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(The New York Times)   New cancer drug that instructs defective DNA to self-destruct could cure half of all cancers, decimate populations of West Virginia, Kentucky, and Alabama   (nytimes.com) divider line 134
    More: Obvious, West Virginia, DNA, cancer types, cure  
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9969 clicks; posted to Main » on 23 Dec 2012 at 12:33 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2012-12-23 11:13:51 AM  
I laughed.
 
2012-12-23 11:16:31 AM  
There's another company called Cellceutix (CTIX, which I am long in) that's got a drug from a completely novel class of compounds that is in Phase I human testing right now.  It also targets the p53 gene, but so far it has shown no toxicity.  None.  Soon it might be possible to go through chemo without losing your hair and half of your body weight.  It's a fantastic time for biotech, I hope these guys figure it all out and save lots of lives (maybe even mine...).
 
2012-12-23 11:25:33 AM  
Well, Maine is going to be heavily depopulated as well.
 
2012-12-23 12:34:09 PM  
Goodbye Arkansas.
 
2012-12-23 12:35:16 PM  
In other news. Producers of Reality Shows fear massive layoffs.
 
2012-12-23 12:35:19 PM  
drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.
 
2012-12-23 12:36:30 PM  

Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.


A poison so subtle it only kills you if you stop taking it.
 
2012-12-23 12:36:51 PM  
You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida.
 
2012-12-23 12:38:28 PM  
If you put Rhode Island on that list, you would not get an objection from me.
 
2012-12-23 12:40:43 PM  
so *that's* what the beginning of Prometheus was all about
 
2012-12-23 12:40:52 PM  
Still no cure for...oh wait.

Cymbal
You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida.

...and Cincinnati.
 
2012-12-23 12:41:19 PM  
Still no cure for Texas?
 
2012-12-23 12:41:58 PM  

Spanky_McFarksalot: drug companies don't cure anything, theres no profit in it.

They'll make it so you have to keep taking for it to work.


This is poisonous stupidity and needs to stop being repeated.
 
2012-12-23 12:43:05 PM  

Cymbal: You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida.


Also left off the list: Iowa, New Jersey, Montana, New Jersey, Utah, and New Jersey.
 
2012-12-23 12:44:07 PM  
Bravo, subby.
 
2012-12-23 12:44:43 PM  

MycroftHolmes: This is poisonous stupidity and needs to stop being repeated.


they cure something, it will be.
 
2012-12-23 12:47:00 PM  
Stem cell research bad!
 
2012-12-23 12:49:07 PM  
You know who else was into destroying defective DNA?
www.historical-library.net
 
2012-12-23 12:49:55 PM  
As someone who is dying because my body can't tell good cells from bad anymore, I don't see any potential problems with this AT ALL.

/Weirdly, was working on a p53-related drug before I got sick.
//Don't think it's related...
 
2012-12-23 12:50:13 PM  
Decimate means to remove 10%

Just saying.
 
2012-12-23 12:51:08 PM  
Don't forget Congress.
 
2012-12-23 12:52:00 PM  
I can't understand the logic of believing you have a drug that will cure deadly forms of cancer and then NOT using it on people who will be long dead before you finish exploring minute toxicity studies.

You can donate your body to science after you die but apparently "Give me the drug, I don't CARE what it might do to me because I KNOW I will be dead in a month without it" just doesnt hold water. Seriously, if I knew I was terminal I would take whatever "might be efficacious according to lab mice" drug they wanted to try out on me.
 
2012-12-23 12:52:06 PM  

NewportBarGuy: Well, Maine is going to be heavily depopulated as well.


Maine? Try New York. There's a population that's been inbreeding for a hundred years.
 
2012-12-23 12:52:33 PM  

Cymbal: You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida.


Must be nice to be such a huge douche that you look down on 28% of the rest of your country.

/fair number of mutants in Ohio as well you douche
 
WD
2012-12-23 12:52:40 PM  

TanSau: Decimate means to remove 10%


FACT: Some words have more than one meaning.
 
2012-12-23 12:53:14 PM  

Spanky_McFarksalot: MycroftHolmes: This is poisonous stupidity and needs to stop being repeated.

they cure something, it will be.


How about infectious diseases? They used to be the leading cause of death, and now idiots can get away with not being vaccinated because they've become so rare.
 
2012-12-23 12:54:09 PM  

Diagonal: Cymbal: You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida.

Also left off the list: Iowa, New Jersey, Montana, New Jersey, Utah, and New Jersey.


Only the parts here in New Jersey that are full of brain dead... oh never mind, just make sure I'm out of there before the destruction starts.
 
2012-12-23 12:56:51 PM  

LabGrrl: dying because my body can't tell good cells from bad anymore...

How lame is that? Fark cancer.
(Crosses fingers)
 
2012-12-23 12:56:58 PM  

Diagonal: Cymbal: You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida.

Also left off the list: Iowa, New Jersey, Montana, New Jersey, Utah, and New Jersey.


And we're now at 20 of 50 states.  Come on, might as well add 5 more so we have a majority and we can now say that America would just be wiped out.  You're almost there already.
 
2012-12-23 12:57:12 PM  

Fizpez: I can't understand the logic of believing you have a drug that will cure deadly forms of cancer and then NOT using it on people who will be long dead before you finish exploring minute toxicity studies.

You can donate your body to science after you die but apparently "Give me the drug, I don't CARE what it might do to me because I KNOW I will be dead in a month without it" just doesnt hold water. Seriously, if I knew I was terminal I would take whatever "might be efficacious according to lab mice" drug they wanted to try out on me.


Which is precisely why it is a good thing that there are mechanisms in place like ethics committees and regulatory agencies to prevent misguided profit-seeking companies from exploiting that desperation.
 
2012-12-23 12:58:32 PM  
WD: FACT: Some words have more than one meaning.

Sure, when used improperly. "Annihilate" would have been the better choice.
 
2012-12-23 01:02:10 PM  

Cymbal: You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida


and England
 
2012-12-23 01:02:33 PM  
this thread was funny and fun
 
2012-12-23 01:03:39 PM  

ultraholland: WD: FACT: Some words have more than one meaning.

Sure, when used improperly. "Annihilate" would have been the better choice.


THIS^^^^^
 
2012-12-23 01:05:07 PM  

justGreg: Fizpez: I can't understand the logic of believing you have a drug that will cure deadly forms of cancer and then NOT using it on people who will be long dead before you finish exploring minute toxicity studies.

You can donate your body to science after you die but apparently "Give me the drug, I don't CARE what it might do to me because I KNOW I will be dead in a month without it" just doesnt hold water. Seriously, if I knew I was terminal I would take whatever "might be efficacious according to lab mice" drug they wanted to try out on me.

Which is precisely why it is a good thing that there are mechanisms in place like ethics committees and regulatory agencies to prevent misguided profit-seeking companies from exploiting that desperation.


I 100% agree that you trying to sell me a drug "because it might save your life" requires the type of oversight provided - but if they are willing to provide it for free I fail to see how I can not make the choice to accept it - regardless of how desperate I may be. I'm not talking about "we have 1000 molecular candidates and want to blindly feed them to people" - but if the lab results show there is some potential for real benefit and you are already at a stage where doctors are comfortable making predictions of your death in the next 3-6 weeks then I think you should have the right to waive those oversights and any claim against the drug company for whatever might happen.

I'd rather be USED as a lab rat in this case, even if it only serves to show this particular drug won't work, then die anyway and have someone else down the line die as well because THEY are now the first test subject.
 
2012-12-23 01:06:14 PM  
Oh come on. How could all of you have forgotten to include Oklahoma on that list?
 
2012-12-23 01:06:19 PM  
Goodnight, moon.
 
2012-12-23 01:06:53 PM  
So they found a cure for Masshole cancer?
 
2012-12-23 01:07:53 PM  

Tell Me How My Blog Tastes: There's another company called Cellceutix (CTIX, which I am long in) that's got a drug from a completely novel class of compounds that is in Phase I human testing right now.  It also targets the p53 gene, but so far it has shown no toxicity.  None.  Soon it might be possible to go through chemo without losing your hair and half of your body weight.  It's a fantastic time for biotech, I hope these guys figure it all out and save lots of lives (maybe even mine...).


Yes it is! Biotech is the future. Understanding how and why matter behaves the way it does, and unraveling the program of DNA is where all the fun and progress are going to be.
 
2012-12-23 01:08:35 PM  

StrikitRich: So they found a cure for Masshole cancer?


Yeah, they burn the leaves off the trees before they start to fall.
 
2012-12-23 01:08:59 PM  

Louisiana_Sitar_Club: LabGrrl: dying because my body can't tell good cells from bad anymore...
How lame is that? Fark cancer.
(Crosses fingers)


Sarcasm detector broken. I'm dying of an autoimmune disease. My body would quite happily eat any cancer cells it found. Unfortunately, it also eats healthy lung tissue. When I get to the lung transplant level, they can't replace mine, because as someone whose immune system rejects ITSELF even on massive immunosuppression, I'm never going to qualify for a transplant. The problem with drugs that work with p53 is that we end up with assloads of anti-p53, which is what you see in Lupus (insert House joke here.)

About 5 years ago, every cancer lab I knew was doing p53, and about 10 years ago, they were all working with CD40, drugs revolving around which were going to cure HIV *and* cancer, and instead just gave all the already immunodeficient mice autoimmune-related *death.*

But we got some great anti-arthritis drugs from those mice.
/Now it's radioprotectants and old forms of radiation.
 
2012-12-23 01:10:24 PM  

Fizpez: but if the lab results show there is some potential for real benefit and you are already at a stage where doctors are comfortable making predictions of your death in the next 3-6 weeks then I think you should have the right to waive those oversights and any claim against the drug company for whatever might happen.

I'd rather be USED as a lab rat in this case, even if it only serves to show this particular drug won't work, then die anyway and have someone else down the line die as well because THEY are now the first test subject.



FWIW, that type of situation is considered and balanced into the equation by both agencies and ethics committees in pretty much the manner you suggest. The bar for a GBM (glioblastoma multiforme) study for example is much lower in terms of required safety and tox data than for a hypertension study. But it really has to be higher than "good rat data" because cancer has been cured in rats hundreds of times.
 
2012-12-23 01:10:25 PM  

Elegy: Cymbal: You forgot Mississippi, Texas, Arizona, Louisiana, Tennessee, Georgia, South Carolina, Arkansas, Alaska, Indiana, and Florida.

Must be nice to be such a huge douche that you look down on 28% of the rest of your country.

/fair number of mutants in Ohio as well you douche


We already covered Cincinnati upthread.
 
2012-12-23 01:11:11 PM  

ultraholland: so *that's* what the beginning of Prometheus was all about


Oh sure. ET gave them the p53 gene, and it ate their DNA, so then we could come in the space ship and the captain could fark the ice queen and then Shaw had the baby they made try to eat her but instead they ate it.

And that is the creation story of kalamari, which we celebrate by rolling xenomorphs up into a big ball and eating them like crab ball soup, which let me tell you reminds me of android hydraulic fluid leaking into their data cores, y'see-
 
2012-12-23 01:12:14 PM  

GAT_00: And we're now at 20 of 50 states. Come on, might as well add 5 more so we have a majority and we can now say that America would just be wiped out. You're almost there already.


We're just going where the truth leads us.
 
2012-12-23 01:14:04 PM  

Fizpez: I can't understand the logic of believing you have a drug that will cure deadly forms of cancer and then NOT using it on people who will be long dead before you finish exploring minute toxicity studies.

You can donate your body to science after you die but apparently "Give me the drug, I don't CARE what it might do to me because I KNOW I will be dead in a month without it" just doesnt hold water. Seriously, if I knew I was terminal I would take whatever "might be efficacious according to lab mice" drug they wanted to try out on me.


Lawyers
 
2012-12-23 01:17:03 PM  

Fark Rye For Many Whores: ultraholland: so *that's* what the beginning of Prometheus was all about

Oh sure. ET gave them the p53 gene, and it ate their DNA, so then we could come in the space ship and the captain could fark the ice queen and then Shaw had the baby they made try to eat her but instead they ate it.

And that is the creation story of kalamari, which we celebrate by rolling xenomorphs up into a big ball and eating them like crab ball soup, which let me tell you reminds me of android hydraulic fluid leaking into their data cores, y'see-


I'm reminded of the harvest of the clam beds on Epsilon VII... the gathering sleds auto detect any substandard product...
 
2012-12-23 01:17:31 PM  

Fizpez: You can donate your body to science after you die but apparently "Give me the drug, I don't CARE what it might do to me because I KNOW I will be dead in a month without it" just doesnt hold water.


"You would have been dead in a month" doesn't hold water against a lawsuit when the patient has to live with some previously unknown side-effect from the medicine.

As long as lawyers are looking for lawsuits, the drug companies have no choice but to keep their stuff away from the public until they're 100% sure that it won't cause some minor inconvenience for the patient.
 
2012-12-23 01:17:34 PM  

Fizpez: Seriously, if I knew I was terminal I would take whatever "might be efficacious according to lab mice" drug they wanted to try out on me.


It turns out that a LOT of drugs that work in mice do not show the same results when the trials move to testing with lower primates.  You get another drop in results when you move from lower primates to humans.  So just because it works with lab mice, don't suddenly expect that it will work with people.

Second, if you happen to die one day earlier from the drug than you would have from cancer, your family can sue the drug maker.  Even if you signed an agreement, they can sue, and because judges like to see their names in the paper, they'll probably fail to dismiss it at a pretrial hearing.  So the drug makers do not have a lot of incentive to switch to human trials too early.

Third, a large number of negative reactions in early trials might sour investor support for drug research.  It might also overwhelm some smaller labs.  So they keep the numbers low.
 
2012-12-23 01:21:22 PM  
cassandraparkin.files.wordpress.com
 
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