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(AP)   In clinical trials of asthma patients taking Singulair, the most common side effects were headache, flu, abdominal pain, cough and suicide   (hosted.ap.org) divider line 107
    More: Scary  
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5187 clicks; posted to Main » on 28 Mar 2008 at 9:50 AM (6 years ago)   |  Favorite    |   share:  Share on Twitter share via Email Share on Facebook   more»



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2008-03-28 10:24:22 AM
loki see loki do: No cake?


img99.imageshack.us
 
2008-03-28 10:24:38 AM
KidKorporate: My little sister is on singulair and she started cutting herself a couple of years ago. A link? Or is she just emo?

WARNING: Singulair mays cause emoitus.
 
2008-03-28 10:25:07 AM
kcjoiner: CelticFrost: Albuterol for me thanks.

Btw, I do find it quite retarded that they get scared when a 'handful' of cases might be attributed to this drug. How many hundreds of thousands of people take it with no problems whatsoever/?!?!? EFF THEM WHO CANT HANDLE IT!ARGHHHHHHHHHHHHHHHHH H!O#UHOI#!HRIO!#RHOH!#R#

Albuterol is banned as of Dec. 31, 2008.
Link (new window)


You should have read your own link. Albuterol will still be available, just that the products containing CFCs will be banned. Non-CFC albuterol inhalers will still exist.

From your link:

This final rule goes into effect in about 40 months, and even when in effect, will not mean that albuterol MDIs will no longer be available, just that they will change.
 
2008-03-28 10:25:20 AM
my cell phone carrier makes me feel that way too.

oh, we aren't talking about Cingular? my bad.
 
2008-03-28 10:26:15 AM
SuperTramp: I do not understand this increase in asthma.

What's with the five year break in your chart?
 
2008-03-28 10:26:37 AM
Researcher guy: So, what's the update on subject 6329?

Researcher gal: Dead, RG.

Researcher guy: Really? Huh. Statistically significant?

Researcher gal: No, of course not. Subject 6329 was 80 year old asthmatic stuntman, died farking three ex-Romanian gymnasts call girls. One of them had her legs wrapped around his throat. That's the way he rolled.

Researcher guy: Well, put it on the label, but leave out the bit about the gymnasts. Don't want to leave ourselves open to a lawsuit.

Researcher gal: Wanna fark?
 
2008-03-28 10:27:04 AM
I tried Singular for a while ... caused muscular spasms in my arm. I've known other people who have had this side effect, and easy bruising as well.

Dropped the Singular and the spasms went away. I'm on the good ol' inhaled steroid Qvar now, and it's a lot better.
 
2008-03-28 10:27:43 AM
Damn pharma's. I'm an allergy sufferer too. I used to take albueteral but then there was that whole thing with cfc's. The new one sucks. It pisses me off that they stopped making it with CFC's. I liked the cfc one. It tasted much better and was 10X's more effective. (The new one makes my mouth taste like ass.)
I liked the effedra based meds for a while. They were very effective in regulating the old asthma, but they had that nice side effect of heart attack and they took them off the market because of meth. I think.
So then I was prescribed Singulair. It's randomly effective. I kinda feel like my asthma would build a tolerance to it. Coming off it sucks, because the asthma gets worse for a period of time. And I think I did notice the suicidal stuff. In hindsight it was sort of like low impulse control combined with a little extra bit of quick emotional reaction.
Haven't refilled my prescription for it in two months. Now.

That is all.
 
2008-03-28 10:27:52 AM
FTA
George Philip, director of research and product development. "But because suicide is a life-threatening event we thought it was important to provide this information in the product label."

Really? Why do I think this person has a PhD?
 
2008-03-28 10:28:52 AM
What? No anal leakage?

Yeah, I'm on Singular also.
I have no issues with Singular.

But don't get me started on how Albuteral was removed from the market because of CDC's and is now Proventil and how horribly ineffective Proventil now is. Grrr...wheeeze.... grrrrr.
 
2008-03-28 10:29:24 AM
Wrong_Intentions: barjockey: Wrong_Intentions: Kids who need inhalers are fun to pick on. Stupid little wimps who can't breathe on their own! All that nerdy weezing is hilarious! Although it does kinda suck if their now committing suicide because of this. I wonder why they'd feel that bad about themselves?

Maybe in a few years, when you turn 13, you won't feel this way. And you'll notice hair in funny places. And you won't think girls are grody anymore.

I was being a little bit sarcastic there, pal. Didn't include that fact in the post 'cause I thought it might be kinda obvious.


This is Fark. The obvious is obviously never obvious.

/sorry
 
2008-03-28 10:30:09 AM
JeffTL: caused muscular spasms in my arm

I had those spasms too, I thought I was getting old and twitcher. I worried that it was the early stages of Parkinsons or something. Damn it.
 
2008-03-28 10:31:18 AM
kcjoiner: Albuterol is banned as of Dec. 31, 2008.
Link (new window)


Actually, that's just the CFC version...they already have a new albuterol that does not use CFCs, the particles are smaller, and it is all around a better product to use and for the environment.

/takes singulair and albuterol
//works in medical education
///laughs at people who get medical info from the local news or TODAY (aka fear-enducing ratings whores)
 
2008-03-28 10:32:59 AM
barjockey: This is Fark. The obvious is obviously never obvious.
/sorry


It's cool. I consider it actually to be kind off an honor to have a Farker think I've 'crossed the line' on what's acceptable in terms of being an asshole. On this site, the bar is raised pretty damn high.
 
2008-03-28 10:33:09 AM
Tom_Thump: cubsfan07: Coma and death

Could be worse.


The condition known as hotdog fingers, children born with the head of a golden retriever, possession by the Prince of Darkness? That sort of thing?

/What was that from? I'd like to get a clip of it.
 
2008-03-28 10:38:55 AM
LowPlainsDrifter Please refrain from future rational posts in the future in order to avoid going over your meted allowance.

img145.imageshack.us
 
2008-03-28 10:39:48 AM
SuperTramp: I do not understand this increase in asthma.

W's fault, obviously.
 
2008-03-28 10:43:38 AM
Great, they are going to Ban Albuterol so now I will Just die in Kickboxing from an asthma attack. DAMN THE MAN .
 
2008-03-28 10:47:17 AM
Singulair works fine since I started taking it... Advair on the other hand... Advair almost caused a divorce in this household due to the depression and for lack of a better term "roid rage" it gave me. 3 weeks on and my mood and everything completely changed. 3 days off and i was back to what my wife calls normal.
 
2008-03-28 10:47:29 AM
Geotpf: kcjoiner: CelticFrost: Albuterol for me thanks.

Btw, I do find it quite retarded that they get scared when a 'handful' of cases might be attributed to this drug. How many hundreds of thousands of people take it with no problems whatsoever/?!?!? EFF THEM WHO CANT HANDLE IT!ARGHHHHHHHHHHHHHHHHH H!O#UHOI#!HRIO!#RHOH!#R#

Albuterol is banned as of Dec. 31, 2008.
Link (new window)

You should have read your own link. Albuterol will still be available, just that the products containing CFCs will be banned. Non-CFC albuterol inhalers will still exist.

From your link:

This final rule goes into effect in about 40 months, and even when in effect, will not mean that albuterol MDIs will no longer be available, just that they will change.


I didn't mean the actual medication itself, I meant the CFC-based albuterol inhaler. Due to this ban there is no generic alternative anymore. All available inhalers are branded now. Which means they are all much more expensive, not to mention less effective. Seems like a cash grab from the pharmaceutical companies to me. Here is some more info.


Asthma's New Expense (new window)

CFC ban will double albuterol inhaler market in US (new window)
 
2008-03-28 10:47:37 AM
I'm a Pharmacy Technician at our local pharmacy and I have never heard of any of my customers want to commit suicide.
 
2008-03-28 10:49:55 AM
However extreme, this does not surprise me as every year about this time I have to decide on a daily basis whether I'm going to endure being a jabberwocky from sneezing literally hundreds of times and dripping nastiness from my nose and mouth or if I'm going to play Requiem for a Dream with some allergy medicine with ephedrine. The worst is when the allergy medicine doesn't work but still gives you the crazy side effects to complement your already miserable state.
 
2008-03-28 10:51:17 AM
kcjoiner: I didn't mean the actual medication itself, I meant the CFC-based albuterol inhaler. Due to this ban there is no generic alternative anymore. All available inhalers are branded now. Which means they are all much more expensive, not to mention less effective. Seems like a cash grab from the pharmaceutical companies to me. Here is some more info.

Why do you hate the environment? Just because you want to breathe without spending an arm and a leg doesn't mean you should be so callous about the OZONE!

/*sarcasm*
 
2008-03-28 10:51:42 AM
Caturday Lover: I'm a Pharmacy Technician at our local pharmacy and I have never heard of any of my customers want to commit suicide.

They're the ones who stop coming back for refills.
 
2008-03-28 10:53:22 AM
barjockey
My wife has MS, her doctors have been trying desperately for years to put her on Tysabri - the MS *WONDER* drug where side effects include: dry mouth, constipation, headaches, DEATH, dizziness, nausea...

Yawn. Those are typical anticholinergic side effects. You just happened to read the label on tysabri. Ever taken ibuprofin? The *WONDER* drug where the side effects include: nausea, dyspepsia, gastrointestinal ulceration/bleeding, raised liver enzymes, diarrhea, epistaxis, headache, dizziness, unexplained rash, salt and fluid retention, hypertension, esophageal ulceration, heart failure, hyperkalaemia, renal impairment, confusion, bronchospasm, rash, Stevens-Johnson syndrome, or even death? WELL, HAVE YOU?

Her doctors are itching for that sweet sweet kick-back even if it costs her her life. The same goes for all of us. The pharmaceutical industry has a vested interest in keeping you sick - and if it causes a new condition - SWEET! They'll invent some more loaded snake-oil for that as well.

Except no. Kickbacks are illegal. More than likely your wife's doctors have read the literature and made the best decision they could. Medicine is a game of odds, usually between the potential adverse effects of the treatment vs. the potential adverse effects of no treatment. If the risk / benefit ratio of treatment is lower than that of no treatment, it is the medical (and legal) standard to recommend treatment, period. It is malpractice to do otherwise. Obviously in your wife's case the physician(s) felt pharmacological intervention was the safest way to go -- even considering the side-effects (risk of PML is about 1/1000).

Anyway, her strict diet, excercise, and supplements have kept her in a long-term state of remission for around 5-6 years now. She walks perfectly, and has full control over her motor skills, etc. No prescription drugs needed.

I'm glad she is doing well, but remember that correlation != causation.
 
2008-03-28 10:56:43 AM
ksatori: kcjoiner: I didn't mean the actual medication itself, I meant the CFC-based albuterol inhaler. Due to this ban there is no generic alternative anymore. All available inhalers are branded now. Which means they are all much more expensive, not to mention less effective. Seems like a cash grab from the pharmaceutical companies to me. Here is some more info.

Why do you hate the environment?

/*sarcasm*


I'm a republican...lol
 
2008-03-28 10:57:39 AM
Seems like a cash grab from the pharmaceutical companies to me.

Thank the tree-huggers.
 
2008-03-28 10:59:13 AM
kcjoiner: I'm a republican...lol

Oh, ok then. Continue your tirade on mother earth. Then again, shouldn't you be supporting Big Pharma's love of money and power as well?

/Isn't generalization FUN?
//Liberal
///But wait, I indirectly work for pharma...does not compute!
 
2008-03-28 11:06:32 AM
Apparently this is true about a lot of allergy/asthma type medicines. My best friend was taking Zyrtec for allergies and asthma, and she became super-depressed, started cutting and taking drugs. She left home once and we didn't know where she went, but she turned up. When she went to a psychologist he asked what medicines she was taking, and she told him about the Zyrtec and he said that he had quite a few patients who were taking that and were severely depressed. When she stopped taking it, she was just fine. A friend's little sister is taking the same thing, and when I told her about the other girl, Rachel, she said she had noticed the same signs in her sister.
 
2008-03-28 11:09:14 AM
Man up, wheezy Nancy.
 
2008-03-28 11:10:16 AM
please explain how using the patented drug instead of the generic equiv will lower its efficacy.

if you use your inhaler more than 3 times a day you are abusing it anyway. Get some corticosteroids already.
 
2008-03-28 11:10:54 AM
AppleJack: However extreme, this does not surprise me as every year about this time I have to decide on a daily basis whether I'm going to endure being a jabberwocky from sneezing literally hundreds of times and dripping nastiness from my nose and mouth or if I'm going to play Requiem for a Dream with some allergy medicine with ephedrine. The worst is when the allergy medicine doesn't work but still gives you the crazy side effects to complement your already miserable state.

Hey AppleJack. I take this great prescription Nasal Spray. Veramyst. I'm usually not a whore for the pharm but that stuff has changed my life. I used to be the guy that sneezed all the time. I had to carry tissue with me where ever I went (Viva, cause it held the nose goblins the best and could be used more then 5 times). I sneezed on average about 5 times a day, more during certain seasons. I blew my nose probably 10 times a day. I take this stuff once a night now, and I almost never sneeze. Maybe once a week. And I only blow my nose nightly after taking a shower.

\Not a sales whore
\\Loves my no sneeze med.
 
2008-03-28 11:15:09 AM
Seems like a cash grab from the pharmaceutical companies to me.

Yeah, thanks to those Big Pharma tools at the ENVIRONMENTAL PROTECTION AGENCY. Seriously, they love President Bush at the EPA. That's why half the offices still hung pictures of President Clinton four years into Bush's term. Because they're tools of Big Pharma.

You know, it's funny how liberals know what's best for everyone, but then when it comes time to stand behind the effects of their decisions it's always the same "not my fault" tune. Maybe--look, I know it's hard to believe---rich, arrogant white kids don't have any clue how their "global warming" BS is going to affect poor communities. Not that they care in the first place.

I blame Bush.
 
2008-03-28 11:18:05 AM
Dangl1ng: Hey AppleJack. I take this great prescription Nasal Spray. Veramyst. I'm usually not a whore for the pharm but that stuff has changed my life. I used to be the guy that sneezed all the time. I had to carry tissue with me where ever I went (Viva, cause it held the nose goblins the best and could be used more then 5 times). I sneezed on average about 5 times a day, more during certain seasons. I blew my nose probably 10 times a day. I take this stuff once a night now, and I almost never sneeze. Maybe once a week. And I only blow my nose nightly after taking a shower.

\Not a sales whore
\\Loves my no sneeze med.


Hmm...maybe this is what I need. I have asthma and seasonal/indoor/animal allergies. I take benadryl every AM, singulair every night. I still sneeze and blow my nose all day...by 8 pm I can't breathe through my nose at all, really irritates the shiat out of those around me, not to mention myself.
 
2008-03-28 11:33:13 AM
They say 20 seconds in the California sunshine is too much these days, ever since we lost the Ozone layer.....But that was before Sunblock 5000.
Just apply a pint to your body and you're good for hours.

See you by the pool!

www.robocoparchive.com

Caution: use of Sunblock 5000 may cause skin cancer
 
2008-03-28 11:35:35 AM
kcjoiner: ksatori: kcjoiner: I didn't mean the actual medication itself, I meant the CFC-based albuterol inhaler. Due to this ban there is no generic alternative anymore. All available inhalers are branded now. Which means they are all much more expensive, not to mention less effective. Seems like a cash grab from the pharmaceutical companies to me. Here is some more info.

Why do you hate the environment?

/*sarcasm*

I'm a republican...lol


images.jupiterimages.com
lol indeed.
 
2008-03-28 11:41:10 AM
More reported cases with a rising population, better reporting stats and broader methods of communication. Who'd have thunk it?
 
2008-03-28 11:46:30 AM
I was prescribed an exotic antibiotic once (can't remember the name now) for which one of the officially listed side effects was "death". No kidding. It was listed that way on all the medical wedsites. "Side effects: Cramps, nausea, headache, death."

Not suicide, or cardiac arrest, or anything like that. Just "death". That was a little unnerving.
 
2008-03-28 11:56:39 AM
satchel13: We should just let the defectives commit suicide and remove the burden that they place on society. The world would be a much happier place.

Bob Cratchett called. He said you're needed back at the office.
 
2008-03-28 12:09:33 PM
mcsestretch: satchel13: We should just let the defectives commit suicide and remove the burden that they place on society. The world would be a much happier place.

Bob Cratchett called. He said you're needed back at the office.


Cratchett is a perfect example of the type of defective person that should commit suicide. All he does is whine about his wages and how hard it is to support his family. I didn't force him to fark his wife and produce Cratchett spawn that he can't support.
 
2008-03-28 12:12:34 PM
When I went to pick up a med that jumped in price from $10 copay to a $25 copay....
I had to use my inhaler.
 
KIA
2008-03-28 12:23:01 PM
My GF seems to think that my behavior has changed since I went on Singulair. I gained 50 lbs, can't sleep through the night, have no energy, and never get any better.

Of course, my asthma was in complete remission before I moved in to the house where she smoked for 15 years and had multiple cats.

But it's clearly my fault and when I want to discuss it, I'm a hypochondriac.
 
2008-03-28 12:27:01 PM
Will somebody please explain to me how the disease influenza can possibly be a side effect of a drug?
 
2008-03-28 12:38:00 PM
phew... dodged a bullet!
 
2008-03-28 12:50:29 PM
knitch: When I went to pick up a med that jumped in price from $10 copay to a $25 copay....
I had to use my inhaler.


Wow. I would love to be in that position.

My stupid insurance plan switched over to a HSA where you have a"bridge" once you empty our the HSA you have a $700 bridge where you have to pay the entire balance until the bridge is done, then you get "traditional" 80/20 PPO style coverage.

My wife is an asthmatic and is taking several asthma drugs (including Singulair ) and a couple of other other drugs including antidepressants. It took less than a month for us to go through the $700 bridge. I think it only too 3 drugs out of the lot to hit $700.

/strong supporter of insurance/prescription reform
 
2008-03-28 12:52:09 PM
ksatori: Hmm...maybe this is what I need. I have asthma and seasonal/indoor/animal allergies. I take benadryl every AM, singulair every night. I still sneeze and blow my nose all day...by 8 pm I can't breathe through my nose at all, really irritates the shiat out of those around me, not to mention myself.

Yeah, it's pretty awesome. I had to go to my allergy doc to get it prescribed. I don't know if a regular doc will prescribe it. My ex hated me because I always had tissue in my pockets and on the night stand. I used to blow my nose like a horn, really. I can honestly say it is one of the best things to happen to me.
Now, asthma wise, I still can't seem to get that under control. Meds seem to be effective for a period of time, eventually become less effective. Claritin, singuliar, zyertec, and symbicort. All work for a while. Currently my symbicort seems to be really effective, but I notice that it's duration is right up until the next dose is due. So I take it before bed, and if I wait until 10pm to take it, I start to have trouble breathing.

\ Asthma/allergies Suck.
 
2008-03-28 01:07:39 PM
blike: More than likely your wife's doctors have read the literature and made the best decision they could. Medicine is a game of odds, usually between the potential adverse effects of the treatment vs. the potential adverse effects of no treatment. If the risk / benefit ratio of treatment is lower than that of no treatment, it is the medical (and legal) standard to recommend treatment, period. It is malpractice to do otherwise. Obviously in your wife's case the physician(s) felt pharmacological intervention was the safest way to go -- even considering the side-effects (risk of PML is about 1/1000).

And that still doesn't always make it. The manufacturer took Bextra off the market, even though it was one of the few arthritis drugs that didn't stress your liver (too much anyway) because there were some reports of possible heart complications. Okay, so tell me that, and let me and my doctor decide if it applies in my case and we should change or not. Nope, just not going to sell it anymore. No further studies, no trials, no good replacement, nothing.
 
2008-03-28 01:31:00 PM
my wife is on 3 inhalers and a pill to help her breathe, and they are working wonders. Unfortunately the pill is Singulair and the one inhaler that doesn't cost more than a week's groceries is Albuterol.

Wonderful news, mate.
 
2008-03-28 01:58:13 PM
"But because suicide is a life-threatening event we thought it was important to provide this information in the product label.", said George Philip, director of research and product development.

Not at all understated, in my opinion.
 
2008-03-28 02:03:59 PM
huntercr:
My stupid insurance plan switched over to a HSA where you have a"bridge" once you empty our the HSA you have a $700 bridge where you have to pay the entire balance until the bridge is done, then you get "traditional" 80/20 PPO style coverage.

My wife is an asthmatic and is taking several asthma drugs (including Singulair ) and a couple of other other drugs including antidepressants. It took less than a month for us to go through the $700 bridge. I think it only too 3 drugs out of the lot to hit $700.

/strong supporter of insurance/prescription reform having someone else pay for my wife's prescriptions


FTFY
 
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