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(BBC)   Think Big Pharma has too much power now? GlaxoSmithKline just bought THE HUMAN GENOME   (bbc.co.uk) divider line 99
    More: Scary, Bristol-Myers Squibb, biotechnology company, GlaxoSmithKline, GSK, lupus, drug companies, HGS, AstraZeneca  
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13908 clicks; posted to Main » on 18 Jul 2012 at 9:30 PM (1 year ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2012-07-18 09:10:03 PM
it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?
 
2012-07-18 09:25:33 PM
www.chicagonow.com

this will get out of hand...yadda yadda yadda
 
2012-07-18 09:31:52 PM
From who, exactly? When do I get my share of the check?
 
2012-07-18 09:32:11 PM
More prescriptions drug overdoses have occurred than street drug overdoses the past several years, Big Pharma legally kills more addicts than cartels do.

/You know, chemically
//Those other shenanigans are just a fun byproduct of prohibition
 
2012-07-18 09:34:50 PM
PonceAlyosha: From who, exactly? When do I get my share of the check?

That's what I wondered. I would have thought we'd progressed beyond the "I discovered it therefore I OWN it" mindset. IT's like syaing the U.S. owns the moon becuase we were the first people to set foot on it. It was always THERE, someone just took the time to map it.
 
2012-07-18 09:35:28 PM
And Uncle Sam handed themselves a patent for 'cannabinoids as neuroprotectants/antioxidants,' despite that pesky, stupid, illogical -- oh, what? You mean they still classify cannabis as scheddule 1, 'no medicinal value'?

/SAY WHAT?
//i can feel my 2nd amendment getting hard...
/this guy would be retarded or dead if not for cannabinoids 'as neuroprotectants'
//ZING
 
2012-07-18 09:35:34 PM
Human Genome Sciences, a corporation, not THE human genome. And they're doing it to get a few of the drugs they owned patents to.
 
2012-07-18 09:35:38 PM
Just to the right of the article:
"GlaxoSmithKline is to pay $3bn (£1.9bn) in the largest healthcare fraud settlement in US history."
 
2012-07-18 09:36:09 PM
Uh, ....no??

FTA:
Drug company GlaxoSmithKline is to buy Human Genome Sciences for about $3bn (£1.9bn), ending a three-month pursuit of the US biotechnology firm.

Unless Human Genome Sciences already HELD rights to the sequence of the human genome, then... this is just a tech acquisition, no different from Facebook buying Face.com. (hint: they didn't buy everybody's faces)
 
2012-07-18 09:36:26 PM
PonceAlyosha: From who, exactly? When do I get my share of the check?

that's a good question. who the fark owned it before?
 
2012-07-18 09:36:38 PM
GSK will gain control of Benlysta, which treats the immune system disorder lupus

thumbs2.modthesims.info

Just getting that out of the way.
 
2012-07-18 09:36:58 PM
Fark please stop adding typos to my comments after i carefully preview them and proofread them multiple times. Thanks.

/ohyou.jpg
 
2012-07-18 09:38:02 PM
www.fileden.com
 
2012-07-18 09:38:13 PM

D_Evans45: Just to the right of the article:
"GlaxoSmithKline is to pay $3bn (£1.9bn) in the largest healthcare fraud settlement in US history."


C'mon, you can totally trust them with your genome. No way they would ever pull any shenanigans with it.
 
2012-07-18 09:39:10 PM
why can't someone just buy Arena Pharmaceuticals? Any price over $15 a share will do.
 
2012-07-18 09:40:03 PM
More proof that Big Medicine is trying to make a profit on the backs of its customers. No sense in developing cures and remedies when there's money to be made in the prolonged treatment of symptoms.
 
2012-07-18 09:40:23 PM
It's a lot cheaper for them to hover around like vultures and wait for the start-ups to do the R&D, and then come in for the kill. I don't think this is good, but maybe I'm just naive and believe that medical science should not be conducted by the ruthless mentality and the same lack of integrity of Wall Street, hedge funds, and Mittens' Cayman Island hundreds of millions.

/HGS is only six miles from here
//interviewed there once
 
2012-07-18 09:40:32 PM
fieldagentaustralia.files.wordpress.com


all your genes are belong to us
 
2012-07-18 09:40:58 PM
Needs effective Lupus meds so she can run the barn

img1.bdbphotos.com
 
2012-07-18 09:42:35 PM
What you did there. I see it.
 
2012-07-18 09:45:47 PM
So does this mean they own all children born from hence forth?

Or do parents have to pay them royalties?

Maybe they will send lawyers after women for infringing on their intellectual property.

Do I still own my semen?
 
2012-07-18 09:46:39 PM
its just a weed man...
 
2012-07-18 09:47:33 PM
thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

I'd say it's a bad shift because it's so hard to get ideas funded through other means. But I'm also currently trying to get an industry job with a bioE phd, so I'm not impartial. But they're mainly doing it to try to avoid the risk/cost of early stage R&D. They let academia develop the ideas, startups do the initial GLP level research, and once something looks promising they gobble it up. It's actually a pretty sweet deal if you're a grad student who is lucky enough to get a project that leads to a commercializable product. When you're in the top level of a startup that is bought out you get major bank, and probably a job with the big company.
 
2012-07-18 09:49:44 PM
Read the article you farkers.. they are buying a company called "Human Genome Science" subby trolled all ya'lls.
 
2012-07-18 09:50:28 PM
That's nothing. I just bought Mars.


canadianfreestuff.com
 
2012-07-18 09:51:09 PM
OK, they can have the Genome. I'll be selling the G Spot...as soon as I find one.
 
2012-07-18 09:53:44 PM
Subby has proven very effective in this case in illustrating how many Farkers take the time to actually RTFA.
 
2012-07-18 09:54:06 PM

Nickninja: thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

I'd say it's a bad shift because it's so hard to get ideas funded through other means. But I'm also currently trying to get an industry job with a bioE phd, so I'm not impartial. But they're mainly doing it to try to avoid the risk/cost of early stage R&D. They let academia develop the ideas, startups do the initial GLP level research, and once something looks promising they gobble it up. It's actually a pretty sweet deal if you're a grad student who is lucky enough to get a project that leads to a commercializable product. When you're in the top level of a startup that is bought out you get major bank, and probably a job with the big company.


Plus, here in the RTP area (there is a GSK R&D site here) many start-ups get special treatment for taxes/facilities/utilities and such where it makes the model cheaper than doing all the R&D in-house at a big pharma site.
 
2012-07-18 09:54:29 PM
David the Genome?
 
2012-07-18 09:54:58 PM
Yeah, great- this will pay off years down the road. Meanwhile, they keep on paying out for getting caught working in grey areas and what do they have in their pipeline? More old people anti-constipation cures? Some more drugs that really have any use in the third world?
 
2012-07-18 09:56:50 PM
I have this vision of Big Pharma researchers going into villages the world order to look for new unique genes, and as soon as they're gone, mercenaries move in and wipe the village off the map to protect the patents.
 
2012-07-18 09:57:10 PM
Nickninja: thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

I'd say it's a bad shift because it's so hard to get ideas funded through other means. But I'm also currently trying to get an industry job with a bioE phd, so I'm not impartial. But they're mainly doing it to try to avoid the risk/cost of early stage R&D. They let academia develop the ideas, startups do the initial GLP level research, and once something looks promising they gobble it up. It's actually a pretty sweet deal if you're a grad student who is lucky enough to get a project that leads to a commercializable product. When you're in the top level of a startup that is bought out you get major bank, and probably a job with the big company.


On the academic side it's a good partnership. The pharmaceutical companies have always actually been pretty bad when it comes to basic science, which is absolutely critical. They recognize that University researchers excel at it so they they usually form partnerships where they allow usage of their massive molecular libraries. Once one or more good candidates are found they can do what they are really good at, which is refinement, trials, etc.

My group has some similar partnerships with GSK for orphan diseases but this is my first time ever being involved in anything on the research side where there was interest.
 
2012-07-18 09:57:18 PM
GleeUnit: Subby has proven very effective in this case in illustrating how many Farkers take the time to actually RTFA.

Come on....I like the idea that they could buy the actual human genome.
 
2012-07-18 10:00:16 PM
thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

Big Pharma had enormous resources they could throw at a problem. For the past decade or so, they have been using a research philosophy called "high throughput screening"; basically, the idea was if you increase the rate and number of drugs you test, you will have more successes. Although this seems to be sound reasoning, it was recently shown that, inexplicably, this method doesn't work. Our current models to test the drugs are no where near as complicated as the human body, and we can rarely predict how it will respond. Thus, despite having thousands upon thousands of compounds to test, this method rarely translates into a viable drug (approximately 1:1,000,000 or less make it to human testing).

In my professional opinion, the problem was never one of cramming more compounds into the pipeline, but rather the lack of viable models in which to test effectiveness and toxicity. You would probably be very surprised how crude the process is.

Now, most research laboratories cannot simply test thousands of random compounds. They're forced to use the "rational design" model, ie they have to have a proposed target and mechanism for how their compounds will work. The research is much slower, but if the researchers are correct, and their model holds up, it provides a backbone for further research into less toxic/more effective compounds. This is why Pharma wants to buy them up at this stage--the leg work, the discovery of a viable target, mechanism of action, and finding an effective class of compound, has been done for them.

I would hope Pharma would continue funding efforts to create more accurate models for testing potential drugs. If they don't want to do the work themselves, it would be nice if they started funding some more promising research.

I apologize if you knew most of this and I sounded like I was talking down to you.

/Grad school and 2 postdocs spent determining mechanisms of various drugs.
//In the lab, not on myself
 
2012-07-18 10:04:15 PM
D_Evans45: /You know, chemically

As long as there's no.... flipper babies!

/there have been a few flipper babies
 
2012-07-18 10:04:32 PM
GATTACA, GATTACA, GATTACA!

/someone had to do it.
 
2012-07-18 10:04:58 PM
Gyrfalcon: GleeUnit: Subby has proven very effective in this case in illustrating how many Farkers take the time to actually RTFA.

Come on....I like the idea that they could buy the actual human genome.


I, too came to complain that you've all been trolled and no one was rtfa but on the other hand if they bought the human genome maybe I could one day have my own replicant

/my own sexy SEXY replicant
 
2012-07-18 10:10:04 PM
Subby pwned me.
 
2012-07-18 10:12:46 PM
I'm not getting worried until the Umbrella Corporation gets involved.
 
2012-07-18 10:13:57 PM

born_yesterday: I apologize if you knew most of this and I sounded like I was talking down to you.


Naw, we're good. But I thought our government was footing the bill for a lot of that research?
 
2012-07-18 10:14:45 PM
**Reads headline, and gets all ready to be outraged and unleash my partially informed, negative opinion about the US patent system**
**Clicks on link, reads article, then starts to giggle**
 
2012-07-18 10:15:14 PM
I wasn't planning on leaving my genome to any heirs, anyway.
 
2012-07-18 10:15:59 PM

Danger Avoid Death: I'm not getting worried until the Umbrella Corporation gets involved.


Try Regenerex, it'll make you feel alive again.
 
2012-07-18 10:22:59 PM

Mr. Potatoass: [www.fileden.com image 355x449]


Wow. I JUST realized the whole symbolism in that scene. Goddamn Gattaca was a good movie.
 
2012-07-18 10:31:32 PM
www.hospitality-industry.com

Wonders what all the fuss is about.
 
2012-07-18 10:32:25 PM
Yaxe: Mr. Potatoass: [www.fileden.com image 355x449]

Wow. I JUST realized the whole symbolism in that scene. Goddamn Gattaca was a good movie.


Damn skippy.

/Worth viewing at least once a year, or so
//Welcome to "favorite"
 
2012-07-18 10:32:43 PM

Nickninja: thomps: it's an interesting shift going on where the big phrarma companies seem to be scaling back their r&d and instead acquiring their next blockbuster drugs from start-ups. anyone with deeper experience in the industry care to weigh in on whether that is a good or bad shift (or if it's even a shift at all)?

I'd say it's a bad shift because it's so hard to get ideas funded through other means. But I'm also currently trying to get an industry job with a bioE phd, so I'm not impartial. But they're mainly doing it to try to avoid the risk/cost of early stage R&D. They let academia develop the ideas, startups do the initial GLP level research, and once something looks promising they gobble it up. It's actually a pretty sweet deal if you're a grad student who is lucky enough to get a project that leads to a commercializable product. When you're in the top level of a startup that is bought out you get major bank, and probably a job with the big company.


One of the issues is that pharma wont even look at your compound unless you have solid Phase 2a data which by then youre firmly in the $50m deep region and its pretty challenging to get anyone to pony up that kind of investment and if you do, your ownership is diluted to almost zero as you have to hand over equity to a dozen different VC firms, each of whom wants a member on your board. And forget about doing an IPO in this economic climate.

I agree with you that pharma is shooting themselves in the foot. First to collapse will be Pfizer who will never be able to recover the revenue they lost with Lipitor going off patent.
 
2012-07-18 10:40:27 PM
You can have my genome when you pry it from my cold dead hands.

Or my hairbrush. Or my toothbrush. Or that glass I was drinking from.

/Whatever
 
2012-07-18 10:55:05 PM

Mr. Potatoass: [www.fileden.com image 355x449]


Why is that funny? Serious question.
 
2012-07-18 11:00:46 PM

PonceAlyosha: From who, exactly? When do I get my share of the check?


OH no Farker- It's a CORPORATION and that means you have to PAY
 
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