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(Nature)   Drinkers rejoice--scientists have grown a rudimentary liver in a dish   (nature.com) divider line 35
    More: Cool, pluripotent stem cells, stem cells, umbilical cords, scaffolds, coax, liver cells, livers, Yokohama  
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1651 clicks; posted to Geek » on 20 Jun 2012 at 1:00 PM (2 years ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2012-06-20 10:21:31 AM
This actually is great news for transplants. Imagine getting a new liver from your own cells without the risk of rejection. I would think this would be great news for those with cancer and need to have the whole original liver yanked out.
 
vpb [TotalFark]
2012-06-20 10:42:56 AM

AirForceVet: This actually is great news for transplants. Imagine getting a new liver from your own cells without the risk of rejection. I would think this would be great news for those with cancer and need to have the whole original liver yanked out.


And FARKers too.

Actually I think this will eventually be the solution to the transplant supply problem. I think we will be manufacturing artificial livers and kidneys before we are growing hamburgers in vats.
 
2012-06-20 10:53:16 AM

AirForceVet: This actually is great news for transplants. Imagine getting a new liver from your own cells without the risk of rejection. I would think this would be great news for those with cancer and need to have the whole original liver yanked out.


I think it would also be quite cool if they could eventually use this to treat certain genetically inherited diseases. Cystic fibrosis comes to mind. They take some of your cells, insert the functional gene for the membrane transporter, then grow a healthy lung and shove it in you.
 
2012-06-20 11:46:59 AM
Japan, I take back everything I ever said about you crazy bastards.
 
2012-06-20 11:59:00 AM
That's nothing new

/I've always had a rudimentary liver
 
2012-06-20 12:25:26 PM
This is great news indeed.

Next up, fava beans & a nice chianti.
 
2012-06-20 12:36:31 PM
If they could only craft some sort of rudimentary lathe now......
 
2012-06-20 01:20:12 PM
Rudimentary liver, dredged in primitive flour and proto-sauteed with ur-onions and Paleobacon.

Mmmmmm Mmm!
 
2012-06-20 01:33:06 PM
Now if they could grow some hearts and kidneys, i might be covered for my old age.....
 
2012-06-20 01:35:47 PM
I'd cry tears of joy but I'm pretty hungover and I don't think I've got the water to spare.
 
2012-06-20 01:40:45 PM
Fabulous!
Throw some onions in there, grill it up & bring it to me.
 
2012-06-20 02:01:13 PM
My liver has a restraining order against me, so I'm really getting a kick...
 
2012-06-20 03:06:33 PM
Ill drink to that. My liver has been holding me back.
 
2012-06-20 03:27:05 PM
"Alright Brain, you don't like me, and I don't like you. But lets just do this, and I can get back to killing you with beer."
 
2012-06-20 03:39:08 PM

devine: "Alright Brain, you don't like me, and I don't like you. But lets just do this, and I can get back to killing you with beer."


That might be too obscure even for fark.
 
2012-06-20 03:48:48 PM
26.media.tumblr.com

APPROVES!



lockers: That might be too obscure even for fark.


No, no it's not. In order to be obscure on Fark you have to refer to a small budget film shot in Hungary and not even released on this side of the planet.
 
2012-06-20 03:51:08 PM

schattenteufel: Fabulous!
Throw some onions in there, grill it up & bring it to me.


You misspelled "throw it straight into the trash". Honest mistake
 
2012-06-20 04:11:22 PM
This was my graduate level and first real job research.

The primary method for creating liver cultures was to extract it from an animal and perfuse it with oxygenated medium simulating blood - thereby preserving form and function, but it's hard to maintain a whole organ successfully over time ex vivo, much less put it into another animal.

The other method is culture, where you digest the structure of the liver with an enzyme solution, free up the hepatocytes, then grow them on a plate with a simulated collagen matrix. Without a matrix to simulate a liver structure (plus the initial damage from the digestion, fractionation and separation steps), the hepatocytes quickly lose their functionality and revert to fibroblast type cells, becoming worthless for metabolic studies. Other cell types which also provided functionality were often lost. Either way, not a good option for a rudimentary liver.

Some culture systems triggered the hepatocytes to stick together in little clusters, which developed their own internal biliary duct structures and maintained their "liver-like" functionality longer. When you put these cells onto an artificial matrix (simulating the trabecular structure of liver tissue) with various growth factors, then pumped fluid through it (or blood), you created the first artificial livers, sort of a dialysis machine. These were tested successfully in pigs in the mid/late 90s and also to a limited extent in humans, but only for short periods since the culture viability deteriorated over time, plus the inherent non-metabolic functionality of the liver (it also manages iron and blood clotting factors) was greatly inhibited or lost altogether. These were experimental setups for people who literally could not keep their existing liver any more but still needed to be kept alive to wait for transplants.

The last option of course is your transplant, either whole organ or single lobes. The liver is pretty good at regenerating itself, so transplanting one lobe from a healthy donor would help the patient recover much better, and beat the cost and other concerns of a whole-organ transplant.

I'll be curious to see how this work goes, since the best option in many cases for patients is something grown from their own pluripotent cells. Go science!

/CSB
//I miss the research, even though it didn't pay well
///My research centered on Tylenol and carcinogen metabolism. In some cases, Tylenol is worse
 
2012-06-20 04:21:32 PM
Why people are against this kind of research is beyond me. We are getting closer to being able to grow our own spare parts, just as long as they go the whole full clones route, that's just creepy, but bits and pieces, I'm all for that
 
2012-06-20 04:43:37 PM
The fark if I'm sharing my bourbon with some liver in a petri dish. Get your own bourbon, petri dish liver!
 
2012-06-20 04:51:08 PM

TabASlotB: The fark if I'm sharing my bourbon with some liver in a petri dish. Get your own bourbon, petri dish liver!


Chianti goes well with liver.
 
2012-06-20 04:54:40 PM
Too little, too late, for me and mine.
 
2012-06-20 04:55:05 PM
www.moondragon.org

/hot
 
2012-06-20 04:57:50 PM

Sasquach: [www.moondragon.org image 400x320]

/hot


And.....wrong thread
 
2012-06-20 05:09:21 PM
Them: If you keep drinking like that, you'll have health problems.
Me: Science will take care of it. Shut up and let me drink in peace.

Scoreboard: Friends and Family - 0; Science, Bourbon, and me - 1

Suck it, losers. Where's my favorite tumbler?
 
2012-06-20 05:13:54 PM

Sasquach: Sasquach: [www.moondragon.org image 400x320]

/hot

And.....wrong thread


Yeah, you should have posted it here.
 
2012-06-20 05:25:25 PM

imontheinternet: Them: If you keep drinking like that, you'll have health problems.
Me: Science will take care of it. Shut up and let me drink in peace.

Scoreboard: Friends and Family - 0; Science, Bourbon, and me - 1

Suck it, losers. Where's my favorite tumbler?


If I ever write a memoir, I may title it Science, Bourbon, and Me.
 
Skr
2012-06-20 05:42:48 PM
So what kind of warranty would this puppy come with? Something like 5 years / 50,000g of Alcohol ?
 
2012-06-20 06:07:31 PM
In related news, 'Dallas' now confirmed for renewal for the next 20 seasons as star Larry Hagman buys in bulk.
 
2012-06-20 06:28:10 PM

dennysgod: Why people are against this kind of research is beyond me. We are getting closer to being able to grow our own spare parts, just as long as they go the whole full clones route, that's just creepy, but bits and pieces, I'm all for that


The idea is not a new one...Link
 
2012-06-20 08:21:23 PM

Sasquach: [www.moondragon.org image 400x320]

/hot


Fetal Alcohol Syndrome?
 
2012-06-20 09:17:38 PM
Get's in line with the tightest pants ever.

upload.wikimedia.org
 
2012-06-20 10:07:03 PM

TypoFlyspray: Rudimentary liver, dredged in primitive flour and proto-sauteed with ur-onions and Paleobacon.

Mmmmmm Mmm!


Could vegetarians eat this? Heck, could I eat this, or would that count as cannibalism?
 
2012-06-21 08:56:23 AM

User1005273: TypoFlyspray: Rudimentary liver, dredged in primitive flour and proto-sauteed with ur-onions and Paleobacon.

Mmmmmm Mmm!

Could vegetarians eat this? Heck, could I eat this, or would that count as cannibalism?


Not sure. I do know that if one limits onesself to nouveau cuisine, this is off the menu.
 
2012-06-21 02:21:01 PM
It's like they say: Get busy livering, or get busy dying.
 
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