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(Nano Werk)   6'4" DNA researchers with full heads of hair, muscular builds, sculpted jawlines and piercing blue eyes say that they've discovered a way to edit any DNA sequence at will   (nanowerk.com) divider line 158
    More: Interesting, DNA, nucleic acid sequence, researchers, animals and plants, Cell Biology, molecular biology, binding proteins, Janet  
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10723 clicks; posted to Geek » on 27 Aug 2013 at 11:03 AM (51 weeks ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2013-08-27 11:58:27 AM

Felgraf: Arkanaut: I don't think editing DNA is going to do much for your looks after you reach adulthood.

I dunno. If we're able to inject a person with something that goes, like, "If you see this sequence, delete and replace with X", you could probably fix some diseases that are 'caused' by your body producing farked up proteins/not producing the right proteins.

Or basically wipe out a lot of cancers.

Obviously that's still a ways away, I suspect.


I was specifically talking about appearance -- the "6'4", muscular build, sculpted jawline" stuff in the headline.  People generally stop growing after age 20 or so, so height and bone structure is probably not going to be affected by DNA therapy.  I suppose you might be able to tweak musculature by inducing more testosterone production, and if melanin is constantly replenished you can do eye color too.  And now that I think about it if there's a gene that induces faster metabolism, so you burn more calories, getting that into your genome might make you thinner.  But otherwise your adult appearance is going to be the same regardless of gene therapy.
 
2013-08-27 11:58:47 AM
Meh... I've already got 6'4", HWP yadda yadda, DNA to donate to a qualifying Farkette.  No editing required!
 
2013-08-27 11:59:20 AM
So how much would it cost to grow a second penis? This is important.
 
2013-08-27 12:01:26 PM
img69.imageshack.us
 
2013-08-27 12:01:38 PM

no icon tact: ORA-01578: ORACLE cell block corrupted (strand # 11, block # 4262)
ORA-01110: strand 11: '/db/oracle/PROD/db/madula_st/cell/sysaux01.dna'


sphotos-a-ord.xx.fbcdn.net
 
2013-08-27 12:03:27 PM

stuffy: 12 inch penis!?


Just hope your doctor uad good hearing, otherwise you will end up with a 12 pianist.
 
2013-08-27 12:06:47 PM

cman: Ethically speaking, editing DNA is perfectly fine

We are in a game against extinction.

Our ancestors wished they could program themselves and give them a leg-up against the rest of the world.

Now we are in a position to do that


Meanwhile we allow anyone to reproduce as Idiocracy slowly takes place.
 
2013-08-27 12:07:52 PM
Great, designer children. Whole generations that look almost identical because their parents followed the current fads in "MetroGenetics"
 
2013-08-27 12:09:18 PM

Boosterspice: The Irresponsible Captain: Can we call immortality therapy "Boosterspice"?

Absolutely!


It must flow.
 
2013-08-27 12:09:50 PM
So... just out of curiosity, let's pretend for a moment that I am not already perfect in every way. In this completely imaginary scenario, instead of being built like a Greek God, I'm 5' 9", overweight, and I'm bow-legged and have a 4 inch penis. Hypothetically. If they found a way to rewrite my genetic code to be more-or-less perfect, would I actually change? Would anything at all happen? Would I die horribly? I can see how it could fix some genetic diseases in a fully grown adult, but could you change your physical build/appearance once you are fully developed, or would that have to happen when you were very young? Not that I would want the gene to give me a huge black wang anyways. I'm just asking for a friend.
 
2013-08-27 12:12:40 PM

piperTom: Researchers are 6'4" (193 cm)?!?  Why so tall?  They'll bump their heads on stuff.  Better to be 5'10" (177cm).


You know how I know you're short?
 
2013-08-27 12:14:54 PM

mod3072: So... just out of curiosity, let's pretend for a moment that I am not already perfect in every way. In this completely imaginary scenario, instead of being built like a Greek God, I'm 5' 9", overweight, and I'm bow-legged and have a 4 inch penis. Hypothetically. If they found a way to rewrite my genetic code to be more-or-less perfect, would I actually change? Would anything at all happen? Would I die horribly? I can see how it could fix some genetic diseases in a fully grown adult, but could you change your physical build/appearance once you are fully developed, or would that have to happen when you were very young? Not that I would want the gene to give me a huge black wang anyways. I'm just asking for a friend.


You might could grow yer wang since its soft tissue, but once your bone's growth plates are fused you arent gonna get taller, your kids would be but not yourself.
 
2013-08-27 12:15:26 PM

LrdPhoenix: dj_spanmaster: And it'll be weaponized into cancer bombs in just 6 months. Yay, biological/chemical warfare!

I bet we'd finally get a cure all for cancer then.  Anti-cancer bomb or something.  Could you imagine how advanced medical technology could get and how quickly if there was a good old fashioned arms race based around genetic weapons?


That term just blew my mind.
 
2013-08-27 12:16:02 PM

cman: Quantum Apostrophe: Except for living longer. That's always bad because atoms have an age.

You do realize that every seven years you are pretty much an entirely different person, right?

Everything on a cellular level changes. You have the same memories, but that is about it


So that's what happened with my ex-wife.

I can't tell what direction this will go, Gattaca or zombie apocalypse.
 
2013-08-27 12:17:01 PM

mod3072: So... just out of curiosity, let's pretend for a moment that I am not already perfect in every way. In this completely imaginary scenario, instead of being built like a Greek God, I'm 5' 9", overweight, and I'm bow-legged and have a 4 inch penis. Hypothetically. If they found a way to rewrite my genetic code to be more-or-less perfect, would I actually change? Would anything at all happen? Would I die horribly? I can see how it could fix some genetic diseases in a fully grown adult, but could you change your physical build/appearance once you are fully developed, or would that have to happen when you were very young? Not that I would want the gene to give me a huge black wang anyways. I'm just asking for a friend.


I figure if there were a way, it'd be to first provide you with a gene that would make transplants and grafts more accepted by your body. That way, all the painful surgery required to Frankenstein your friend would at least have a chance to work. All that, would only leave your friend with a farked up personality... which may be possible to fix with a talk show host gene - though, I'd prefer your friend doesn't change a thing, and come be my wing man at the local bar.
 
2013-08-27 12:19:35 PM
Robin Thicke sees what you did there,  Subs.
 
2013-08-27 12:19:46 PM

arbitterm: Great, designer children. Whole generations that look almost identical because their parents followed the current fads in "MetroGenetics"


Or were custom designed by their parents to beat all the other kids at something. Sure, some parents treat their kids like fashion accessories, some treat them as ways to live vicariously.
Amazingly, we've already come up with words to describe the results.
Enhanced intelligence? Mentat, or Alpha.
Enhanced strength? Elemental or Beta.
Enhanced strength but dumb as a rock? Genejack.
You're not genegeneered, just the product of your parents bumping uglies? Stravaging freebirth.
 
2013-08-27 12:20:33 PM
img199.imageshack.us
 
2013-08-27 12:22:37 PM

piperTom: Researchers are 6'4" (193 cm)?!?  Why so tall?


Cause some of us chicks are tall.  ;-)
 
2013-08-27 12:24:11 PM

Felgraf: Quantum Apostrophe: Except for living longer. That's always bad because atoms have an age.

You realize that people aren't necessarily mocking the idea of living longer, just mocking your 'proof' that immortality has to be possible because 'atoms don't age', right?

/Or maybe you don't.
//By the way, I seem to recall that we don't *know* that protons don't have a half life-and in some models, they do. It has not yet been experimentally verified, mind.
///So atoms might very well age.


I enjoy the thought that the components of atoms aren't actually "aware" of time, because they are "immortal", and simply move around.  And I like thinking about how this thought experiment might explain the two slit experiment.

But yeah, to suggest that because those components are immortal, things that are made of them are also immortal is as silly as saying that because of the way our climate moves water around, the oceans will always be the same.

It's the changes that we're trying to overcome here, not the half-life of carbon or some shiat.

/Is that seriously an argument QA makes?
 
2013-08-27 12:24:28 PM
Penis? Nah. Leave ol' Johnny like he is. (Mayyyybe a baculum, but the possibility of fractures during some of the better positions must be taken into account).

Gimme fingers that don't cramp up after a full night of teh sex and Gene Simmons' tongue.

/When the lady cries tears of joy. For real. That's when you know it's worth it.
//I got goddamn carpal tunnel after one of "those" weekends, had to bandage my hand and make up a dumb story about falling down a flight of stairs
///OK, I do want something like an elephant's trunk down there, but it would take forever, cost a brazillion and stick peanuts up my ass so it's a definite maybe
 
2013-08-27 12:25:33 PM

p4p3rm4t3: [570x350 from http://img199.imageshack.us/img199/6332/x6go.jpg image 570x350]


The last chicken in the shop.
 
2013-08-27 12:27:01 PM
Big deal. I've been manipulating my DNA for years.
 
2013-08-27 12:27:47 PM

Felgraf: Arkanaut: I don't think editing DNA is going to do much for your looks after you reach adulthood.

I dunno. If we're able to inject a person with something that goes, like, "If you see this sequence, delete and replace with X", you could probably fix some diseases that are 'caused' by your body producing farked up proteins/not producing the right proteins.

Or basically wipe out a lot of cancers.

Obviously that's still a ways away, I suspect.


we do that already with gene therapy, or at least so I understand the process, and IIRC we basically do a completely replacement of all the cells in our body about every 7 years or so, so IF you were able to infect every cell in your body with new DNA code that turned on or off certain genes, then it seems like yes, gradually you would be "reformed in favor of your new matrix" so to speak....thought he transition could be VERY weird....


So actual science-talking person want to explain to me why I'm an idiot now?
 
2013-08-27 12:27:55 PM

Arkanaut: Felgraf: Arkanaut: I don't think editing DNA is going to do much for your looks after you reach adulthood.

I dunno. If we're able to inject a person with something that goes, like, "If you see this sequence, delete and replace with X", you could probably fix some diseases that are 'caused' by your body producing farked up proteins/not producing the right proteins.

Or basically wipe out a lot of cancers.

Obviously that's still a ways away, I suspect.

I was specifically talking about appearance -- the "6'4", muscular build, sculpted jawline" stuff in the headline.  People generally stop growing after age 20 or so, so height and bone structure is probably not going to be affected by DNA therapy.  I suppose you might be able to tweak musculature by inducing more testosterone production, and if melanin is constantly replenished you can do eye color too.  And now that I think about it if there's a gene that induces faster metabolism, so you burn more calories, getting that into your genome might make you thinner.  But otherwise your adult appearance is going to be the same regardless of gene therapy.


Oh! Yes. On that I agree, then.
 
2013-08-27 12:31:47 PM
Doctor Bashir, I Presume
 
2013-08-27 12:32:02 PM
I know you all just want to gab on about superficial things but this development means much less than what the headline implies.  It's big news in molecular biology but don't expect to see any practical developments outside of that field for awhile if ever.
 
2013-08-27 12:33:50 PM

p4p3rm4t3: [570x350 from http://img199.imageshack.us/img199/6332/x6go.jpg image 570x350]


Lager! The only thing that can kill a vindaloo
 
2013-08-27 12:44:28 PM

BeesNuts: Felgraf: Quantum Apostrophe: Except for living longer. That's always bad because atoms have an age.

You realize that people aren't necessarily mocking the idea of living longer, just mocking your 'proof' that immortality has to be possible because 'atoms don't age', right?

/Or maybe you don't.
//By the way, I seem to recall that we don't *know* that protons don't have a half life-and in some models, they do. It has not yet been experimentally verified, mind.
///So atoms might very well age.

I enjoy the thought that the components of atoms aren't actually "aware" of time, because they are "immortal", and simply move around.  And I like thinking about how this thought experiment might explain the two slit experiment.

But yeah, to suggest that because those components are immortal, things that are made of them are also immortal is as silly as saying that because of the way our climate moves water around, the oceans will always be the same.

It's the changes that we're trying to overcome here, not the half-life of carbon or some shiat.

/Is that seriously an argument QA makes?


Well, an argument I've seen him make is that since atoms last for ever, it should be *possible* to achieve human immortality.

Which is... just... a weird leap of logic. Much like the objects he seems to deride. Or "We're living longer now than we have in the past, therefore human immortality is possible."

Not so say I don't think we *shouldn't* research human immortality. I just don't think we have proof that it's *possible*.
 
2013-08-27 12:44:41 PM

dj_spanmaster: And it'll be weaponized into cancer bombs in just 6 months. Yay, biological/chemical warfare!


We already have those, they are called nuclear weapons.
 
2013-08-27 12:55:43 PM

doubled99: Big deal. I've been manipulating my DNA for years.


Most of mine just winds up in a sock ...
 
2013-08-27 12:56:40 PM

dj_spanmaster: And it'll be weaponized into cancer bombs in just 6 months. Yay, biological/chemical warfare!


Pretty much ANY technological advancement can be weaponized. Kzinti Lesson, and all. Fark, I can think of ways to weaponize a *teddy bear*.

If you want technology  that *could* be weaponized to stop being researched, you would, almost literally, have to stop all research everywhere. Forever.
 
2013-08-27 12:57:37 PM
Apparrntly he gets pretty defensive if you bring up immortality pills.
 
2013-08-27 01:01:44 PM
as long as it doesn't end up like  gundam seed i'm ok with this.
 
2013-08-27 01:01:47 PM
upload.wikimedia.org

So, Plasmids. We're talking about Plasmids here, right?


Anyway, I'm looking forward to evolving, today!
 
2013-08-27 01:02:09 PM

phenn: piperTom: Researchers are 6'4" (193 cm)?!?  Why so tall?

Cause some of us chicks are tall.  ;-)


You're already spoken for, IIRC, so you don't count. ;^)

/178 cm tall

BTW, don't they use 3d printing machines to make the new sequences?
 
2013-08-27 01:03:08 PM
Can it restore my foreskin?
 
2013-08-27 01:08:02 PM
6'1 is where it's at.  Short enough to fit into cars, tall enough to be awesome.
 
2013-08-27 01:08:25 PM

cman: You do realize that every seven years you are pretty much an entirely different person, right?

Everything on a cellular level changes. You have the same memories, but that is about it


Even those are fluid. We don't record memories like a video, and every time we recall a memory and "put it back" the memory can become altered.

Magorn: we do that already with gene therapy, or at least so I understand the process, and IIRC we basically do a completely replacement of all the cells in our body about every 7 years or so, so IF you were able to infect every cell in your body with new DNA code that turned on or off certain genes, then it seems like yes, gradually you would be "reformed in favor of your new matrix" so to speak....thought he transition could be VERY weird....


So actual science-talking person want to explain to me why I'm an idiot now?


Because it would take more than simply replacing your cells to alter your appearance. Your appearance has been shaped over the course of your life and is determined in a huge way by the things that aren't cells (like bone for instance).

And yes, we have some gene therapies that work, particularly ones for some ocular diseases, but there we are fixing biochemical and genetic problems. Some subtle changes, like say eye or hair colour we could mostly do with genetic editing but things like facial features and height? Not a chance, at least not anytime soon. We just don't know enough about what to change plus those things are only partially genetic anyway.
 
2013-08-27 01:17:40 PM
Man, we are going to be oneboring race in the future...
 
2013-08-27 01:22:23 PM

Saiga410: OK but what if a blokes name is Jim or Steve, or Gary.  Why are people named Will only allowed this treatement?


As a 6'2" Blue eyed, square jawed, Will; is there a reference I am missing?
 
2013-08-27 01:25:09 PM
i1.ytimg.com
Approves.
 
2013-08-27 01:32:42 PM

Burr: Man, we are going to be oneboring race in the future...


When everybody is 6'4 with chiseled features and rock-hard abs, my paunchy, balding, ugly mug will make me a sex god because of how "exotic" I look...or at least that's what I keep telling myself.
 
2013-08-27 01:32:52 PM

DrRatchet: So, Plasmids. We're talking about Plasmids here, right?


Anyway, I'm looking forward to evolving, today!


Nope. Well you do insert a plasmid in to the cell to express the TALEN system, but that is just to get the editing machinery in to the cell. The TALEN system is derived from a plant defense mechanism. Basically it is a bunch of engineered proteins that bind to DNA that they are designed to target. One way you can use them is in pairs that then cleave a section of DNA. If you put in replacement DNA with the TALEN's you can substitute it in.

Why we won't use this for editing DNA in people, although it can be used on genomic DNA, is efficiency. Only a portion of the designed TALENs end up working, only a few of the cells you try and get the TALENs in to are properly "transfected", and some won't assemble right and cut, etc. We looked in to using TALENs for some research projects and it was a huge amount of effort to get successfully edited cells. It just isn't appropriate for much beyond cell culture work and some model organisms that you can work with in very large numbers.
 
2013-08-27 01:34:50 PM

Ishidan: arbitterm: Great, designer children. Whole generations that look almost identical because their parents followed the current fads in "MetroGenetics"

Or were custom designed by their parents to beat all the other kids at something. Sure, some parents treat their kids like fashion accessories, some treat them as ways to live vicariously.
Amazingly, we've already come up with words to describe the results.
Enhanced intelligence? Mentat, or Alpha.
Enhanced strength? Elemental or Beta.
Enhanced strength but dumb as a rock? Genejack.
You're not genegeneered, just the product of your parents bumping uglies? Stravaging freebirth.


good to see another BattleTech fan
 
2013-08-27 01:49:35 PM

Felgraf: Quantum Apostrophe: Except for living longer. That's always bad because atoms have an age.

You realize that people aren't necessarily mocking the idea of living longer, just mocking your 'proof' that immortality has to be possible because 'atoms don't age', right?

/Or maybe you don't.
//By the way, I seem to recall that we don't *know* that protons don't have a half life-and in some models, they do. It has not yet been experimentally verified, mind.
///So atoms might very well age.


What's the worst is that in threads with ASTONISHINGLY great news for life extension like this, he leads with crap like that instead of "holy shiat! We are one step closer to the thing I dream about!"

I sense that if he were the only person made immortal, it would end for him like Burgess Meredith in the Twilight Zone.
 
2013-08-27 01:50:44 PM

Arkanaut: Felgraf: Arkanaut: I don't think editing DNA is going to do much for your looks after you reach adulthood.

I dunno. If we're able to inject a person with something that goes, like, "If you see this sequence, delete and replace with X", you could probably fix some diseases that are 'caused' by your body producing farked up proteins/not producing the right proteins.

Or basically wipe out a lot of cancers.

Obviously that's still a ways away, I suspect.

I was specifically talking about appearance -- the "6'4", muscular build, sculpted jawline" stuff in the headline.  People generally stop growing after age 20 or so, so height and bone structure is probably not going to be affected by DNA therapy.  I suppose you might be able to tweak musculature by inducing more testosterone production, and if melanin is constantly replenished you can do eye color too.  And now that I think about it if there's a gene that induces faster metabolism, so you burn more calories, getting that into your genome might make you thinner.  But otherwise your adult appearance is going to be the same regardless of gene therapy.


They stop growing because DNA says so. Tell the DNA to keep doing this function in a specific way and it should still work no? Isn't this the type of control over DNA we are discussing?
 
2013-08-27 01:56:10 PM

Felgraf: BeesNuts: Felgraf: Quantum Apostrophe: Except for living longer. That's always bad because atoms have an age.

You realize that people aren't necessarily mocking the idea of living longer, just mocking your 'proof' that immortality has to be possible because 'atoms don't age', right?

/Or maybe you don't.
//By the way, I seem to recall that we don't *know* that protons don't have a half life-and in some models, they do. It has not yet been experimentally verified, mind.
///So atoms might very well age.

I enjoy the thought that the components of atoms aren't actually "aware" of time, because they are "immortal", and simply move around.  And I like thinking about how this thought experiment might explain the two slit experiment.

But yeah, to suggest that because those components are immortal, things that are made of them are also immortal is as silly as saying that because of the way our climate moves water around, the oceans will always be the same.

It's the changes that we're trying to overcome here, not the half-life of carbon or some shiat.

/Is that seriously an argument QA makes?

Well, an argument I've seen him make is that since atoms last for ever, it should be *possible* to achieve human immortality.

Which is... just... a weird leap of logic. Much like the objects he seems to deride. Or "We're living longer now than we have in the past, therefore human immortality is possible."

Not so say I don't think we *shouldn't* research human immortality. I just don't think we have proof that it's *possible*.


Why would we want that?  I'll take this opportunity to say fark no we shouldn't be working on immortality until we have our societies general shiat together.  We are failing to feed, clothe, and educate the kids we have now, let alone them, their kids, their kids' kids... We're spending too much on health care and getting bad outcomes.

If we don't fix those problems first, we're bad at priorities.
 
2013-08-27 01:59:35 PM

piperTom: Researchers are 6'4" (193 cm)?!? Why so tall?


Social benefits.
Perceived alpha status.
It is the reason we elect tall people as president and to corporate boardrooms.
Researchers studying dating sites tweaked fake male profiles to see what factors generated the most positive responses. Taking generic person X, they found that adding 2 inches to his stated height had the same effect as giving him $50,000 in stated additional income. Chicks like tall guys.
 
vpb [TotalFark]
2013-08-27 01:59:45 PM
So we can tailor people for different purposes?  Maybe we can call the various models Alphas, Betas, Deltas, etc.
 
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