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(Science Daily) Interesting Scientists find sixth nucleotide especially common in brain. Search continues for Sixth Beatle   (sciencedaily.com) divider line 14
More: Interesting, nucleotides, DNA, X chromosomes, postdoctoral fellow, Nature Neuroscience, human genetics, Scientists discover, University of Wisconsin-Madison  
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1327 clicks; posted to Geek » on 01 Nov 2011 at 2:11 PM   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»   |    Get this fabulous T-Shirt and impress the methane out of your friends! shirt it!



14 Comments   (+0 »)
   
 
Rent is too damn high
2011-11-01 02:17:09 PM
woa.
 
natmar_76
2011-11-01 02:41:57 PM
This is big, like Kim Kardashian's disgusting floppy ass big.
 
warren marshall
2011-11-01 03:36:58 PM
I just took a molecular biology course and we only went over 5 nucleotides, one of which isn't found in DNA. So which is the fifth? Just methylated cytosine?
 
Rent is too damn high
2011-11-01 03:56:08 PM
warren marshall: I just took a molecular biology course and we only went over 5 nucleotides, one of which isn't found in DNA. So which is the fifth? Just methylated cytosine?

Do you mean uracil?
 
warren marshall
2011-11-01 04:01:51 PM
Uracil is a RNA nucleotide; it's not found in DNA (replaced by thymine) .

But in the article they said their "sixth" nucleotide is 5-hydroxymethylcytosine. So I'm wondering if the fifth the dehydroxylated version.
 
Rent is too damn high
2011-11-01 04:06:46 PM
warren marshall: Uracil is a RNA nucleotide; it's not found in DNA (replaced by thymine) .

But in the article they said their "sixth" nucleotide is 5-hydroxymethylcytosine. So I'm wondering if the fifth the dehydroxylated version.

Oh, now I know what you mean. Yes I think it's referring to 5-methylcytosine.
 
Doc Daneeka
2011-11-01 05:08:04 PM
It's not "a new base." It's just modified cytosine.

5-hmC resembles 5-methylcytosine (5-mC), another modified DNA base that scientists have been studying for decades.

We've known for a long time that DNA can be epigenetically modified by methylation. All this new finding is is a slightly different modification.
 
gruntmints
2011-11-01 06:40:08 PM
Peptide cake, anyone?

1.bp.blogspot.com
 
theorellior [TotalFark]
2011-11-01 07:01:40 PM
gruntmints: Peptide cake, anyone?

With mint frosting.
 
gruntmints
2011-11-01 08:31:05 PM
theorellior: gruntmints: Peptide cake, anyone?

With mint frosting.

You are my new best friend.
 
gozar_the_destroyer
2011-11-01 10:30:56 PM
theorellior: gruntmints: Peptide cake, anyone?

With mint frosting.

(ring...ring)
 
Chameleon [TotalFark]
2011-11-01 11:04:18 PM
Rent is too damn high: warren marshall: Uracil is a RNA nucleotide; it's not found in DNA (replaced by thymine) .

But in the article they said their "sixth" nucleotide is 5-hydroxymethylcytosine. So I'm wondering if the fifth the dehydroxylated version.

Oh, now I know what you mean. Yes I think it's referring to 5-methylcytosine.

Inosine, would be my guess. Also, uracil is still a nucleotide, just not a deoxynucleotide.
 
Silly_Sot
2011-11-02 01:06:44 AM
The actual interesting thing about 5hmC is that it may be an intermediate stage in demethylation. We've not found a specific C-demethylase enzyme, so the 5hmC step may be the missing piece.
 
Rent is too damn high
2011-11-02 03:07:36 AM
Chameleon: Rent is too damn high: warren marshall: Uracil is a RNA nucleotide; it's not found in DNA (replaced by thymine) .

But in the article they said their "sixth" nucleotide is 5-hydroxymethylcytosine. So I'm wondering if the fifth the dehydroxylated version.

Oh, now I know what you mean. Yes I think it's referring to 5-methylcytosine.

Inosine, would be my guess. Also, uracil is still a nucleotide, just not a deoxynucleotide.

Link (new window)
Looking it up there's obviously more than 5 or even 6 nucleobases. Also uracil isn't a nucleotide but a nucleobase. Uridine monophosphate is a nucleotide.
 
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