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(US News)   Doctors struggle with "totally untreatable" tuberculosis in South Africa. Well, nice knowing you all   (usnews.com) divider line 61
    More: Scary, South African, Emerging Infectious Diseases, lung disease, tuberculosis, George V, Durban  
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8585 clicks; posted to Main » on 11 Feb 2013 at 6:04 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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Archived thread
2013-02-11 06:09:55 PM
7 votes:

GAT_00: BronyMedic: ecmoRandomNumbers: My mom's health department has been dealing with this for 3 years, submitter. It's already here.

Going to say it's been here for a long time.

XDR-MDR TB is one of the few reasons in a modern age someone can get an involuntary quarantine order placed upon them by a court.

And medical science hasn't created any fundamentally new antibiotics in decades.  It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.


Oh please regale us with your knowledge.
MFK
2013-02-11 06:18:27 PM
5 votes:
please. There's no profit margin in treating common killer diseases. All of big pharma's R&D has been sunk into "treatments" instead of "cures" anyway. You "cure" a patient, and you'll never see them again, but if you "treat" a disease, well... you've got yourself a customer who is totally dependent on your wares.
2013-02-11 06:02:37 PM
4 votes:
Hey uh.

Maybe we start treating antibacterial misuse as mass murder.

Because it is.
2013-02-11 05:28:43 PM
4 votes:
Time to bring back the sanatoriums.
2013-02-11 06:54:23 PM
3 votes:

wildcardjack: Okay, GAT_00's utter screw up aside, the future probably is going to call for selective or engineered viruses that love the bacterium we want to wage war on.

Of course, I can start the conspiracy theories already. "Virus-based-antibiotics are a known cause of various cancers and these new cures for bacterial infections is just a scheme to increase the incidence of cancer which they make more money treating". See, the treatment isn't even outta the labs and I already have the Alex Jones take on it.

/If I weren't trying to fight it I'd write it.


Phage therapy was investigated in the USSR during the cold war, when antibiotics were not easy for the communists to come by. The problem with phages, however, is that each phage is specific to the bacterium which it attacks and kills, meaning that multiorganism infections, or unknown infections, would render it useless. So if you had a patient in sepsis or in a situation where time was critical, you're pretty much screwed. In addition, you have the problem of phages sometimes imparting factors which increase the virulence or lethality of bacteria as well. Take Enterohemorrhagic E. Coli - it requires a gene imparted by a phage before it produces the EH toxin. Then you have the problem of your patient's own immune system. Things like stomach acid, and the general density of white blood cells in the GI tract were designed to kill foreign antigens, and you risk provoking an immune response by bloodstream administration.
2013-02-11 06:21:25 PM
3 votes:

Moonfisher: But by all means, let's keep ignoring the developing nations where these diseases are developing. Let's keep allowing their antibiotic supplies to be cut off by lack of funding or political strife. That will never come back and bite us in the ass. And only private industry should be developing pills; that way we won't develop new, nonprofitable antibiotics in lieu of more psychotropics for compulsive shopping and other first world problems.


The problem is not that they can't get antibiotics. The problem is that there is poor compliance with TB antibiotic therapy, which allows drug resistance to form. TB is not something you take a two week course of antibiotics for, and it's not a big deal if you stop at day 8 instead of day 10. It's a six month to a year course of antibiotics, and Mycobacterium Tuberculosis rapidly develops resistance to antibiotics when taken improperly.
2013-02-11 06:16:56 PM
3 votes:
Sometimes I wonder if I'll see a real deal plague in my lifetime.
/scary shiat
2013-02-11 06:16:42 PM
3 votes:
But by all means, let's keep ignoring the developing nations where these diseases are developing. Let's keep allowing their antibiotic supplies to be cut off by lack of funding or political strife. That will never come back and bite us in the ass. And only private industry should be developing pills; that way we won't develop new, nonprofitable antibiotics in lieu of more psychotropics for compulsive shopping and other first world problems.
2013-02-11 06:09:29 PM
3 votes:
Baby, can you dig your man?
2013-02-11 05:07:42 PM
3 votes:
3.bp.blogspot.com

Why Johnny Ringo. You look like someone just walked over your grave.
2013-02-11 09:41:24 PM
2 votes:

Yogimus: To be so sure of something so wrong...


Uh, what? 10 to 14 days for most antibiotics is the usual prescribing range. Very few conditions, usually sexually transmitted diseases, can be treated by a single dose of antibiotics orally, and at the very least most require 7 days. One to two weeks is a good bet for any course.

And yes. Stopping taking the course when you "feel better" is a recipe for promoting the development of resistant strains of bacteria.
2013-02-11 07:26:41 PM
2 votes:

angrymacface: Whatever. You're probably a paid shill. We know the truth and you people won't be able to hide it forever.


Riiiiiiiight. Well, I guess you can go that route when you have no other response that's possible.

1.bp.blogspot.com
2013-02-11 07:24:33 PM
2 votes:

Virtuoso80: TB ain't good, but it's not contagious enough to be a global killer. Europe lived with TB (consumption) for centuries with no cure or treatment.


Some of us don't long for the days of feudalism to return.
2013-02-11 07:20:39 PM
2 votes:

Big Ramifications: Fark's resident big mouth left wing moron is in da house!


Your right wing tears are delicious.

mediacdn.snorgcontent.com
2013-02-11 07:02:28 PM
2 votes:

Deep Contact: Can't believe so many are sick in Tampa Bay.


Really? It's Florida. That's like God's waiting room.
2013-02-11 06:50:56 PM
2 votes:
Okay, GAT_00's utter screw up aside, the future probably is going to call for selective or engineered viruses that love the bacterium we want to wage war on.

Of course, I can start the conspiracy theories already. "Virus-based-antibiotics are a known cause of various cancers and these new cures for bacterial infections is just a scheme to increase the incidence of cancer which they make more money treating". See, the treatment isn't even outta the labs and I already have the Alex Jones take on it.

/If I weren't trying to fight it I'd write it.
2013-02-11 06:42:34 PM
2 votes:

BronyMedic: You didn't just misuse a word...


Reminds me of the whole "clip vs magazine" thing that we saw so much a while back.  GAT_00 can no longer have an opinion on medicine, bacteria, or disease.
2013-02-11 06:42:30 PM
2 votes:

Moonfisher: In America, you are correct. In a developing nation, however, what you call noncompliance is a euphemism that shifts the blame to the patient when said patient lacks the agency to comply. Many of the poor and ill in these nations have to travel miles and miles to access a clinic, do not have access to clean water or proper nutr


There is also the problem that any long term antibiotics will be sold of given to someone else as they appear to have a more urgent need of them.  So if your happen to be a mother with TB and your kid has an infected scratch, the kid gets the antibiotics (and the TB too!)
2013-02-11 06:32:56 PM
2 votes:

Moonfisher: BronyMedic: Moonfisher: But by all means, let's keep ignoring the developing nations where these diseases are developing. Let's keep allowing their antibiotic supplies to be cut off by lack of funding or political strife. That will never come back and bite us in the ass. And only private industry should be developing pills; that way we won't develop new, nonprofitable antibiotics in lieu of more psychotropics for compulsive shopping and other first world problems.

The problem is not that they can't get antibiotics. The problem is that there is poor compliance with TB antibiotic therapy, which allows drug resistance to form. TB is not something you take a two week course of antibiotics for, and it's not a big deal if you stop at day 8 instead of day 10. It's a six month to a year course of antibiotics, and Mycobacterium Tuberculosis rapidly develops resistance to antibiotics when taken improperly.

In America, you are correct. In a developing nation, however, what you call noncompliance is a euphemism that shifts the blame to the patient when said patient lacks the agency to comply. Many of the poor and ill in these nations have to travel miles and miles to access a clinic, do not have access to clean water or proper nutr


Lol, kids ran into me and made me bump submit button. Anyway... They do not have access to clean water or proper nutrition and social/political upheaval can interrupt their supplies. I highly recommend Paul Farmer's "Infections and Inequalities" for some insight into how these things are developing and why they are so hard to treat.
2013-02-11 06:29:50 PM
2 votes:

BronyMedic: Moonfisher: But by all means, let's keep ignoring the developing nations where these diseases are developing. Let's keep allowing their antibiotic supplies to be cut off by lack of funding or political strife. That will never come back and bite us in the ass. And only private industry should be developing pills; that way we won't develop new, nonprofitable antibiotics in lieu of more psychotropics for compulsive shopping and other first world problems.

The problem is not that they can't get antibiotics. The problem is that there is poor compliance with TB antibiotic therapy, which allows drug resistance to form. TB is not something you take a two week course of antibiotics for, and it's not a big deal if you stop at day 8 instead of day 10. It's a six month to a year course of antibiotics, and Mycobacterium Tuberculosis rapidly develops resistance to antibiotics when taken improperly.


In America, you are correct. In a developing nation, however, what you call noncompliance is a euphemism that shifts the blame to the patient when said patient lacks the agency to comply. Many of the poor and ill in these nations have to travel miles and miles to access a clinic, do not have access to clean water or proper nutr
2013-02-11 06:24:12 PM
2 votes:
Has there been any work on phage therapy and TB? I don't know much about it but I remeber a few years back there was talk about using it on resistant MRSA
2013-02-11 06:21:17 PM
2 votes:
...And a hearty FU to all those morons who've used anti-biotics when they didn't need to.

/should never have been available over the counter, anywhere
//grumble
2013-02-11 06:21:13 PM
2 votes:
...scribbles on bucket list, "Do... not... go... to... South Africa... ever..."
2013-02-11 05:59:16 PM
2 votes:

ecmoRandomNumbers: My mom's health department has been dealing with this for 3 years, submitter. It's already here.


Going to say it's been here for a long time.

XDR-MDR TB is one of the few reasons in a modern age someone can get an involuntary quarantine order placed upon them by a court.
2013-02-11 02:38:07 PM
2 votes:
President Madagascar now in process of shutting... down... everything.
2013-02-12 01:57:28 PM
1 votes:

Fark Rye For Many Whores: Hey uh.

Maybe we start treating antibacterial misuse as mass murder.

Because it is.



Bacteria love sharing antibiotic-resistance-conferring plasmids under stressful environments. Most people don't realize just how easily they do so--especially when exposed to conditions that weaken their cell membranes.

...but if you're looking for the Real(tm) culprits, look no further than the agricultural industry, which is allowed to feed unlimited amounts of antibiotics to livestock whenever they want--without a prescription of any sort. We'd like to blame sick people who take antibiotics for colds, but in reality, it's daily antibiotic supplementation of livestock that's probably the real problem.
2013-02-11 10:45:15 PM
1 votes:

Kibbler: Meanwhile, they've created crops that are Roundup-resistant, and so now there are weeds that are Roundup-resistant.

So now they're creating crops that are Agent Orange-resistant and they're spraying crops with Agent Orange.


Roundup was a god-send to cotton farmers here in the late 90s. Now morning glory is completely resistant to it in some places in the South and the resistance is actually moving westward to here. You can only spray so much chemical on a field before it becomes futile and prohibitive in cost. Looks like they're going to have to start hiring Mexicans and teenagers again to pull out morning glory.
2013-02-11 09:23:55 PM
1 votes:

Macular Degenerate: Three years of painful skin delamination as a side effect of drug regimen? I think I'd rather take the sweet, sweet kiss of death.


SJS and TEN are pretty rare, I think the rate is like 1 in 1,000,000 Doses.

You're more likely to get struck by lightning, to be honest.
2013-02-11 08:52:13 PM
1 votes:
Lost Thought 00:   And yet the population of India still exists

Or pretty much any country in East Asia.  You haven't seen human population density, until you've visited over there.  Other than SARS killing a few dozen people at best, why hasn't there been any much nastier epidemic killing tens of hundreds of thousands of folks over there?

Actually, that would suck... got relatives there.
2013-02-11 07:45:53 PM
1 votes:

stappawho: Moral of the story, your friend is simply nasty and not doing himself any favors.


He works in education, has four kids of his own and for a time his wife ran day-care out of their house. He basically lives in a petri dish.

The strangest part is he has mild OCD and still isnt a hand-washer.
2013-02-11 07:42:34 PM
1 votes:
Meanwhile, they've created crops that are Roundup-resistant, and so now there are weeds that are Roundup-resistant.

So now they're creating crops that are Agent Orange-resistant and they're spraying crops with Agent Orange.
2013-02-11 07:42:02 PM
1 votes:

Egalitarian: OK don't google that.


Good advice, never google any condition involving the skin
2013-02-11 07:39:18 PM
1 votes:
FTFA, regarding side effects of treating drug-resistant TB: Stevens-Johnson syndrome in which layers of skin separate ...

OK don't google that. Look I warned you. Don't even click on the Wikipedia page.That clam-tongue will haunt your dreams forever.
2013-02-11 07:34:50 PM
1 votes:
Quote from article: "which can't be said for some more innocuous bacteria that have developed drug resistances, such as gonorrhea.

Anyone imagine an explanation about giving their other half the clap containing the phrase: "but don't worry, it's innocuous."

Seriously whilst it's an African problem at present, it's just a hop, skip and a plane ride to the rest of the world.  I know because when I first came to the U.S. I did not have any type of TB.  Now I likely have latent TB, thanks to some tosser walking around coughing & hacking all over the place.

/ Thanking the Big Pharma gods, taking meds and the bug shouldn't harm me - so all will be well.
2013-02-11 07:34:20 PM
1 votes:

GAT_00: d medical science hasn't created any fundamentally new antibiotics in decades. It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.


heh - you said antibiotics treating viruses.  That's funny.

But yeah, just lectured by dad the other day about this, when he offered to let me have some of his "left over" antibiotics to treat my arm after a bit of a mishap I had.  After questioning, turns out he's one of THEM who stop taking antibiotics once the problem "goes away" per his perspective.  Boo.  Told him that if he didn't think the doctor knew what they were talking about when they told him how many to take, then he shouldn't take the pills at all; take all or none, people.  Don't just take some of them.
2013-02-11 07:17:44 PM
1 votes:

angrymacface: He most certainly does.


upload.wikimedia.org

No, he doesn't. It's an inane conspiracy theory passed around by people who like to sound intellectually superior to the masses of sheeple they regard everyone else as. In reality, it requires a complete suspension of knowledge in the human factor of any conspiracy theory, namely that no one is motivated by anything other than money, and that everyone's silence is able to be bought off. Even assuming the above two are true, it requires such human competence as for there to be no evidence, at all, of the conspiracy occuring, and no evidence of the supposed "cures" being suppressed.

In this case, most cases of TB are highly curable using either a single drug, or combination of drugs. However, M. Tuberculosis also RAPIDLY develops drug resistance when those drugs are taken improperly.

You shouldn't attribute conspiracy to what is explainable by evolution. You look like a dipshiat.
xcv
2013-02-11 07:17:17 PM
1 votes:
~30 years ago when my mom was in med school the instructor told the students to get a look at TB cases while they were rotating through a clinic in rural Central America, but they'd 'never see a TB patient back in the US.'
2013-02-11 07:16:55 PM
1 votes:

Smeggy Smurf: .

 boss induced involuntary sobriety


All kidding aside, I'm totally stealing this and plan to use it as often as possible
2013-02-11 07:10:20 PM
1 votes:

angrymacface: Yogimus: MFK: to "treatments" instead of "cures" anyway. You "cure" a patient, and you'll never see them again, but if you "treat" a disease, well... you've got yourself a customer who is totally de

^ and then comes this guy.

He's got a point, though.


No, he doesn't.
2013-02-11 07:06:56 PM
1 votes:

Smeggy Smurf: GAT_00: BronyMedic: GAT_00: BronyMedic: GAT_00: And medical science hasn't created any fundamentally new antibiotics in decades.  It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.

[www.theappleclan.com image 610x250]

Yes, I misused a word.  My bad.

You didn't just misuse a word...

[img209.imageshack.us image 400x256]

But you knew what I meant, you knew what I should have said.

Now would be a good time to get a laugh, admit you screwed the pooch and move on.  Blame it on global warming or boss induced involuntary sobriety


I'm not pretending that I didn't screw up.  That would be stupid.
2013-02-11 07:06:27 PM
1 votes:

Fark Rye For Many Whores: Hey uh.

Maybe we start treating antibacterial misuse as mass murder.

Because it is.


Ok, can we deal with the anti vaxers in the same manner?
2013-02-11 06:51:13 PM
1 votes:

doglover: There's sweeping your teamate with barrel of a painball gun in the heat of a match, and then there's pointing a loaded .50 cal turret at a school with children inside. Totally different orders of magnitude.


You're assuming I accidentally shot James in the balls in the "heat of the match", and not because I found out he was hitting on my wife.
2013-02-11 06:47:09 PM
1 votes:

stevenboof: BronyMedic: You didn't just misuse a word...

Reminds me of the whole "clip vs magazine" thing that we saw so much a while back.  GAT_00 can no longer have an opinion on medicine, bacteria, or disease.


www.johnnythefool.com
2013-02-11 06:46:14 PM
1 votes:
Like many bacterial diseases, tuberculosis has been evolving

HERESY!
2013-02-11 06:45:11 PM
1 votes:

GAT_00: BronyMedic: ecmoRandomNumbers: My mom's health department has been dealing with this for 3 years, submitter. It's already here.

Going to say it's been here for a long time.

XDR-MDR TB is one of the few reasons in a modern age someone can get an involuntary quarantine order placed upon them by a court.

And medical science hasn't created any fundamentally new antibiotics in decades.  It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.


Paging Doctor Morbo, paging Doctor Morbo
2013-02-11 06:37:43 PM
1 votes:

BronyMedic: GAT_00: BronyMedic: GAT_00: And medical science hasn't created any fundamentally new antibiotics in decades.  It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.

[www.theappleclan.com image 610x250]

Yes, I misused a word.  My bad.

You didn't just misuse a word...

[img209.imageshack.us image 400x256]


But you knew what I meant, you knew what I should have said.
2013-02-11 06:34:58 PM
1 votes:

Moonfisher: I highly recommend Paul Farmer's "Infections and Inequalities" for some insight into how these things are developing and why they are so hard to treat.


I'll go look up the book, thanks!
2013-02-11 06:31:28 PM
1 votes:

GAT_00: BronyMedic: GAT_00: And medical science hasn't created any fundamentally new antibiotics in decades.  It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.

[www.theappleclan.com image 610x250]

Yes, I misused a word.  My bad.


You didn't just misuse a word...

img209.imageshack.us
2013-02-11 06:29:39 PM
1 votes:
It's a reckoning.
2013-02-11 06:28:46 PM
1 votes:
Welp, it's been a good go.  See you all in hell, I'll be by the Faygo stand.
2013-02-11 06:27:40 PM
1 votes:
upload.wikimedia.org

No??
2013-02-11 06:24:21 PM
1 votes:

BronyMedic: The problem is not that they can't get antibiotics. The problem is that there is poor compliance with TB antibiotic therapy, which allows drug resistance to form. TB is not something you take a two week course of antibiotics for, and it's not a big deal if you stop at day 8 instead of day 10. It's a six month to a year course of antibiotics, and Mycobacterium Tuberculosis rapidly develops resistance to antibiotics when taken improperly.


polymer release? in my subdermal?!... it's more common than you think!
2013-02-11 06:23:14 PM
1 votes:
oh whatever, it's just a passing phage...
2013-02-11 06:19:58 PM
1 votes:

MFK: please. There's no profit margin in treating common killer diseases. All of big pharma's R&D has been sunk into "treatments" instead of "cures" anyway. You "cure" a patient, and you'll never see them again, but if you "treat" a disease, well... you've got yourself a customer who is totally dependent on your wares.


You missed your turnoff to NaturalNews.com. Since you're willing to demonstrate your obvious ignorance of how difficult TB is to treat, or how easy it is to garner resistance to the antibiotics used to treat it combined with poor regiment compliance by patients,  we're just going to point and laugh at you instead.
2013-02-11 06:19:55 PM
1 votes:
Pig pile on GAT_00!

Yes, that was pretty stupid, even for you.
2013-02-11 06:17:18 PM
1 votes:
I'm your huckleberry
2013-02-11 06:15:37 PM
1 votes:

GAT_00: And medical science hasn't created any fundamentally new antibiotics in decades.  It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.


Oh wow. That's... That's something special.
2013-02-11 06:13:37 PM
1 votes:

GAT_00: And medical science hasn't created any fundamentally new antibiotics in decades.  It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.


www.theappleclan.com
2013-02-11 06:09:20 PM
1 votes:
This is why I don't wash my hands with soap when I pee.  I will outlive you all.
2013-02-11 06:05:41 PM
1 votes:

BronyMedic: ecmoRandomNumbers: My mom's health department has been dealing with this for 3 years, submitter. It's already here.

Going to say it's been here for a long time.

XDR-MDR TB is one of the few reasons in a modern age someone can get an involuntary quarantine order placed upon them by a court.


And medical science hasn't created any fundamentally new antibiotics in decades.  It's why so many viruses are adapting to basically everything, on top of bad treatment regimens and failures to finish taking full doses.
2013-02-11 03:01:17 PM
1 votes:
My mom's health department has been dealing with this for 3 years, submitter. It's already here.
 
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