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(Mother Nature Network) Spiffy Scientists discover a drug designed to fight cancer reverses Alzheimer's in mice. Still no cure for cancer   (mnn.com) divider line 65
More: Spiffy, Alzheimer's Disease, drug policy, cure for cancer, cognitive impairment, incurable, lead author, Georgetown University Medical Center, Alzheimer's Disease International  
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4229 clicks; posted to Main » on 10 Feb 2012 at 1:50 PM   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»   |    Get this fabulous T-Shirt and impress the methane out of your friends! shirt it!



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2012-02-10 01:38:22 PM
Yeah, but you won't forget that you have cancer, so there's that.
 
2012-02-10 01:55:09 PM
Speaking as one who has watched family members die of cancer and families wither while a loved one slips away with Alzheimer's--neither is a good death but any hope for an Alzheimer's cure is the best news I have heard in a long time.
 
2012-02-10 01:55:35 PM
Isn't this how Planet of the Apes started?
 
2012-02-10 01:56:52 PM
*sighs* only 10 years too late for grandma.
 
2012-02-10 01:59:24 PM
Who the hell cares if mice have Alzheimer's?
 
2012-02-10 02:00:01 PM
again?

Link (new window)
 
2012-02-10 02:00:39 PM
Good thing, 'cause we've been having a problem around here with mice forgetting where they put their reading glasses.

/twelve years too late for mom
 
2012-02-10 02:00:57 PM
I wonder how you "reverse" Alzheimer's. Once tissue d neurons die, so do the memories they held. I understand that memory is not a single bit of info but te replay of intertwined elements so there is some redundancy.

Additionally I wonder that if I had a clause in my will stating that I'd volunteer for early drug trials while too far gone to directly consent but do so through my trustee speaking for me if it would be held up in court.

If ever in a terminal disease situation where huge pain and grief wold hit my family, I already ave a "way out plan" that's not messy and traumatic. I hope never to use it.
 
2012-02-10 02:01:13 PM
Either we've done this before (new window) or I've had Alzhiemers and am recovering from it....
 
2012-02-10 02:01:16 PM
Wasn't this already....oh I get it.

Did you hear there's a drug designed to fight cancer reverses Alzheimer's in mice?
 
2012-02-10 02:06:02 PM
Dinodork: again?

Link (new window)


Maybe Subby has Alzheimer's.
 
2012-02-10 02:06:04 PM
Wasn't there some Athlete's Foot medication in the UK that did something similar?

Here it is. (new window)

/no longer protected by a patent, either
 
2012-02-10 02:06:35 PM
Do we have a cure for mice, yet?
 
2012-02-10 02:07:56 PM
ThisKidsAlright: Wasn't this already....oh I get it.

Did you hear there's a drug designed to fight cancer reverses Alzheimer's in mice?


Yeah, but you won't forget that you have cancer, so there's that.

/ Circle of Life Fark
 
2012-02-10 02:11:27 PM
clearly white mice cause cancer
 
2012-02-10 02:14:53 PM
Algernon?
 
2012-02-10 02:15:30 PM
dj1s: Do we have a cure for mice, yet?

Caturday.
 
2012-02-10 02:18:23 PM
Chemotherapy seems to affect ones memory and speech. My wife got dosed up with cisplatin years ago and she still has problems with that. Wonder if one day this might help.
 
2012-02-10 02:21:03 PM
Joe boater: Chemotherapy seems to affect ones memory and speech. My wife got dosed up with cisplatin years ago and she still has problems with that. Wonder if one day this might help.

Sadly that could only be the case if Chemotherapy caused plaque to build up in her brain. So this particular drug doesn't seem to be what you've been hoping for.

But I'm VERY optimistic about medicine in the future and I hope you are too.
 
2012-02-10 02:21:04 PM
How'd they figure out the mouse had Alzheimers? Did the mouse's grandmouse say that nanna accused him of stealing her shower cap?

/ no granny, I didn't take your shower cap
 
2012-02-10 02:24:08 PM
Balchinian: Who the hell cares if mice have Alzheimer's?


I forget.
 
2012-02-10 02:26:06 PM
I, for one, think we were all safer when the mice couldn't remember what was the same thing they did every night.
 
2012-02-10 02:26:45 PM
Leeds: Algernon?

Came for Charly, leaving satisfied.

www.filmbuffonline.com
/four months late for him
 
2012-02-10 02:27:02 PM
Viagra was also developed initially as a drug to fight hypertension but... screw hypertension, it gives boners.
 
2012-02-10 02:28:13 PM
Hurry up, we gotta save Pratchett.

upload.wikimedia.org

Loosing you mind has to be a terrible way to go.
 
2012-02-10 02:28:19 PM
I feel like the "still no cure for cancer" meme was invented for a moment like this.
 
2012-02-10 02:32:01 PM
*Smug comment
 
2012-02-10 02:32:19 PM
lohphat: I wonder how you "reverse" Alzheimer's. Once tissue d neurons die, so do the memories they held. I understand that memory is not a single bit of info but te replay of intertwined elements so there is some redundancy.

Additionally I wonder that if I had a clause in my will stating that I'd volunteer for early drug trials while too far gone to directly consent but do so through my trustee speaking for me if it would be held up in court.

If ever in a terminal disease situation where huge pain and grief wold hit my family, I already ave a "way out plan" that's not messy and traumatic. I hope never to use it.


Would you be willing to share it? I need an advanced directive, and could use some ideas.
 
2012-02-10 02:36:46 PM
How do they GIVE alzheimer's to mice?
 
2012-02-10 02:36:47 PM
Leeds: Joe boater: Chemotherapy seems to affect ones memory and speech. My wife got dosed up with cisplatin years ago and she still has problems with that. Wonder if one day this might help.

Sadly that could only be the case if Chemotherapy caused plaque to build up in her brain. So this particular drug doesn't seem to be what you've been hoping for.

But I'm VERY optimistic about medicine in the future and I hope you are too.


Oh, I am very happy and excited about the advances in cancer research. Things have come along way in the 7 years since my wife was treated for it. One day soon I expect doctors will be telling some cancer patients "take two of these and call me in the morning". No more IV's, needles, heavy metals and radiation.
 
2012-02-10 02:37:27 PM
well as I said in the earlier thread. excitement should always be tempered since we can perform all sorts of miraculous feats in mice that we can't do in humans, but yikes, this research is really amazing


Actual Grown-up version (abstract with link to full text if you have a subscrip)
 
2012-02-10 02:38:50 PM
id10ts: How do they GIVE alzheimer's to mice?

they genetically engineer mice that are missing the protein that clears away the evil plaque. it is far from a perfect simulation for the illness, and it may be more similar to early onset Alzheimers (which TP has)
 
2012-02-10 02:46:17 PM
beaverfetus: id10ts: How do they GIVE alzheimer's to mice?

they genetically engineer mice that are missing the protein that clears away the evil plaque. it is far from a perfect simulation for the illness, and it may be more similar to early onset Alzheimers (which TP has)


Er, I'm not a neurobio person, nor am I a mouse person but my assumption is the mouse strain they used (APPswe/PS1Δe9 (APP/PS1)) overexpresses the precursor to the "evil plaque."
 
2012-02-10 02:46:40 PM
There once was this country mouse with Alzheimer. His cousin, a city mouse with cancer told him "Come to the city. You'll love it here."

The country mouse with Alzheimer went to the city and lived with his cousin, The country mouse with Alzheimer was amazed at the huge buildings, the cars and all the people. How could a poor mouse survive in such a place? He couldn't sleep at night because of the noise.

His cousin tried to show him how to hunt for food. The country mouse with Alzheimer was amazed. "In the country, food is everywhere. In the barn, in the house, even in the field. Why would a poor mouse want to live where he's scrounging garbage bins for scraps?

Disgusted, the country mouse with Alzheimer left the city to go home to his quiet little place on the farm. But before he left, he told the city mouse with cancer, "You should come to the country. See how nice it is to live in peace and quiet and enjoy an abundance of foods."

Sadly, the country mouse with Alzheimer forgot how to get to his home. They found him at an Native American Bingo Parlor. Since he had lost his wallet, they had no idea who he was and placed him in a nursing home where he died.

Unaware of the previous paragraph, the city mouse with Cancer went to the country. He was amazed at the amount of food that was available and how quiet it was. He was investigating the farm house when he was chased by a vicious cat. He had to run and run and run to escape. "Never in the big city did I ever have to face a horrible cat" cried the city mouse. That night, even though it was very quiet, the city mouse with Cancer could not sleep. He was afraid the cat would get him.

The next day, his Cancer came out of remission and he rushed himself to the country hospital. Because it was a country hospital, they did not stock his expensive anti cancer meds nor would they accept his PPO because of the Out of Pocket Expenses and he died.

The End

/try reading it in Christopher Walken's voice.
 
2012-02-10 02:50:14 PM
id10ts: How do they GIVE alzheimer's to mice?

beaverfetus: they genetically engineer mice that are missing the protein that clears away the evil plaque. it is far from a perfect simulation for the illness, and it may be more similar to early onset Alzheimers (which TP has)


There are also studies showing that it may be transmissible, or at least inducible following inoculation with Aβ or tau in susceptible mice.
 
2012-02-10 02:50:53 PM
Ellamenopea:
Would you be willing to share it? I need an advanced directive, and could use some ideas.


No. Because I learned it via a close friend using it for depression-related suicide. I'll only discuss it with thse I personally know are of sound mind not to misuse it.

Suffice to say, it's abundant and not a controlled substance or traumatic injury related.
 
2012-02-10 02:52:39 PM
id10ts: How do they GIVE alzheimer's to mice?

Make them watch Fox News.
 
2012-02-10 02:52:56 PM
lohphat: Suffice to say, it's abundant and not a controlled substance or traumatic injury related.

Dihydrogen monoxide? I knew it.
 
2012-02-10 02:57:42 PM
lennavan: beaverfetus: id10ts: How do they GIVE alzheimer's to mice?

they genetically engineer mice that are missing the protein that clears away the evil plaque. it is far from a perfect simulation for the illness, and it may be more similar to early onset Alzheimers (which TP has)

Er, I'm not a neurobio person, nor am I a mouse person but my assumption is the mouse strain they used (APPswe/PS1Δe9 (APP/PS1)) overexpresses the precursor to the "evil plaque."


nahhh i think it under expresses a protein used to cleave the precursor to the evil plaque

make sense?

i'm not 100% sure, but I don't feel like reading this in detail
 
2012-02-10 03:02:11 PM
now for a really interesting question:

what happened to human beings that already have had this drug who have alzheimers disease? AD is common, cancer is common. I'm sure there are patients that have received bexarotene who have AD...
 
2012-02-10 03:07:21 PM
K.B.O. Winston: Wasn't there some Athlete's Foot medication in the UK that did something similar?

Here it is. (new window)

/no longer protected by a patent, either


no patent = no money = happy dying a miserable death
 
2012-02-10 03:11:11 PM
An Alzheimer's cure would excite me a lot more than a cancer cure. Although I suppose that's because (obviously) there are many kinds of cancer that can be treated, while there isn't a helluva lot that can be done for Alzheimer's right now.
 
2012-02-10 03:13:15 PM
lohphat: I wonder how you "reverse" Alzheimer's. Once tissue d neurons die, so do the memories they held. I understand that memory is not a single bit of info but te replay of intertwined elements so there is some redundancy.

It's been a long time since I looked into this disease in detail; last I heard, we know very little about the mechanism by which Alzheimer's does its nasty work. Perhaps the underlying cellular patterns aren't heavily damaged, but the buildup of tangles and plaques act as inhibitors to the orderly flow of neurochemical activity and make the memories impossible to retrieve? Someone with actual medical training could (I hope) hop in and clear that up.

If ever in a terminal disease situation where huge pain and grief wold hit my family, I already ave a "way out plan" that's not messy and traumatic. I hope never to use it.

Make sure your life insurance company doesn't find out, and you're all set. They'll use suicide as an excuse to yank your coverage, and "I have a plan" can count as suicide to an actuarial.
 
2012-02-10 03:15:24 PM
beaverfetus: what happened to human beings that already have had this drug who have alzheimers disease? AD is common, cancer is common. I'm sure there are patients that have received bexarotene who have AD...

That's a good point. Why isn't there some doctor somewhere going, "Um, hey, guys? My patient's Alzheimer's just cleared up."
 
2012-02-10 03:18:04 PM
Quick Fixer: t's been a long time since I looked into this disease in detail; last I heard, we know very little about the mechanism by which Alzheimer's does its nasty work. Perhaps the underlying cellular patterns aren't heavily damaged, but the buildup of tangles and plaques act as inhibitors to the orderly flow of neurochemical activity and make the memories impossible to retrieve? Someone with actual medical training could (I hope) hop in and clear that up.

not my specialty but I think you are right about us not knowing about the exact mechanism of cognitive deficit. It is certainly more than just neuronal loss. I think they are increasingly thinking that circulating intraplasma (non desposited) levels of AB protein actually in part cause issues, which is why there has been some success with antibody treatments etc.
 
2012-02-10 03:18:34 PM
Where are the nanobots? Little army of microscopic robots that can scrub your arteries, colon, and brain.
 
2012-02-10 03:18:50 PM
Quick Fixer: Make sure your life insurance company doesn't find out, and you're all set. They'll use suicide as an excuse to yank your coverage, and "I have a plan" can count as suicide to an actuarial.

It's not in writing -- only a group of close friends know.
 
2012-02-10 03:19:42 PM
K.B.O. Winston: Wasn't there some Athlete's Foot medication in the UK that did something similar?


I dunno Brain. How are we gonna convince Granny to rub her feet on 'er brain?
 
2012-02-10 03:21:50 PM
beaverfetus: nahhh i think it under expresses a protein used to cleave the precursor to the evil plaque

make sense?

i'm not 100% sure, but I don't feel like reading this in detail


I'm actually not clear on how you would "underexpress" something. I've heard misexpress and overexpress but not underexpress.

APP is the precursor to the evil plaque Link (new window)

And PS1 promotes the cleavage of APP into the evil plaque. Link (new window)

So rather than give the mouse the plaque itself, you give the mouse the things that make the plaque. Anyway, these were my assumptions based on the genotype APPswe/PS1Δe9 (APP/PS1) and I'm going off of what I recall from the handful of alzheimer related talks I've seen.

But like you, I guess I'm too lazy to sift through other pubmed articles to figure it out. Since it's published, in Science, I'm sure it's a standard model.
 
2012-02-10 03:45:00 PM
Andulamb: beaverfetus: what happened to human beings that already have had this drug who have alzheimers disease? AD is common, cancer is common. I'm sure there are patients that have received bexarotene who have AD...

That's a good point. Why isn't there some doctor somewhere going, "Um, hey, guys? My patient's Alzheimer's just cleared up."


This is actually covered in TFA.
 
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