  

WhoopAssWayne: Yes, I'm hoping it was just some transitory thing with the diet I was on. But look, I have 2-3 stiff drinks a night - have for years. After reading up on this - these two enzymes they check - it could be 1) short term and mean nothing, 2) medium term, change your diet, or 3) Indicating permanent, irreversible liver damage. Those stiff drinks.... I've had my share.


Get you an appointment with a GI doctor, and see if they'll look at your lab tests and give you guidance on it. Unfortunately, the two enzymes they check alone aren't enough to rule in or out a specific condition, they're looked at with other labs and your overall physical health and assessment findings.

Eating a high protein diet, for example, with low carb intake can cause elevations in both. But it's important to rule out other factors to be sure of that.
 
2014-04-13 12:51:41 AM  

Iczer: /I think they're just good guys."


Leaving satisfied.

Wubba wubba dub dubs.
 
2014-04-13 12:53:08 AM  

hardinparamedic: Get you an appointment with a GI doctor


ALT and AST are at 4 to 5 times the multiple of the average. Thank you so much for the advice. This is exactly what my doctor said. If the next blood test comes back with liver enzymes high, he is going to give me a referral to a GI, and I am going to go, Maybe it's my diet, maybe it's the alcohol, I don't know. After reading up on ALT/AST - how it can be super short term OR be an indicator of permanent damage - I'm just freaked out right now.
 
2014-04-13 12:55:47 AM  

WhoopAssWayne: After reading up on ALT/AST - how it can be super short term OR be an indicator of permanent damage - I'm just freaked out right now.


Don't be. One of our doctors has a saying: Could be something, could be nothing. Unless you're turning yellow, having severe pain over your right upper quadrant of your abdomen, find your belly is swelling and feels like a waterbed, or are vomiting up blood - I would't necessarily get freaked out and panic. Just get your follow up done, and go from there, WAW.

WebMD can convice you that you have ebola and cancer at the same time.
 
2014-04-13 01:00:47 AM  

hardinparamedic: WebMD can convice you that you have ebola and cancer at the same time.


LoL - Yeah, I convinced my wife not look anything up because if she did, she'd always have it. Her ENT agreed.

hardinparamedic: having severe pain over your right upper quadrant of your abdomen


I have. When I stopped drinking tequila shots it went away.
 
2014-04-13 01:15:40 AM  

WhoopAssWayne: Alicious: If it is diagnosed early enough, it is reversible.

Yes, I'm hoping it was just some transitory thing with the diet I was on. But look, I have 2-3 stiff drinks a night - have for years. After reading up on this - these two enzymes they check - it could be 1) short term and mean nothing, 2) medium term, change your diet, or 3) Indicating permanent, irreversible liver damage. Those stiff drinks.... I've had my share.


I wouldn't stress too much over it. See the GI specialist that your doctor recommends and go from there.
Both my mom and I have NAFLD. It can run in families as well. My mom is tiny and literally can nurse a can of beer for a week (She uses aluminum foil to stuff in the opening of the can and uses a small juice glass for her beer). The doctors kept telling her she had to cut down on her alcohol consumption. We both had a huge laugh at that advice.

I am not tiny and I am diabetic so diet and exercise has been the way for me so far. I also have had periods of time where I was on heavy duty anti-inflammatory medications. I've had elevated liver enzymes for over a decade and no signs of liver damage so far.
 
2014-04-13 01:16:24 AM  

JoieD'Zen: I know 2 people that got this treatment. 1 died of liver cancer after treatment, the other got cirrhosis and died. The good news is they had good insurance and didn't leave spouses too far in debt.


Are you sure it was the same drug? This one is only in the study phase, and was only given to people who already had cirrhosis.
 
2014-04-13 01:18:25 AM  

hardinparamedic: WebMD can convice you that you have ebola and cancer at the same time.


But what if I really do have ebola and cancer at the same time?

I guess the ebola would kill me first, so I wouldn't have to worry too much about the cancer, so I would have that going for me.

The last symptom I researched on the internet turned out to have about 1000 or so possible causes, some serious, some not so serious.

This is why I take anything I read on the internet with a healthy dose of salt.  Well, I also read on the interwebs that too much salt can be bad for you, so I took an extra dose when I read that.

I think I'm going to die.  Eventually.
 
2014-04-13 01:21:25 AM  

Ambivalence: Isn't that the same treatment that costs $20-30k?  Seems obvious the company that makes it would find a more marketable condition to use it on.


It costs a thousand dollars a day, and it lasts for weeks.  A lot of people with the disease are not getting treated, because the insurance companies are waiting for them to be near organ failure before approving the treatment.  Probably in the hopes that as many patients die as possible, before receiving the expensive treatment.
 
2014-04-13 01:24:33 AM  

WhoopAssWayne: ALT and AST are at 4 to 5 times the multiple of the average. Thank you so much for the advice. This is exactly what my doctor said. If the next blood test comes back with liver enzymes high, he is going to give me a referral to a GI, and I am going to go, Maybe it's my diet, maybe it's the alcohol, I don't know. After reading up on ALT/AST - how it can be super short term OR be an indicator of permanent damage - I'm just freaked out right now.


It may be a good idea to ask for that GI referral anyway.  I did a stint in rehab after a six year period of hard boozing where I all but blew my liver out. After getting off the sauce and undergoing treatment, I went from edge-of-death to transplant candidate to more-than-likely ok in the course of a year. My treatment regimen is nowhere near as expensive as this one, though I have one drug that costs $1300 for a thirty day supply. I've been fortunate to have good health insurance. If you think you might have the slightest problem with the bottle, seek out help before it's too late.
 
2014-04-13 01:29:21 AM  

Alicious: My mom is tiny and literally can nurse a can of beer for a week (She uses aluminum foil to stuff in the opening of the can and uses a small juice glass for her beer)


LoL - she must be a total sweet heart! Good for her.
 
2014-04-13 02:14:32 AM  

Some Coke Drinking Guy: Ambivalence: Isn't that the same treatment that costs $20-30k?  Seems obvious the company that makes it would find a more marketable condition to use it on.

It costs a thousand dollars a day, and it lasts for weeks.  A lot of people with the disease are not getting treated, because the insurance companies are waiting for them to be near organ failure before approving the treatment.  Probably in the hopes that as many patients die as possible, before receiving the expensive treatment.


The people who are waiting for the already approved and available drugs are on the liver transplant list. Right now that seems to be the requirement for some insurance companies to authorize paying for it.
 
2014-04-13 02:17:05 AM  

lindalouwho: Some Coke Drinking Guy: Ambivalence: Isn't that the same treatment that costs $20-30k?  Seems obvious the company that makes it would find a more marketable condition to use it on.

It costs a thousand dollars a day, and it lasts for weeks.  A lot of people with the disease are not getting treated, because the insurance companies are waiting for them to be near organ failure before approving the treatment.  Probably in the hopes that as many patients die as possible, before receiving the expensive treatment.

The people who are waiting for the already approved and available drugs are on the liver transplant list. Right now that seems to be the requirement for some insurance companies to authorize paying for it.


Whoops...I mean the only people who currently might be approved by insurance are those on the list.

/past my bedtime
 
2014-04-13 02:41:03 AM  

dramatools: If you think you might have the slightest problem with the bottle


If you are still there, please respond.
 
2014-04-13 02:43:57 AM  
Hepatitis C treatment cures over 90 percent of patients with cirrhosis

Lsherm: It doesn't cure cirrhosis, it reduces the HepC count to zero.  You'll still need to deal with the liver damage.


Yeah, somebody wrote that headline a little off.
It reads like "Hey, guess what? It turns out this HepC treatment does wonders on patients with cirrhosis."
The I read the article.
 
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