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(National Academy of Sciences)   A vaccine for Alzheimer's may be on its way. Would have been done two years ago but the lead researcher just wandered off one day   (pnas.org) divider line 22
    More: Interesting, Alzheimer's Disease, lipids, Osaka University, neurodegenerative diseases, cognitive functions, amyloids, vaccines, ligands  
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1655 clicks; posted to Geek » on 16 Jan 2013 at 1:19 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2013-01-16 09:35:43 AM
Vaccine....must be a gov't mind control secret program..the only reasonable explanation!
 
2013-01-16 10:04:14 AM
A preclinical Alzheimers result? I'm not even going to try to stifle my yawn.
 
2013-01-16 10:42:47 AM
Great headline subby!
 
2013-01-16 01:22:22 PM
Oh, is THAT what all that technical gibberish said?
 
2013-01-16 01:24:25 PM
Damn, I had something witty to post, but I can't remember what it was...
 
2013-01-16 01:27:07 PM
c10184100.r0.cf2.rackcdn.com

Approves
 
2013-01-16 01:31:46 PM
media.tumblr.com

Approved
 
2013-01-16 01:35:59 PM
Last time I checked mice aren't people, wake me up when we have some clinical data.
 
2013-01-16 01:52:24 PM
There's a vaccine for Alzheimers on it's way, too.
 
2013-01-16 01:54:35 PM
Since Alheimers got my grandma and we got front row seats to that 6 year spiral of awful I'll just go ahead and latch on to any scrap of good news related to this, if it's all right with you.
 
2013-01-16 02:00:46 PM
I guess they didn't have the fake bus stop in front of the research facility.
 
2013-01-16 02:46:18 PM
So Monophosphoryl lipid A stimulates clearance of beta-amyloid. Okay, interesting.

Yeah, waiting for human data like everyone else in the thread. Who greenlights technical articles from the literature?

/CSB: At a journal club in graduate school, a guy kept talking about a prior study in "Pee-Nas." The accepted way to refer to the journal is by the initials, i.e. Pee En Ay Ess, which sounds less -- wang-y, as it were.
//Well, it was funny at the time. I guess you just had to be there.
 
2013-01-16 03:09:46 PM
That's not a vaccine, it's a drug treatment. And if it were really exciting, it'd be in Nature/Science and not Paper Not Accepted by Science
 
2013-01-16 03:29:18 PM
all i know is that when i see an article from PNAS, in my head, i hear a voice shouting: PEEeeNAAAss!

you know, like penis?
 
2013-01-16 03:37:59 PM
Why'd I come here again....
 
2013-01-16 04:00:03 PM

TofuTheAlmighty: That's not a vaccine, it's a drug treatment. And if it were really exciting, it'd be in Nature/Science and not Paper Not Accepted by Science


It has been in Nature and Lancet since the setbacks in Phase II in 2004. They've been reporting on it on and off again since 2008.
 
2013-01-16 04:16:55 PM
Interesting. Would love to see a more explicit detailing as to why MPL stimulation caused the clearance.

More to the point, I'd want to see whether such therapy avoids the micro-lesions that resulted from antibody therapy in human trials.
 
2013-01-16 08:00:41 PM

TofuTheAlmighty: That's not a vaccine, it's a drug treatment. And if it were really exciting, it'd be in Nature/Science and not Paper Not Accepted by Science


Dude, you must publish in some pretty high-impact places to look down your nose at a paper in PNAS.

And I'm not saying that just because my most-cited paper was published in PNAS. Which actually felt kinda lame, because it was rejected by some other respectable journals. We submitted it to PNAS through the peer-review track, not giving to a NAS member to communicate -- but the editor who reviewed it happened to be my graduate advisor's graduate advisor.

So, feels like a cheap victory, although it got cited a lot. I'm not even in science any more. Sigh.
 
2013-01-16 08:31:14 PM

Fizpez: Since Alheimers got my grandma and we got front row seats to that 6 year spiral of awful I'll just go ahead and latch on to any scrap of good news related to this, if it's all right with you.


Sorry to hear that. Alzheimer's got my grandmother about seven and a half years ago.

I really, REALLY hope this thing pans out. It would be a real wonder if it works like they think it does.
 
2013-01-16 08:51:44 PM

Fizpez: Since Alheimers got my grandma and we got front row seats to that 6 year spiral of awful I'll just go ahead and latch on to any scrap of good news related to this, if it's all right with you.


My mother was diagnosed with Alzheimers at 59, she is 64 now. It sucks having a mom that doesn't know your name and will never know the joy of grandkids. Any hope of a treatment brings joy to my brother and I......
 
2013-01-16 11:12:58 PM
I love PNAS.
 
2013-01-17 09:33:18 AM
Good thing since we will need to ban guns for old people.
 
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