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(BBC)   Think Big Pharma has too much power now? GlaxoSmithKline just bought THE HUMAN GENOME   (bbc.co.uk) divider line 99
    More: Scary, Bristol-Myers Squibb, biotechnology company, GlaxoSmithKline, GSK, lupus, drug companies, HGS, AstraZeneca  
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13911 clicks; posted to Main » on 18 Jul 2012 at 9:30 PM (2 years ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2012-07-18 09:10:03 PM
it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?
 
2012-07-18 09:25:33 PM
www.chicagonow.com

this will get out of hand...yadda yadda yadda
 
2012-07-18 09:31:52 PM
From who, exactly? When do I get my share of the check?
 
2012-07-18 09:32:11 PM
More prescriptions drug overdoses have occurred than street drug overdoses the past several years, Big Pharma legally kills more addicts than cartels do.

/You know, chemically
//Those other shenanigans are just a fun byproduct of prohibition
 
2012-07-18 09:34:50 PM
PonceAlyosha: From who, exactly? When do I get my share of the check?

That's what I wondered. I would have thought we'd progressed beyond the "I discovered it therefore I OWN it" mindset. IT's like syaing the U.S. owns the moon becuase we were the first people to set foot on it. It was always THERE, someone just took the time to map it.
 
2012-07-18 09:35:28 PM
And Uncle Sam handed themselves a patent for 'cannabinoids as neuroprotectants/antioxidants,' despite that pesky, stupid, illogical -- oh, what? You mean they still classify cannabis as scheddule 1, 'no medicinal value'?

/SAY WHAT?
//i can feel my 2nd amendment getting hard...
/this guy would be retarded or dead if not for cannabinoids 'as neuroprotectants'
//ZING
 
2012-07-18 09:35:34 PM
Human Genome Sciences, a corporation, not THE human genome. And they're doing it to get a few of the drugs they owned patents to.
 
2012-07-18 09:35:38 PM
Just to the right of the article:
"GlaxoSmithKline is to pay $3bn (£1.9bn) in the largest healthcare fraud settlement in US history."
 
2012-07-18 09:36:09 PM
Uh, ....no??

FTA:
Drug company GlaxoSmithKline is to buy Human Genome Sciences for about $3bn (£1.9bn), ending a three-month pursuit of the US biotechnology firm.

Unless Human Genome Sciences already HELD rights to the sequence of the human genome, then... this is just a tech acquisition, no different from Facebook buying Face.com. (hint: they didn't buy everybody's faces)
 
2012-07-18 09:36:26 PM
PonceAlyosha: From who, exactly? When do I get my share of the check?

that's a good question. who the fark owned it before?
 
2012-07-18 09:36:38 PM
GSK will gain control of Benlysta, which treats the immune system disorder lupus

thumbs2.modthesims.info

Just getting that out of the way.
 
2012-07-18 09:36:58 PM
Fark please stop adding typos to my comments after i carefully preview them and proofread them multiple times. Thanks.

/ohyou.jpg
 
2012-07-18 09:38:02 PM
www.fileden.com
 
2012-07-18 09:38:13 PM

D_Evans45: Just to the right of the article:
"GlaxoSmithKline is to pay $3bn (£1.9bn) in the largest healthcare fraud settlement in US history."


C'mon, you can totally trust them with your genome. No way they would ever pull any shenanigans with it.
 
2012-07-18 09:39:10 PM
why can't someone just buy Arena Pharmaceuticals? Any price over $15 a share will do.
 
2012-07-18 09:40:03 PM
More proof that Big Medicine is trying to make a profit on the backs of its customers. No sense in developing cures and remedies when there's money to be made in the prolonged treatment of symptoms.
 
2012-07-18 09:40:23 PM
It's a lot cheaper for them to hover around like vultures and wait for the start-ups to do the R&D, and then come in for the kill. I don't think this is good, but maybe I'm just naive and believe that medical science should not be conducted by the ruthless mentality and the same lack of integrity of Wall Street, hedge funds, and Mittens' Cayman Island hundreds of millions.

/HGS is only six miles from here
//interviewed there once
 
2012-07-18 09:40:32 PM
fieldagentaustralia.files.wordpress.com


all your genes are belong to us
 
2012-07-18 09:40:58 PM
Needs effective Lupus meds so she can run the barn

img1.bdbphotos.com
 
2012-07-18 09:42:35 PM
What you did there. I see it.
 
2012-07-18 09:45:47 PM
So does this mean they own all children born from hence forth?

Or do parents have to pay them royalties?

Maybe they will send lawyers after women for infringing on their intellectual property.

Do I still own my semen?
 
2012-07-18 09:46:39 PM
its just a weed man...
 
2012-07-18 09:47:33 PM
thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

I'd say it's a bad shift because it's so hard to get ideas funded through other means. But I'm also currently trying to get an industry job with a bioE phd, so I'm not impartial. But they're mainly doing it to try to avoid the risk/cost of early stage R&D. They let academia develop the ideas, startups do the initial GLP level research, and once something looks promising they gobble it up. It's actually a pretty sweet deal if you're a grad student who is lucky enough to get a project that leads to a commercializable product. When you're in the top level of a startup that is bought out you get major bank, and probably a job with the big company.
 
2012-07-18 09:49:44 PM
Read the article you farkers.. they are buying a company called "Human Genome Science" subby trolled all ya'lls.
 
2012-07-18 09:50:28 PM
That's nothing. I just bought Mars.


canadianfreestuff.com
 
2012-07-18 09:51:09 PM
OK, they can have the Genome. I'll be selling the G Spot...as soon as I find one.
 
2012-07-18 09:53:44 PM
Subby has proven very effective in this case in illustrating how many Farkers take the time to actually RTFA.
 
2012-07-18 09:54:06 PM

Nickninja: thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

I'd say it's a bad shift because it's so hard to get ideas funded through other means. But I'm also currently trying to get an industry job with a bioE phd, so I'm not impartial. But they're mainly doing it to try to avoid the risk/cost of early stage R&D. They let academia develop the ideas, startups do the initial GLP level research, and once something looks promising they gobble it up. It's actually a pretty sweet deal if you're a grad student who is lucky enough to get a project that leads to a commercializable product. When you're in the top level of a startup that is bought out you get major bank, and probably a job with the big company.


Plus, here in the RTP area (there is a GSK R&D site here) many start-ups get special treatment for taxes/facilities/utilities and such where it makes the model cheaper than doing all the R&D in-house at a big pharma site.
 
2012-07-18 09:54:29 PM
David the Genome?
 
2012-07-18 09:54:58 PM
Yeah, great- this will pay off years down the road. Meanwhile, they keep on paying out for getting caught working in grey areas and what do they have in their pipeline? More old people anti-constipation cures? Some more drugs that really have any use in the third world?
 
2012-07-18 09:56:50 PM
I have this vision of Big Pharma researchers going into villages the world order to look for new unique genes, and as soon as they're gone, mercenaries move in and wipe the village off the map to protect the patents.
 
2012-07-18 09:57:10 PM
Nickninja: thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

I'd say it's a bad shift because it's so hard to get ideas funded through other means. But I'm also currently trying to get an industry job with a bioE phd, so I'm not impartial. But they're mainly doing it to try to avoid the risk/cost of early stage R&D. They let academia develop the ideas, startups do the initial GLP level research, and once something looks promising they gobble it up. It's actually a pretty sweet deal if you're a grad student who is lucky enough to get a project that leads to a commercializable product. When you're in the top level of a startup that is bought out you get major bank, and probably a job with the big company.


On the academic side it's a good partnership. The pharmaceutical companies have always actually been pretty bad when it comes to basic science, which is absolutely critical. They recognize that University researchers excel at it so they they usually form partnerships where they allow usage of their massive molecular libraries. Once one or more good candidates are found they can do what they are really good at, which is refinement, trials, etc.

My group has some similar partnerships with GSK for orphan diseases but this is my first time ever being involved in anything on the research side where there was interest.
 
2012-07-18 09:57:18 PM
GleeUnit: Subby has proven very effective in this case in illustrating how many Farkers take the time to actually RTFA.

Come on....I like the idea that they could buy the actual human genome.
 
2012-07-18 10:00:16 PM
thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

Big Pharma had enormous resources they could throw at a problem. For the past decade or so, they have been using a research philosophy called "high throughput screening"; basically, the idea was if you increase the rate and number of drugs you test, you will have more successes. Although this seems to be sound reasoning, it was recently shown that, inexplicably, this method doesn't work. Our current models to test the drugs are no where near as complicated as the human body, and we can rarely predict how it will respond. Thus, despite having thousands upon thousands of compounds to test, this method rarely translates into a viable drug (approximately 1:1,000,000 or less make it to human testing).

In my professional opinion, the problem was never one of cramming more compounds into the pipeline, but rather the lack of viable models in which to test effectiveness and toxicity. You would probably be very surprised how crude the process is.

Now, most research laboratories cannot simply test thousands of random compounds. They're forced to use the "rational design" model, ie they have to have a proposed target and mechanism for how their compounds will work. The research is much slower, but if the researchers are correct, and their model holds up, it provides a backbone for further research into less toxic/more effective compounds. This is why Pharma wants to buy them up at this stage--the leg work, the discovery of a viable target, mechanism of action, and finding an effective class of compound, has been done for them.

I would hope Pharma would continue funding efforts to create more accurate models for testing potential drugs. If they don't want to do the work themselves, it would be nice if they started funding some more promising research.

I apologize if you knew most of this and I sounded like I was talking down to you.

/Grad school and 2 postdocs spent determining mechanisms of various drugs.
//In the lab, not on myself
 
2012-07-18 10:04:15 PM
D_Evans45: /You know, chemically

As long as there's no.... flipper babies!

/there have been a few flipper babies
 
2012-07-18 10:04:32 PM
GATTACA, GATTACA, GATTACA!

/someone had to do it.
 
2012-07-18 10:04:58 PM
Gyrfalcon: GleeUnit: Subby has proven very effective in this case in illustrating how many Farkers take the time to actually RTFA.

Come on....I like the idea that they could buy the actual human genome.


I, too came to complain that you've all been trolled and no one was rtfa but on the other hand if they bought the human genome maybe I could one day have my own replicant

/my own sexy SEXY replicant
 
2012-07-18 10:10:04 PM
Subby pwned me.
 
2012-07-18 10:12:46 PM
I'm not getting worried until the Umbrella Corporation gets involved.
 
2012-07-18 10:13:57 PM

born_yesterday: I apologize if you knew most of this and I sounded like I was talking down to you.


Naw, we're good. But I thought our government was footing the bill for a lot of that research?
 
2012-07-18 10:14:45 PM
**Reads headline, and gets all ready to be outraged and unleash my partially informed, negative opinion about the US patent system**
**Clicks on link, reads article, then starts to giggle**
 
2012-07-18 10:15:14 PM
I wasn't planning on leaving my genome to any heirs, anyway.
 
2012-07-18 10:15:59 PM

Danger Avoid Death: I'm not getting worried until the Umbrella Corporation gets involved.


Try Regenerex, it'll make you feel alive again.
 
2012-07-18 10:22:59 PM

Mr. Potatoass: [www.fileden.com image 355x449]


Wow. I JUST realized the whole symbolism in that scene. Goddamn Gattaca was a good movie.
 
2012-07-18 10:31:32 PM
www.hospitality-industry.com

Wonders what all the fuss is about.
 
2012-07-18 10:32:25 PM
Yaxe: Mr. Potatoass: [www.fileden.com image 355x449]

Wow. I JUST realized the whole symbolism in that scene. Goddamn Gattaca was a good movie.


Damn skippy.

/Worth viewing at least once a year, or so
//Welcome to "favorite"
 
2012-07-18 10:32:43 PM

Nickninja: thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

I'd say it's a bad shift because it's so hard to get ideas funded through other means. But I'm also currently trying to get an industry job with a bioE phd, so I'm not impartial. But they're mainly doing it to try to avoid the risk/cost of early stage R&D. They let academia develop the ideas, startups do the initial GLP level research, and once something looks promising they gobble it up. It's actually a pretty sweet deal if you're a grad student who is lucky enough to get a project that leads to a commercializable product. When you're in the top level of a startup that is bought out you get major bank, and probably a job with the big company.


One of the issues is that pharma wont even look at your compound unless you have solid Phase 2a data which by then youre firmly in the $50m deep region and its pretty challenging to get anyone to pony up that kind of investment and if you do, your ownership is diluted to almost zero as you have to hand over equity to a dozen different VC firms, each of whom wants a member on your board. And forget about doing an IPO in this economic climate.

I agree with you that pharma is shooting themselves in the foot. First to collapse will be Pfizer who will never be able to recover the revenue they lost with Lipitor going off patent.
 
2012-07-18 10:40:27 PM
You can have my genome when you pry it from my cold dead hands.

Or my hairbrush. Or my toothbrush. Or that glass I was drinking from.

/Whatever
 
2012-07-18 10:55:05 PM

Mr. Potatoass: [www.fileden.com image 355x449]


Why is that funny? Serious question.
 
2012-07-18 11:00:46 PM

PonceAlyosha: From who, exactly? When do I get my share of the check?


OH no Farker- It's a CORPORATION and that means you have to PAY
 
2012-07-18 11:01:11 PM
Wait! They're just acquiring a company "called" Human Gen ... oh ... I get it now.
 
2012-07-18 11:02:01 PM

AverageAmericanGuy: More proof that Big Medicine is trying to make a profit on the backs of its customers. No sense in developing cures and remedies when there's money to be made in the prolonged treatment of symptoms.


That genuinely does not make sense. Unless the underlying premise to your argument is that most people are cartoonishly evil.

/doesn't wake up in the morning and ask "What evil can I do today?"
//...but maybe everyone else does
 
2012-07-18 11:04:34 PM
i.huffpost.com

I dream of Genome.
 
2012-07-18 11:04:57 PM
Wow, in the first 49 comments only like 4 people read the article (and/or know anything about biotechnology).

Human Genome Sciences is a biotech company based in Rockville, MD.

The human genome was sequenced by the Human Genome Project and was funded by the U.S. government (meaning the sequence is in the public domain; I believe you can download it).

I will concede that the BBC gave the article a very misleading headline though, one which could have easily been corrected with the addition of the word Sciences.
 
2012-07-18 11:06:14 PM
Neutrophil extra-cellular traps (NETS) are fairly recently discovered immune responses, where our body's predominate immune cells actually spit out its own DNA against invading bacterial pathogens in an effort to trap and poison them. In the confusion the immune system may become sensitized to our very own DNA, hanging around everywhere like gutted rotten fish. Anti-DNA antibodies are marquee clinical findings in Lupus auto-immune disease.
 
2012-07-18 11:11:57 PM

Friend of the Devil: Wow, in the first 49 comments only like 4 people read the article (and/or know anything about biotechnology).

Human Genome Sciences is a biotech company based in Rockville, MD.

The human genome was sequenced by the Human Genome Project and was funded by the U.S. government (meaning the sequence is in the public domain; I believe you can download it).

I will concede that the BBC gave the article a very misleading headline though, one which could have easily been corrected with the addition of the word Sciences.


Lighten up, francis. We understand that it's a strictly corporate venture, one company buying another.

/doesn't mean we can't have fun with the implications of the headline.
 
2012-07-18 11:16:43 PM
i1082.photobucket.com
 
2012-07-18 11:22:51 PM

Evil High Priest: Mr. Potatoass: [www.fileden.com image 355x449]

Why is that funny? Serious question.


Not intended to be funny.
How much public money was put into the human genome project? (I don't have that answer)
How much faith do you have in large corporations to act in humanity's best interests?
Have you seen the film?
 
2012-07-18 11:27:33 PM

Friend of the Devil: Wow, in the first 49 comments only like 4 people read the article (and/or know anything about biotechnology).

Human Genome Sciences is a biotech company based in Rockville, MD.

The human genome was sequenced by the Human Genome Project and was funded by the U.S. government (meaning the sequence is in the public domain; I believe you can download it).

I will concede that the BBC gave the article a very misleading headline though, one which could have easily been corrected with the addition of the word Sciences.


There ya go.

joesprimalscream.files.wordpress.com
 
2012-07-18 11:32:06 PM
Sucks to be them: I just bought the natural numbers, and they owe me a royalty every time they write a whole number of pennies on a check.
 
2012-07-18 11:40:23 PM
upload.wikimedia.org

Must be getting a kick outta this.
 
2012-07-18 11:40:24 PM

thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?


Not all are. Novartis is keeping it's R&D strong and actually expanding in some areas. They've got one of the healthier pipelines and they haven't been going merger crazy, well, other than Alcon. They've had drugs go off patent and that's certainly impacted the bottom line.

/Not a scientist
//Doesn't play one on TV
///High throughput screening helps when you have industrial robotics.
 
2012-07-19 12:45:04 AM
HGSI has had its ups and downs. Each time a new trial bombs its a risky investment. Megacorp must know something is on the horizon. Maybe they just like the traffic in Rockville. The 101 has nothing on 270 on a 104f Day.
/not a prime I was going somewhere ahh forget it im 86.
 
2012-07-19 01:03:23 AM

Crudbucket: [upload.wikimedia.org image 250x362]

Must be getting a kick outta this.


I'm wondering if I should be proud or ashamed that I know who that is.

HELA!
 
2012-07-19 01:37:52 AM

born_yesterday: thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

Big Pharma had enormous resources they could throw at a problem. For the past decade or so, they have been using a research philosophy called "high throughput screening"; basically, the idea was if you increase the rate and number of drugs you test, you will have more successes. Although this seems to be sound reasoning, it was recently shown that, inexplicably, this method doesn't work. Our current models to test the drugs are no where near as complicated as the human body, and we can rarely predict how it will respond. Thus, despite having thousands upon thousands of compounds to test, this method rarely translates into a viable drug (approximately 1:1,000,000 or less make it to human testing).

In my professional opinion, the problem was never one of cramming more compounds into the pipeline, but rather the lack of viable models in which to test effectiveness and toxicity. You would probably be very surprised how crude the process is.

Now, most research laboratories cannot simply test thousands of random compounds. They're forced to use the "rational design" model, ie they have to have a proposed target and mechanism for how their compounds will work. The research is much slower, but if the researchers are correct, and their model holds up, it provides a backbone for further research into less toxic/more effective compounds. This is why Pharma wants to buy them up at this stage--the leg work, the discovery of a viable target, mechanism of action, and finding an effective class of compound, has been done for them.

I would hope Pharma would continue funding efforts to create more accurate models for testing potential drugs. If they don't want to ...


Thank you for stating this. Used to work at a University here in the U.S. doing tech support for a small department in the College of Pharmacy. Talked to the grad students/post docs to learn what they were doing.

You are absolutely correct. The amount of drug cures they were churning out was tremendous: probably 8 or 9 a week for cancer alone. However, the FDA had to sample them all (origination of grant, which lab is not busy, etc). Gonna take a lot of time to put all those samples in a petri dish.
 
2012-07-19 01:40:13 AM

D_Evans45: More prescriptions drug overdoses have occurred than street drug overdoses the past several years, Big Pharma legally kills more addicts than cartels do.

/You know, chemically
//Those other shenanigans are just a fun byproduct of prohibition


Um. Citations?
 
2012-07-19 01:44:35 AM

JustinCase: D_Evans45: More prescriptions drug overdoses have occurred than street drug overdoses the past several years, Big Pharma legally kills more addicts than cartels do.

/You know, chemically
//Those other shenanigans are just a fun byproduct of prohibition

Um. Citations?


Citations
 
2012-07-19 01:48:14 AM

Crudbucket: JustinCase: D_Evans45: More prescriptions drug overdoses have occurred than street drug overdoses the past several years, Big Pharma legally kills more addicts than cartels do.

/You know, chemically
//Those other shenanigans are just a fun byproduct of prohibition

Um. Citations?

Citations


Thank you. Off to read...
 
2012-07-19 01:58:13 AM

JustinCase: Crudbucket: JustinCase: D_Evans45: More prescriptions drug overdoses have occurred than street drug overdoses the past several years, Big Pharma legally kills more addicts than cartels do.

/You know, chemically
//Those other shenanigans are just a fun byproduct of prohibition

Um. Citations?

Citations

Thank you. Off to read...


Trends in Unintentional Drug Overdose Deaths from the Senate Judiciary Subcommittee on Crime and Drugs (from 2008).
 
2012-07-19 02:04:28 AM
They make my epilepsy medication so there goes my hope for a cure...
 
2012-07-19 02:12:52 AM

Crudbucket: [upload.wikimedia.org image 250x362]

Must be getting a kick outta this.


"The Immortal Life" (by Rebecca Skloot) is a fascinating read. Great reference. +1
 
2012-07-19 02:21:43 AM
 
2012-07-19 02:24:43 AM
You all just don't get it do you? Who do you think runs Congress? Big Pharma. It's the big pharmaceutical companies that make all the big decisions. Big Pharma paves your roads. Big Pharma delivers your mail. Who do you think teaches your kids how to read? Teachers? Try again: Big Pharma. Big Pharma took us to war in Vietnam, synthesized crack, and killed Kennedy. Big Pharma came from outer space, invented Ben Franklin, started a liiiiittle company called... The Internet. Big Pharma polluted the oceans with high-fructose corn syrup. They're everywhere. Don't you get it? Even your heart medication is made by Big Pharma.
 
2012-07-19 02:37:40 AM
Now Hiring All Positions: Please submit resumes to hr[nospam-﹫-backwards]p­r­oc­l­lery­t­*co­m
 
2012-07-19 03:49:47 AM
FTFA: Biotech companies are looking to acquire a new pipeline of drugs to replace older medicines that analysts say are expiring in record numbers.


Not saying that the older medicines don't work perfectly well and might even be safer and more effective than any new shiat they may dream up, just that the older medicines are expiring, that is, their patents are expiring, and therefore, they will not be as rapaciously profitable as before. So get ready to have some weird new experimental drug pushed on you that makes your ass fall off and one of your legs shorter than the other, instead of your old tried and true, now generic, remedy.
 
2012-07-19 03:56:31 AM

Danger Avoid Death: I'm not getting worried until the Umbrella Corporation gets involved.


www.xopl.com
 
2012-07-19 04:06:27 AM

Coelacanth: I have this vision of Big Pharma researchers going into villages the world order to look for new unique genes, and as soon as they're gone, mercenaries move in and wipe the village off the map to protect the patents.


Don't laugh!

A private company patented the specific genome from a Papua (funny spell check doesn't know Papua .. good ole American software) tribe - they got it from one peep, now no one else in that specific genotype can go to a pharma company and give them their genes.

Honestly patents and trademarks have gotten out of control - and I place 99% of the blame on the USoA. Mickey Mouse was reaching the 'open source' level and heaps of vested interests went into action with their lobbyists and money and before we know it we have had changes to centuries old rules - ie, I can print myself a copies of 1984 in Oz and sell them, but if I tried it in the USoA I would be guilty of infringement.

You peeps have lost control of your power structure, its no longer "by the people for the people", its more like "for the rich, bugger the people" (we all like Mickey Mouse and they made billions off of it, they just wanted to make billions more).

Some similar giggles can be had from the massive distortion of the Olympics we have seen ... personally I still think the athletes should be nude :D
 
2012-07-19 04:17:56 AM

Passive Aggressive Larry: You all just don't get it do you? Who do you think runs Congress? Big Pharma. It's the big pharmaceutical companies that make all the big decisions. Big Pharma paves your roads. Big Pharma delivers your mail. Who do you think teaches your kids how to read? Teachers? Try again: Big Pharma. Big Pharma took us to war in Vietnam, synthesized crack, and killed Kennedy. Big Pharma came from outer space, invented Ben Franklin, started a liiiiittle company called... The Internet. Big Pharma polluted the oceans with high-fructose corn syrup. They're everywhere. Don't you get it? Even your heart medication is made by Big Pharma.



That reminds me of the guy who wrote a song about his penis.

my penis fights fires
it fixes flat tires
my penis has saved many lives
my penis it pees
it speaks japanese
in the indy 500 it drives


my penis plays chess
it cleans up a mess
it's an olympic athelete
oh the places it's been
it can play violin
my penis works on wall street

CHORUS
but this penis is a curse!
it's bad and it's getting worse
cause I'm always in the way
I can't live up to his name
this penis is a king
and many other things
it's a prophet and a god
and me I'm just a fraud
me I'm just a fraud


my penis is smart
and it's got a big heart
and I've heard that it's famous in France
my penis is rich
and it's got perfect pitch
I keep it right here in my pants


with a phd
it can spell bourgeoisie
this penis deserving of praise
it's off the hook
my penis can cook
have you tried his bouillabaisse?


(chorus)


my penis is large
and it always takes charge
and the president calls for advise
my penis is strong
and it's never wrong
it's won the nobel prize twice


this penis of mine
turns pee into wine
it ends all suffering and strife
it's got no foreskin
but it died for your sins
and then it came back to life


(chorus)


this penis is not mine
it's all of space and time
it's everything that's good
it's not well understood

this penis is the world
it's every boy and girl
it's more than what it seems
it's all your hopes and dreams


bow down before my penis!
bow down before my penis!
bow down before my penis!
my penis is your god!
bow down before my penis!
my penis is your god!
my penis
have you seen us?
me and my penis
 
2012-07-19 04:23:41 AM

Passive Aggressive Larry: You all just don't get it do you? Who do you think runs Congress? Big Pharma. It's the big pharmaceutical companies that make all the big decisions. Big Pharma paves your roads. Big Pharma delivers your mail. Who do you think teaches your kids how to read? Teachers? Try again: Big Pharma. Big Pharma took us to war in Vietnam, synthesized crack, and killed Kennedy. Big Pharma came from outer space, invented Ben Franklin, started a liiiiittle company called... The Internet. Big Pharma polluted the oceans with high-fructose corn syrup. They're everywhere. Don't you get it? Even your heart medication is made by Big Pharma.


You know (though I am sure you personally are not ...) that is exactly how the marketing firms hired by big business (to manage public perception of their brands) operate on the internet - make the doubters look like idiots. These marketing firms actively participate in low level internet stuff, have alts they use (who may even be respected on said sites) to smother or at least distract criticism.

Watch the doco 'Battle for Brooklyn' and understand exactly who/what the motivation was behind those poor misguided peeps who belonged to B.U.I.L.D. - I felt sooo sorry for them. Wonder if NY has its cheap housing development yet, or do you just have a for profit stadium....?

The amount of so called 'Environmental Groups' who are funded my big industry is getting scary (usually without most of the low level members even having a clue that their passion has been manipulated) - need I even mention the Tea Baggers (poor peeps defending tax cuts for the 1% - I mean what the fark?!?!).
 
2012-07-19 06:17:02 AM
To map the very stuff of life; to look into the genetic mirror and watch a million generations march past. That, friends, is both our curse and our proudest achievement. For it is in reaching to our beginnings that we begin to learn who we truly are.
Academician Prokhor Zakharov, "Address to the Faculty"

Meh, +1 talents per base and immunity to an attack that no one uses any ways.
 
2012-07-19 07:45:05 AM

Danger Avoid Death: I'm not getting worried until the Umbrella Corporation gets involved.




I look foward to this:
www.wildsoundmovies.com
This, not so much:
www.capcom-europe.com
 
2012-07-19 08:12:49 AM
I believe I can show prior art that would invalidate this patent. I've had the human genome for years.
 
2012-07-19 08:14:53 AM
Well, it is about time for Glaxo to change their name again.
 
2012-07-19 08:21:56 AM
So... with a PhD in biology, is this a good time to go to the dark side and work for Big Pharma?
 
2012-07-19 08:32:16 AM

thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?


I live down the road from HGS and have worked with them for 14 years. This is an incredible turn for them considering they were teetering on the edge of oblivion for a long time.

This was the largest unclaimed low-hanging fruit in MD. Almost all of the other companies here have been bought out. It used to be that there were tons of startup companies hoping to get development contracts with major pharma. Venture capital is getting harder to get because of problems with the economy. After the majority of these small companies go away, my guess is that pharma will start contracting with academia for more and more basic research.

When a pharma company has monetary issues, R and D suffers and all they want to do is produce drugs to make money. They have to keep the pipeline of potential drugs full. Merck bought Schering Plough for their pipeline, for instance ( I call them Schmerck now). They kept the process development group from Schering and laid off the superfluous 23,000 employees. This stuff really hurts but the story is so common now. I wouldn't be surprised to see HGS liquidated in a similar fashion.
 
2012-07-19 08:56:13 AM

algrant33: Uh, ....no??

FTA:
Drug company GlaxoSmithKline is to buy Human Genome Sciences for about $3bn (£1.9bn), ending a three-month pursuit of the US biotechnology firm.

Unless Human Genome Sciences already HELD rights to the sequence of the human genome, then... this is just a tech acquisition, no different from Facebook buying Face.com. (hint: they didn't buy everybody's faces)


I wouldn't be so sure about that, from what I understand about Face.com.
 
2012-07-19 09:15:37 AM
Do you suppose that GlaxoSmithKline has research facilities in the Arklay Mountains?

/this can't possibly end well
 
2012-07-19 10:00:45 AM

Marcintosh: PonceAlyosha: From who, exactly? When do I get my share of the check?

OH no Farker- It's a CORPORATION and that means you have to PAY


cdn.sheknows.com

they have to PET
 
2012-07-19 10:10:45 AM

khonshu: Wait! They're just acquiring a company "called" Human Gen ... oh ... I get it now.


You're probably the only one that got it up to this point in the thread. Buncha morans.
 
2012-07-19 10:44:58 AM

whatshisname: That's nothing. I just bought Mars.


[canadianfreestuff.com image 450x301]


Oh yeah, big guy?

I just bought the Milky way with the change in my pocket:

couponclippindaddy.com
 
2012-07-19 11:43:00 AM
Behold, their new logo: www.nervarchives.com
 
2012-07-19 02:05:41 PM

JustinCase: D_Evans45: More prescriptions drug overdoses have occurred than street drug overdoses the past several years, Big Pharma legally kills more addicts than cartels do.

/You know, chemically
//Those other shenanigans are just a fun byproduct of prohibition

Um. Citations?


"Overdose deaths involving opioid pain relievers (OPR), also known as opioid analgesics, have increased and now exceed deaths involving heroin and cocaine combined. This report describes the use and abuse of OPR by state." Source: CDC website.


There was an article on the main page a week or two ago, more up to date information, stating that prescription drugs have been killing more people than cocaine and heroin since 2008, and is only rising:
 
2012-07-19 02:07:29 PM
USA Today

http://www.usatoday.com/news/nation/story/2012-07-10/opana-painkiller - addiction/56137086/1

Thanks to prescription painkillers, overdoses now exceed traffic accidents as a cause of death in the United States.
 
2012-07-19 02:08:04 PM
http://articles.latimes.com/2011/sep/17/local/la-me-drugs-epidemic-201 10918
 
2012-07-19 02:55:42 PM

Langdon_777: Passive Aggressive Larry: You all just don't get it do you? Who do you think runs Congress? Big Pharma. It's the big pharmaceutical companies that make all the big decisions. Big Pharma paves your roads. Big Pharma delivers your mail. Who do you think teaches your kids how to read? Teachers? Try again: Big Pharma. Big Pharma took us to war in Vietnam, synthesized crack, and killed Kennedy. Big Pharma came from outer space, invented Ben Franklin, started a liiiiittle company called... The Internet. Big Pharma polluted the oceans with high-fructose corn syrup. They're everywhere. Don't you get it? Even your heart medication is made by Big Pharma.

You know (though I am sure you personally are not ...) that is exactly how the marketing firms hired by big business (to manage public perception of their brands) operate on the internet - make the doubters look like idiots. These marketing firms actively participate in low level internet stuff, have alts they use (who may even be respected on said sites) to smother or at least distract criticism.

Watch the doco 'Battle for Brooklyn' and understand exactly who/what the motivation was behind those poor misguided peeps who belonged to B.U.I.L.D. - I felt sooo sorry for them. Wonder if NY has its cheap housing development yet, or do you just have a for profit stadium....?

The amount of so called 'Environmental Groups' who are funded my big industry is getting scary (usually without most of the low level members even having a clue that their passion has been manipulated) - need I even mention the Tea Baggers (poor peeps defending tax cuts for the 1% - I mean what the fark?!?!).


I don't doubt that you know a lot more about this than I do, I was just being a wise-ass and making a reference to this.
 
2012-07-19 04:21:19 PM
And I liked it :D

I got most of the idea from an Oz TV show called The Gruen Transer (just spoof your ip on firefox if u cannot watch it ;)

The marketers were up front and honest and surprising, and sometimes scary in their insights.
 
2012-07-19 04:52:11 PM

Ambivalence: PonceAlyosha: From who, exactly? When do I get my share of the check?

That's what I wondered. I would have thought we'd progressed beyond the "I discovered it therefore I OWN it" mindset. IT's like syaing the U.S. owns the moon becuase we were the first people to set foot on it. It was always THERE, someone just took the time to map it.


You know how I know you guys DRTFA?
 
2012-07-19 05:42:28 PM

Passive Aggressive Larry: I was just being a wise-ass and making a reference to this.



Still no cure for Bullet Cancer.

/Bullet cancer
 
2012-07-19 11:32:38 PM

Langdon_777: Coelacanth: I have this vision of Big Pharma researchers going into villages the world order to look for new unique genes, and as soon as they're gone, mercenaries move in and wipe the village off the map to protect the patents.

Don't laugh!

A private company patented the specific genome from a Papua (funny spell check doesn't know Papua .. good ole American software) tribe - they got it from one peep, now no one else in that specific genotype can go to a pharma company and give them their genes.

Honestly patents and trademarks have gotten out of control - and I place 99% of the blame on the USoA. Mickey Mouse was reaching the 'open source' level and heaps of vested interests went into action with their lobbyists and money and before we know it we have had changes to centuries old rules - ie, I can print myself a copies of 1984 in Oz and sell them, but if I tried it in the USoA I would be guilty of infringement.

You peeps have lost control of your power structure, its no longer "by the people for the people", its more like "for the rich, bugger the people" (we all like Mickey Mouse and they made billions off of it, they just wanted to make billions more).

Some similar giggles can be had from the massive distortion of the Olympics we have seen ... personally I still think the athletes should be nude :D


I wasn't laughing. Over the years I've noticed a pattern of Big Pharma going to remote villages in countries where there's an imminent threat of civil violence breaking out. From the intensity of the fighting that occurred afterwards, I doubt those villages exist anymore. I'm not saying Big Pharma starts civil wars for profit, but they are the most opportunistic corporate bastards there is.
 
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