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(BBC)   Uganda says ebola is now under controlla   (bbc.co.uk) divider line 57
    More: Followup, Uganda, MSF, ebola, outbreaks  
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2533 clicks; posted to Main » on 12 Aug 2012 at 2:18 AM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2012-08-12 02:04:59 AM
Is the Ayatollah of Rock and Rolla their spokesman now?
 
2012-08-12 02:23:40 AM
secularnewsdaily.s3.amazonaws.com
 
2012-08-12 02:24:00 AM
RE
OPEN
EVERYTHING
 
2012-08-12 02:25:06 AM
What Uganda do about it?
 
2012-08-12 02:25:27 AM

PacManDreaming: Is the Ayatollah of Rock and Rolla their spokesman now?


Lord Humungus is unavailable for comment.
 
2012-08-12 02:27:09 AM
FTFA: The last confirmed death from Ebola took place 11 days ago, MSF epidemiologist Dr Paul Roddy told the BBC.

But he warned that if a pocket of the virus was missed it could erupt once more.


Why are people in Uganda walking around with pockets full of ebola? That's just asking for trouble, especially on laundry day.
 
2012-08-12 02:28:32 AM
We totally have this! Don't worry about it.

Anyone seen a few people who flew out last week?

/I like to singa, about the moona and the juna and the springa...
 
2012-08-12 02:31:31 AM
PacManDreaming
Is the Ayatollah of Rock and Rolla their spokesman now?

Nah, he quit and moved to Arizona to buy a condo made of stona.
 
2012-08-12 02:32:52 AM
A booglia dee,A bogglia a dee da
 
2012-08-12 02:34:36 AM

Ed Finnerty: FTFA: The last confirmed death from Ebola took place 11 days ago, MSF epidemiologist Dr Paul Roddy told the BBC.

But he warned that if a pocket of the virus was missed it could erupt once more.

Why are people in Uganda walking around with pockets full of ebola? That's just asking for trouble, especially on laundry day.


Even worse, ebola is dry clean only
 
2012-08-12 02:34:48 AM
They still don't know what its natural reservoir is, right? Monkeys or bats, maybe? It'll be back again someday.
 
2012-08-12 02:35:30 AM
When are they going to learn to stop eating monkey meat?
 
2012-08-12 02:40:19 AM
I would pusstulate, that it's not!
 
2012-08-12 02:41:07 AM
Surely you've heard the Ebola Polka by KQRS.
 
2012-08-12 02:43:57 AM
This is the kind of thing you have to watch out for when you eat de poo poo
 
2012-08-12 02:48:54 AM
Uganda says ebola is now under controlla

I read this in Owl Jolson's voice. I love to singa, about the moona and the june-a and the springa...
 
2012-08-12 02:50:40 AM

Captain_Ballbeard: When are they going to learn to stop eating monkey meat?


When are monkeys going to learn not to be so delicious?
 
2012-08-12 02:52:34 AM

jaspyrnyte: This is the kind of thing you have to watch out for when you eat de poo poo


But do you have to when you licka da anus?
 
2012-08-12 03:18:49 AM
FTFA: He said there had been 19 confirmed and probable deaths during the outbreak.

Uh... probable deaths? I had no idea Schrödinger's cat was Ugandan. But I hope they'll let us know when they figure out whether people are dead or not.

/Wife and 7-month-old landed are there right now.
 
2012-08-12 03:21:49 AM

detroitdoesntsuckthatbad: jaspyrnyte: This is the kind of thing you have to watch out for when you eat de poo poo

But do you have to when you licka da anus?

"The what?"

"de poo poo!"

comedycentral.mtvnimages.com
 
2012-08-12 03:28:57 AM
Yeah Judge, itsa hertz.
 
2012-08-12 03:37:15 AM
Has anyone notified Madagascar? Is it OK to start everything back up?
 
2012-08-12 03:40:13 AM
out on a limb prediction

based solely on a laymans info


i predict that they will find that the resevoir is in the soil itself - where a previous animal has died of it and even where it has been "shed"
 
2012-08-12 03:45:09 AM
I thought Uganda was all Jesusy. Can't they just pray the ebola away?
 
2012-08-12 04:02:10 AM
Imagine the fatality rate of Ebola with the transmission rate of influenza

/no, let's not
 
xcv
2012-08-12 04:07:26 AM

sillydragon: I thought Uganda was all Jesusy. Can't they just pray the ebola away?


Obviously HIV didn't eliminate teh gays so ebola is God is trying a scorched earth method.
 
2012-08-12 04:20:46 AM

ktybear: Imagine the fatality rate of Ebola with the transmission rate of influenza

/no, let's not


Ever heard of Spanish flu? Killed 100 million of those pesky humans dead.

George Orwell had some thoughts on disease that have never left me:

"Numéro 57's eyes were still open, his mouth also open, his small face contorted into an expression of agony. What most impressed me, however, was the whiteness of his face. It had been pale before, but now it was little darker than die sheets. As I gazed at the tiny, screwed-up face it struck me that dlis disgusting piece of refuse, waiting to be carted away and dumped on a slab in the dissecting room, was an example of 'natural' death, one of the things you pray for in the Litany. There you are, then, I thought, that's what is waiting for you, twenty, thirty, forty years hence: that is how the lucky ones die, the ones who live to be old. One wants to live, of course, indeed one only stays alive by virtue of the fear of death, but I think now, as I thought then, that it's better to die violently and not too old. People talk about the horrors of war, but what weapon has man invented that even approaches in cruelty some of the commoner diseases? 'Natural' death, almost by definition, means something slow, smelly and painful."
 
2012-08-12 04:31:58 AM
I am glad there is no disease where you die by pooping out your eyes until you die forever.
 
2012-08-12 04:55:56 AM
991.com
 
2012-08-12 04:56:38 AM

Robert Poopsmith: I am glad there is no disease where you die by pooping out your eyes until you die forever.


Well no, but if you threaten Prince Baron with a treason charge while standing too close to a platform of spikes... this happens:
www.thiel-a-vision.com
 
2012-08-12 05:05:20 AM
Uganda was once a vacation spot. Like Vegas it's not as cool as it once was.
 
2012-08-12 05:30:28 AM

Betep: Uganda was once a vacation spot. Like Vegas it's not as cool as it once was.


img41.imageshack.us

A lot more excitement back then.
 
2012-08-12 05:55:07 AM

Captain_Ballbeard: When are they going to learn to stop eating monkey meat?


Oh, you mean eating monkey meat.
 
2012-08-12 06:19:08 AM

Captain_Ballbeard: When are they going to learn to stop eating monkey meat?


Probably when they stop letting eyeballs roll down the street.

/obscure?
 
2012-08-12 06:30:22 AM

Betep: Uganda was once a vacation spot.


What, back in the colonial days?! Surely not in the politically unstable early days of independence, or in the Idi Amin years, or during the post-Amin coups... although in the last maybe 20 years, and especially in the past 10, I'd say it's becoming much more of one, what with hiking in the hills to see gorillas in the wild and stuff like that. I read that Bill Gates was doing that just this past week.
 
2012-08-12 07:26:28 AM
Uganda, ebola, it's under contolla,
Down in Kokomo,
We'll get there fast and then we'll die real slow
That's where we wanna go,
Down in Kokomo
 
2012-08-12 08:17:47 AM
Where's the unlikely tag?
 
2012-08-12 08:40:19 AM

PacManDreaming: Is the Ayatollah of Rock and Rolla their spokesman now?


Corporal 'Stitch' Jones would like a word.
 
2012-08-12 08:59:59 AM

Linkster: I would pusstulate, that it's not!


Ebola is more of a bleeding from every orifice, pooping your intestinal lining, vomiting up blood, and dying either from massive hemorrhaging or organ failure. Pus, not so much.
 
2012-08-12 09:07:22 AM
I was going to post a picture of a dead Ebola victim bleeding out of every orifice, but I forgot that those pictures are why I keep getting banned.

So I'll just post technical stuffs.


technabob.com

www.umm.edu

Ebola virus (EBOV) causes severe disease in humans and in nonhuman primates in the form of viral hemorrhagic fever. EBOV is a select agent, World Health Organization Risk Group 4 Pathogen (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogen, Centers for Disease Control and Prevention Category A Bioterrorism Agent, and listed as a Biological Agent for Export Control by the Australia Group.

Ebola virus (abbreviated EBOV) was first described in 1976.[1][2][3] Today, the virus is the single member of the species Zaire ebolavirus, which is included into the genus Ebolavirus, family Filoviridae, order Mononegavirales. The name Ebola virus is derived from the Ebola River (a river that was at first thought to be in close proximity to the area in Zaire where the first recorded Ebola virus disease outbreak occurred) and the taxonomic suffix virus.[4] Ebola virus is pronounced ɛ'bɒlə vɑɪrəs (IPA) or eh-bo-luh v-eye-ruhs in English phonetic notation.[4] According to the rules for taxon naming established by the International Committee on Taxonomy of Viruses (ICTV), the name Ebola virus is always to be capitalized, but is never italicized, and may be abbreviated (with EBOV being the official abbreviation).

Ebola virus was first introduced as a possible new "strain" of Marburg virus in 1977 by two different research teams.[1][2] At the same time, a third team introduced the name Ebola virus.[3] In 2000, the virus name was changed to Zaire Ebola virus,[5][6] and in 2005 to Zaire ebolavirus.[7][8] However, most scientific articles continued to refer to Ebola virus or used the terms Ebola virus and Zaire ebolavirus in parallel. Consequently, in 2010, the name Ebola virus was reinstated.[4] Previous abbreviations for the virus were EBOV-Z (for Ebola virus Zaire) and most recently ZEBOV (for Zaire Ebola virus or Zaire ebolavirus). In 2010, EBOV was reinstated as the abbreviation for the virus.[4]

A virus of the species Zaire ebolavirus is an Ebola virus if it has the properties of Zaire ebolaviruses and if its genome diverges from that of the prototype Zaire ebolavirus, Ebola virus variant Mayinga (EBOV/May), by ≤10% at the nucleotide level.[4]

Virology

[edit]Structure
Electron micrographs of EBOV show them to have the characteristic threadlike structure of a filovirus.[9] EBOV VP30 is around 288 amino acids long.[10] The virions are tubular in general form but variable in overall shape and may appear as the classic shepherd's crook or eyebolt, as a U or a 6, or coiled, circular, or branched; laboratory techniques, such as centrifugation, may be the origin of some of these formations.[11] Virions are generally 80 nm in diameter with a lipid bilayer anchoring the glycoprotein which projects 7 to 10 nm long spikes from its surface.[12] They are of variable length, typically around 800 nm, but may be up to 1000 nm long. In the center of the virion is a structure called nucleocapsid, which is formed by the helically wound viral genomic RNA complexed with the proteins NP, VP35, VP30, and L.[13] It has a diameter of 80 nm and contains a central channel of 20-30 nm in diameter. Virally encoded glycoprotein (GP) spikes 10 nm long and 10 nm apart are present on the outer viral envelope of the virion, which is derived from the host cell membrane. Between envelope and nucleocapsid, in the so-called matrix space, the viral proteins VP40 and VP24 are located.[14]
[edit]Genome
Each virion contains one molecule of linear, single-stranded, negative-sense RNA, 18,959 to 18,961 nucleotides in length. The 3′ terminus is not polyadenylated and the 5′ end is not capped. It was found that 472 nucleotides from the 3' end and 731 nucleotides from the 5' end are sufficient for replication.[15] It codes for seven structural proteins and one non-structural protein. The gene order is 3′ - leader - NP - VP35 - VP40 - GP/sGP - VP30 - VP24 - L - trailer - 5′; with the leader and trailer being non-transcribed regions, which carry important signals to control transcription, replication, and packaging of the viral genomes into new virions. The genomic material by itself is not infectious, because viral proteins, among them the RNA-dependent RNA polymerase, are necessary to transcribe the viral genome into mRNAs because it is a negative sense RNA virus, as well as for replication of the viral genome. Sections of the NP and the L genes from filoviruses have been identified as endogenous in the genomes of several groups of small mammals.[16]
[edit]Replication
Being acellular, viruses do not grow through cell division; instead, they use the machinery and metabolism of a host cell to produce multiple copies of themselves, and they assemble in the cell.[13]
The virus attaches to host receptors through the glycoprotein (GP) surface peplomer and is endocytosed into macropinosomes in the host cell [17]
Viral membrane fuses with vesicle membrane, nucleocapsid is released into the cytoplasm
Encapsidated, negative-sense genomic ssRNA is used as a template for the synthesis (3' - 5') of polyadenylated, monocistronic mRNAs
Using the host cell's machinery, translation of the mRNA into viral proteins occurs
Viral proteins are processed, glycoprotein precursor (GP0) is cleaved to GP1 and GP2, which are heavily glycosylated. These two molecules assemble, first into heterodimers, and then into trimers to give the surface peplomers. Secreted glycoprotein (sGP) precursor is cleaved to sGP and delta peptide, both of which are released from the cell.
As viral protein levels rise, a switch occurs from translation to replication. Using the negative-sense genomic RNA as a template, a complementary +ssRNA is synthesized; this is then used as a template for the synthesis of new genomic (-)ssRNA, which is rapidly encapsidated.
The newly formed nucleocapsids and envelope proteins associate at the host cell's plasma membrane; budding occurs, destroying the cell.


 
2012-08-12 09:51:34 AM
I was going to say: "Read "The Hot Zone" if you never want to sleep again, because Ebola's that scary", but you guys don't read, so...
 
2012-08-12 10:00:17 AM

JWMcLoud: I was going to say: "Read "The Hot Zone" if you never want to sleep again, because Ebola's that scary", but you guys don't read, so...


I reread that whenever I need to be reminded that nature is just a teeny bit away from deciding to take us all out.
 
2012-08-12 10:01:44 AM

JWMcLoud: I was going to say: "Read "The Hot Zone" if you never want to sleep again, because Ebola's that scary", but you guys don't read, so...

Sorry to disappoint, but I've read that book. And "The Cat in the Hat."
 
2012-08-12 10:11:47 AM

vossiewulf: Uganda says ebola is now under controlla

I read this in Owl Jolson's voice. I love to singa, about the moona and the june-a and the springa...


icanhascheezburger.files.wordpress.com
 
2012-08-12 10:15:47 AM

JWMcLoud: I was going to say: "Read "The Hot Zone" if you never want to sleep again, because Ebola's that scary", but you guys don't read, so...


No, but I read The Andromeda Strain, so I know that all I have to do is keep myself drunk, and I'll be immune!
 
2012-08-12 10:38:26 AM

JWMcLoud: I was going to say: "Read "The Hot Zone" if you never want to sleep again, because Ebola's that scary", but you guys don't read, so...


Especially when you read the graphic description of what happens to someone who is just about to die from Ebola.
 
2012-08-12 10:45:01 AM
they forgot to write: and on a rolla!
 
2012-08-12 11:55:25 AM

Bondith: PacManDreaming
Is the Ayatollah of Rock and Rolla their spokesman now?

Nah, he quit and moved to Arizona to buy a condo made of stona.


But Moses supposes erroneously...
 
2012-08-12 12:01:33 PM

tillerman35: Bondith: PacManDreaming
Is the Ayatollah of Rock and Rolla their spokesman now?

Nah, he quit and moved to Arizona to buy a condo made of stona.

But Moses supposes erroneously...


I think Moses might've been on LSD if he thought his toeses were made out of roses.
 
2012-08-12 12:32:30 PM
farm3.staticflickr.com

What a puny plan...
 
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