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(Yahoo)   NyanyanyanyanyanyanyaDEAD   (news.yahoo.com) divider line 45
    More: Sad, cats, marty, incurable, little buddy, Rick Astley  
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11152 clicks; posted to Geek » on 02 Nov 2012 at 6:53 AM (2 years ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2012-11-02 06:59:38 AM  
Don't scare me like that. By the headline, I thought Adam West had died.
 
2012-11-02 07:00:29 AM  
Pop-tart and pussy. Two great tastes...
 
2012-11-02 07:04:55 AM  
Poot lil dead kitty with rainbows coming out of it's butt.
/has a sad
 
2012-11-02 07:06:56 AM  

adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.

 
2012-11-02 07:16:31 AM  
...Katamari Damacy.
 
2012-11-02 07:16:38 AM  

adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.


No, Batman can't die.
 
2012-11-02 07:22:31 AM  

adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.


I thought so too, but then I realized that Adam West would warrant a NEWSFLASH tag.
 
2012-11-02 07:24:09 AM  
I too thought Batman was dead.

img.photobucket.com
 
2012-11-02 07:29:59 AM  

Tommy Moo: adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.

I thought so too, but then I realized that Adam West would warrant a NEWSFLASH tag.


He would indeed.
 
2012-11-02 07:38:13 AM  
hastac.org
 
2012-11-02 07:47:51 AM  
Just in time for Cat... oh wait.
 
2012-11-02 07:58:24 AM  
I genuinely hope that cat burns in hell.
 
2012-11-02 08:02:26 AM  
24.media.tumblr.com
RIP Artie, The Strongest Man in the World
 
2012-11-02 08:05:44 AM  
NOOOOOOOO.

in honor we played played the song for the office
 
2012-11-02 08:10:23 AM  
RIP Catman
 
2012-11-02 08:18:47 AM  

Tommy Moo: adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.

I thought so too, but then I realized that Adam West would warrant a NEWSFLASH tag.


This. At least that, or I was prepared to rant about it if he was dead and didn't get the tag.
 
2012-11-02 08:31:34 AM  
www.teecraze.com

Goodnight, kitty
 
2012-11-02 08:31:54 AM  

adm_crunch: Don't scare me like that. By the headline, I thought Adam West had died.


DUDE ME TOO!

/subby sucks
 
2012-11-02 08:32:03 AM  
Don't scare me like that. By the headline, I thought the Banana Splits had died.
 
2012-11-02 08:42:29 AM  
Don't scare me like that. By the headline, I thought Bowzer had died.
 
2012-11-02 09:06:52 AM  
Never ceases to amaze me what passes for a greenlight these days. Thanks modmins.
 
2012-11-02 09:18:26 AM  
Don't scare me like that. By the headline, I thought Curly Howard had died.

/again
 
2012-11-02 09:36:54 AM  
Should have gotten his cat vaccinated.
 
2012-11-02 09:44:51 AM  

dababler: Should have gotten his cat vaccinated.


Great. All we need now are a bunch of autistic cats.
 
2012-11-02 09:49:15 AM  

Xanlexian: dababler: Should have gotten his cat vaccinated.

Great. All we need now are a bunch of autistic cats.


I thought mine had Aspergers. As it turns out he's just a cat.
 
2012-11-02 09:50:04 AM  
That's sad news...

/has that as a ringtone on my phone for a crazy cat lady
 
2012-11-02 09:54:02 AM  
Don't scare me like that. By the headline, I thought Red 5 was standing by..
 
2012-11-02 09:57:05 AM  
It's very sad to lose a cat when they're so very young (Marty was 3).

6.mshcdn.com
 
2012-11-02 09:59:38 AM  
FIP is a horrible kitty cat disease. It is incurable, always fatal and sometimes can't even be diagnosed until after a necropsy is done.

I've lost two cats to this - I hate it when I hear about others having to go through it.
 
2012-11-02 10:50:48 AM  

Xanlexian: dababler: Should have gotten his cat vaccinated.

Great. All we need now are a bunch of autistic cats.


Too late.

farm4.static.flickr.com
 
2012-11-02 11:14:21 AM  
Gentlemen, we can rebuild him. We have the technology. We have the capability to build the world's first bionic cat. Nyan Hat will be that cat.

http://www.youtube.com/watch?v=jA-_RWewYXA

BetterNYAN, stronNYAN, NYANer. NYANNYANNyannyannyan...
 
2012-11-02 11:19:50 AM  

dababler: Should have gotten his cat vaccinated.


There is no vaccine for FIP.
 
2012-11-02 11:43:50 AM  
He will be missed.
 
2012-11-02 12:37:28 PM  

dababler: Should have gotten his cat vaccinated.


So much THIS. Add to it that his other cat died. Some people should not have pets.
 
2012-11-02 01:26:36 PM  

notyomama: dababler: Should have gotten his cat vaccinated.

There is no vaccine for FIP.


I think they're thinking about either Feline Leukemia or FIV.
 
2012-11-02 02:23:23 PM  

Contents Under Pressure: dababler: Should have gotten his cat vaccinated.

So much THIS. Add to it that his other cat died. Some people should not have pets.


With a vaccine that doesn't exist?
 
2012-11-02 02:24:38 PM  
Goddamn it, I hate hearing about people loosing pets but then I learned that Marty was the inspiration for Nyan Cat and he looked a lot like my old cat Leffe:

i56.photobucket.com

He was my best friend for 9 years and he got really sick and had to be put down almost exactly a year ago.

I still think about him all the time.

Have fun playing in rainbows and pop tarts together with Leffe, Marty.

/*dusty in here*
 
2012-11-02 02:24:44 PM  
Ah, my bad. One exists, but is ineffective. Meaning he may *HAVE* vaccinated the cat.
 
2012-11-02 02:34:29 PM  

Felgraf: Contents Under Pressure: dababler: Should have gotten his cat vaccinated.

So much THIS. Add to it that his other cat died. Some people should not have pets.

With a vaccine that doesn't exist?


Indeed.

It's the same principle about how you're a bad parent for not getting your child an AIDS and Cancer vaccine.
 
2012-11-02 03:07:50 PM  

dababler: Should have gotten his cat vaccinated.


Unfortunately, FIP is one of the few fatal infectious diseases of cats for which really effective vaccination doesn't exist (yes, there is an FIP vaccine, but it doesn't really work all that well and is still controversial among vets); we still aren't 100% sure if it's even possible to really vaccinate cats against it.

FIP has been tentatively linked to a feline coronavirus related to Feline Enteric Coronavirus but one of the complicating factors is that it's now thought FIPV develops from a mutation in FECV when a cat has been previously infected with FECV and resulting from a mutation in the FECV the cat carries (which does not normally make kitties sick)--there really ISN'T a good analogue with human diseases, because we don't really have any kind of infectious disease that arises from a harmless virus (that everyone carries) mutating into Captain Trips in a few unlucky people (who are ALL Patient Zero).

(The REAL human analogue would be if you had a mild 24-hour cold that spontaneously mutated into SARS while you still had the cold (bascally, FECV virus mutates to where it can invade white blood cells and infect them, and it causes a massive cytokine storm in kitteh). Primates don't really HAVE anything like FIP (in that the virus causing the disease is a mutated version of an innocuous virus in such a way that EVERY patient with it is Patient Zero) so it's been particularly difficult to find the cause; also, since FIP is likely caused by a benign virus spontaneously mutating into something akin to Kitty Cholera-SARS virus, that's going to be a lot harder to develop an effective vaccine for, especially as coronaviruses are known to mutate pretty rapidly and it's entirely likely that every kitty with FIP may have a different virus strain.)

Even some human bacterial diseases that are out there (and we know how they work) tend to be hard to actually effectively vaccinate against--we have cholera vaccines, but hardly any infectious disease or tropical medicine specialist really RECOMMENDS them because they don't work worth a damn (only about 60-70 percent effectiveness). Same for typhoid vaccine--for whatever reason, those vaccines just aren't terribly immunogenic (in the case of cholera, it's complicated by the fact that cholera bacteria that can give you actual cholera are THEMSELVES infected with a virus that makes them pathogenic, so cholera in particular is tricky to make a working vaccine against).

In the case of FIP, this is even further complicated by both a) the virus becoming infectious (and deadly) inside the kitty (all FIPV infections are from their own bad luck of having FECV that had the mutation that turns it into FIP--the FIP virus proper only lives in macrophages) AND its primary target being a certain type of white blood cell--imagine an infectious disease that in its own way was (immunologically) some farked-up mix of cholera and HIV and you get the idea. :P (And yes, cats who are immunocompromised have a higher chance of getting FIP from a pre-existing FECV infection--young kitties, unfortunately, tend to be among the vulnerable as well. Also--much like with HIV infection in humans--there are genetic factors in cats involved; there are known genes that increase likelihood of a cat contracting FIP if a "bad mutation" occurs.)

And FIP vaccination is even LESS effective than cholera vaccination, which should give you an idea of why even a lot of vets don't offer it routinely. Pretty much to effectively vaccinate against FIP you really have to vaccinate against FECV, and you run into the exact problem that you run into with cholera vaccination--it's one of those rare diseases where the "neutered" version isn't all that immunogenic against the disease that actually makes people sick, and it's difficult (without possibly some genetic engineering which people WILL WHARGARBL about) to make a vaccine that works without giving the patient the disease. (The fact that there does seem to be a fairly strong tie to genetic susceptibility doesn't help, either--even in feral cat colonies where FIP exists, almost all kitties have FECV infection but only 8-20% get the "bad mutation" and go into FIP.)

Even worse still for the prospect of an effective FIP vaccine, it turns out that most immunity that is actually effective against FIPV is with cellular immunity--not humoral/antibody-based immunity...and it's the latter how vaccination works. Basically, kitties with good cellular immunity can fight off FECV when it mutates to FIPV, whilst kitties who don't have good cellular immunity can go into FIP. (Yes, this is basically a similar issue to not only problems with cholera vaccination but issues we've run into developing an effective HIV vaccine.) In fact, for kitties with poor cellular immunity who've been vaccinated against FECV, it can throw them into the full-blown cytokine storm (and thus fatal FIP--FIP is actually a misnomer, and should really be called "feline cytokine-storm peritonitis").

It's actually a surprisingly difficult disease to protect kitties against--more on the relationship here.

About the only thing that's been found effective is an immunostimulant which is still very much in clinical trials in cats (and probably unavailable outside of one or two specialised veterinary research hospitals)--I guess you could feed them elderberries en masse, as there's been some experimentation with elderberry extract with humans in cytokine storms, but there's not much to help with that otherwise, sadly.
 
2012-11-02 06:14:35 PM  
I'd like to thank Great Porn Dragon for saying "Shut up you retarded, unknowing, stupid-arse fartbag of a human being" in a much nicer, kinder way than I could ever have. His genuine effort to educate a horrible human being, despite their ignorance of a very serious and deadly animal disease is truly a scourge on this planet, is admirable. I commend him for his efforts. Personally, the only words I could have wasted upon dababler and Contents Under Pressure were curses to their mothers and families.

GPD - You are a much better person than I. For that, I salute you.

www.appygamesblog.com
 
2012-11-02 07:36:54 PM  

Contents Under Pressure: dababler: Should have gotten his cat vaccinated.

So much THIS. Add to it that his other cat died. Some people should not have pets.


As noted before (and I'll just give the Cliff's Notes version this time instead of the wall of text):

a) There's a goodly 50% chance he COULD have had the cat vaccinated and it still not work--the only approved FIP vaccine is next to worthless in its effectiveness (studies give anywhere from maybe a less than 10% effectiveness rate on the optimistic end to actually making susceptible kitties more vulnerable to FIP according to at least one study)--the only reason it was approved is because right now that's all we have to fight FIP, and the vaccine was approved before it was recognised FIP is actually the result of a virus that mutates inside a kitty.

b) Because almost all studies show that the FIP vaccine (which is a nasal insufflation vaccine, much like some of the newer human flu vacs like Flumist--now picture a vet trying to give this to a kitty, with the knowledge that high stress in kitties increases their risk of going into FIP) does Sweet Fark All to actually PREVENT FIP, most vets don't routinely give the vaccine--and the veterinary equivalent of the AMA actually explicitly says not to give it routinely because it's not terribly effective. (The recommendations are about the same as for cholera vaccine in humans (speaking of vaccines rarely recommended)--if kitty will be in a high-stress, high-cat-density situation where there are likely to be infected kitties, they MIGHT give the vac, otherwise, no.)

c) FIP is misnamed, and probably should be better termed "Feline Immunogenic Peritonitis"--it's basically caused when (to put it in very simple terms) it turns from basically Kitty Stomach Bug to Kitty Intestinal SARS due to an unfortunate mix of the virus mutating (where it can infect a certain type of white blood cell) and a pre-existing genetic susceptibility (problems with a certain kind of immunity that's not normally an issue unless it's one of those bugs that antibodies can't take care of). Basically how kitties die of FIP is NOT dissimilar to how humans die of H5N1 "bird flu" or how they die of SARS--their own bodies' attempts to fight off the bug actually end up essentially poisoning the kitty (in what is commonly termed a "cytokine storm").

d) Because FIP is the result of an infection that starts out as the kitty equivalent of a 24-hour cold that goes into Gut SARS due to a mutation of the virus in the kitty (the mutant virus never shows up outside of the white blood cells it infects; the regular virus infects the kitty intestines) and the way that vaccines work also triggers the immune system bits that throw kitties into FIP...we don't know how, or even if, we can make a vaccine that can work against FIP. (There's a similar issue with cholera vaccines; cholera is caused by a bacteria (Vibrio cholerae) that in turn has been infected and is "sick" with a virus (Bacteriophage CTXφ) that targets bacteria--and also causes the vibrios to produce a toxin that causes the body to purge all its fluids out. If we make vaccines with vibrios that aren't "sick" with that virus, they make a vaccine that doesn't work very well--only about 50 percent effective.)

e) The two things that MIGHT work to either prevent or treat FIP involve an immune booster that boosts "cell based immunity" in cats that are sick with FIP (unfortunately these meds are very experimental and very expensive and hard to get) and--based on research in humans--maybe meds that can calm down the "cytokine storm" that kills cats with FIP. Unfortunately, we're not so good with this even in humans yet, much less kitteh (who can't handle some of the drugs we use to treat this in humans).

f) The big things that increase the likelihood that a cat with the "kitty gut bug" might have that "gut bug" transmogrify into FIP are its preexisting genetic susceptibility and how stressed it is and how crowded its living situations are--cats from crowded catteries and crowded shelters (not legit ethical cat breeders and dedicated cat fosters so much, I'm thinking more "the three-day holding room at the Humane Society" and kitten mills) tend to be very susceptible because they're very stressed and in crowded conditions, often with other sick cats. Old cats and kittens also tend to be susceptible--old cats because they're old, kittens because their immune systems are just starting up from being weaned by Mom.

In short--your comment is roughly as inappropriate as, say, telling parents that they're Evil Bad Naughty Evil People Of Evil because the kid they adopted from Kenya has Burkitt's lymphoma because OH GOD WHY DID YOU NOT GET BABBY THE CHICKENPOX SHOT (no matter that there IS no vaccine that works for mononucleosis--yes, Burkitt's lymphoma and mono are caused by the same virus (Epstein-Barr virus)--and despite the fact that despite both being herpesviruses the chickenpox shot does NOT work for mono, and despite the fact that sub-Saharan African populations in particular are known to have susceptibility to EBV triggering Burkitt's lymphoma).
 
2012-11-02 08:07:29 PM  

Professor_Falken: I'd like to thank Great Porn Dragon for saying "Shut up you retarded, unknowing, stupid-arse fartbag of a human being" in a much nicer, kinder way than I could ever have. His genuine effort to educate a horrible human being, despite their ignorance of a very serious and deadly animal disease is truly a scourge on this planet, is admirable. I commend him for his efforts. Personally, the only words I could have wasted upon dababler and Contents Under Pressure were curses to their mothers and families.

GPD - You are a much better person than I. For that, I salute you.

[www.appygamesblog.com image 685x360]


My second response...wasn't quite so nice, I admit, but I did try because there might well be people who aren't aware that there are still deadly diseases (and somewhat common ones, at that) in companion animals that we really don't have any good way to prevent or treat.

And in the case of FIP, it's not even just felines--ferrets can also get "ferret FIP" through their own coronavirus infections that "go SARS-ish", SARS itself is in the same virus family (the coronaviruses), and it would seem coronavirus infections can "go bad" fairly easily especially in Carnivora.

If anyone is interested in more info on the latest re FIP research, there's a good summary by Winn Feline Health (which can be best described as the Cat Fanciers Association's "veterinary auxillary" and has been working with breeders in developing a test for genetic susceptibility to FIP).

(And seriously, if anyone wants to help in Nyancat's memory...one thing you can do is to fund research into fighting FIP. In addition to immunostimulants, feline interferon omega has actually effected some outright cures but unfortunately is only available in Europe at this time; some have had some luck with vets importing Virbagen Omega (the feline interferon omega) under compassionate-use exemptions but encouraging the manufacturer and veterinary schools to do a formal clinical trial would make it possible to actually make it available to kitties in the US (and frankly it's the best shot we have--could well revolutionise treatment of FIP much as interferon treatment has revolutionised treatment of Kaposi's sarcoma in humans). There really is not enough research money available for stuff like this, alas.)

(The Center for Companion Animal Health at UC-Davis may be the leading university-affiliated veterinary hospital doing research on FIP treatment and developing a genetic test for FIP susceptibility (and thus letting vets know which kitties will need preventative treatment to prevent FIP--as noted, FIP happens when kitties with pre-existing genetic susceptibility get a "Dr. Jekyll" of a virus and it mutates inside them and goes "Mr. Hyde"). There's also a memorial trust being maintained explicitly for FIP research for UK Farkers,)
 
2012-11-05 11:43:10 AM  

ultraholland: NOOOOOOOO.

in honor we played played the song for the office


wow, so you didnt just play it. you PLAYED played it. nice.
 
2012-11-05 04:04:05 PM  
Sucks. We thought our 4 month old kitten had FIP. Needless to say it freaked us the hell out. Fortunately turned out not to be the case.
 
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