MidnightSkulker: Science reporting goes like this:Paper: "We found a small but measurable positive effect of substance X in this extremely narrow animal model."Media: "CANCER CURE FOUND"
LabGrrl: hstein3: I don't suppose you petitioned the company to appeal to said decision, did you? Can't say how it would turn out, but you never know when it comes to this sort of thing.Oh yes. Rejected at three different levels, the last one with the threat of revoking my coverage altogether. It could make a grrl go tin foil hat./Some of the questions from the interview with the first rare disease doc only made sense if I'd been a spy.
hstein3: I don't suppose you petitioned the company to appeal to said decision, did you? Can't say how it would turn out, but you never know when it comes to this sort of thing.
LabGrrl: I literally have appointment in one week, so, fingers crossed. My rare disease guy is crap, so my local pulmo is trying to step up his game (he does research, but until recently not on this.) My insurance company refused to pay for a dude at a schmancy institute who was willing to foot the bill for most of my treatment in his study...his hospital would still be charging for lab work, etc., they preferred to send me only an hour away to a place that charges them more. Best healthcare in the world...USA! USA!
Radak: jaybeezey: And it should be available in 10-15yrs to the ultra rich.Good, because that's when I'm planning to get cancer./and I have some time to work on the ultra rich part
hstein3: That's disappointing to hear. Rare, unnamed autoimmune condition is the sort of thing that should make most scientists start asking for blood and tissue samples. I wish I still had connections at a university so I could at least point you at somebody, but these things are always complicated. Methotrexate is nasty stuff, it's part of the reason we're working on RA. I hope you (and your doc) find something better in the future.
LabGrrl: hstein3: As far as your own case goes, is your case written up in any medical journals? As an immunologist, I'm incredibly curious. (Also sympathetic.)Only 2 lines in a metastudy...Since we haven't found a good treatment, I'm boring reading. More treatments for autoimmune diseases are an awesomesauce thing. I've already washed out of azathioprine, CellCept and some other immunosuppressant. I'm at 'stable' on high dose steroids and mtx, but they are crap drugs...the side effects are almost as bad as not breathing.A lot of people think having a rare disease doc is like House, but in my experience they don't care what you have or why you have it, only if their drug of choice is working.
hstein3: As far as your own case goes, is your case written up in any medical journals? As an immunologist, I'm incredibly curious. (Also sympathetic.)
Jument: Skarekrough: So, can I start smoking again or not?This. I just got back from Italy. Everyone there smokes like a chimney. A true cure for cancer will be huge money, and personally I would probably take up occasional smoking again.
LabGrrl: The harder question is not how do we make it not temporary, but how do we make it temporary.
Vodka Zombie: Cancer will never be cured. In America, cancer is just too much of a welcome cash cow for just about every facet of the American health care/health insurance industry, and finding an easy cure would cost them billions in profits. It's much better for them to convince you that you're going to die and subject you to an obscenely expensive regimen of treatments and medications and surgeries that can bleed every last penny from your bank accounts.
Mr Guy: The real problem with curing cancer is what happens when you don't remove the original source. What happens when you don't find the virus, or the microscopic radioactive particle, or the genetic damage? The thing about cancers that it's not just a "disease", it's a description of a particular way in which the body can kill itself if your basic units of life get corrupted. Tumors aren't much more than human pearls, and there's a flaw that must be removed in there somewhere. How could a drug like this not be temporary? Seems like it could only be permanently effective for cancers caused by known virus infections. Otherwise, what stops whatever damage caused the tumor from just doing it again?
LabGrrl: blipponaut: LabGrrl: Oh, yeah, let's mess with CD47. You know, the protein screwed up in some autoimmune diseases, like the one I'm dying of, where my body takes the "do not eat" label off of healthy lung tissue. That's a GREAT IDEA. What could possibly do wrong?You're really dying of some disease related to this? I'm sorry to hear that.I've a form of Interstitial Lung Disease so rare it has no name. Almost all the other patients developed it at 65, and I got it at 37. We literally have no idea how my long my lifespan could be, but yup, it's thought to be related to CD47 (primarily because it's unresponsive to treatments for CD40-related disease.) My body om nom noms my lungs (and other tissues) because it doesn't recognize the signal *not* to.Long story short, all these 'new' cancer drugs that use the immune response have a slow, lingering, painful death from rare autoimmune diseases as a potential side effect. Just think, the experimental procedures keeping me alive could keep them alive, too. yay.
Alonjar: Or, you know... this new research could give them better understanding of CD47 manipulation, which could lead to a cure or fix for your problem.NO WAIT YOU'RE RIGHT! STOP. STOP. EVERYBODY STOP. HALT THE RESEARCH! LabGrrl on fark says its not a good idea!Phew, that was a close one. Zombie apocalypse averted!
Feepit: Is this the same study posted to Fark several days ago?*checks link*Yup! Same exact one.
give me doughnuts: Edsel: As usual, the media takes a lab discovery and runs with it... Will be really curious to see what the effects on healthy tissues are. Unless there's a way to target this only to cancer cells, may be pointless.There are already several ways to specifically target cancer cells. If one of them can be adapted to work with this treatment, then it should leave healthy tissues alone.
Monkeyfark Ridiculous: "Although macrophages also attacked blood cells expressing CD47 when mice were given the antibody, the researchers found that the decrease in blood cells was short-lived; the animals turned up production of new blood cells to replace those they lost from the treatment, the team reports online today in the Proceedings of the National Academy of Sciences. "I know it's only mice so far but this sounds promising.
blipponaut: LabGrrl: Oh, yeah, let's mess with CD47. You know, the protein screwed up in some autoimmune diseases, like the one I'm dying of, where my body takes the "do not eat" label off of healthy lung tissue. That's a GREAT IDEA. What could possibly do wrong?You're really dying of some disease related to this? I'm sorry to hear that.
Archae hippy: Killing cancer cells is easy (see the first few posts, or boobies or what ever).Blocking HUMAN CD47 makes implanted HUMAN tumors more susceptible to the mouse immune system. Normal MOUSE cells are also more susceptible, but much less so. I hate cancer, but this extremely preliminary.
LabGrrl: Oh, yeah, let's mess with CD47. You know, the protein screwed up in some autoimmune diseases, like the one I'm dying of, where my body takes the "do not eat" label off of healthy lung tissue. That's a GREAT IDEA. What could possibly do wrong?
I_Am_Weasel: Sgygus: Cyanide?No. Apparently it's silica gel.FTA:The drug works by blocking a protein called CD47 that is essentially a "do not eat" signal to the body's immune system
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