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(BBC)   Spiffy: for the first time, adult cells transformed back into embryonic stem cells. Iffy: the mice they tried it on basically turned into walking tumors   (bbc.co.uk) divider line 30
    More: Interesting, stem cells, embryonic stem cells, tissues, regenerative medicine, genetic modifications, embryos, brain cells  
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2279 clicks; posted to Geek » on 11 Sep 2013 at 4:40 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



30 Comments   (+0 »)
   
View Voting Results: Smartest and Funniest
 
2013-09-11 03:57:13 PM  
s24.postimg.org
 
2013-09-11 04:16:58 PM  
My god, you've created Fox News viewers! You monsters!
 
2013-09-11 04:45:46 PM  
What happens if you try the procedure on a naked mole rat?
 
2013-09-11 04:46:59 PM  
Deadpool Rodents?
 
2013-09-11 04:51:52 PM  

Fano: Deadpool Rodents?


24.media.tumblr.com
/ask and ye shall receive
 
2013-09-11 04:58:43 PM  
And we are one step closer to the zombie apocalypse.
 
2013-09-11 04:59:55 PM  

ArcadianRefugee: And we are one step closer to the zombie apocalypse.


Bring it. as if anything will happen around me to any degree.
 
2013-09-11 05:00:00 PM  

ArcadianRefugee: And we are one step closer to the zombie apocalypse.


But we'll have new Cheesy Tumor brand snacks to keep us from being peckish between meals, so...
 
2013-09-11 05:15:15 PM  

maltedmothball: Fano: Deadpool Rodents?

[24.media.tumblr.com image 500x375]
/ask and ye shall receive


Wait, is that a Deadpool squirrel? That's hilarious, given the one superhero that terrifies him.
 
2013-09-11 05:24:40 PM  
img818.imageshack.us

I've got a growth I would like for her to examine
 
2013-09-11 05:27:22 PM  

SordidEuphemism: maltedmothball: Fano: Deadpool Rodents?

[24.media.tumblr.com image 500x375]
/ask and ye shall receive

Wait, is that a Deadpool squirrel? That's hilarious, given the one superhero that terrifies him.


Well we need to give Catpool something to do while he wasn't being chased around by Dogpool


I'm not joking.
 
2013-09-11 05:29:11 PM  

The Stealth Hippopotamus: SordidEuphemism: maltedmothball: Fano: Deadpool Rodents?

[24.media.tumblr.com image 500x375]
/ask and ye shall receive

Wait, is that a Deadpool squirrel? That's hilarious, given the one superhero that terrifies him.

Well we need to give Catpool something to do while he wasn't being chased around by Dogpool


I'm not joking.


This brings up several questions about the existence of the Carpool lane.
 
2013-09-11 05:36:10 PM  

Smoking GNU: This brings up several questions about the existence of the Carpool lane.


There are no questions! The Bea Arthur travels where and when it wants to!!

img809.imageshack.us
 
2013-09-11 05:49:14 PM  
Science declares war on cancer.
Makes more cancer.

/its a start,I guess.
 
2013-09-11 06:02:13 PM  
Nice gamer references, but you guys missed the obvious one:

encrypted-tbn3.gstatic.com

Being what essentially is a sentient tumor can be kinda fun in the right conditions:

images.wikia.com
 
2013-09-11 06:21:11 PM  
upload.wikimedia.org
 
2013-09-11 06:50:45 PM  
Misleading headline. We've been inducing adult terminally differentiated cells back into pluripotent stem cells for some time, it's a pretty big field. But we do it in cell culture. This is interesting in that they induced it in tissue in an actual organism. Not surprised at the tumors though, there is a whole burgeoning body of literature on stem cells and carcinogenesis.
 
2013-09-11 07:04:06 PM  
Definitely one of those "aw, fark moments that happen in science."

And they happen. You keep going.

On the plus side, I'm sure none of the atoms involved had an age.
 
2013-09-11 07:23:16 PM  

The Stealth Hippopotamus: [img818.imageshack.us image 592x400]

I've got a growth I would like for her to examine


Still no cure for duckface.
 
2013-09-11 07:36:59 PM  
At least we now know Glenn Beck came from
 
2013-09-11 07:58:47 PM  
Hey, I bet I could get a grant to examine this as a weapon, at least a phase I award.
 
2013-09-11 08:29:45 PM  

washington-babylon: Nice gamer references, but you guys missed the obvious one:



Being what essentially is a sentient tumor can be kinda fun in the right conditions:


Yeah, that's probably how it would really work.
 
2013-09-11 10:17:23 PM  

erewhon: Hey, I bet I could get a grant to examine this as a weapon, at least a phase I award.


Probably the only way to keep funding for it from getting cut....
 
2013-09-12 01:39:34 AM  
This could be avoided by simply using embryonic stem cells. To quote Wikipedia, "Embryonic stem cells (ES cells) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage embryo.[1] Human embryos reach the blastocyst stage 4-5 days post fertilization, at which time they consist of 50-150 cells."

Besides, it says in the Bible that life comes with breath: YHWH breathes the breath of life into Adam, he does not combine egg and sperm. Not only can a blastocyst not feel or think, it can't even breathe.

You don't even need to cause an abortion to get that: you can keep reservoirs of male and female gametes and combine them in vitro at will.

It's too bad most of the legends of Roman persecutions of early Christians were only myths. They should have nipped that in the bud ASAP: after the destruction of Herod's temple, certainly after the Bar Kokhba revolt was crushed, the Jews would have gladly helped crush that pseudobiblical mystery cult in exchange for better treatment. Surely a religion that decides that gelatin from pig bones is essentially inert (might as well be wood) could tell the difference between a blastocyst and a taxpayer, especially if doing so cured cancer.
 
2013-09-12 02:11:34 AM  

Podna: erewhon: Hey, I bet I could get a grant to examine this as a weapon, at least a phase I award.

Probably the only way to keep funding for it from getting cut....


Hey, if you can't make it work well, maybe you can make it work badly.
 
2013-09-12 08:02:37 AM  

The One True TheDavid: This could be avoided by simply using embryonic stem cells. To quote Wikipedia, "Embryonic stem cells (ES cells) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage embryo.[1] Human embryos reach the blastocyst stage 4-5 days post fertilization, at which time they consist of 50-150 cells."

Besides, it says in the Bible that life comes with breath: YHWH breathes the breath of life into Adam, he does not combine egg and sperm. Not only can a blastocyst not feel or think, it can't even breathe.

You don't even need to cause an abortion to get that: you can keep reservoirs of male and female gametes and combine them in vitro at will.

It's too bad most of the legends of Roman persecutions of early Christians were only myths. They should have nipped that in the bud ASAP: after the destruction of Herod's temple, certainly after the Bar Kokhba revolt was crushed, the Jews would have gladly helped crush that pseudobiblical mystery cult in exchange for better treatment. Surely a religion that decides that gelatin from pig bones is essentially inert (might as well be wood) could tell the difference between a blastocyst and a taxpayer, especially if doing so cured cancer.


Yes, you are smarter than everyone.  You knew the perfect time to bring up your crybaby anti-Christian rant in a place where it wasn't needed. You've been validated.
 
2013-09-12 08:13:21 AM  

entropic_existence: Misleading headline. We've been inducing adult terminally differentiated cells back into pluripotent stem cells for some time, it's a pretty big field. But we do it in cell culture. This is interesting in that they induced it in tissue in an actual organism. Not surprised at the tumors though, there is a whole burgeoning body of literature on stem cells and carcinogenesis.


Yeah, I think it's the "pluripotent" part that is the problem.

Here's my plan:

1.  Determine how to drive pluripotent stem cell differentiation into that of a particular sub-tissue of organ through manipulation of gene expression and communication with the extracellular environment.
2. ???
3.  PROFIT!!!!
 
2013-09-12 08:20:42 AM  
Tyrell: The facts of life: To make an alteration in the evolvement of an organic life system is fatal. A coding sequence cannot be revised once it's been established.Roy: Why not?Tyrell: Because by the second day of incubation, any cells that have undergone reversion mutations give rise to revertant colonies like rats leaving a sinking ship; then the ship sinks.Roy: What about EMS recombination?Tyrell: We've already tried it. Ethyl methane sulfonate is an alkylating agent and a potent mutagen. It created a virus so lethal the subject was dead before he left the table.Roy: Then a repressor protein that blocks the operating cells.Tyrell: Wouldn't obstruct replication, but it does give rise to an error in replication so that the newly formed DNA strand carries a mutation and you've got a virus again. But this - all of this is academic. You were made as well as we could make you.Roy: But not to last.Tyrell: The light that burns twice as bright burns half as long, and you have burned so very very brightly, Roy. Look at you. You're the prodigal son. You're quite a prize!
 
2013-09-12 10:28:52 AM  

born_yesterday: 1.  Determine how to drive pluripotent stem cell differentiation into that of a particular sub-tissue of organ through manipulation of gene expression and communication with the extracellular environment.
2. ???
3.  PROFIT!!!!


Yeah, my guess is they wanted to do a first try figuring the surrounding tissue would already be putting out enough signalling molecules to guide differentiation of the embryonic stem cells, turns out that isn't true, which is still valuable to know. For non-embryonic stem cells it is true. You can add cardiac stem cells to a decellularized scaffold and there are enough appropriate signalling molecules in the extra cellular matrix so they will differentiate properly into the three cardiac muscle types for instance.
 
2013-09-12 12:58:05 PM  
The One True TheDavid:
It's too bad most of the legends of Roman persecutions of early Christians were only myths. They should have nipped that in the bud ASAP: after the destruction of Herod's temple, certainly after the Bar Kokhba revolt was crushed, the Jews would have gladly helped crush that pseudobiblical mystery cult in exchange for better treatment. Surely a religion that decides that gelatin from pig bones is essentially inert (might as well be wood) could tell the difference between a blastocyst and a taxpayer, especially if doing so cured cancer.

Roman religions weren't exactly without dumbshiat elements, and the problem has always been the dumbshiat interpretations of religious people not anything specific from the religion itself.
 
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