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(Deccan Herald)   First there was bad cholesterol, then there was good cholesterol, now there is "ugly" cholesterol which makes a person 3 times more likely to have heart disease   (deccanherald.com) divider line 57
    More: Followup, good cholesterol, bad cholesterol, heart disease, coronary arteries, University of Copenhagen, cholesterol, preventive medicines, blood levels  
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5061 clicks; posted to Main » on 22 Jan 2013 at 11:34 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2013-01-22 09:17:57 PM
There are also ugly hearts, which make a person 3 times more likely to quote Murray Rothbard.
 
2013-01-22 09:22:57 PM
In before the inevitable pictures of ugly fat people.
 
2013-01-22 09:28:25 PM

fusillade762: In before the inevitable pictures of ugly fat people.


Do you need both in this sentence, really?
 
2013-01-22 11:01:30 PM
Hmm, have they merely found a catchy word for "everything that is neither LDL-C nor HDL-C," which technically isn't the same as very-low-density-lipoprotein (VLDL). There's a fair bit of research that suggests non-HDL-C and ApoB have predictive value for CV risk, and it appears this study is adding to that body of research and helping to inform the debate as to which numbers have the greatest predictive value.

Disclaimer: I'm hardly a lipidologist, I picked those other studies pretty much at random, so I may be underestimating this study's significance, and I'm already one beer into the night, so here's the paper, have at it, pre-med and cardio nerds: Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease
 
2013-01-22 11:39:27 PM
I think we can all agree that Cholesterol Kardashian is the ugly one.
 
zez
2013-01-22 11:40:54 PM
Everybodys got a ugly heart
Everybodys got a ugly heart
Lay down your money and you play your part
Everybodys got a ugly uuugggggly heart
 
2013-01-22 11:44:07 PM

fusillade762: In before the inevitable pictures of ugly fat people.


i.imgur.com
 
2013-01-22 11:45:02 PM
There is also 'fugly' cholesterol, which is literally comprised of fudge and chicken skins.
 
2013-01-22 11:45:15 PM
"Ugly Cholesterol" is this person's stupid name for what is more broadly known as triglycerides.
 
2013-01-22 11:46:16 PM
there are two kinds of people my friend: those who are fat and those who aren't
 
2013-01-22 11:46:42 PM
Bullshiat. Everyone knows that stress is the number one risk. Come on!
 
2013-01-22 11:51:04 PM
Just another way to push meds.
 
2013-01-22 11:52:38 PM
Ugly Korea too?
 
2013-01-22 11:52:46 PM
I have cholesterol. Dietary. Familial. Any other kind you care to name. Eggs were good, then they were bad, now they are good again (maybe) or bad. Gonna live or die. Meh - have one hell of a run at it, still know how to laugh, fark, care.

/Correlation not equal to cause and effect.
//Physiology & biochem (no pharma) at a medical school, so fark all you EMT's, PhD's, MD's
///Live a while, die.
////Have fun, help people in between.
 
2013-01-22 11:55:06 PM
Which foods have "studly" cholesterol that'll enlarge the ol' wanger?
 
2013-01-23 12:02:42 AM
Here's one for the anti and pro gun people
i.imgur.com
 
2013-01-23 12:08:01 AM
clearancebinreview.com

/agrees
 
2013-01-23 12:10:25 AM

Enigmamf: "Ugly Cholesterol" is this person's stupid name for what is more broadly known as triglycerides.


I thought they were talking about VLDL
 
2013-01-23 12:10:33 AM

Twilight Farkle: Hmm, have they merely found a catchy word for "everything that is neither LDL-C nor HDL-C," which technically isn't the same as very-low-density-lipoprotein (VLDL). There's a fair bit of research that suggests non-HDL-C and ApoB have predictive value for CV risk, and it appears this study is adding to that body of research and helping to inform the debate as to which numbers have the greatest predictive value.

Disclaimer: I'm hardly a lipidologist, I picked those other studies pretty much at random, so I may be underestimating this study's significance, and I'm already one beer into the night, so here's the paper, have at it, pre-med and cardio nerds: Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease


I cloned, expressed and tested the many homologs of the cytodine deaminase that creates the splice variants of ApoB

/Now I'm a waiter. Meh.
 
2013-01-23 12:12:19 AM
Professor Borge Nordestgaard = made-up name
 
2013-01-23 12:15:22 AM
High cholesterol levels is a symptom, not the underlying disease.

But by all means, keep pretending you know what you're doing and keep poisoning us all with statins.
 
2013-01-23 12:17:12 AM
Aint payin' for another damm test.
 
2013-01-23 12:22:45 AM

Gelatinous: High cholesterol levels is a symptom, not the underlying disease.

But by all means, keep pretending you know what you're doing and keep poisoning us all with statins.


Please explain. I know that statins are somewhat ineffective unless choloesterol is insanely high, but how are they poison.
 
2013-01-23 12:24:39 AM
I am going to let everyone in on a secret. Eat well and exercise everyday.

I should write a book.
 
2013-01-23 12:31:19 AM
www.klkkfm.com

Well, I can't be with ugly girls no more...on a count of my cholesterol being what it is.
 
2013-01-23 12:33:15 AM

Gelatinous: High cholesterol levels is a symptom, not the underlying disease.

But by all means, keep pretending you know what you're doing and keep poisoning us all with statins.


THIS! Correlation does not equal cause and effect. I have serious reaction (rhabdomyolysis) to all statins - not fun, life threatening. Strangely enough, no one can tell me whether it is a direct effect of the drug or a result of the buildup of HMGCoA - FDA privacy, and a felony to reveal drug manufacturers' data (have a grad school buddy who works for FDA).

Is it possible that drug companies are lying bastards? - GIS Pfizer, fines.
 
2013-01-23 12:46:36 AM

pellies: I cloned, expressed and tested the many homologs of the cytodine deaminase that creates the splice variants of ApoB

/Now I'm a waiter. Meh.


I futz with computers and read this guy's blog. Meh.

(Srsly, congrats, you made it several years further past the point at which my brain melted!)

I'm still waiting to see the extent to which controlling lipid biomarkers like LDL/HDL/ApoB ( /VLDL/everythingelse?) actually decreases CV events, and this study is a piece in that puzzle. I'm skeptical on fenofibrates, statins are pretty awesome, but I'd like to see if EPA or EPA+statins can stand up to a real outcomes study. (LGT another fark thread where I srsly nerded out. I still have both a personal and small financial interest in the outcome of that study and am in no condition to even pretend to do moar research tonight. /ethanol)

Enigmamf: "Ugly Cholesterol" is this person's stupid name for what is more broadly known as triglycerides.


Naw, it's total TG minus HDL minus LDL. It's whatever's left including VLDL, but it's not exclusive VLDL. The paper actually lists 'em all by name, but I'm not going to pretend to HEY, stop reading me and start paying attention to the dude who actually knows something about how our bodies crank this stuff out. Might be that it's only really effective in certain patient subgroups or those with family/friends with familial hypercholesterolemia, but knowing is half the battle.
 
2013-01-23 12:50:52 AM
Well, when the different kinds of cholesterol fight it out in the abandoned spaghetti western graveyard that is my heart, I'll let you know how it goes.


I have the feeling that it will involve an orchestra and two more movies.
 
2013-01-23 12:59:12 AM
I was told my bad cholesterol was good and my good cholesterol wad bad. Doctor told me to drink a glass of wine every night and walk 30 minutes a day. Maybe I'll throw some honey nut cheerios in there since I'm on a health kick.

/good cholesterol was really low. I think it runs in my family
 
2013-01-23 01:00:40 AM

Swoop1809: I think it runs in my family


Either that ir they ain't got a farkin" clue
 
2013-01-23 01:11:21 AM

Enigmamf: "Ugly Cholesterol" is this person's stupid name for what is more broadly known as triglycerides.


Those little bastards are why I had to cut back on drinking. That number has been steadily climbing for a couple of years. A month ago it was at 250. I figure a 50% reduction in drunkeness and commuting by bike a couple times a week once it warms up ought to do the trick. A bit more salad, a little less carbs can't hurt either.
 
2013-01-23 01:13:57 AM
Force-blocking the page for non-Javascript browsers makes the Intarwebs sad.
 
2013-01-23 01:17:47 AM

Twilight Farkle: Hmm, have they merely found a catchy word for "everything that is neither LDL-C nor HDL-C," which technically isn't the same as very-low-density-lipoprotein (VLDL). There's a fair bit of research that suggests non-HDL-C and ApoB have predictive value for CV risk, and it appears this study is adding to that body of research and helping to inform the debate as to which numbers have the greatest predictive value.

Disclaimer: I'm hardly a lipidologist, I picked those other studies pretty much at random, so I may be underestimating this study's significance, and I'm already one beer into the night, so here's the paper, have at it, pre-med and cardio nerds: Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease


Finally someone to ask... is eating eggs bad for you, or good??
 
2013-01-23 01:19:34 AM
How does anyone else eat this "ugly" cholesterol when it's so obvious your mom ate all of it?
 
2013-01-23 01:20:21 AM
fusillade762: In before the inevitable pictures of ugly fat people.

Do you need both in this sentence, really?


Sure - there are plenty of ugly people who are not fat.

/good cholesterol was really low. I think it runs in my family

Try taking Niacin. I raised mine 10 pts (from 30 to 40) by doing that.

/It will make your skin flush for ~20 min, several hours after you take it. I take mine at night and sleep through it. You may not be as heavy a sleeper though.
//The no-flush stuff is worthless. It is the chemical reaction that causes the flush that gives you the extra HDL.
 
2013-01-23 01:21:20 AM

Enigmamf: "Ugly Cholesterol" is this person's stupid name for what is more broadly known as triglycerides.


is it possible that we could stop dumbing this shiat down?
HDL,
LDL
triglycerides

HOW hard is that?
and just tell the patient which is too high and which is too low
TADA
rocket science
 
2013-01-23 01:23:45 AM
So I guess Strange and Charm cholesterol will be discovered next?
 
2013-01-23 01:36:14 AM

Spartan_Manhandler: Force-blocking the page for non-Javascript browsers makes the Intarwebs sad.


And their preferred browsers? The links at the bottom of the get a new browser page are IE6 SP1 and Netscape 7.1 (403'd)
 
2013-01-23 01:51:53 AM

bongo98902: Spartan_Manhandler: Force-blocking the page for non-Javascript browsers makes the Intarwebs sad.

And their preferred browsers? The links at the bottom of the get a new browser page are IE6 SP1 and Netscape 7.1 (403'd)


Hit ESC really quickly - the page renders in full before the Javashiat redirect derps it up.
 
2013-01-23 01:52:31 AM

Oznog: Twilight Farkle: Hmm, have they merely found a catchy word for "everything that is neither LDL-C nor HDL-C," which technically isn't the same as very-low-density-lipoprotein (VLDL). There's a fair bit of research that suggests non-HDL-C and ApoB have predictive value for CV risk, and it appears this study is adding to that body of research and helping to inform the debate as to which numbers have the greatest predictive value.

Disclaimer: I'm hardly a lipidologist, I picked those other studies pretty much at random, so I may be underestimating this study's significance, and I'm already one beer into the night, so here's the paper, have at it, pre-med and cardio nerds: Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease

Finally someone to ask... is eating eggs bad for you, or good??


Yes!
 
2013-01-23 01:55:22 AM
So that's what's wrong with me. There's a Mexican standoff going on inside of me.

/Blondie!
 
2013-01-23 01:55:39 AM

SpdrJay: Which foods have "studly" cholesterol that'll enlarge the ol' wanger?


Of all the places that should store fat and colesterol solids, figures that your prick is last.
 
2013-01-23 02:01:15 AM

Swoop1809: I was told my bad cholesterol was good and my good cholesterol wad bad. Doctor told me to drink a glass of wine every night and walk 30 minutes a day. Maybe I'll throw some honey nut cheerios in there since I'm on a health kick.

/good cholesterol was really low. I think it runs in my family


Try eliminating wheat. For other reasons, I dropped it 5 weeks before my second round of blood work, and all my cholesterol levels immediately went to (or headed for) normal values. I made no other lifestyle changes (well, except eating several pints of Ben & Jerry's for the first few weeks to make up for the missing calories).

Yes, it's anecdotal, and no, I don't know what happens if you replace everything with "gluten free" alternatives.
 
2013-01-23 02:13:57 AM

pellies: but how are they poison


crabsno termites: rhabdomyolysis


Basically this. Virtually all my immediate family members have been put on them, and all of them developed pain and muscle weakness within months. Only one of them, my uncle, stayed on them; he was certain the doctor knew what he was talking about. My uncle was on statins for three years, had an unexpected heart attack, and died while they were trying to put the pacemaker in. Other than one congenital valve defect on the other side, there is no history of heart problems in my family.

Again, anecdotal. Along with the hundreds (thousands?) of other anecdotes online. Also, read about statins and CoQ10, if you like. Big pharma is not going to give up its multi-billion-dollar cash cow that it can basically get insurance companies to force you to take. Thanks, modern medicine.
 
2013-01-23 02:24:06 AM

Gelatinous: pellies: but how are they poison

crabsno termites: rhabdomyolysis

Basically this. Virtually all my immediate family members have been put on them, and all of them developed pain and muscle weakness within months. Only one of them, my uncle, stayed on them; he was certain the doctor knew what he was talking about. My uncle was on statins for three years, had an unexpected heart attack, and died while they were trying to put the pacemaker in. Other than one congenital valve defect on the other side, there is no history of heart problems in my family.

Again, anecdotal. Along with the hundreds (thousands?) of other anecdotes online. Also, read about statins and CoQ10, if you like. Big pharma is not going to give up its multi-billion-dollar cash cow that it can basically get insurance companies to force you to take. Thanks, modern medicine.


Muscle pain may be a precursor to rhabdo. I had rust colored stains on my body, myoglobinuria, bunch of other shiat. As retired nutritionist (read "applied biochemist/physiologist), believe that CoQ10 is mostly BS, but have had multiple, unexplained problems since being on statins - neuro, physio, cardio.

/Anecdotal evidence is NOT to be discounted. Unless you happen to be in the business for money.
 
2013-01-23 03:10:55 AM

crabsno termites: Gelatinous: High cholesterol levels is a symptom, not the underlying disease.

But by all means, keep pretending you know what you're doing and keep poisoning us all with statins.

THIS! Correlation does not equal cause and effect. I have serious reaction (rhabdomyolysis) to all statins - not fun, life threatening. Strangely enough, no one can tell me whether it is a direct effect of the drug or a result of the buildup of HMGCoA - FDA privacy, and a felony to reveal drug manufacturers' data (have a grad school buddy who works for FDA).


Depends on the drug. (FWIW, cerivastatin was withdrawn for the market for precisely this reason - and it's a damn good reason, but it's also a potential side effect with other drugs in the class.) Sounds like you both rolled a natural 1 on the d20 (or d200) save vs. genetics, and I'm glad you and your relatives (mostly) stopped using these drugs. Statins aren't poison, but it sounds like in your cases, they appear to have been doing far more harm to you than good. You did right by discontinuing usage. For those who didn't roll a natural 1, you'll also be pleased to note that BMY/SNY's Plavix (anticoagulant) and PFE's Lipitor (atorvastatin) are now off-patent as of mid-2012 and can be made by generic manufacturers for the princely sum of ten bucks a month. The cash cow's been milked, and sent out to pasture in her retirement.

You raise a very important issue on clinical data. For companies and investors, there may be such things as "successful" and "failed" clinical trials, but for scientists, there are no failed experiments, only more data. By the time there's enough data for a company to declare a "success" or a "failure", the money's already been spent, and IMO there's no moral justification not to release the data.

I think it's a farking shame that All The Trials aren't reported, but there's a movement afoot to try and fix that. All trials should be registered, and all results should be reported.
 
2013-01-23 03:22:36 AM
Face it. No matter what the FARK you do, something is out there to kill you.

Apparently every food is dangerous, processed or not, organic or not, every meat has the potential to cement your arteries closed and a vegan diet can leave you open to diseases, mineral deficiencies and/or poison you depending how the brows is grown.

The sun, air, rain and dirt can kill you. Your clothing can kill you -- even if made from natural fibers.

Currently, I know of nothing which cannot possibly kill you. Especially in foods.

If you enjoy anything, stop it! It has an even greater chance of killing you.
 
2013-01-23 04:55:38 AM
What ugly cholesterol might look like

img2-2.timeinc.net

Now give me some sketti!
 
2013-01-23 05:05:51 AM

Twilight Farkle: crabsno termites: Gelatinous: High cholesterol levels is a symptom, not the underlying disease.

But by all means, keep pretending you know what you're doing and keep poisoning us all with statins.

THIS! Correlation does not equal cause and effect. I have serious reaction (rhabdomyolysis) to all statins - not fun, life threatening. Strangely enough, no one can tell me whether it is a direct effect of the drug or a result of the buildup of HMGCoA - FDA privacy, and a felony to reveal drug manufacturers' data (have a grad school buddy who works for FDA).

Depends on the drug. (FWIW, cerivastatin was withdrawn for the market for precisely this reason - and it's a damn good reason, but it's also a potential side effect with other drugs in the class.) Sounds like you both rolled a natural 1 on the d20 (or d200) save vs. genetics, and I'm glad you and your relatives (mostly) stopped using these drugs. Statins aren't poison, but it sounds like in your cases, they appear to have been doing far more harm to you than good. You did right by discontinuing usage. For those who didn't roll a natural 1, you'll also be pleased to note that BMY/SNY's Plavix (anticoagulant) and PFE's Lipitor (atorvastatin) are now off-patent as of mid-2012 and can be made by generic manufacturers for the princely sum of ten bucks a month. The cash cow's been milked, and sent out to pasture in her retirement.

You raise a very important issue on clinical data. For companies and investors, there may be such things as "successful" and "failed" clinical trials, but for scientists, there are no failed experiments, only more data. By the time there's enough data for a company to declare a "success" or a "failure", the money's already been spent, and IMO there's no moral justification not to release the data.

I think it's a farking shame that All The Trials aren't reported, but there's a movement afoot to try and fix that. All trials should be registered, and all results should be reported.


Well said. My formal schooling ended in 1975, then I began to learn. Am now old tired. Used to be young and stupid; am no longer young. Thank you.
 
2013-01-23 06:05:12 AM

Dumski: Bullshiat. Everyone knows that stress is the number one risk. Come on!


Keep smoking.
 
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