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(CNN)   New drug helps obese lab rats lose weight without diet or exercise. Fark: Drug was developed to fight canker sores   (cnn.com) divider line 39
    More: Spiffy, diet pills, Nature Medicine, body temperatures  
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2069 clicks; posted to Geek » on 11 Feb 2013 at 1:39 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2013-02-11 10:31:30 AM
Oh good.

An excuse for some to eat whatever the hell they want, not exercise and try and justify it.

The researchers should have been able to tell by the fact the rats just sat there, ate everything and site and said "fark you" when they put in the running wheel.
 
2013-02-11 10:46:15 AM

I_Am_Weasel: An excuse for some to eat whatever the hell they want, not exercise and try and justify it.


First World Personal liberties, am I right?

Also, this:
www.mcpeepants.com
 
2013-02-11 10:56:05 AM
give me, give me, give me!!


Can see what happens when I pair it with my diet and exercise program!
 
2013-02-11 11:22:45 AM

The Stealth Hippopotamus: Can see what happens when I pair it with my diet and exercise program!


After only a week!

i.cdn.turner.com

And if you feel the urge to crawl on the ceiling, or lick the dead bugs out of a lamp fixture, go for it! South Bronx Paradise, Baby!
 
2013-02-11 01:52:18 PM
i've been stuck in a rut losing weight. i've lost 65 lbs already. been holding steady  (roughly) for two years. i run 15-25 miles a week. i travel a lot for work and the diet is what is probably holding me back. my kids asked me why i keep running. I told them I really like to eat. if i want to eat what i want or close to it...i have to exercise. the key is when i can't exercise is to hold back on the food.

its not like i'm scarfing down junk all the time but every once in while..i want some chips or some other stuff that i can't normally have.

need to jump start the exercise to get thru this holding point.

i would not even start on this drug though. once you stop...it comes back. i really don't want to be on a medication for life...that helps exploit unhealthy behaviour.
 
2013-02-11 02:03:57 PM
So it fights cankers and cankles?
 
2013-02-11 02:09:50 PM
Fatties of America will still manage to stay fat.
 
2013-02-11 02:09:52 PM

Tanukis_Parachute: i've been stuck in a rut losing weight. i've lost 65 lbs already. been holding steady  (roughly) for two years. i run 15-25 miles a week. i travel a lot for work and the diet is what is probably holding me back. my kids asked me why i keep running. I told them I really like to eat. if i want to eat what i want or close to it...i have to exercise. the key is when i can't exercise is to hold back on the food.

its not like i'm scarfing down junk all the time but every once in while..i want some chips or some other stuff that i can't normally have.

need to jump start the exercise to get thru this holding point.

i would not even start on this drug though. once you stop...it comes back. i really don't want to be on a medication for life...that helps exploit unhealthy behaviour.


I'm guessing the journalists neglected to add a proper qualifier in there. It says they made the mice fat by übering up their diet, and lost it while consuming the same diet on the medication but when the medication was stopped they gained it back. They never said if they dialed back the diet or not. I'm guessing not.

As described in the article, often people have trouble losing weight because dialing back the calories often tends to dial back the metabolism. This would be used to get through that, get to a healthy weight at a non weight gaining level of caloric intake.

I mean, ideally. I'm sure plenty of ppl will just use it to maintain mediocre weight while stuffing themselves like hogs.
 
2013-02-11 02:10:08 PM

Tanukis_Parachute: need to jump start the exercise to get thru this holding point.


Have you tried weight training?  Increasing your muscle mass and density has a huge effect on increasing your resting metabolism.  Adding muscle now can melt fat later on down the road.
 
2013-02-11 02:17:26 PM

neongoats: Tanukis_Parachute: i've been stuck in a rut losing weight. i've lost 65 lbs already. been holding steady  (roughly) for two years. i run 15-25 miles a week. i travel a lot for work and the diet is what is probably holding me back. my kids asked me why i keep running. I told them I really like to eat. if i want to eat what i want or close to it...i have to exercise. the key is when i can't exercise is to hold back on the food.

its not like i'm scarfing down junk all the time but every once in while..i want some chips or some other stuff that i can't normally have.

need to jump start the exercise to get thru this holding point.

i would not even start on this drug though. once you stop...it comes back. i really don't want to be on a medication for life...that helps exploit unhealthy behaviour.

I'm guessing the journalists neglected to add a proper qualifier in there. It says they made the mice fat by übering up their diet, and lost it while consuming the same diet on the medication but when the medication was stopped they gained it back. They never said if they dialed back the diet or not. I'm guessing not.

As described in the article, often people have trouble losing weight because dialing back the calories often tends to dial back the metabolism. This would be used to get through that, get to a healthy weight at a non weight gaining level of caloric intake.

I mean, ideally. I'm sure plenty of ppl will just use it to maintain mediocre weight while stuffing themselves like hogs.


I'd probably use it to drop 20 lbs and then limit myself to a weight maintaining caloric count.   The weight loss caloric count is the hard part.
 
2013-02-11 02:58:59 PM
Experts say that's an especially important concern because if the drug is ever used in humans for weight loss, patients would likely need to stay on the drug indefinitely, or else see the weight return.

How fortunate for the drug companies.
 
2013-02-11 03:04:37 PM
Adipose?
 
2013-02-11 03:07:13 PM

lilbjorn: Experts say that's an especially important concern because if the drug is ever used in humans for weight loss, patients would likely need to stay on the drug indefinitely, or else see the weight return.

How fortunate for the drug companies.


Google says the current retail price for the drug is $20/5g tube. It's also off patent, which implies that if it becomes the most popular drug in history it could see for as little as aspirin.
 
2013-02-11 03:22:02 PM

Stone Meadow: lilbjorn: Experts say that's an especially important concern because if the drug is ever used in humans for weight loss, patients would likely need to stay on the drug indefinitely, or else see the weight return.

How fortunate for the drug companies.

Google says the current retail price for the drug is $20/5g tube. It's also off patent, which implies that if it becomes the most popular drug in history it could see for as little as aspirin.


Oh, they'll fix that.  You just weight and see.
 
2013-02-11 03:29:43 PM
Hang on, let's not get ahead of ourselves. We need to be careful that we're not reading too much into the first fluffy article that shows up on the web.

For example, was this a proper clinical science trial, with laser machines and such?

In the mouse study, the researchers took pains to make sure that it was the drug, and not something else, that was making the mice lose weight. They used a laser machine to trace the mice to see if perhaps the weight loss was because they moved around more while on the drug.

Okay, good. Now, are they ABSOLUTELY SURE this will work?

Hopes are high, even though many drugs that work in mice do not work in humans. If amlexanox works in humans -- and that's a big if...

Good, so there's no doubt in anyone's mind this is a wonder drug. But we're not done yet. What about any potential problems?

One concern will be whether these drugs, by increasing energy expenditure and body temperature, may have unintended consequences on other systems, such as the heart.Experts say that's an especially important concern because if the drug is ever used in humans for weight loss, patients would likely need to stay on the drug indefinitely, or else see the weight return.

If you translate that from the clinical jargon, what these scienticians are trying to say is that nothing can possibly go wrong.

So, this seems legit. It's perfectly safe to assume that this miracle drug will have you skinny before bathing suit season this year. In fact, you can probably just go ahead and start eating whatever you want.
 
2013-02-11 03:31:31 PM
To hell with the weight loss - does it actually work on canker sores?

/motherfarkers
 
2013-02-11 03:38:06 PM

lewismarktwo: Stone Meadow: lilbjorn: Experts say that's an especially important concern because if the drug is ever used in humans for weight loss, patients would likely need to stay on the drug indefinitely, or else see the weight return.

How fortunate for the drug companies.

Google says the current retail price for the drug is $20/5g tube. It's also off patent, which implies that if it becomes the most popular drug in history it could see for as little as aspirin.

Oh, they'll fix that.  You just weight and see.


rlv.zcache.com
 
2013-02-11 03:55:18 PM
Why are rats the ones always benefiting from the millions of dollars that get pumped into science? So far we've cured their cancer, HIV, weight gain, grown new ears for them and soon we will be making them immortal....when's the last time any of this awesome stuff actually made it to the actual humans?
 
2013-02-11 04:10:24 PM
There was glowing predictions for PPAR-delta  (google 'marathon mouse') some years ago too, and look at how that turned out.

/went poof, apparently
 
F42
2013-02-11 04:14:18 PM
They don't move more. The movement is exactly the same. The increased energy expenditure was due to something called thermogenesis

It's winter and I want some of that.
 
2013-02-11 04:19:12 PM
Some horrible side effect will be discovered soon ...

Nature abhors easy.
 
2013-02-11 04:45:13 PM
well, when the canker goes away,  you lost weight!   Ta Da!
 
2013-02-11 05:24:02 PM

nmemkha: Some horrible side effect will be discovered soon ...

Nature abhors easy.


They will definitely find some hardly occurring side effect and blow it way out of proportion with out a doubt.
 
2013-02-11 05:27:40 PM
Gilda Radner did a bit skit on SNL news with a canker/cancer punchline.

/Oh! Never mind!
 
2013-02-11 05:34:37 PM

lewismarktwo: nmemkha: Some horrible side effect will be discovered soon ...

Nature abhors easy.

They will definitely find some hardly occurring side effect and blow it way out of proportion with out a doubt.


I personally know someone who got heart damage from taking Fen-Phen.

Your argument is invalid.
 
2013-02-11 06:07:36 PM

nmemkha: lewismarktwo: nmemkha: Some horrible side effect will be discovered soon ...

Nature abhors easy.

They will definitely find some hardly occurring side effect and blow it way out of proportion with out a doubt.

I personally know someone who got heart damage from taking Fen-Phen.

Your argument is invalid.


I'm not sure you know what invalidates arguments.
 
2013-02-11 07:21:45 PM

lewismarktwo: nmemkha: lewismarktwo: nmemkha: Some horrible side effect will be discovered soon ...

Nature abhors easy.

They will definitely find some hardly occurring side effect and blow it way out of proportion with out a doubt.

I personally know someone who got heart damage from taking Fen-Phen.

Your argument is invalid.

I'm not sure you know what invalidates arguments.


And right to Ad Hominem

1/10
 
2013-02-11 07:28:49 PM
"They don't move more. The movement is exactly the same. The increased energy expenditure was due to something called thermogenesis meaning they generate a little bit of heat,"

It's winter and I want some of that.


THIS!
Losing weight AND having warm hands and feet! Sign me up!
 
2013-02-11 07:56:47 PM

Wolf892: Why are rats the ones always benefiting from the millions of dollars that get pumped into science? So far we've cured their cancer, HIV, weight gain, grown new ears for them and soon we will be making them immortal....when's the last time any of this awesome stuff actually made it to the actual humans?


I've often thought that mousey veterinary science must be like being Bones on Star Trek compared to other fields of animal medicine.
 
2013-02-11 08:03:34 PM
What I am understanding is that rat fat is comprised of the same tissue as canker sores.
 
2013-02-11 08:10:05 PM

nmemkha: lewismarktwo: nmemkha: lewismarktwo: nmemkha: Some horrible side effect will be discovered soon ...

Nature abhors easy.

They will definitely find some hardly occurring side effect and blow it way out of proportion with out a doubt.

I personally know someone who got heart damage from taking Fen-Phen.

Your argument is invalid.

I'm not sure you know what invalidates arguments.

And right to Ad Hominem

1/10


It's not ad hominem to point out that you haven't invalidated any arguments with your little anecdote, but I know what you're trying to do here and it won't work.
 
2013-02-11 08:47:32 PM
Using a drug for another purpose it wasn't originally intended for is not new.
For instance, Rogaine was originally intended to be used for heart problems, but the men who used it reported that their hair grew back.  So it became the miracle hair regrowth drug we now know today.
 
2013-02-11 08:58:14 PM
Now I know why your mom stayed slim all these years.
 
2013-02-11 09:13:38 PM
www.smbc-comics.com
/Relevant
//And hot
 
2013-02-11 09:44:29 PM

lewismarktwo: nmemkha: lewismarktwo: nmemkha: lewismarktwo: nmemkha: Some horrible side effect will be discovered soon ...

Nature abhors easy.

They will definitely find some hardly occurring side effect and blow it way out of proportion with out a doubt.

I personally know someone who got heart damage from taking Fen-Phen.

Your argument is invalid.

I'm not sure you know what invalidates arguments.

And right to Ad Hominem

1/10

It's not ad hominem to point out that you haven't invalidated any arguments with your little anecdote, but I know what you're trying to do here and it won't work.


Don't you have pharmaceuticals to sell or is this your job?
 
2013-02-12 10:43:39 AM

Girion47: neongoats: Tanukis_Parachute: i've been stuck in a rut losing weight. i've lost 65 lbs already. been holding steady  (roughly) for two years. i run 15-25 miles a week. i travel a lot for work and the diet is what is probably holding me back. my kids asked me why i keep running. I told them I really like to eat. if i want to eat what i want or close to it...i have to exercise. the key is when i can't exercise is to hold back on the food.

its not like i'm scarfing down junk all the time but every once in while..i want some chips or some other stuff that i can't normally have.

need to jump start the exercise to get thru this holding point.

i would not even start on this drug though. once you stop...it comes back. i really don't want to be on a medication for life...that helps exploit unhealthy behaviour.

I'm guessing the journalists neglected to add a proper qualifier in there. It says they made the mice fat by übering up their diet, and lost it while consuming the same diet on the medication but when the medication was stopped they gained it back. They never said if they dialed back the diet or not. I'm guessing not.

As described in the article, often people have trouble losing weight because dialing back the calories often tends to dial back the metabolism. This would be used to get through that, get to a healthy weight at a non weight gaining level of caloric intake.

I mean, ideally. I'm sure plenty of ppl will just use it to maintain mediocre weight while stuffing themselves like hogs.

I'd probably use it to drop 20 lbs and then limit myself to a weight maintaining caloric count.   The weight loss caloric count is the hard part.


Being obese makes it difficult to do serious cardio. You get tired faster and it's physically painful shuffling around excess weight quickly. Having a way to directly melt off the pounds through increased metabolism would be a minor miracle. As you get lighter, you can exercise more and more without putting undue stress on your joints and running out of breath, so your natural metabolic rate will rise. Combine it with strength training and you could end up with a metabolism that would support a healthy weight with a reasonable diet, even without the drugs. The only people who would be hooked for life would be those expecting to drop tons of weight and continue living like hogs.

I lost a bunch of weight a year ago by cutting excess sugar out of my diet and adding light exercise daily, and then hit a plateau where I'd either have to start exercising a lot harder (difficult for me as I damaged a knee a few years ago and the extra weight puts a lot of stress on it) or go on a really restrictive diet plan, which has failed everyone I know that's tried it. I'm trying to build muscle now to help burn more fat, but I would love being able to "cheat" with a drug like this.
 
2013-02-12 12:04:03 PM
Cthulhu_is_my_homeboy: I lost a bunch of weight a year ago by cutting excess sugar out of my diet and adding light exercise daily, and then hit a plateau where I'd either have to start exercising a lot harder (difficult for me as I damaged a knee a few years ago and the extra weight puts a lot of stress on it) or go on a really restrictive diet plan, which has failed everyone I know that's tried it. I'm trying to build muscle now to help burn more fat, but I would love being able to "cheat" with a drug like this.

I was obese for several years until about a year ago, and couldn't do any serious cardio because I would be all out of breath in seconds, had chest pains, etc. Then I went on the "New Atkins Diet" and started riding my bicycle 10 miles slightly down hill to work (first once a week, then twice, then 3x). Since then I've lost 40+ pounds down into the top of the normal BMI range; have lots more energy, and power through my ride.

I had tried to lose weight many times before, but Atkins was the key tp success for me. It calls for very low carbs and lots of fat: about 3:1 fat to protein, with almost no carbs. The high fat content quickly turns off your appetite so you end up eating less total calories, leading to steady weight loss. Give it a try...you'll like it.
 
2013-02-12 02:11:01 PM
Sounds like a uncoupler. Those work great, until you end up getting a bit too much, then it's a pretty gruesome death.

Also, you end up with lots of free radical generation from it, which isn't all that good for you. We used to have some uncouplers that were classified war gases, really butt awful stuff.

Cthulhu: you can do this 'at home' with readily available uncouplers, right now. If you're very very very careful, they'll work for you, no doubt. If you # up, you can die a miserable death: there's basically no way of stopping it once it starts, other than being hooked to a hypothermia machine and given a dantrolene IV, which DID work one time for one patient.

Also, you will sweat like a peeg and feel like you're glowing all the time, especially at first when your volume to surface area ratio is bad. You also need a heart that's in pretty good shape, also your kidneys and liver will take a mild beating, and some people that push it too hard end up with early cataracts. But it'll work. Your search term of choice is: 2,4-dinitrophenol, or more simply, DNP.

In truth, people take this stuff all the time and get away with it, but it requires a steady hand and a lot of self-control with the titration. Any "more is better, and lots more is lots better" is an invitation for Darwin to pay a call.
 
2013-02-12 04:38:28 PM
Anyone who says that fat people should only diet and exercise to lose weight are no better than the tards who say that women should only abstain from sex if they don't want to get pregnant.
 
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