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(YLE (Finland))   Finnish team discovers virus that causes Type 1 diabetes, announce progress toward a vaccine. Too stunned and happy to even attempt snark   (yle.fi) divider line 125
    More: Cool, Finnish, diabetes, vaccines, clinical trials, polio  
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9444 clicks; posted to Main » on 22 Oct 2013 at 1:33 PM (25 weeks ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2013-10-22 05:00:06 PM

cretinbob: jst3p: If I were a betting man I would wager he didn't know that.

and you'd lose


I'm not saying it's a bad thing, and isn't going to help any one. But it will only benefit some people out of all those who will end up getting it. The vast majority of those who end up being innoculated will be just handing over their money to Big Pharma.
I'm also not an anti-vaccine nutjob.
Tetanus shots are great, Chicken Pox vaccine is about paretal convenience.


Gaah. MATH. Do the MATH. Autocorrect!
 
2013-10-22 05:00:14 PM
Wow, you guys have perfected the art of being mean as hell...I stand in awe of you. It's GOOD news, people, what the hell are you fighting about?
 
2013-10-22 05:08:38 PM

Loreweaver: shaddix: Type 1 CAN be caused by a virus, but that isn't the only cause. This will help some, but not the majority. The majority of people with type 1 DM have some environmental factor other than a virus that causes it. This is evidenced by the fact that identical twins do not always both get it. It's split about 50/50 if an identical twin gets Type 1 or not if the other sibling has it.

Methinks you don't understand that the presence of a virus has nothing to do with genetics. As in, just because they are genetically identical does NOT mean they will both have the virus in their systems.


Put simply, per my endocrinologist - genetic disposition, environmental trigger.
 
2013-10-22 05:12:11 PM

snocone: roadkillontheweb: As long as Lilly doesn't step in and shut it down.
They are making a killing manufacturing and selling insulin and I doubt they will look kindly on loosing that income.

They are safe, Plenty of current patients in pipeline. But, it would be nice to shut down a lot of future PROFIT FROM HUMAN SUFFERING.


You people should go back to your conspiracy theory wack-a-doo websites.

If this vaccine/stopping this virus is the answer then whoever created this will be in the making vaccines for kids game forever (heaven forbid they profit from time and money they spent curing diabetes, what terrible humans). And Eli Lilly will still be making insulin for people that currently have diabetes and for fat people.
 
2013-10-22 05:18:23 PM

cretinbob: Chicken Pox vaccine is about paretal convenience.



WTF, no it's not. As someone that got chicken pox in early adulthood, I WISH the vaccine had been around when I was a kid, it sucked balls. Plus I now have the chance of getting shingles in my later life. So F off.

If you're a parent and don't want to prevent your child from getting a virus that can cause them and others they spread it to harm later in life you should just have an abortion an save us from your future typhoid mary.

what the hell is wrong with people in this thread.
 
2013-10-22 05:51:40 PM
Is it the sole cause of type1? My GED in biology says no.
 
2013-10-22 06:13:05 PM

Government Fromage: soakitincider: as a type 1 diabetic it's good to see that a vaccine is being worked on, but for those of us that actually have it, we need a solution as well.

This.

/in the same boat


This.

/on a MM723
 
2013-10-22 06:55:15 PM

Felgraf: /Also the physicsts that go "OH, you do something other than physics. Or science. CLEARLY YOU ARE A LESSER HUMAN" suck and are assholes


This may be urban legend, but I heard once that Richard Feynman felt that if he knew DNA would be discovered and revolutionize biology, he would have become a molecular biologist.
 
2013-10-22 07:02:30 PM

pedobearapproved: cretinbob: Chicken Pox vaccine is about paretal convenience.


WTF, no it's not. As someone that got chicken pox in early adulthood, I WISH the vaccine had been around when I was a kid, it sucked balls. Plus I now have the chance of getting shingles in my later life. So F off.

If you're a parent and don't want to prevent your child from getting a virus that can cause them and others they spread it to harm later in life you should just have an abortion an save us from your future typhoid mary.

what the hell is wrong with people in this thread.



Well said.

I've had shingles, and it is not fun. I second that F off.
 
2013-10-22 08:11:36 PM
So my understanding of this may be a bit flawed, but if Type 1 is caused by a virus would we not see more instances of multiple members in a family getting it at the same time? Let's use my family as an example. My nephew was diagnosed with Type 1 at age 4, roughly 7 years later I also was diagnosed as a Type 1 at age 21. Finally my mother was 10 years later. (Her case was fairly odd, she got it in her 60's,) Pretty big gap there.

My family has some strange susceptibility to auto immune diseases. That makes 3 type 1's, 1 Lupus Nephritis and 2 with Celiac.
 
2013-10-22 08:38:38 PM

cretinbob: jst3p: If I were a betting man I would wager he didn't know that.

and you'd lose


I'm not saying it's a bad thing, and isn't going to help any one. But it will only benefit some people out of all those who will end up getting it. The vast majority of those who end up being innoculated will be just handing over their money to Big Pharma.
I'm also not an anti-vaccine nutjob.
Tetanus shots are great, Chicken Pox vaccine is about paretal convenience.


Chicken pox vaccine early on may help stave off shingles when older.
 
2013-10-22 09:45:24 PM

ko_kyi: This may be urban legend, but I heard once that Richard Feynman felt that if he knew DNA would be discovered and revolutionize biology, he would have become a molecular biologist.


Might be apocryphal, but Feynman was definitely one of the physicists that didn't look down on people for NOT doing physics. And was very patient (and, indeed, eager) to try and explain physics stuff to non-physicists.

I also know he didn't like organizations that prided themselves on exclusivity/how much BETTER they were than  everyone else. (He wrote a.. really, REALLY scathing letter to MENSA after they asked him to join.)
 
2013-10-22 09:47:02 PM

ginandbacon: I have a paternal aunt with type I so I have been following these stories for decades and I feel like nothing ever gets past trials in mice. But hope springs eternal so I'll keep hoping.



The best laid plans of Mice and Men usually work out about equal.
 
2013-10-22 10:04:18 PM

TheShavingofOccam123: what_now: Diabeetus is caused by a virus? I would never have thought that.

Which is why I work in finance, not science.

I had a friend who was certain she got the diabeetus after a few days of fever, loss of appetite, feeling rundown. She was active, not overweight, didn't have a terrible diet.

One of her nephews she hung around a lot in his youth also developed it after a few days of fever, loss of appetite, feeling rundown and at around the same age as she did. Maybe there's some dormancy with the virus. Who knows. but evidently she was correct. And btw they're Nordic stock. Doo dooddley doo doo.


My old pet cat came down with type 1 diabetes after a case of pancreatitis.  Definitely an infection of some kind.
 
2013-10-22 10:08:15 PM
When an intruder invades your body-like a cold virus or bacteria on a thorn that pricks your skin-your immune system protects you. It tries to identify, kill and eliminate the invaders that might hurt you. But sometimes problems with your immune system cause it to mistake your body's own healthy cells as invaders and then repeatedly attacks them. This is called an autoimmune disease. ("Autoimmune" means immunity against the self.)

http://www.niams.nih.gov/Health_Info/Autoimmune/#2


The list of diseases that fall into the autoimmune category includes
alopecia areata
autoimmune hemolytic anemia
autoimmune hepatitis
dermatomyositis
diabetes (type 1)
some forms of juvenile idiopathic arthritis
glomerulonephritis
Graves' disease
Guillain-Barré syndrome
idiopathic thrombocytopenic purpura
myasthenia gravis
some forms of myocarditis
multiple sclerosis
pemphigus/pemphigoid
pernicious anemia
polyarteritis nodosa
polymyositis
primary biliary cirrhosis
psoriasis
rheumatoid arthritis
scleroderma/systemic sclerosis
Sjögren's syndrome
systemic lupus erythematosus
some forms of thyroiditis
some forms of uveitis
vitiligo
granulomatosis with polyangiitis (Wegener's)

Don't catch a virus, if you can help it.
 
2013-10-22 11:08:31 PM
The US will be near last at a working drug fighting it tooth and nail... because of what it would do to their pocketbooks.
 
2013-10-23 01:19:15 AM

BKITU: what_now: Diabeetus is caused by a virus? I would never have thought that.

Which is why I work in finance, not science.

Insulin-dependent-because-your-pancreas-is-broken-diabeetus, not stop-ingesting-six-donuts-and-two-liters-of-soda-every-day-you-farking -moron-diabeetus.


Exactly. This is the more rare type of diabetes that usually little kids/very young people get "just because fark you that's why" no matter what they do. Not the kind of diabetes old people/pigs worfing whole bags of doritos and a few gallons of mtn dew a day get.

So they're curing the kind that actually deserves a cure.
 
2013-10-23 03:00:12 AM

jeffdo1: So my understanding of this may be a bit flawed, but if Type 1 is caused by a virus would we not see more instances of multiple members in a family getting it at the same time? Let's use my family as an example. My nephew was diagnosed with Type 1 at age 4, roughly 7 years later I also was diagnosed as a Type 1 at age 21. Finally my mother was 10 years later. (Her case was fairly odd, she got it in her 60's,) Pretty big gap there.

My family has some strange susceptibility to auto immune diseases. That makes 3 type 1's, 1 Lupus Nephritis and 2 with Celiac.



Please allow me to turn your misunderstanding on its head.  The scenario your family experienced fits perfectly into the notion of viral induced disease.  You've established a genetic susceptibility to auto-immune disease.  Since the virus is not transmissible from person to person, it is essentially a random environmental exposure that leads to infection.  Most exposures do not lead to infection.  In the case of your family, most exposures still might not lead to infection, but any given exposure is more likely to lead to an infection for your family, than it is for an average individual.

So the individuals within your family contract the disease at random points in their lives, including in the case of your Mother, at a time way outside the bell curve.  They were exposed every so often, and it was only a matter of time until the exposure lead to an infection that caused diabetes.

In most families, the susceptibility to auto-immune disease does not exist, so the likelihood of contracting the disease, even if exposed to the virus, is far less.  It is rare enough that during the typical family life cycle, only a single individual might have an infection that leads to diabetes.  This is more typical of the pattern of appearance of the disease.

Your family might be an interesting case study in looking for a genetic link to auto-immune susceptibility.
 
2013-10-23 03:41:25 AM
Hate to be the bearer of bad news but it will not pass trials. Big Pharma doesn't make money curing diseases, they make it by treating them. There is too much money in Diabetes to cure it.
 
2013-10-23 04:27:15 AM
Terrible Old Man:

Exactly. This is the more rare type of diabetes that usually little kids/very young people get "just because fark you that's why" no matter what they do. Not the kind of diabetes old people/pigs worfing whole bags of doritos and a few gallons of mtn dew a day get.

So they're curing the kind that actually deserves a cure.


As a T1 diabetic, I am usually a diabetes snob, but there are plenty of Type 2 diabetics who didn't bring it on themselves, either. Not all Type 2 diabetes is lifestyle-related (but a lot of it is, and the current epidemic of T2 diabetes definitely is).
 
2013-10-23 10:22:35 AM

Sofa King Smart: Banned on the Run: soakitincider: as a type 1 diabetic it's good to see that a vaccine is being worked on, but for those of us that actually have it, we need a solution as well.

Until we figure out how to unring a bell, you're hosed :(

not true... if you know what caused the loss of islet cells (virus or immune response).. if it was actually the virus killing the insulin producing islet cells... you can get more of those (the problem in the past was that whatever was in the system that killed them in the first place would also kill any new ones)... but if it was the virus that was attacking islet cells... and they can produce a vaccine... then add back in some new functioning islet cells...  maybe?  something?

btw the wiki on the enterovirus is kind of frightening.


Yep.  The "flaccid paralysis" sublink sounds like an embarrassing sexual thing, but a cousin of mine over in England had something like that...he was basically bedridden for ten years.  And lucky to have survived it, at that.
 
2013-10-23 10:23:49 AM

arkansized: cretinbob: jst3p: If I were a betting man I would wager he didn't know that.

and you'd lose


I'm not saying it's a bad thing, and isn't going to help any one. But it will only benefit some people out of all those who will end up getting it. The vast majority of those who end up being innoculated will be just handing over their money to Big Pharma.
I'm also not an anti-vaccine nutjob.
Tetanus shots are great, Chicken Pox vaccine is about paretal convenience.

Chicken pox vaccine early on may help stave off shingles when older.


Yeah, but vinyl siding is just plain ugly...
 
2013-10-23 11:02:39 AM
Oh and the friend who believes she developed Type 1 diabetes from a viral infection is currently dying of Cadasil Syndrome--she's terminal with only family visitation now.

So, virus--Type 1--Cadasil.

/When do I get my Nobel Prize in Medicine
 
2013-10-23 03:36:08 PM

Odin's Other Eye: Terrible Old Man:

Exactly. This is the more rare type of diabetes that usually little kids/very young people get "just because fark you that's why" no matter what they do. Not the kind of diabetes old people/pigs worfing whole bags of doritos and a few gallons of mtn dew a day get.

So they're curing the kind that actually deserves a cure.

As a T1 diabetic, I am usually a diabetes snob, but there are plenty of Type 2 diabetics who didn't bring it on themselves, either. Not all Type 2 diabetes is lifestyle-related (but a lot of it is, and the current epidemic of T2 diabetes definitely is).


Psst, word: "Diet soda"
 
2013-10-23 05:39:15 PM

snocone: Odin's Other Eye: Terrible Old Man:

Exactly. This is the more rare type of diabetes that usually little kids/very young people get "just because fark you that's why" no matter what they do. Not the kind of diabetes old people/pigs worfing whole bags of doritos and a few gallons of mtn dew a day get.

So they're curing the kind that actually deserves a cure.

As a T1 diabetic, I am usually a diabetes snob, but there are plenty of Type 2 diabetics who didn't bring it on themselves, either. Not all Type 2 diabetes is lifestyle-related (but a lot of it is, and the current epidemic of T2 diabetes definitely is).

Psst, word: "Diet soda"


?? Wut?
 
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