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(The New York Times)   New cancer drug that instructs defective DNA to self-destruct could cure half of all cancers, decimate populations of West Virginia, Kentucky, and Alabama   (nytimes.com) divider line 134
    More: Obvious, West Virginia, DNA, cancer types, cure  
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9966 clicks; posted to Main » on 23 Dec 2012 at 12:33 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2012-12-23 01:22:09 PM

Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.


No. This is stupid and a foolish, ignorant, idiotically PARANOID statement and I will tell you why.

A cancer cure, or at least a nigh-100% treatment for several types of cancer, IS A LICENSE TO PRINT MONEY.

This isn't farking polio or smallpox. Cancer is not going to 'stop existing' once we develop an effective cure, even if we distribute it *Freely*, because CANCER IS YOUR OWN BODY GOING @#%#@ BUGNUTS. PEOPLE WILL STILL GET IT.

I'm not lying, I put statments like this up there with "ZOMG The GUBBMIN'T GONNA USE THE UN TO TAKE MAH GUNS!" in terms of paranoia. Do I believe pharmaceutical companies are benevolent? Fark no! But at the very least, in terms of *cancer*, *your argument makes no sense*.
 
2012-12-23 01:23:28 PM
i1079.photobucket.com
 
2012-12-23 01:23:55 PM

Fizpez: I'd rather be USED as a lab rat in this case, even if it only serves to show this particular drug won't work, then die anyway and have someone else down the line die as well because THEY are now the first test subject.


So lets say that you had a prognosis of 6 months to live.  You start taking the drugs and you're dead in 2 weeks.  You just lost months of your life where you could have said goodbye to your friends and family, traveled the world, or done whatever else was on your bucket list.

If you wait till the cancer if more advanced so you can do those things, suddenly you may find that you're in a stage of cancer too far advanced for the trials to work.  They're not going to want to test on you because you'll drag their case averages down.
 
2012-12-23 01:25:25 PM

Felgraf: A cancer cure, or at least a nigh-100% treatment for several types of cancer, IS A LICENSE TO PRINT MONEY.


which is why they won't cure it even if they could. It worth to much money.

so thanks for agreeing with me.
 
2012-12-23 01:25:57 PM

Felgraf: Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.

No. This is stupid and a foolish, ignorant, idiotically PARANOID statement and I will tell you why.

A cancer cure, or at least a nigh-100% treatment for several types of cancer, IS A LICENSE TO PRINT MONEY.

This isn't farking polio or smallpox. Cancer is not going to 'stop existing' once we develop an effective cure, even if we distribute it *Freely*, because CANCER IS YOUR OWN BODY GOING @#%#@ BUGNUTS. PEOPLE WILL STILL GET IT.

I'm not lying, I put statments like this up there with "ZOMG The GUBBMIN'T GONNA USE THE UN TO TAKE MAH GUNS!" in terms of paranoia. Do I believe pharmaceutical companies are benevolent? Fark no! But at the very least, in terms of *cancer*, *your argument makes no sense*.


It's still LESS MONEY than they currently get. Not that I think they would suppress a cure.
 
2012-12-23 01:26:39 PM
Utah beats all other states at skiing. Ours is just better; deal with it Colorado.

We also beat all other states at inbreeding

I could be wrong, but I am pretty sure that more of your tax dollars are going to pay for medical problems caused by inbreeding in Utah than West Virginia, Maine and Kentucky put together.
 
2012-12-23 01:27:22 PM

Felgraf: Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.

No. This is stupid and a foolish, ignorant, idiotically PARANOID statement and I will tell you why.

A cancer cure, or at least a nigh-100% treatment for several types of cancer, IS A LICENSE TO PRINT MONEY.

This isn't farking polio or smallpox. Cancer is not going to 'stop existing' once we develop an effective cure, even if we distribute it *Freely*, because CANCER IS YOUR OWN BODY GOING @#%#@ BUGNUTS. PEOPLE WILL STILL GET IT.

I'm not lying, I put statments like this up there with "ZOMG The GUBBMIN'T GONNA USE THE UN TO TAKE MAH GUNS!" in terms of paranoia. Do I believe pharmaceutical companies are benevolent? Fark no! But at the very least, in terms of *cancer*, *your argument makes no sense*.


Thanks for saying this, by the way. All the lab staff I know living the lush ten-thousandaire lifestyle, working 60 hours a week and making minimum wage after you take out the price of their student loans out are too busy sleeping on the one weekend a year many of them have off to make this comment, and it needs to be repeated... A LOT.
Anyone who thinks that 'big pharma' is hiding 'teh cure' has never met the people working on teh treatmenzt.
 
2012-12-23 01:28:27 PM
I guess this means no reunion show for the cast of Jersey Shore.
 
2012-12-23 01:28:29 PM

Spanky_McFarksalot: which is why they won't cure it even if they could. It worth to much money.

so thanks for agreeing with me.


... No, because, see, if one company releases a cure that works *much better* than their competitors (who, lets say, are intentionally sabatoging it!), then everyone will BY THE #@$%@# ONE THAT WORKS.

Do you realize that for your argument to be true *all the scientists* performing the research have to be in on it, too? (And before you go "Well, yeah, they're doing it for the money!", no. You generally do not go into science for the money.)

Look. You really, really sound like those people that INSIST that there must be a conspiracy amongst EVERY SINGLE SCIENTIST that supports global warming.
 
2012-12-23 01:28:39 PM

TanSau: Decimate means to remove 10%


No it doesnt. Not any more. That was it's original meaning, back in the dawn of time.
Now:  Kill, destroy, or remove a large percentage of.

Sucks to be you, living in the past, unwilling or unable to realize that languages "change."
LOL
 
2012-12-23 01:29:14 PM

Benjamin Orr: [cassandraparkin.files.wordpress.com image 739x530]


nice
 
2012-12-23 01:30:07 PM
I thought fark had a rule about postings to websites which require passwords.
Stupid NYT
 
2012-12-23 01:30:31 PM

TanSau: Decimate means to remove 10%

Just saying.


Every tenth soldier.
 
2012-12-23 01:30:56 PM

Diagonal: , Utah.


Oops, I missed this. I was about to say "No one mentioned Utah? Oh, Fark, I am disappoint"

Inbreeding in West Virginia, Kentucky, etc is accidental. People there won't marry a cousin if there is someone cute and who isn't related they can hook up with.

Polygamist cultists in Utah think it is God's Will that they impregnate their nieces.

And your tax dollars pay for it all.
 
2012-12-23 01:30:58 PM

Quantum Apostrophe: Tell Me How My Blog Tastes: There's another company called Cellceutix (CTIX, which I am long in) that's got a drug from a completely novel class of compounds that is in Phase I human testing right now.  It also targets the p53 gene, but so far it has shown no toxicity.  None.  Soon it might be possible to go through chemo without losing your hair and half of your body weight.  It's a fantastic time for biotech, I hope these guys figure it all out and save lots of lives (maybe even mine...).

Yes it is! Biotech is the future. Understanding how and why matter behaves the way it does, and unraveling the program of DNA is where all the fun and progress are going to be.


I know this is the field you're pushing for when you gloom 'n' doom other threads, but it's so pleasantly surprising seeing you positive about scientific progress that it actually brightened my day a little bit. Thanks for that. :)

\ We're still all leaving on 3D-printed spaceships
 
2012-12-23 01:31:51 PM

lewismarktwo: It's still LESS MONEY than they currently get. Not that I think they would suppress a cure.


Why? They could just charge more than what they're currently charging.

When the demand for the good is "You die/have a higher chance of dying if you don't get this", the elasticity in price tends to be reaallllyyyy low.

LabGrrl: Felgraf: Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.

No. This is stupid and a foolish, ignorant, idiotically PARANOID statement and I will tell you why.

A cancer cure, or at least a nigh-100% treatment for several types of cancer, IS A LICENSE TO PRINT MONEY.

This isn't farking polio or smallpox. Cancer is not going to 'stop existing' once we develop an effective cure, even if we distribute it *Freely*, because CANCER IS YOUR OWN BODY GOING @#%#@ BUGNUTS. PEOPLE WILL STILL GET IT.

I'm not lying, I put statments like this up there with "ZOMG The GUBBMIN'T GONNA USE THE UN TO TAKE MAH GUNS!" in terms of paranoia. Do I believe pharmaceutical companies are benevolent? Fark no! But at the very least, in terms of *cancer*, *your argument makes no sense*.

Thanks for saying this, by the way. All the lab staff I know living the lush ten-thousandaire lifestyle, working 60 hours a week and making minimum wage after you take out the price of their student loans out are too busy sleeping on the one weekend a year many of them have off to make this comment, and it needs to be repeated... A LOT.
Anyone who thinks that 'big pharma' is hiding 'teh cure' has never met the people working on teh treatmenzt.


Yeah, I'm a physics grad student (Though some of my work could eventually have medical applications! Yay nanotech), and I sort of get... confused when people suggest scientists are engaging in a conspiracy "FOR THE MONEY", or to get all that "sweet grant money", etc. It's like "You... don't really understand what motivates *most* people who go into the sciences, do you?"
 
2012-12-23 01:32:14 PM

Felgraf: Do you realize that for your argument to be true *all the scientists* performing the research have to be in on it, too?


never said the people working on it didn't want to find a cure, I said the drug companies wouldn't let it out if they did.

The big drug companies need their workers to toil away for their stock holders so they wouldn't tell them they don't really want a cure.
 
2012-12-23 01:32:20 PM
 
2012-12-23 01:34:05 PM

Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.


and no one with cancer in the universe would care.
a "cure" which I need to take forever, but allows me to not die from cancer?
Yah, I am ok with that.
 
2012-12-23 01:37:03 PM

Spanky_McFarksalot: MycroftHolmes: This is poisonous stupidity and needs to stop being repeated.

they cure something, it will be.


Why don't you go ahead and whip up a cure for us? Easy, right? They're just sitting on all those cures they have?

We'll wait. We'll even make you filthy stinking rich when you're done.

Are you done yet?
 
2012-12-23 01:37:21 PM

Spanky_McFarksalot: Felgraf: Do you realize that for your argument to be true *all the scientists* performing the research have to be in on it, too?

never said the people working on it didn't want to find a cure, I said the drug companies wouldn't let it out if they did.

The big drug companies need their workers to toil away for their stock holders so they wouldn't tell them they don't really want a cure.


The current trend in laboratory research design is big, giant, shared workspaces (which, by the way, and apropos of nothing, I hate.) Entire floors of buildings with 50 lab tables and 30 PIs. Trust me, we know when other labs are having pizza for lunch, when a PI has PMS and when stuff goes wrong (or right.)
Lab staff is paid such crap that even those who would not put a 'supressed' cure on protocol-online would sell one to the highest bidder in seconds.
Really, if you're not the PI, or trying to become one, the only hope you have of making serious fundage is your lab having the next cure and your name being on the paper.
 
2012-12-23 01:39:37 PM

Dokushin: Why don't you go ahead and whip up a cure for us? Easy, right? They're just sitting on all those cures they have?


They've had hundreds of billions of dollars, an army of scientists and many decades to try.

I couldn't do any worse.
 
2012-12-23 01:40:09 PM

GardenWeasel: Fizpez: I can't understand the logic of believing you have a drug that will cure deadly forms of cancer and then NOT using it on people who will be long dead before you finish exploring minute toxicity studies.

You can donate your body to science after you die but apparently "Give me the drug, I don't CARE what it might do to me because I KNOW I will be dead in a month without it" just doesnt hold water. Seriously, if I knew I was terminal I would take whatever "might be efficacious according to lab mice" drug they wanted to try out on me.

Lawyers


Clients
 
2012-12-23 01:40:15 PM

Diagonal: Cymbal: You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida.

Also left off the list: Iowa, New Jersey, Montana, New Jersey, Utah, and New Jersey.


And SW Virginia
 
2012-12-23 01:44:19 PM

Poppa Zit: I'm reminded of the harvest of the clam beds on Epsilon VII... the gathering sleds auto detect any substandard product...


It's a good place to work, the scanners being so efficient most of the clams are free. "Substandard" my ass, most of them the company won't take but will give you only a mild radio frequency throbbing in the stellar cartography range.

Some say it's beaming out mostly in a certain direction towards Eridani but I say there's no proof and anyway being so close in frequency to microwaves it warms the ketchup for dipping.
 
2012-12-23 01:46:59 PM

LabGrrl: Louisiana_Sitar_Club: LabGrrl: dying because my body can't tell good cells from bad anymore...
How lame is that? Fark cancer.
(Crosses fingers)

Sarcasm detector broken. I'm dying of an autoimmune disease. My body would quite happily eat any cancer cells it found. Unfortunately, it also eats healthy lung tissue. When I get to the lung transplant level, they can't replace mine, because as someone whose immune system rejects ITSELF even on massive immunosuppression, I'm never going to qualify for a transplant. The problem with drugs that work with p53 is that we end up with assloads of anti-p53, which is what you see in Lupus (insert House joke here.)

About 5 years ago, every cancer lab I knew was doing p53, and about 10 years ago, they were all working with CD40, drugs revolving around which were going to cure HIV *and* cancer, and instead just gave all the already immunodeficient mice autoimmune-related *death.*

But we got some great anti-arthritis drugs from those mice.
/Now it's radioprotectants and old forms of radiation.


Ah, gotcha. I just misunderstood. I have someone very close recently diagnosed with multiple myeloma and an excess of one antibody (pg, something, I think R - quite frankly it's just a blur of terms right now) has blown her kidneys out. That instantly came to mind when I read your post and thought you were dealing with something similar.
(fingers crossed for both of you)
 
2012-12-23 01:49:10 PM

Spanky_McFarksalot: never said the people working on it didn't want to find a cure, I said the drug companies wouldn't let it out if they did.


So, what, they murder the scientists who worked on it? What exactly keeps them from going public if they found a cure that worked in humans, aside from potential financial ruin? Eventually, *someone* wuold leak it.
 
2012-12-23 01:50:51 PM

Louisiana_Sitar_Club:
Ah, gotcha. I just misunderstood. I have someone very close recently diagnosed with multiple myeloma and an excess of one antibody (pg, something, I think R - quite frankly it's just a blur of terms right now) has blown her kidneys out. That instantly came to mind when I read your post and thought you were dealing with something similar.
(fingers crossed for both of you)


No prob, I was over-sharing. All of these "turn the immune system to 11" stories in the non-science press just piss me off. Almost as much as the "rich lab people hiding the cure" people.
Turning the immune system up to 11 is not a good thing.
 
2012-12-23 01:51:47 PM

Spanky_McFarksalot: Dokushin: Why don't you go ahead and whip up a cure for us? Easy, right? They're just sitting on all those cures they have?

They've had hundreds of billions of dollars, an army of scientists and many decades to try.

I couldn't do any worse.


More to the point, you couldn't do any better. But hey -- that science stuff is easy, right? It's clearly a conspiracy that they aren't finding new stuff faster. You fixed a toaster the other day, so the human body is automatically president.
 
2012-12-23 01:53:46 PM

Felgraf: So, what, they murder the scientists who worked on it? What exactly keeps them from going public if they found a cure that worked in humans, aside from potential financial ruin? Eventually, *someone* wuold leak it.


who said they found a cure? I never did. and I certainly never said they would kill scientists who found a cure.

You're sounding paranoid.
 
2012-12-23 01:55:34 PM
New Jersey makes that list.
 
2012-12-23 02:03:00 PM

Spanky_McFarksalot: who said they found a cure? I never did. and I certainly never said they would kill scientists who found a cure.

You're sounding paranoid.


You said/suggested they'd supress any cure they found. That would, basically, probably require murdering *every* person who knew about it, because most of the people who*do* research like this are in it because *THEY WANT TO CURE CANCER*.
 
2012-12-23 02:04:17 PM
Still no cure for Kansas.
 
2012-12-23 02:08:38 PM
farm1.staticflickr.com
 
2012-12-23 02:32:03 PM

Spanky_McFarksalot: Felgraf: Do you realize that for your argument to be true *all the scientists* performing the research have to be in on it, too?

never said the people working on it didn't want to find a cure, I said the drug companies wouldn't let it out if they did.

The big drug companies need their workers to toil away for their stock holders so they wouldn't tell them they don't really want a cure.


You are demonstrating yourself to be a full-on moron.
 
2012-12-23 02:34:39 PM

justGreg: You are demonstrating yourself to be a full-on moron.


no the scientists who have wasted hundreds of billions in research dollars with no progress have demonstrated themselves to be full-on morons.

They can't even cure the cold.

Yeah, good job guys.
 
2012-12-23 02:37:48 PM

Spanky_McFarksalot: justGreg: You are demonstrating yourself to be a full-on moron.

no the scientists who have wasted hundreds of billions in research dollars with no progress have demonstrated themselves to be full-on morons.

They can't even cure the cold.

Yeah, good job guys.


OK, so you're just a troll, and not even a particularly good one.
 
2012-12-23 02:38:35 PM

justGreg: OK, so you're just a troll, and not even a particularly good one.


good enough to get to you to respond, twice.
 
2012-12-23 02:42:28 PM

Benjamin Orr: [cassandraparkin.files.wordpress.com image 739x530]


Yep.
 
2012-12-23 02:46:24 PM

Spanky_McFarksalot: justGreg: You are demonstrating yourself to be a full-on moron.

no the scientists who have wasted hundreds of billions in research dollars with no progress have demonstrated themselves to be full-on morons.

They can't even cure the cold.

Yeah, good job guys.


There are dozens of small, start up biotech firms all over the world working on this problem right now.  If any one of them has a compound that works, big pharma will swoop in and buy it.  They will pay, on average, a billion dollars or more for something that has this kind of multi-cancer curing potential.  You're suggesting that big pharma's management, and their shareholders, will let them just sit on that investment.  That they'll simply not sell a product that could be worth in the tens of billions of dollars.  You're a moron.  They'll sell it.  That's how biotech works.  Please, don't defend yourself anymore.

Your argument is basically, "they haven't yet, so they must not want to."  Please, go scream at some clouds and let the rest of us discuss this rationally.
 
2012-12-23 02:47:06 PM
It's not just Cinci, it's basically everything south of I70.
 
2012-12-23 02:51:49 PM

Tell Me How My Blog Tastes: Your argument is basically, "they haven't yet, so they must not want to."  Please, go scream at some clouds and let the rest of us discuss this rationally.


if they haven't yet they must be incompetent and should all be fired.

how many billions of dollars and decades more will they waste?
 
2012-12-23 03:02:05 PM

MycroftHolmes: Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.

This is poisonous stupidity and needs to stop being repeated.


I agree. According to Spanky McLunatic drug companies would never have allowed these diseases to be virtually eradicated (in the US):

1. Smallpox
2. Malaria
3. Typhoid
4. Rickets
5. Scurvy
6. Cholera
7. Rabies (as a disease that kills humans)
8. Measles
9. Mumps
10. Rubella
11. Polio
12. Rinderpest
13. Guinea Worm Disease
14. Hookworm
15. Lymphatic filariasis
16. Onchocerciasis (River Blindness)
17. Yaws
18. Typhus
19. Leprosy

and on and on and on...

As you can see, diseases aren't as simple as a company coming forward and giving us a pill so it is not as simple as a company deciding to 'not invent' or not market a cure.
 
2012-12-23 03:02:26 PM
Anybody else read the start of the zombie apocalypse in that article?
 
2012-12-23 03:05:49 PM

TanSau: Decimate means to remove 10%

Just saying.


i.usatoday.net
Impressed.
 
2012-12-23 03:07:48 PM
Speaking as someone who may well have a Bad Gene for a familial cancer syndrome (likely Lynch syndrome, but not gettin' tested until I'm sure the insurance company can't deny coverage if the answer is "yes"):

a) At least this might be helpful for folks with FAP (one of a number of p53-linked cancer syndromes) assuming the drug doesn't cause lupus (which has been the negative side effect of prior attempts--this does seem to use a different mechanism, so we'll see how primate and human trials go).

b) To really get rid of all the familial cancer syndromes (and a lot of spontaneous cancer syndromes) you also need something that can fix missense errors that the cellular repair mechanisms don't catch or help the body find these better. (This is what is specifically broken in Lynch syndrome--put in layman's terms, the genes in Lynch cancers tend to have a lot of "typos" and "bits of missing text" that aren't caught by the body's usual "typo flagger". Put in smartphone user's lingo--let's just say folks with Lynch syndrome have a particularly wonky version of Genetic Autocorrect that doesn't exactly correct typing errors or tends to correct them in the most inappropriate manner possible.)

c) IF it turns out that this is not something that is p53-specific...well, hopefully it'll be less ouchy in price than colonoscopies are and hopefully it's not one of those things that's going to inspire a Change.org petition because the Damn Insurance Company Won't Pay For The Lifesaving Miracle Drug. :P
 
2012-12-23 03:12:05 PM
Let's make the list as follows: Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming.

Why no Delaware? What the fark is a Delaware?
 
2012-12-23 03:30:21 PM
Three years later:
2.bp.blogspot.com
 
2012-12-23 03:39:35 PM

Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.


Actually there is tremendous profit in the cure because cancer will not be eradicated such as polio or small pox. As well, finding a legitimate cure to one or more forms of cancer means huge initial profits and taking the lion share of the market while increasing capital resources for the company while reducing over the long term those of the competition. Pharmaceutical companies do not do the bulk of medical research, and to not utilize the research first means the competition will.

There is, in fact, profit in any cure; what people are looking at is the pharmaceutical industry as a whole with long term profits of treatment versus cure in isolation, which is a drastic oversimplification.
 
2012-12-23 03:53:36 PM

Indolent: Goodbye Arkansas.


That's what I came here to say! WHY do people keep forgetting Arkansas?
 
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