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(Chicago Trib)   Scientists create embryo with DNA from one man and two women, publish first ever scientific article prominently featuring the word "Giggity"   (chicagotribune.com) divider line 54
    More: Interesting, DNA, scientific article, mitochondrial DNA, Oregon Health & Science University, embryos, bioethics, incurable, ova  
•       •       •

2402 clicks; posted to Geek » on 24 Oct 2012 at 5:14 PM (2 years ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2012-10-24 03:12:06 PM  
Did the other scientists get to watch? I'll be in my lab.
 
2012-10-24 04:00:02 PM  
This is a truly remarkable breakthrough. From a purely scientific POV, if this proved successful over the long term, we could literally eliminate some of the most devastating and painful defects that hit human offspring, not to mention the myriad of other physical and mental diseases that we have definitively traced to genetic defects. If successful, we could prevent untold suffering for millions around the world that would have been afflicted as the defective genes were passed on over and over again, not to mention the massive amount of money saved from lifetimes of treatments for said illnesses.

There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.
 
2012-10-24 05:09:31 PM  
Two women at the same time?
 
2012-10-24 05:18:27 PM  

shanrick: Two women at the same time?


It was a $1 million dollar grant.
 
2012-10-24 05:19:46 PM  

Grand_Moff_Joseph: There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.


Call me cynical, but I'd put better odds on the Khan thing.

On the plus side, the sooner we get the Eugenics Wars out of the way, the sooner we can catch up with the rest of Star Trek.
 
2012-10-24 05:23:43 PM  
encrypted-tbn3.gstatic.com

Life imitates art.
 
2012-10-24 05:31:28 PM  
Hmmm...God's not going to like this one bit.
 
2012-10-24 05:34:07 PM  
On average, it's got 3 tits.
 
2012-10-24 05:34:54 PM  

Diogenes: Hmmm...God's not going to like this one bit.


Lets make a new one then.
 
2012-10-24 05:35:55 PM  

Grand_Moff_Joseph: . From a purely scientific POV, if this proved successful over the long term, we could literally eliminate some of the most devastating and painful defects that hit human offspring, not to mention the myriad of other physical and mental diseases that we have definitively traced to genetic defects.


We could do the same thing by screening embryos and not allowing the ones with bad genes to gestate. We don't need magic 3 parent embryos.

But then people start getting pissed off, calling it eugenics, and calling me a nazi.
 
2012-10-24 05:37:33 PM  

Grand_Moff_Joseph: This is a truly remarkable breakthrough. From a purely scientific POV, if this proved successful over the long term, we could literally eliminate some of the most devastating and painful defects that hit human offspring, not to mention the myriad of other physical and mental diseases that we have definitively traced to genetic defects. If successful, we could prevent untold suffering for millions around the world that would have been afflicted as the defective genes were passed on over and over again, not to mention the massive amount of money saved from lifetimes of treatments for said illnesses.

There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.


This technique, if it works, won't do most of that. It could potentially help some women with mitochondrial diseases have kids without those diseases but probably only if they had the money. Also, I'd be interested to know about the long term viability of offspring created this way.
 
2012-10-24 05:39:47 PM  

Honest Bender: Grand_Moff_Joseph: . From a purely scientific POV, if this proved successful over the long term, we could literally eliminate some of the most devastating and painful defects that hit human offspring, not to mention the myriad of other physical and mental diseases that we have definitively traced to genetic defects.

We could do the same thing by screening embryos and not allowing the ones with bad genes to gestate. We don't need magic 3 parent embryos.

But then people start getting pissed off, calling it eugenics, and calling me a nazi.


Actually, in the case of mitochondrial inheritance there is no reassortment. It's maternal only (except in a few rare cases), thus if the mother has the disease, so will the kiddo.
 
2012-10-24 05:40:00 PM  
SCIENCE!
 
2012-10-24 05:40:08 PM  
Make her for me:

www.fleen.com
 
2012-10-24 05:41:11 PM  
www.larryniven.net

Approves
 
2012-10-24 05:42:41 PM  

Grand_Moff_Joseph: From a purely scientific POV, if this proved successful over the long term, we could literally eliminate some of the most devastating and painful defects that hit human offspring


Keep in mind that this technique only eliminates defective genes in the mitochondrial DNA. The majority of our DNA is in the cell nucleus, which is still prone to a host of genetic diseases.

Replacing defective genes within the nucleus is a lot different than replacing the mDNA of a cell.


Honest Bender: We could do the same thing by screening embryos and not allowing the ones with bad genes to gestate.


See: PGD, a common procedure in IVF treatments.
 
2012-10-24 05:50:34 PM  

shanrick: Two women at the same time?


Stile4aly: shanrick: Two women at the same time?

It was a $1 million dollar grant.


I was going to go with $1 million embryo. Excellent work.
 
2012-10-24 06:02:28 PM  

roughridersfan: Make her for me:

Friday.jpg


I read that book (ensnared by the cover)

claycollinsblog-cdn.s3.amazonaws.com

/oblig
 
2012-10-24 06:02:31 PM  
patrick.net

What the scientist may look like.
 
2012-10-24 06:10:23 PM  

bingo the psych-o: Diogenes: Hmmm...God's not going to like this one bit.

Lets make a new one then.


1.bp.blogspot.com

Yes, the old God had his chance.
 
2012-10-24 06:13:55 PM  
So on one hand, we have potential mothers who know their mDNA will produce offspring who will suffer terribly. OTOH, we have unfounded fears that this solution may cause unspecified problems that may not appear for generations.

Hell, let's do it and see what happens. Isn't that what science is all about, or has it become a timid and futile attempt to foresee the future?

Only the rich will be able to afford this experimental procedure that insurance won't cover. Be nice to use them as guinea pigs for a change.

Yes, some kids may be born with unexpected problems. But they either would not have been born at all or they would have been born with expected problems.

We have to take some risks or we'll never cure this baby shortage that threatens the human race. Right?
 
2012-10-24 06:16:19 PM  

BarkingUnicorn: Only the rich will be able to afford this experimental procedure that insurance won't cover. Be nice to use them as guinea pigs for a change.


Well, I'm all for that.
 
2012-10-24 06:23:52 PM  
images2.wikia.nocookie.net 


/best pic I could find, but I'm sure you get it
 
2012-10-24 06:26:29 PM  
Crazy-ass nutjob christians will start screeching about the "sanctity of life" and make claims of "playing god" because this research involves embryos in 5... 4... 3... 2...
 
2012-10-24 06:33:26 PM  

Keyser_Soze_Death: [www.larryniven.net image 224x300]

Approves


Is that supposed to be a Pearson's Puppeteer? They look nothing like that.
 
2012-10-24 06:35:56 PM  

Dinjiin: Grand_Moff_Joseph: From a purely scientific POV, if this proved successful over the long term, we could literally eliminate some of the most devastating and painful defects that hit human offspring

Keep in mind that this technique only eliminates defective genes in the mitochondrial DNA. The majority of our DNA is in the cell nucleus, which is still prone to a host of genetic diseases.

Replacing defective genes within the nucleus is a lot different than replacing the mDNA of a cell.


Honest Bender: We could do the same thing by screening embryos and not allowing the ones with bad genes to gestate.

See: PGD, a common procedure in IVF treatments.


Good points. Still, a step in the right direction though (I hope)
 
2012-10-24 06:48:45 PM  

Olympic Trolling Judge: On the plus side, the sooner we get the Eugenics Wars out of the way, the sooner we can catch up with the rest of Star Trek.


Psssst... Star Trek is fiction.... Show me verterium cortenide on the Periodic Table of Elements....

Tillmaster: Is that supposed to be a Pearson's Puppeteer? They look nothing like that.


They're not spelled anything like that either.
 
2012-10-24 06:52:36 PM  
I thought that was how they came up with Rachel Maddow.
 
2012-10-24 07:05:40 PM  

Tillmaster: Keyser_Soze_Death: [www.larryniven.net image 224x300]

Approves

Is that supposed to be a Pearson's Puppeteer? They look nothing like that.


Check where the image is linked from (and your spelling too). ;p
 
2012-10-24 07:08:53 PM  
The British government is asking for public comment on the technology before it decides whether to allow its use in the future. One concern it cites is whether such DNA alteration could be an early step down a slippery slope toward "designer babies" - ordering up, say, a petite, blue-eyed girl or tall, dark-haired boy.

news.priceperhead.com4.bp.blogspot.com
Yes, I'm sure everyone will be rushing to order children that look nothing like them.
 
2012-10-24 07:10:46 PM  

Keyser_Soze_Death: Tillmaster: Keyser_Soze_Death: [www.larryniven.net image 224x300]

Approves

Is that supposed to be a Pearson's Puppeteer? They look nothing like that.

Check where the image is linked from (and your spelling too). ;p


Pff, Larry Niven? What does he know about them? Probably just some noob with a blog who heard about the stories from his brother or k'zin.
 
2012-10-24 07:14:40 PM  

shanrick: Two womenchicks at the same time?

 


FTFY
 
2012-10-24 07:15:07 PM  

verbal_jizm: BarkingUnicorn: Only the rich will be able to afford this experimental procedure that insurance won't cover. Be nice to use them as guinea pigs for a change.

Well, I'm all for that.


Millions of copies of Bill Gates and Zukerbergs.

How quaint.
 
2012-10-24 07:54:04 PM  

you have pee hands: On average, it's got 3 tits.


3 tits? Awesome!

( . )( . )( . )
/Awesome
 
2012-10-24 08:07:14 PM  

roughridersfan: Make her for me:

[www.fleen.com image 290x300]


I'll be happy to wait for Friday.
 
2012-10-24 08:57:26 PM  
The British government is asking for public comment on the technology before it decides whether to allow its use in the future. One concern it cites is whether such DNA alteration could be an early step down a slippery slope toward "designer babies" - ordering up, say, a petite, blue-eyed girl or tall, dark-haired boy.

If Gundam Seed taught me anything, it's that designer babies grow up to be angst-fuelled mech pilots/Mary Sues, and that's not a good thing.
 
2012-10-24 08:58:51 PM  
They also created an embryo using DNA from five men. His pants are expected to fit him like a glove.
 
2012-10-24 09:17:50 PM  
sharetv.org

Binaum there, done that.
 
2012-10-24 09:39:25 PM  

Grand_Moff_Joseph: There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.


Or this.
http://en.wikipedia.org/wiki/XYY_syndrome
 
2012-10-24 09:55:43 PM  
I know this, if there is one thing we really need in this world right now, it's the ability to add even more people to it.
 
2012-10-24 10:47:28 PM  

Olympic Trolling Judge: Grand_Moff_Joseph: There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.

Call me cynical, but I'd put better odds on the Khan thing.

On the plus side, the sooner we get the Eugenics Wars out of the way, the sooner we can catch up with the rest of Star Trek.


Except genetics don't work that way. "Remember, genes are NOT blueprints. This means you can't, for example,
insert "the genes for an elephant's trunk" into a giraffe and get a
giraffe with a trunk. There -are- no genes for trunks. What you CAN do
with genes is chemistry, since DNA codes for chemicals. For instance,
we can in theory splice the native plants' talent for nitrogen fixation
into a terran plant."
 
2012-10-24 10:48:14 PM  

LordOfThePings: [sharetv.org image 200x300]

Binaum there, done that.


Honey, get the milk from behind the radiator, it's time to get Frisky!
 
2012-10-25 12:03:29 AM  
And the state of California wasted no time getting a ballot proposition requiring all genetically-modified people to be properly branded.
 
2012-10-25 12:53:45 AM  

you have pee hands: On average, it's got 3 tits.


Men have tits. They are usually non functional.
 
2012-10-25 01:59:59 AM  

thatboyoverthere: Olympic Trolling Judge: Grand_Moff_Joseph: There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.

Call me cynical, but I'd put better odds on the Khan thing.

On the plus side, the sooner we get the Eugenics Wars out of the way, the sooner we can catch up with the rest of Star Trek.

Except genetics don't work that way. "Remember, genes are NOT blueprints. This means you can't, for example,
insert "the genes for an elephant's trunk" into a giraffe and get a
giraffe with a trunk. There -are- no genes for trunks. What you CAN do
with genes is chemistry, since DNA codes for chemicals. For instance,
we can in theory splice the native plants' talent for nitrogen fixation
into a terran plant."




uhhh... genes code for proteins, not "chemicals". 

/discovered a few meself, actually.
 
2012-10-25 08:23:52 AM  

bemused outsider: thatboyoverthere: Olympic Trolling Judge: Grand_Moff_Joseph: There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.

Call me cynical, but I'd put better odds on the Khan thing.

On the plus side, the sooner we get the Eugenics Wars out of the way, the sooner we can catch up with the rest of Star Trek.

Except genetics don't work that way. "Remember, genes are NOT blueprints. This means you can't, for example,
insert "the genes for an elephant's trunk" into a giraffe and get a
giraffe with a trunk. There -are- no genes for trunks. What you CAN do
with genes is chemistry, since DNA codes for chemicals. For instance,
we can in theory splice the native plants' talent for nitrogen fixation
into a terran plant."



uhhh... genes code for proteins, not "chemicals". 

/discovered a few meself, actually.


Quoting Alpha Centuari there. Still the quote is pretty true. You can't just modify a few genes and come up with a super strong, intelligence, sociopath. We still have no idea what genes are responsible for intelligence if there are any. And sociopathy is mostly nurture.
 
2012-10-25 10:25:35 AM  
"Arise, Serpentor, Arise!"
upload.wikimedia.org
 
2012-10-25 10:27:44 AM  
Also would have accepted:

Mitt Romney will be thrilled.

img2.timeinc.net
 
2012-10-25 10:41:16 AM  

thatboyoverthere: bemused outsider: thatboyoverthere: Olympic Trolling Judge: Grand_Moff_Joseph: There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.

Call me cynical, but I'd put better odds on the Khan thing.

On the plus side, the sooner we get the Eugenics Wars out of the way, the sooner we can catch up with the rest of Star Trek.

Except genetics don't work that way. "Remember, genes are NOT blueprints. This means you can't, for example,
insert "the genes for an elephant's trunk" into a giraffe and get a
giraffe with a trunk. There -are- no genes for trunks. What you CAN do
with genes is chemistry, since DNA codes for chemicals. For instance,
we can in theory splice the native plants' talent for nitrogen fixation
into a terran plant."



uhhh... genes code for proteins, not "chemicals". 

/discovered a few meself, actually.

Quoting Alpha Centuari there. Still the quote is pretty true. You can't just modify a few genes and come up with a super strong, intelligence, sociopath. We still have no idea what genes are responsible for intelligence if there are any. And sociopathy is mostly nurture.



Hmmm....
Pop-culture reference detected.
System failure.

/bemused outsider gotta be outsider!
 
2012-10-25 10:59:30 AM  

thatboyoverthere: Olympic Trolling Judge: Grand_Moff_Joseph: There's only one problem: The power to implement and control advancements like this are left in our easily corrupted hands. We are just as liable to cure thousands of diseases with this knowledge as we are to create genetic armies of Khans o ransack the world.

Call me cynical, but I'd put better odds on the Khan thing.

On the plus side, the sooner we get the Eugenics Wars out of the way, the sooner we can catch up with the rest of Star Trek.

Except genetics don't work that way. "Remember, genes are NOT blueprints. This means you can't, for example,
insert "the genes for an elephant's trunk" into a giraffe and get a
giraffe with a trunk. There -are- no genes for trunks. What you CAN do
with genes is chemistry, since DNA codes for chemicals. For instance,
we can in theory splice the native plants' talent for nitrogen fixation
into a terran plant."


Academician Prokhor Zakharov, "Nonlinear Genetics"

You forgot this.
 
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