FARK.com: (7448459) The obesity gene helps protect against depression. So how come I still feel sad after eating an entire cheesecake?

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		The obesity gene helps protect against depression. So how come I still feel sad after eating an entire cheesecake? (theatlantic.com)		51
		More: Interesting, Molecular Psychiatry, underweight, depressions, genes, obesity, eating

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1330 clicks; posted to Main » on 23 Nov 2012 at 7:56 AM | Favorite | share:

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colinspooky		2012-11-23 03:11:07 AM

cheesecake not big enough - start again

cman		2012-11-23 07:27:53 AM

How come people use "how come" in 2012?

FirstNationalBastard		2012-11-23 07:37:58 AM

Let's just end this thread now...

i286.photobucket.com

TheOmni		2012-11-23 07:40:03 AM

I always feel sad when I'm all out of cheesecake.

PicoDelSol		2012-11-23 07:45:40 AM

Spoon over Marin		2012-11-23 07:50:15 AM

Nurglitch		2012-11-23 08:02:57 AM

cman: How come people use "how come" in 2012?

I prefer "why come?" Get with the times, daddy-o.

1nsanilicious		2012-11-23 08:14:05 AM

Subby could have easily said "Scientists discover that fat people are jolly".

sexorcisst		2012-11-23 08:15:25 AM

The obesity gene helps protect against ~~depression~~ getting laid.

Father_Jack		2012-11-23 08:15:44 AM

FirstNationalBastard: Let's just end this thread now...

[cdn.ebaumsworld.com image 638x482]

dear god what is that thing

Spoon over Marin		2012-11-23 08:22:15 AM

dopekitty74		2012-11-23 08:22:17 AM

Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

monoski		2012-11-23 08:22:52 AM

So that is why Honey Boo-boo is so happy.

dopekitty74		2012-11-23 08:25:29 AM

And on another note, maybe we're happy because we eat and enjoy good food instead of starving ourselves for an ideal look?

Nurglitch		2012-11-23 08:29:50 AM

dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

As a chubby-chaser, I'd like to encourage more pictures that show how the obesity gene helps protect depression.

Snarfangel		2012-11-23 08:45:24 AM

The obesity gene helps protect against depression. So how come I still feel sad after eating an entire cheesecake?

JUST WHEN I MANAGED TO LOOSE 5 POUNDS FROM MY BUTT

I AM SICK OF THIS STUPID MEN WORLD

Nogale		2012-11-23 08:48:15 AM

Because obese people are known for their joie de vivre.

Nogale		2012-11-23 08:52:06 AM

dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

Based on these figures (heh), you're long past "chunky." But it's not about aesthetics - it's about health. What is your blood pressure? Cholesterol level? Blood sugar level? Can you run a mile, and if so, in what time? How many situps can you do?

If you're healthy, rock on, girl. If not - you have a problem, and the fact that you're getting laid isn't going to solve it. And I speak as a former fat person.

/Former fatty who just bested her 10K personal best by 7 minutes

starsrift		2012-11-23 08:56:08 AM

Nogale: ...If you're healthy, rock on, girl. If not - you have a problem, and the fact that you're getting laid isn't going to solve it...

I dunno, it's a good bit of cardio. Depends on how often and for how long.

Real Women Drink Akvavit		2012-11-23 08:57:34 AM

dopekitty74: And on another note, maybe we're happy because we eat and enjoy good food instead of starving ourselves for an ideal look?

THIS. My weight fluctuates wildly, but I've never given it much thought. I worked in one very poorly organized, more under staffed than usual restaurant for a time and wore a pedometer to work one day for kicks and giggles. I logged over 10 miles in one shift, so that explained why I was quite thin. Nearly anorexic looking. The restaurant I was just working at for nearly a decade closed, so now I'm a chubster again. I do not care, I will still slaughter the rest of that pumpkin pie today! It's all the pie's fault anyway.

/no one ever suspects the pie

WhippingBoy		2012-11-23 09:04:47 AM

The "obesity gene"? I think you mean lack of dignity, will power, and self respect. Yeah, I can see how that would make someone depressed.

I_Love_Cheesecake		2012-11-23 09:06:14 AM

I've even got my own t-shirt:

rlv.zcache.com

Smackledorfer		2012-11-23 09:20:17 AM

dancindan84		2012-11-23 09:46:49 AM

The obesity gene helps protect against depression.

Couches everywhere beg to differ.

Lady Beryl Ersatz-Wendigo		2012-11-23 09:49:21 AM

"I am trying to convince everyone that the secret to world happiness lies in fat women." - James Watson

My very existence improves your quality of life, so pass the freaking cheesecake.

1nsanilicious		2012-11-23 09:53:03 AM

dancindan84: The obesity gene helps protect against depression.

Couches everywhere beg to differ.

Depression, not folding in upon itself like a collapsed star.

I wonder if its possible to get so fat that you collapse in on yourself like a MAD magazine and look thin and like someone else

Nogale		2012-11-23 09:55:40 AM

Smackledorfer: Nogale: dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

Based on these figures (heh), you're long past "chunky." But it's not about aesthetics - it's about health. What is your blood pressure? Cholesterol level? Blood sugar level? Can you run a mile, and if so, in what time? How many situps can you do?

If you're healthy, rock on, girl. If not - you have a problem, and the fact that you're getting laid isn't going to solve it. And I speak as a former fat person.

/Former fatty who just bested her 10K personal best by 7 minutes

Thats a huge fluctuation in time.

Did you run this one downhill with the wind behind you?

It was a hilly course, with most of the uphills after the 7k mark. Also cold and rainy, most of us were soaked through by the time we started. Waterlogged sneakers - hardly optimal conditions.

1nsanilicious		2012-11-23 09:59:33 AM

Is she striking a pose or about to take a dump?

Also, it looks like she is wearing a thong, is that like regular underwear that's stretched itself into a thong?

kettir		2012-11-23 10:09:10 AM

cman: How come people use "how come" in 2012?

when I see the last of "could care less," then you will see the last of "how come."

WhippingBoy		2012-11-23 10:14:58 AM

What happened to the "thyroid" excuse? Are we now replacing that with the "obesity gene" excuse?

How about just putting down the fork?

theorellior		2012-11-23 10:18:17 AM

I'm glad people already covered the stupid men world we live in.

shortymac		2012-11-23 10:52:04 AM

It's more "Food is my drug" than actually protecting against depression.

Instead of turning to Alcohol, Cigarettes, and other drugs, we turn to food.

TheGreenMonkey		2012-11-23 10:55:22 AM

dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

BIE?
__________________________________________________

Being overweight helps fight depression? Interesting theory, and that could explin why since I've put on a ~~few several~~ quite a lot of extra pounds it doesn't affect me so much anymore, certainly not as much as in the past. I've been depressed since my late teen years, and although it comes and goes it is certainly not as detrimental as previously. (And yes, I do get laid quite frequently)

/loves me some curvy women
//loves me some not so curvy women

dopekitty74		2012-11-23 11:10:29 AM

Nogale: dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

Based on these figures (heh), you're long past "chunky." But it's not about aesthetics - it's about health. What is your blood pressure? Cholesterol level? Blood sugar level? Can you run a mile, and if so, in what time? How many situps can you do?

If you're healthy, rock on, girl. If not - you have a problem, and the fact that you're getting laid isn't going to solve it. And I speak as a former fat person.

/Former fatty who just bested her 10K personal best by 7 minutes

If you think i'm gonna run with these things, you've got to be kidding.... Also, situps are a no-go because of my boobs and back. Plus fibromyalgia doesn't help either. I walk alot, eat very little fast food or pop, blood pressure is fine, cholesterol and blood sugar also fine (just had bloodwork done a few months back, and i was working at kfc at that point, so if it was gonna be high, it would've been then)

i eat lots of fish, veggies, rice and homemade soups and such. Stay away from processed food wherever possible.

dopekitty74		2012-11-23 11:15:11 AM

WhippingBoy: The "obesity gene"? I think you mean lack of dignity, will power, and self respect. Yeah, I can see how that would make someone depressed.

Um, that's exactly the opposite of what the article is saying.

It says people with a specific gene that makes them tend to be larger makes them happier

dopekitty74		2012-11-23 11:21:10 AM

TheGreenMonkey: dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

BIE?
__________________________________________________

Being overweight helps fight depression? Interesting theory, and that could explin why since I've put on a few several quite a lot of extra pounds it doesn't affect me so much anymore, certainly not as much as in the past. I've been depressed since my late teen years, and although it comes and goes it is certainly not as detrimental as previously. (And yes, I do get laid quite frequently)

/loves me some curvy women
//loves me some not so curvy women

How can you have BIE if you don't have an EIP?

WhippingBoy		2012-11-23 11:21:31 AM

dopekitty74: WhippingBoy: The "obesity gene"? I think you mean lack of dignity, will power, and self respect. Yeah, I can see how that would make someone depressed.

Um, that's exactly the opposite of what the article is saying.

It says people with a specific gene that makes them tend to be larger makes them happier

My point is that there's no such thing as an "obesity gene"; it's yet another rationalization for fatties to use to explain their lack of dignity and will-power.

dopekitty74		2012-11-23 11:24:19 AM

Nurglitch: dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

As a chubby-chaser, I'd like to encourage more pictures that show how the obesity gene helps protect depression.

I repeat:

How can you have BIE if you don't have an EIP?

dopekitty74		2012-11-23 11:26:04 AM

WhippingBoy: dopekitty74: WhippingBoy: The "obesity gene"? I think you mean lack of dignity, will power, and self respect. Yeah, I can see how that would make someone depressed.

Um, that's exactly the opposite of what the article is saying.

It says people with a specific gene that makes them tend to be larger makes them happier

My point is that there's no such thing as an "obesity gene"; it's yet another rationalization for fatties to use to explain their lack of dignity and will-power.

Your doctorate in genetics please?

I'm sorry sir, but this diploma from the Hollywood Doctor School just won't cut it...

Savage Bacon		2012-11-23 11:48:32 AM

dopekitty74: Nurglitch: dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

As a chubby-chaser, I'd like to encourage more pictures that show how the obesity gene helps protect depression.

I repeat:

How can you have BIE if you don't have an EIP?

*raises hand*

I have EIP!

TheGreenMonkey		2012-11-23 11:58:58 AM

dopekitty74: TheGreenMonkey: dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

BIE?
__________________________________________________

Being overweight helps fight depression? Interesting theory, and that could explin why since I've put on a few several quite a lot of extra pounds it doesn't affect me so much anymore, certainly not as much as in the past. I've been depressed since my late teen years, and although it comes and goes it is certainly not as detrimental as previously. (And yes, I do get laid quite frequently)

/loves me some curvy women
//loves me some not so curvy women

How can you have BIE if you don't have an EIP?

Interesting, I didn't realize it wasn't displayed. Had been previously. Fixed

QuickDirtyOS		2012-11-23 12:02:48 PM

Kudos to subby !

martid4		2012-11-23 12:21:03 PM

I'd hit that!

4.bp.blogspot.com

Zel		2012-11-23 12:29:34 PM

Lots of us do have EIP ;)

I'm not quite a geneticist but I work with a few of them. The idea is this gene is actually a marker for an ancestral mutation that has statistical association to 8% increase in BMI. The mechanism is still unknown because the body is so complex. It's a fat depositor protein and thats going to have impacts on everything from metabolism to neural development.

dopekitty74		2012-11-23 12:38:29 PM

Zel: Lots of us do have EIP ;)

I'm not quite a geneticist but I work with a few of them. The idea is this gene is actually a marker for an ancestral mutation that has statistical association to 8% increase in BMI. The mechanism is still unknown because the body is so complex. It's a fat depositor protein and thats going to have impacts on everything from metabolism to neural development.

Your E is not IP either, hun.

Snarfangel		2012-11-23 12:45:18 PM

Zel: Lots of us do have EIP ;)

Please, even if you do have an Extremely Irritating Partner, how do you think they feel when you tell everyone? I bet it hurts a lot.

So please, talk it over with them first before you tell the whole world about your EIP.

dopekitty74		2012-11-23 12:51:27 PM

I hear Krispy Kritter has an EIP like that.. Poor fellow...

Zel		2012-11-23 12:55:41 PM

No I got rid of the extremely irritating partner a couple years ago.

Oh, strange, the email was set to tf only. my mistake.

-- to be relevant I looked up the mutation the article is talking about
http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=9939609

It seems to be nearly 50% prevalent in african and european populations, about about 15% in east asian populations. A common mutation like that will be spread around pretty evenly and must have a very small effect. Strong effects are selected for or against more harshly, but this mutation has survived thousands of generations. It's not that the FTO gene is present in some people, just this version of it. The statistics don't lie, but they don't say a whole lot either.

The molecular bio talks about chemical signaling for other gene regulation, so it's not a clear mechanism. also interesting, Entrez, a biology encyclopedia says FTO "Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis." supporting the hypothesis that energy storage is the root here.

dopekitty74		2012-11-23 03:34:08 PM

Zel: No I got rid of the extremely irritating partner a couple years ago.

Oh, strange, the email was set to tf only. my mistake.

-- to be relevant I looked up the mutation the article is talking about
http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=9939609

It seems to be nearly 50% prevalent in african and european populations, about about 15% in east asian populations. A common mutation like that will be spread around pretty evenly and must have a very small effect. Strong effects are selected for or against more harshly, but this mutation has survived thousands of generations. It's not that the FTO gene is present in some people, just this version of it. The statistics don't lie, but they don't say a whole lot either.

The molecular bio talks about chemical signaling for other gene regulation, so it's not a clear mechanism. also interesting, Entrez, a biology encyclopedia says FTO "Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis." supporting the hypothesis that energy storage is the root here.

Guessing the space between the names would be an underscore, off to the BIE mobile!

Smackledorfer		2012-11-23 05:26:48 PM

dopekitty74: Nogale: dopekitty74: Happily chunky, from a long line of happily chunky family, thus disproving the fat people don't get laid theory above. Besides, haven't you heard of chubby chasers?

/5'2", 200lbs, 38F boobs

Based on these figures (heh), you're long past "chunky." But it's not about aesthetics - it's about health. What is your blood pressure? Cholesterol level? Blood sugar level? Can you run a mile, and if so, in what time? How many situps can you do?

If you're healthy, rock on, girl. If not - you have a problem, and the fact that you're getting laid isn't going to solve it. And I speak as a former fat person.

/Former fatty who just bested her 10K personal best by 7 minutes

If you think i'm gonna run with these things, you've got to be kidding.... Also, situps are a no-go because of my boobs and back. Plus fibromyalgia doesn't help either. I walk alot, eat very little fast food or pop, blood pressure is fine, cholesterol and blood sugar also fine (just had bloodwork done a few months back, and i was working at kfc at that point, so if it was gonna be high, it would've been then)

i eat lots of fish, veggies, rice and homemade soups and such. Stay away from processed food wherever possible.

You are morbidly obese, do not pretend otherwise. I'm 5 inches taller than you and muscled, and I'm an overweight man.

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